AvaliaÃÃo da funÃÃo renal em pacientes com doenÃa pulmonar obstrutiva crÃnica atravÃs de biomarcadores

Detalhes bibliográficos
Autor(a) principal: Natalia Morais de Andrade
Data de Publicação: 2016
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFC
Texto Completo: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18971
Resumo: Chronic Obstructive Pulmonary Disease (COPD) is characterized by airflow obstruction caused by inhaling toxic particles and gases. Patients affected by COPD present many comorbidities, such as chronic kidney disease (CKD). Objective. To access renal function in patients with COPD through new biomarkers. Methodology. Was conducted a prospective study with 36 patients followed in two hospitals in the city of Fortaleza / CE - Brazil. General data and clinical trials and laboratory evaluation, assessment of renal function was estimated glomerular filtration rate (GFR) and new biomarkers were evaluation. Neutrophil gelatinase-associated lipocalin was quantified in blood and urine; Monocyte chemotactic protein (MCP-1) was quantified in urine and Galectin-3 was quantified in blood. Results. Changes in the values of GFR that showed higher in the COPD group than in the control group. Similar results were found with albumin values. Nevertheless, the figures showed no overt kidney damage. Evaluation of biomarkers only the MCP-1 and galectin-3 met with high levels in the study group. Association with renal dysfunction parameters (TFG) and pulmonary (FEV1) in COPD group, only galectin-3 showed a strong inverse association. Conclusion. COPD patients have a kidney disease diagnosed by the expression of biomarkers. Thus, the use of new biomarkers is of great importance for the diagnosis of subclinical or underdiagnosed CKD.
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spelling info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisAvaliaÃÃo da funÃÃo renal em pacientes com doenÃa pulmonar obstrutiva crÃnica atravÃs de biomarcadoresEvaluation of renal function in patients with chronic obstructive pulmonary disease using biomarkers2016-11-08Elizabeth de Francesco Daher18772919353http://lattes.cnpq.br/4855968398515646Alice Maria Costa Martins43431690300http://lattes.cnpq.br/7532334620264577Eanes Delgado Barros Pereira24731005353Daniela Gardano Bucharles Mont'Alverne94020337934http://lattes.cnpq.br/3584422771001181 Claudia Maria Costa de Oliveira20912080353http://lattes.cnpq.br/450002923834725401067188436http://lattes.cnpq.br/0026634750109652Natalia Morais de AndradeUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em CiÃncias MÃdicasUFCBRMEDICINA Chronic Obstructive Pulmonary Disease (COPD) is characterized by airflow obstruction caused by inhaling toxic particles and gases. Patients affected by COPD present many comorbidities, such as chronic kidney disease (CKD). Objective. To access renal function in patients with COPD through new biomarkers. Methodology. Was conducted a prospective study with 36 patients followed in two hospitals in the city of Fortaleza / CE - Brazil. General data and clinical trials and laboratory evaluation, assessment of renal function was estimated glomerular filtration rate (GFR) and new biomarkers were evaluation. Neutrophil gelatinase-associated lipocalin was quantified in blood and urine; Monocyte chemotactic protein (MCP-1) was quantified in urine and Galectin-3 was quantified in blood. Results. Changes in the values of GFR that showed higher in the COPD group than in the control group. Similar results were found with albumin values. Nevertheless, the figures showed no overt kidney damage. Evaluation of biomarkers only the MCP-1 and galectin-3 met with high levels in the study group. Association with renal dysfunction parameters (TFG) and pulmonary (FEV1) in COPD group, only galectin-3 showed a strong inverse association. Conclusion. COPD patients have a kidney disease diagnosed by the expression of biomarkers. Thus, the use of new biomarkers is of great importance for the diagnosis of subclinical or underdiagnosed CKD.A DoenÃa Pulmonar Obstrutiva CrÃnica (DPOC) à caracterizada por obstruÃÃo do fluxo aÃreo ocasionada pela inalaÃÃo de partÃculas e gases tÃxicos. Os pacientes acometidos pela DPOC apresentam muitas comorbidades evidentes bem como alteraÃÃes subdiagnosticadas como a doenÃa renal crÃnica. Objetivo. Avaliar a funÃÃo renal de pacientes com DPOC atravÃs de novos biomarcadores. Metodologia. Foi realizado um estudo prospectivo com 36 pacientes acompanhados em dois hospitais da cidade de Fortaleza/CE. Foram coletados dados gerais e clÃnicos dos participantes e realizadas avaliaÃÃo laboratorial geral, avaliaÃÃo da funÃÃo renal atravÃs do cÃlculoda Taxa de FiltraÃÃo Glomerular (TFG) e avaliaÃÃo de novos biomarcadores. A Lipocalina associada à gelatinase de neutrÃfilos (NGAL) foi quantificada no sangue e na urina; a ProteÃna QuimiotÃtica de MonÃcitos (MCP-1) foi quantificada na urina e a Galectina-3 foi quantificada no sangue. Resultados. Ocorreram alteraÃÃes nos valores da TFG que se apresentaram mais baixos no grupo DPOC do que no grupo controle. Resultado semelhante foi encontrado com os valores da albumina. Apesar disso, os valores nÃo demonstraram lesÃo renal evidente. Na avaliaÃÃo dos biomarcadores apenas o MCP-1 e a galectina-3 encontraram-se com os nÃveis mais elevados no grupo de estudo em relaÃÃo ao grupo controle. Jà na associaÃÃo com os parÃmetros de disfunÃÃo renal (TFG) e pulmonar (VEF1) nos grupo DPOC, apenas a galectina-3 mostrou uma correlaÃÃo inversa significativa com TFG e VEF1. ConclusÃo. Pacientes com DPOC apresentam uma doenÃa renal diagnosticada atravÃs da expressÃo de biomarcadores. Assim, o uso de novos biomarcadores à de grande importÃncia para o diagnÃstico da doenÃa renal crÃnica subclÃnica. Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgicohttp://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18971application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:31:42Zmail@mail.com -
dc.title.pt.fl_str_mv AvaliaÃÃo da funÃÃo renal em pacientes com doenÃa pulmonar obstrutiva crÃnica atravÃs de biomarcadores
dc.title.alternative..fl_str_mv Evaluation of renal function in patients with chronic obstructive pulmonary disease using biomarkers
title AvaliaÃÃo da funÃÃo renal em pacientes com doenÃa pulmonar obstrutiva crÃnica atravÃs de biomarcadores
spellingShingle AvaliaÃÃo da funÃÃo renal em pacientes com doenÃa pulmonar obstrutiva crÃnica atravÃs de biomarcadores
Natalia Morais de Andrade
MEDICINA
title_short AvaliaÃÃo da funÃÃo renal em pacientes com doenÃa pulmonar obstrutiva crÃnica atravÃs de biomarcadores
title_full AvaliaÃÃo da funÃÃo renal em pacientes com doenÃa pulmonar obstrutiva crÃnica atravÃs de biomarcadores
title_fullStr AvaliaÃÃo da funÃÃo renal em pacientes com doenÃa pulmonar obstrutiva crÃnica atravÃs de biomarcadores
title_full_unstemmed AvaliaÃÃo da funÃÃo renal em pacientes com doenÃa pulmonar obstrutiva crÃnica atravÃs de biomarcadores
title_sort AvaliaÃÃo da funÃÃo renal em pacientes com doenÃa pulmonar obstrutiva crÃnica atravÃs de biomarcadores
author Natalia Morais de Andrade
author_facet Natalia Morais de Andrade
author_role author
dc.contributor.advisor1.fl_str_mv Elizabeth de Francesco Daher
dc.contributor.advisor1ID.fl_str_mv 18772919353
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/4855968398515646
dc.contributor.referee1.fl_str_mv Alice Maria Costa Martins
dc.contributor.referee1ID.fl_str_mv 43431690300
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/7532334620264577
dc.contributor.referee2.fl_str_mv Eanes Delgado Barros Pereira
dc.contributor.referee2ID.fl_str_mv 24731005353
dc.contributor.referee3.fl_str_mv Daniela Gardano Bucharles Mont'Alverne
dc.contributor.referee3ID.fl_str_mv 94020337934
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/3584422771001181
dc.contributor.referee4.fl_str_mv Claudia Maria Costa de Oliveira
dc.contributor.referee4ID.fl_str_mv 20912080353
dc.contributor.referee4Lattes.fl_str_mv http://lattes.cnpq.br/4500029238347254
dc.contributor.authorID.fl_str_mv 01067188436
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/0026634750109652
dc.contributor.author.fl_str_mv Natalia Morais de Andrade
contributor_str_mv Elizabeth de Francesco Daher
Alice Maria Costa Martins
Eanes Delgado Barros Pereira
Daniela Gardano Bucharles Mont'Alverne
Claudia Maria Costa de Oliveira
dc.subject.cnpq.fl_str_mv MEDICINA
topic MEDICINA
dc.description.sponsorship.fl_txt_mv Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico
dc.description.abstract.por.fl_txt_mv Chronic Obstructive Pulmonary Disease (COPD) is characterized by airflow obstruction caused by inhaling toxic particles and gases. Patients affected by COPD present many comorbidities, such as chronic kidney disease (CKD). Objective. To access renal function in patients with COPD through new biomarkers. Methodology. Was conducted a prospective study with 36 patients followed in two hospitals in the city of Fortaleza / CE - Brazil. General data and clinical trials and laboratory evaluation, assessment of renal function was estimated glomerular filtration rate (GFR) and new biomarkers were evaluation. Neutrophil gelatinase-associated lipocalin was quantified in blood and urine; Monocyte chemotactic protein (MCP-1) was quantified in urine and Galectin-3 was quantified in blood. Results. Changes in the values of GFR that showed higher in the COPD group than in the control group. Similar results were found with albumin values. Nevertheless, the figures showed no overt kidney damage. Evaluation of biomarkers only the MCP-1 and galectin-3 met with high levels in the study group. Association with renal dysfunction parameters (TFG) and pulmonary (FEV1) in COPD group, only galectin-3 showed a strong inverse association. Conclusion. COPD patients have a kidney disease diagnosed by the expression of biomarkers. Thus, the use of new biomarkers is of great importance for the diagnosis of subclinical or underdiagnosed CKD.
A DoenÃa Pulmonar Obstrutiva CrÃnica (DPOC) à caracterizada por obstruÃÃo do fluxo aÃreo ocasionada pela inalaÃÃo de partÃculas e gases tÃxicos. Os pacientes acometidos pela DPOC apresentam muitas comorbidades evidentes bem como alteraÃÃes subdiagnosticadas como a doenÃa renal crÃnica. Objetivo. Avaliar a funÃÃo renal de pacientes com DPOC atravÃs de novos biomarcadores. Metodologia. Foi realizado um estudo prospectivo com 36 pacientes acompanhados em dois hospitais da cidade de Fortaleza/CE. Foram coletados dados gerais e clÃnicos dos participantes e realizadas avaliaÃÃo laboratorial geral, avaliaÃÃo da funÃÃo renal atravÃs do cÃlculoda Taxa de FiltraÃÃo Glomerular (TFG) e avaliaÃÃo de novos biomarcadores. A Lipocalina associada à gelatinase de neutrÃfilos (NGAL) foi quantificada no sangue e na urina; a ProteÃna QuimiotÃtica de MonÃcitos (MCP-1) foi quantificada na urina e a Galectina-3 foi quantificada no sangue. Resultados. Ocorreram alteraÃÃes nos valores da TFG que se apresentaram mais baixos no grupo DPOC do que no grupo controle. Resultado semelhante foi encontrado com os valores da albumina. Apesar disso, os valores nÃo demonstraram lesÃo renal evidente. Na avaliaÃÃo dos biomarcadores apenas o MCP-1 e a galectina-3 encontraram-se com os nÃveis mais elevados no grupo de estudo em relaÃÃo ao grupo controle. Jà na associaÃÃo com os parÃmetros de disfunÃÃo renal (TFG) e pulmonar (VEF1) nos grupo DPOC, apenas a galectina-3 mostrou uma correlaÃÃo inversa significativa com TFG e VEF1. ConclusÃo. Pacientes com DPOC apresentam uma doenÃa renal diagnosticada atravÃs da expressÃo de biomarcadores. Assim, o uso de novos biomarcadores à de grande importÃncia para o diagnÃstico da doenÃa renal crÃnica subclÃnica.
description Chronic Obstructive Pulmonary Disease (COPD) is characterized by airflow obstruction caused by inhaling toxic particles and gases. Patients affected by COPD present many comorbidities, such as chronic kidney disease (CKD). Objective. To access renal function in patients with COPD through new biomarkers. Methodology. Was conducted a prospective study with 36 patients followed in two hospitals in the city of Fortaleza / CE - Brazil. General data and clinical trials and laboratory evaluation, assessment of renal function was estimated glomerular filtration rate (GFR) and new biomarkers were evaluation. Neutrophil gelatinase-associated lipocalin was quantified in blood and urine; Monocyte chemotactic protein (MCP-1) was quantified in urine and Galectin-3 was quantified in blood. Results. Changes in the values of GFR that showed higher in the COPD group than in the control group. Similar results were found with albumin values. Nevertheless, the figures showed no overt kidney damage. Evaluation of biomarkers only the MCP-1 and galectin-3 met with high levels in the study group. Association with renal dysfunction parameters (TFG) and pulmonary (FEV1) in COPD group, only galectin-3 showed a strong inverse association. Conclusion. COPD patients have a kidney disease diagnosed by the expression of biomarkers. Thus, the use of new biomarkers is of great importance for the diagnosis of subclinical or underdiagnosed CKD.
publishDate 2016
dc.date.issued.fl_str_mv 2016-11-08
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
status_str publishedVersion
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dc.identifier.uri.fl_str_mv http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18971
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dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.publisher.program.fl_str_mv Programa de PÃs-GraduaÃÃo em CiÃncias MÃdicas
dc.publisher.initials.fl_str_mv UFC
dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFC
instname:Universidade Federal do Ceará
instacron:UFC
reponame_str Biblioteca Digital de Teses e Dissertações da UFC
collection Biblioteca Digital de Teses e Dissertações da UFC
instname_str Universidade Federal do Ceará
instacron_str UFC
institution UFC
repository.name.fl_str_mv -
repository.mail.fl_str_mv mail@mail.com
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