InvestigaÃÃo da aÃÃo central do timol em modelos comportamentais de ansiedade, depressÃo e convulsÃo em camundongos

Detalhes bibliográficos
Autor(a) principal: Mariana Lima Fernandes
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFC
Texto Completo: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10762
Resumo: Thymol (2-isopropyl-5-methyl-phenol) an isomer of Carvacrol. Present as large colorless crystals or white crystalline powder. It is a monoterpene essential oil extracted from various herbs, and the main component of the essential oil of rosemary-pepper (Lippia sidoides), constituting approximately 48% of its composition. This paper presents the behavioral actions of thymol in animal models of anxiety, depression, seizures and sedation, such as elevated plus maze (EPM), open field, rota rod, forced swim, tail suspension, seizure induced by pentylenetetrazol and pentobarbital-induced sleep time. Thymol was administered orally in male mice at doses of 25mg/kg and 50mg / kg. The results showed that thymol at both doses studied did cause muscula relaxament activits change locomotor activity on the test rota rod nor the number of crossings in the open field test, but reducedThe grooming was reduced with the administration of thymol in the open field test. At both doses studied LCE thymol increased all parameters observed suggesting a possible anxiolytic effect. Flumazenil, an antagonist of GABA / benzodiazepine, reversed this effect. In the test of sleep time induced by pentobarbital thymol not alter the latency but increased sleep duration. Although this test is sensitive to CNS depressant agents but is not specific for compounds which would interfere with the biotransformation of pentobarbital. In the test of pentylenetetrazol-induced seizures, thymol increased latency of seizure at the dose of 50mg/kg, however was not able to change the mortality of animals. Thymol showed antidepressant effect in the forced swim test and the tail suspension. This effect was reversed by pretreatment of animals with PCPA (a serotonin synthesis inhibitor), Prazosin and Yohimbine (adrenoreceptor antagonists), SCH23390 and Sulpiride (dopamine receptor antagonists). These results suggest that thymol shows anxiolytic effects probably associated with the GABAergic system and antidepressant effects associated with the serotonergic, noradrenergic and dopaminergic without causing sedation.
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spelling info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisInvestigaÃÃo da aÃÃo central do timol em modelos comportamentais de ansiedade, depressÃo e convulsÃo em camundongos2012-11-29Francisca ClÃa FlorenÃo de Sousa31636020372http://lattes.cnpq.br/1180465052181572Danielle MacÃdo Gaspar50160176387http://lattes.cnpq.br/1566937332957369Gisela Costa CamarÃo06001734372http://lattes.cnpq.br/881251533662289380764070363http://lattes.cnpq.br/6295544741163726Mariana Lima FernandesUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em FarmacologiaUFCBRAnxiety, Depression, ThymolFARMACOLOGIAThymol (2-isopropyl-5-methyl-phenol) an isomer of Carvacrol. Present as large colorless crystals or white crystalline powder. It is a monoterpene essential oil extracted from various herbs, and the main component of the essential oil of rosemary-pepper (Lippia sidoides), constituting approximately 48% of its composition. This paper presents the behavioral actions of thymol in animal models of anxiety, depression, seizures and sedation, such as elevated plus maze (EPM), open field, rota rod, forced swim, tail suspension, seizure induced by pentylenetetrazol and pentobarbital-induced sleep time. Thymol was administered orally in male mice at doses of 25mg/kg and 50mg / kg. The results showed that thymol at both doses studied did cause muscula relaxament activits change locomotor activity on the test rota rod nor the number of crossings in the open field test, but reducedThe grooming was reduced with the administration of thymol in the open field test. At both doses studied LCE thymol increased all parameters observed suggesting a possible anxiolytic effect. Flumazenil, an antagonist of GABA / benzodiazepine, reversed this effect. In the test of sleep time induced by pentobarbital thymol not alter the latency but increased sleep duration. Although this test is sensitive to CNS depressant agents but is not specific for compounds which would interfere with the biotransformation of pentobarbital. In the test of pentylenetetrazol-induced seizures, thymol increased latency of seizure at the dose of 50mg/kg, however was not able to change the mortality of animals. Thymol showed antidepressant effect in the forced swim test and the tail suspension. This effect was reversed by pretreatment of animals with PCPA (a serotonin synthesis inhibitor), Prazosin and Yohimbine (adrenoreceptor antagonists), SCH23390 and Sulpiride (dopamine receptor antagonists). These results suggest that thymol shows anxiolytic effects probably associated with the GABAergic system and antidepressant effects associated with the serotonergic, noradrenergic and dopaminergic without causing sedation.O Timol (2-isopropil-5-metil-fenol) um isÃmero do Carvacrol. Apresenta-se como cristal incolor grandes ou pà cristalino branco. à um monoterpeno extraÃdo do Ãleo essencial de diversas plantas aromÃticas, sendo o componente principal do Ãleo essencial do alecrim-pimenta (Lippia sidoides), constituindo aproximadamente 48% da sua composiÃÃo. Este trabalho avaliou as aÃÃes comportamentais do timol em modelos animais de ansiedade, depressÃo, convulsÃo e sedaÃÃo, tais como labirinto em cruz elevado (LCE), campo aberto, rota rod, nado forÃado, suspensÃo da cauda, convulsÃo induzida por pentilenotetrazol e tempo de sono induzido por pentobarbital. Timol foi administrado por via oral, em camundongos machos, em doses Ãnicas de 25mg/Kg ou 50 mg/Kg. Os resultados mostraram que o timol nas duas doses estudadas, nÃo causou efeito relaxante muscular no teste do rota Rod nem alterou o nÃmero de cruzamentos no teste do campo aberto, mas reduziu o grooming. No LCE ambas as doses estudadas do timol aumentaram todos os parÃmetros observados sugerindo um possÃvel efeito ansiolÃtico. O flumazenil, um antagonista dos receptores GABAA/BenzodiazepÃnico, reverteu este efeito. No teste do tempo de sono induzido por pentobarbital o timol nÃo alterou a latÃncia, mas aumentou a duraÃÃo do sono. Entretanto este teste embora sendo sensÃvel para agentes depressores do SNC nÃo à especÃfico pois compostos que possam interferir com a biotransformaÃÃo do pentobarbital. No teste da convulsÃo induzida por pentilenotetrazol, timol aumentou a latÃncia da convulsÃo na dose de 50mg/Kg, no entanto nÃo foi capaz de alterar a latÃncia de morte e a mortalidade dos animais. Timol apresentou efeito antidepressivo no teste do nado forÃado e da suspensÃo da cauda. Este efeito foi revertido pelo prÃ-tratamento dos animais com PCPA (um inibidor da sÃntese de serotonina), Prazosina e Ioimbina (antagonistas dos receptores adrenÃrgicos), SCH23390 e Sulpirida (antagonistas dos receptores dopaminÃrgicos). Estes resultados sugerem que o timol apresenta efeitos ansiolÃticos provavelmente relacionados com o sistema GABAÃrgico e efeitos antidepressivos associados aos sistemas serotonÃrgico, noradrenÃrgico e dopaminÃrgico sem causar sedaÃÃo. nÃo hÃhttp://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10762application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:23:54Zmail@mail.com -
dc.title.pt.fl_str_mv InvestigaÃÃo da aÃÃo central do timol em modelos comportamentais de ansiedade, depressÃo e convulsÃo em camundongos
title InvestigaÃÃo da aÃÃo central do timol em modelos comportamentais de ansiedade, depressÃo e convulsÃo em camundongos
spellingShingle InvestigaÃÃo da aÃÃo central do timol em modelos comportamentais de ansiedade, depressÃo e convulsÃo em camundongos
Mariana Lima Fernandes
Anxiety, Depression, Thymol
FARMACOLOGIA
title_short InvestigaÃÃo da aÃÃo central do timol em modelos comportamentais de ansiedade, depressÃo e convulsÃo em camundongos
title_full InvestigaÃÃo da aÃÃo central do timol em modelos comportamentais de ansiedade, depressÃo e convulsÃo em camundongos
title_fullStr InvestigaÃÃo da aÃÃo central do timol em modelos comportamentais de ansiedade, depressÃo e convulsÃo em camundongos
title_full_unstemmed InvestigaÃÃo da aÃÃo central do timol em modelos comportamentais de ansiedade, depressÃo e convulsÃo em camundongos
title_sort InvestigaÃÃo da aÃÃo central do timol em modelos comportamentais de ansiedade, depressÃo e convulsÃo em camundongos
author Mariana Lima Fernandes
author_facet Mariana Lima Fernandes
author_role author
dc.contributor.advisor1.fl_str_mv Francisca ClÃa FlorenÃo de Sousa
dc.contributor.advisor1ID.fl_str_mv 31636020372
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/1180465052181572
dc.contributor.referee1.fl_str_mv Danielle MacÃdo Gaspar
dc.contributor.referee1ID.fl_str_mv 50160176387
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/1566937332957369
dc.contributor.referee2.fl_str_mv Gisela Costa CamarÃo
dc.contributor.referee2ID.fl_str_mv 06001734372
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/8812515336622893
dc.contributor.authorID.fl_str_mv 80764070363
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/6295544741163726
dc.contributor.author.fl_str_mv Mariana Lima Fernandes
contributor_str_mv Francisca ClÃa FlorenÃo de Sousa
Danielle MacÃdo Gaspar
Gisela Costa CamarÃo
dc.subject.eng.fl_str_mv Anxiety, Depression, Thymol
topic Anxiety, Depression, Thymol
FARMACOLOGIA
dc.subject.cnpq.fl_str_mv FARMACOLOGIA
dc.description.sponsorship.fl_txt_mv nÃo hÃ
dc.description.abstract.por.fl_txt_mv Thymol (2-isopropyl-5-methyl-phenol) an isomer of Carvacrol. Present as large colorless crystals or white crystalline powder. It is a monoterpene essential oil extracted from various herbs, and the main component of the essential oil of rosemary-pepper (Lippia sidoides), constituting approximately 48% of its composition. This paper presents the behavioral actions of thymol in animal models of anxiety, depression, seizures and sedation, such as elevated plus maze (EPM), open field, rota rod, forced swim, tail suspension, seizure induced by pentylenetetrazol and pentobarbital-induced sleep time. Thymol was administered orally in male mice at doses of 25mg/kg and 50mg / kg. The results showed that thymol at both doses studied did cause muscula relaxament activits change locomotor activity on the test rota rod nor the number of crossings in the open field test, but reducedThe grooming was reduced with the administration of thymol in the open field test. At both doses studied LCE thymol increased all parameters observed suggesting a possible anxiolytic effect. Flumazenil, an antagonist of GABA / benzodiazepine, reversed this effect. In the test of sleep time induced by pentobarbital thymol not alter the latency but increased sleep duration. Although this test is sensitive to CNS depressant agents but is not specific for compounds which would interfere with the biotransformation of pentobarbital. In the test of pentylenetetrazol-induced seizures, thymol increased latency of seizure at the dose of 50mg/kg, however was not able to change the mortality of animals. Thymol showed antidepressant effect in the forced swim test and the tail suspension. This effect was reversed by pretreatment of animals with PCPA (a serotonin synthesis inhibitor), Prazosin and Yohimbine (adrenoreceptor antagonists), SCH23390 and Sulpiride (dopamine receptor antagonists). These results suggest that thymol shows anxiolytic effects probably associated with the GABAergic system and antidepressant effects associated with the serotonergic, noradrenergic and dopaminergic without causing sedation.
O Timol (2-isopropil-5-metil-fenol) um isÃmero do Carvacrol. Apresenta-se como cristal incolor grandes ou pà cristalino branco. à um monoterpeno extraÃdo do Ãleo essencial de diversas plantas aromÃticas, sendo o componente principal do Ãleo essencial do alecrim-pimenta (Lippia sidoides), constituindo aproximadamente 48% da sua composiÃÃo. Este trabalho avaliou as aÃÃes comportamentais do timol em modelos animais de ansiedade, depressÃo, convulsÃo e sedaÃÃo, tais como labirinto em cruz elevado (LCE), campo aberto, rota rod, nado forÃado, suspensÃo da cauda, convulsÃo induzida por pentilenotetrazol e tempo de sono induzido por pentobarbital. Timol foi administrado por via oral, em camundongos machos, em doses Ãnicas de 25mg/Kg ou 50 mg/Kg. Os resultados mostraram que o timol nas duas doses estudadas, nÃo causou efeito relaxante muscular no teste do rota Rod nem alterou o nÃmero de cruzamentos no teste do campo aberto, mas reduziu o grooming. No LCE ambas as doses estudadas do timol aumentaram todos os parÃmetros observados sugerindo um possÃvel efeito ansiolÃtico. O flumazenil, um antagonista dos receptores GABAA/BenzodiazepÃnico, reverteu este efeito. No teste do tempo de sono induzido por pentobarbital o timol nÃo alterou a latÃncia, mas aumentou a duraÃÃo do sono. Entretanto este teste embora sendo sensÃvel para agentes depressores do SNC nÃo à especÃfico pois compostos que possam interferir com a biotransformaÃÃo do pentobarbital. No teste da convulsÃo induzida por pentilenotetrazol, timol aumentou a latÃncia da convulsÃo na dose de 50mg/Kg, no entanto nÃo foi capaz de alterar a latÃncia de morte e a mortalidade dos animais. Timol apresentou efeito antidepressivo no teste do nado forÃado e da suspensÃo da cauda. Este efeito foi revertido pelo prÃ-tratamento dos animais com PCPA (um inibidor da sÃntese de serotonina), Prazosina e Ioimbina (antagonistas dos receptores adrenÃrgicos), SCH23390 e Sulpirida (antagonistas dos receptores dopaminÃrgicos). Estes resultados sugerem que o timol apresenta efeitos ansiolÃticos provavelmente relacionados com o sistema GABAÃrgico e efeitos antidepressivos associados aos sistemas serotonÃrgico, noradrenÃrgico e dopaminÃrgico sem causar sedaÃÃo.
description Thymol (2-isopropyl-5-methyl-phenol) an isomer of Carvacrol. Present as large colorless crystals or white crystalline powder. It is a monoterpene essential oil extracted from various herbs, and the main component of the essential oil of rosemary-pepper (Lippia sidoides), constituting approximately 48% of its composition. This paper presents the behavioral actions of thymol in animal models of anxiety, depression, seizures and sedation, such as elevated plus maze (EPM), open field, rota rod, forced swim, tail suspension, seizure induced by pentylenetetrazol and pentobarbital-induced sleep time. Thymol was administered orally in male mice at doses of 25mg/kg and 50mg / kg. The results showed that thymol at both doses studied did cause muscula relaxament activits change locomotor activity on the test rota rod nor the number of crossings in the open field test, but reducedThe grooming was reduced with the administration of thymol in the open field test. At both doses studied LCE thymol increased all parameters observed suggesting a possible anxiolytic effect. Flumazenil, an antagonist of GABA / benzodiazepine, reversed this effect. In the test of sleep time induced by pentobarbital thymol not alter the latency but increased sleep duration. Although this test is sensitive to CNS depressant agents but is not specific for compounds which would interfere with the biotransformation of pentobarbital. In the test of pentylenetetrazol-induced seizures, thymol increased latency of seizure at the dose of 50mg/kg, however was not able to change the mortality of animals. Thymol showed antidepressant effect in the forced swim test and the tail suspension. This effect was reversed by pretreatment of animals with PCPA (a serotonin synthesis inhibitor), Prazosin and Yohimbine (adrenoreceptor antagonists), SCH23390 and Sulpiride (dopamine receptor antagonists). These results suggest that thymol shows anxiolytic effects probably associated with the GABAergic system and antidepressant effects associated with the serotonergic, noradrenergic and dopaminergic without causing sedation.
publishDate 2012
dc.date.issued.fl_str_mv 2012-11-29
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dc.publisher.program.fl_str_mv Programa de PÃs-GraduaÃÃo em Farmacologia
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dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFC
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