Preconditioning with ternatina on myocardial infarction induced by isoproterenol in rats

Detalhes bibliográficos
Autor(a) principal: Carmelo Silveira Carneiro LeÃo Filho
Data de Publicação: 2011
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFC
Texto Completo: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8505
Resumo: Acute myocardial infarction (AMI) is one of the most common causes of death in our country. As population ages, such illness have its prevalence rates increased. In order to analyse drug effects over myocardial lesions as a result of AMI, the myocardial infarction induction model by means of the administration of isoproterenol in rats is one of the most used at all, given the capability of that substance of mimicking the myocardial injury observed in humans. In the present study, preconditioning with intra-peritoneal ternatin, at a dose of 1 mg/kg was used. Fourteen consecutive days were assessed in the isoproterenol-induced MI (120 mg/kg) in Wistar rats. Myocardial lesions induced by isoproterenol was indicated by the rise in biochemical markers levels, such as SGOT (serum glutamic oxaloacetic transaminase) and troponin I, reduction in the activity of catalase enzyme in the myocardial tissue, as well as by histopathological changes assessed in the apex of the left ventricle. It was also evaluated mortality rates, hemoglobin and SGPT (serum glutamic pyruvic transaminase) serum concentrations, leukocytes, neutrophils counts and renal function. Preconditioning with ternatin unveiled protective effects within the myocardial infarction induced by isoproterenol in rats, once it diminished mortality rates, attenuated SGOT and troponin I concentrations, preserved catalase levels in the myocardium and diminished histopathological changes in the apex of the left ventricle Possible pathways accountable for such good results, reducing the degree of myocardial injury in this experimental essay, might be related to the antioxidant properties attributable to ternatin.
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spelling info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisPreconditioning with ternatina on myocardial infarction induced by isoproterenol in ratsPrÃ-condicionamento com ternatina no infarto do miocÃrdio induzido por isoproterenol em ratos 2011-09-14Jose Glauco Lobo Filho07428278368Manoel Odorico de Moraes Filho04854543353http://lattes.cnpq.br/0701679734111287Mohammed Saad Lahlou00745857469http://lattes.cnpq.br/484677184756994566606730406Carmelo Silveira Carneiro LeÃo FilhoUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em CirurgiaUFCBRmyocardial infarction, isoproterenol, ternatinCIRURGIAAcute myocardial infarction (AMI) is one of the most common causes of death in our country. As population ages, such illness have its prevalence rates increased. In order to analyse drug effects over myocardial lesions as a result of AMI, the myocardial infarction induction model by means of the administration of isoproterenol in rats is one of the most used at all, given the capability of that substance of mimicking the myocardial injury observed in humans. In the present study, preconditioning with intra-peritoneal ternatin, at a dose of 1 mg/kg was used. Fourteen consecutive days were assessed in the isoproterenol-induced MI (120 mg/kg) in Wistar rats. Myocardial lesions induced by isoproterenol was indicated by the rise in biochemical markers levels, such as SGOT (serum glutamic oxaloacetic transaminase) and troponin I, reduction in the activity of catalase enzyme in the myocardial tissue, as well as by histopathological changes assessed in the apex of the left ventricle. It was also evaluated mortality rates, hemoglobin and SGPT (serum glutamic pyruvic transaminase) serum concentrations, leukocytes, neutrophils counts and renal function. Preconditioning with ternatin unveiled protective effects within the myocardial infarction induced by isoproterenol in rats, once it diminished mortality rates, attenuated SGOT and troponin I concentrations, preserved catalase levels in the myocardium and diminished histopathological changes in the apex of the left ventricle Possible pathways accountable for such good results, reducing the degree of myocardial injury in this experimental essay, might be related to the antioxidant properties attributable to ternatin.O infarto agudo do miocÃrdio (IAM) à uma das principais causas de morte em nosso paÃs. Com o envelhecimento da populaÃÃo a tendÃncia à que se aumente a incidÃncia desta afecÃÃo. Para se estudar efeitos de drogas sobre a lesÃo miocÃrdica decorrente de IAM, um dos modelos experimentais mais utilizados à a induÃÃo de infarto do mocÃrdio (IM) com administraÃÃo de isoproterenol em ratos, uma vez que esta substÃncia causa uma lesÃo miocÃrdica semelhante à observada em IAM nos humanos. Nesse estudo o prÃ-condicionamento com ternatina administrada por via intraperitoneal, na dose de 1 mg/kg do animal, por catorze dias consecutivos, foi avaliado no IM induzido por isoproterenol (120 mg/kg do animal) em ratos Wistar. A lesÃo miocÃrdica induzida pelo isoproterenol foi indicada pela elevaÃÃo de marcadores bioquÃmicos, como transaminase glutÃmico-oxalacÃtica (TGO) e troponina I, reduÃÃo da atividade da enzima catalase no tecido miocÃrdico, bem como por alteraÃÃes histopatolÃgicas avaliadas na regiÃo do Ãpice do ventrÃculo esquerdo. Avaliou-se ainda a mortalidade, as concentraÃÃes sÃricas de transaminase glutÃmico-pirÃvica (TGP), hemoglobina, contagem de leucÃcitos e neutrÃfilos e marcadores da funÃÃo renal. O prÃ-tratamento com ternatina apresentou efeitos protetores no infarto do miocÃrdio induzido por isoproterenol em ratos, uma vez que dimunuiu a taxa de mortalidade, atenuou as elevaÃÃes de TGO e troponina I; preservou a atividade da enzima catalase e reduziu o grau de alteraÃÃes histopatolÃgicas. PossÃveis mecanismos de aÃÃo responsÃveis pelos efeitos benÃficos em reduzir o grau de lesÃo miocÃrdica neste modelo experimental podem estar relacionados a propriedades antioxidantes da ternatina. CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superiorhttp://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=8505application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:21:32Zmail@mail.com -
dc.title.en.fl_str_mv Preconditioning with ternatina on myocardial infarction induced by isoproterenol in rats
dc.title.alternative.pt.fl_str_mv PrÃ-condicionamento com ternatina no infarto do miocÃrdio induzido por isoproterenol em ratos
title Preconditioning with ternatina on myocardial infarction induced by isoproterenol in rats
spellingShingle Preconditioning with ternatina on myocardial infarction induced by isoproterenol in rats
Carmelo Silveira Carneiro LeÃo Filho
myocardial infarction, isoproterenol, ternatin
CIRURGIA
title_short Preconditioning with ternatina on myocardial infarction induced by isoproterenol in rats
title_full Preconditioning with ternatina on myocardial infarction induced by isoproterenol in rats
title_fullStr Preconditioning with ternatina on myocardial infarction induced by isoproterenol in rats
title_full_unstemmed Preconditioning with ternatina on myocardial infarction induced by isoproterenol in rats
title_sort Preconditioning with ternatina on myocardial infarction induced by isoproterenol in rats
author Carmelo Silveira Carneiro LeÃo Filho
author_facet Carmelo Silveira Carneiro LeÃo Filho
author_role author
dc.contributor.advisor1.fl_str_mv Jose Glauco Lobo Filho
dc.contributor.advisor1ID.fl_str_mv 07428278368
dc.contributor.referee1.fl_str_mv Manoel Odorico de Moraes Filho
dc.contributor.referee1ID.fl_str_mv 04854543353
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/0701679734111287
dc.contributor.referee2.fl_str_mv Mohammed Saad Lahlou
dc.contributor.referee2ID.fl_str_mv 00745857469
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/4846771847569945
dc.contributor.authorID.fl_str_mv 66606730406
dc.contributor.author.fl_str_mv Carmelo Silveira Carneiro LeÃo Filho
contributor_str_mv Jose Glauco Lobo Filho
Manoel Odorico de Moraes Filho
Mohammed Saad Lahlou
dc.subject.eng.fl_str_mv myocardial infarction, isoproterenol, ternatin
topic myocardial infarction, isoproterenol, ternatin
CIRURGIA
dc.subject.cnpq.fl_str_mv CIRURGIA
dc.description.sponsorship.fl_txt_mv CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior
dc.description.abstract.por.fl_txt_mv Acute myocardial infarction (AMI) is one of the most common causes of death in our country. As population ages, such illness have its prevalence rates increased. In order to analyse drug effects over myocardial lesions as a result of AMI, the myocardial infarction induction model by means of the administration of isoproterenol in rats is one of the most used at all, given the capability of that substance of mimicking the myocardial injury observed in humans. In the present study, preconditioning with intra-peritoneal ternatin, at a dose of 1 mg/kg was used. Fourteen consecutive days were assessed in the isoproterenol-induced MI (120 mg/kg) in Wistar rats. Myocardial lesions induced by isoproterenol was indicated by the rise in biochemical markers levels, such as SGOT (serum glutamic oxaloacetic transaminase) and troponin I, reduction in the activity of catalase enzyme in the myocardial tissue, as well as by histopathological changes assessed in the apex of the left ventricle. It was also evaluated mortality rates, hemoglobin and SGPT (serum glutamic pyruvic transaminase) serum concentrations, leukocytes, neutrophils counts and renal function. Preconditioning with ternatin unveiled protective effects within the myocardial infarction induced by isoproterenol in rats, once it diminished mortality rates, attenuated SGOT and troponin I concentrations, preserved catalase levels in the myocardium and diminished histopathological changes in the apex of the left ventricle Possible pathways accountable for such good results, reducing the degree of myocardial injury in this experimental essay, might be related to the antioxidant properties attributable to ternatin.
O infarto agudo do miocÃrdio (IAM) à uma das principais causas de morte em nosso paÃs. Com o envelhecimento da populaÃÃo a tendÃncia à que se aumente a incidÃncia desta afecÃÃo. Para se estudar efeitos de drogas sobre a lesÃo miocÃrdica decorrente de IAM, um dos modelos experimentais mais utilizados à a induÃÃo de infarto do mocÃrdio (IM) com administraÃÃo de isoproterenol em ratos, uma vez que esta substÃncia causa uma lesÃo miocÃrdica semelhante à observada em IAM nos humanos. Nesse estudo o prÃ-condicionamento com ternatina administrada por via intraperitoneal, na dose de 1 mg/kg do animal, por catorze dias consecutivos, foi avaliado no IM induzido por isoproterenol (120 mg/kg do animal) em ratos Wistar. A lesÃo miocÃrdica induzida pelo isoproterenol foi indicada pela elevaÃÃo de marcadores bioquÃmicos, como transaminase glutÃmico-oxalacÃtica (TGO) e troponina I, reduÃÃo da atividade da enzima catalase no tecido miocÃrdico, bem como por alteraÃÃes histopatolÃgicas avaliadas na regiÃo do Ãpice do ventrÃculo esquerdo. Avaliou-se ainda a mortalidade, as concentraÃÃes sÃricas de transaminase glutÃmico-pirÃvica (TGP), hemoglobina, contagem de leucÃcitos e neutrÃfilos e marcadores da funÃÃo renal. O prÃ-tratamento com ternatina apresentou efeitos protetores no infarto do miocÃrdio induzido por isoproterenol em ratos, uma vez que dimunuiu a taxa de mortalidade, atenuou as elevaÃÃes de TGO e troponina I; preservou a atividade da enzima catalase e reduziu o grau de alteraÃÃes histopatolÃgicas. PossÃveis mecanismos de aÃÃo responsÃveis pelos efeitos benÃficos em reduzir o grau de lesÃo miocÃrdica neste modelo experimental podem estar relacionados a propriedades antioxidantes da ternatina.
description Acute myocardial infarction (AMI) is one of the most common causes of death in our country. As population ages, such illness have its prevalence rates increased. In order to analyse drug effects over myocardial lesions as a result of AMI, the myocardial infarction induction model by means of the administration of isoproterenol in rats is one of the most used at all, given the capability of that substance of mimicking the myocardial injury observed in humans. In the present study, preconditioning with intra-peritoneal ternatin, at a dose of 1 mg/kg was used. Fourteen consecutive days were assessed in the isoproterenol-induced MI (120 mg/kg) in Wistar rats. Myocardial lesions induced by isoproterenol was indicated by the rise in biochemical markers levels, such as SGOT (serum glutamic oxaloacetic transaminase) and troponin I, reduction in the activity of catalase enzyme in the myocardial tissue, as well as by histopathological changes assessed in the apex of the left ventricle. It was also evaluated mortality rates, hemoglobin and SGPT (serum glutamic pyruvic transaminase) serum concentrations, leukocytes, neutrophils counts and renal function. Preconditioning with ternatin unveiled protective effects within the myocardial infarction induced by isoproterenol in rats, once it diminished mortality rates, attenuated SGOT and troponin I concentrations, preserved catalase levels in the myocardium and diminished histopathological changes in the apex of the left ventricle Possible pathways accountable for such good results, reducing the degree of myocardial injury in this experimental essay, might be related to the antioxidant properties attributable to ternatin.
publishDate 2011
dc.date.issued.fl_str_mv 2011-09-14
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.publisher.program.fl_str_mv Programa de PÃs-GraduaÃÃo em Cirurgia
dc.publisher.initials.fl_str_mv UFC
dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFC
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instname_str Universidade Federal do Ceará
instacron_str UFC
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