The combined use of the aqueous extract of aroeira (40%) and aloe vera dry extract (10%)on treatment of traumatic ulcers of Wistar rats

Detalhes bibliográficos
Autor(a) principal: Guilherme Morais de Lima Mota
Data de Publicação: 2015
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFC
Texto Completo: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16434
Resumo: The oral mucosa is one of the human body areas most frequently traumatized and usually presents traumatic ulcers. There are different treatment choices among which both professionals and patients may follow in order to treat oral ulcerations, for instance, formulations from plants extract among other natural products. The use of phytotherapics has a long history of success, however the associated use of substances still has poor scientific background. The aroeira-do-sertÃo (Myracrondruon urundeva AllemÃo) and Aloe vera (Aloe barbadensis Miller) have anti-ulcerogenic and anti-inflammatory proven activity when used as isolated substances and have been largely prescribed by health care professionals. The goal of this study was to evaluate the combined use of the aqueous extract of aroeira (10%) with the dry extract of aloe vera (40%) on the treatment of traumatic ulcers, as well as its toxicity. Traumatic ulcers were surgically created on the oral mucosa of Wistar rats and further exposed to the test solution containing both aroeira e aloe vera, twice a day. The animals from test and control grups were sacrificed by euthanasia after 01, 05 and 10 days. The oral ulcers were measured and histologically evaluated. Their corporeal mass were compared and a hematological analysis performed. Stomach, kidneys, liver and spleen were removed and microscopically investigated for signs of toxicity. According to the results, the combined solution of aroeira and aloe vera did not present systemic toxicity, neither had any influence on the ulcers healing performance, despite having reduced its initial growth.
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spelling info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisThe combined use of the aqueous extract of aroeira (40%) and aloe vera dry extract (10%)on treatment of traumatic ulcers of Wistar ratsAvaliaÃÃo dos extratos conjugados de aroeira-do-sertÃo (myracrodruon urundeuva allemÃo) e aloe vera (aloe barbadensis miller) em modelo experimental de Ãlcera traumÃtica em ratos2015-09-28Fernando Schemelzer de Moraes Bezerra13419803320Ana Paula Negreiros Nunes Alves19242662372http://lattes.cnpq.br/5522921433940881 FabrÃcio Bitu Sousa44079117353http://buscatextual.cnpq.br/buscatextual/visualizacv.jsp?id=K4705026P9SÃrgio Luis da Silva Pereira14967209890http://lattes.cnpq.br/375140040517544654857015315http://lattes.cnpq.br/1267016502070557Guilherme Morais de Lima MotaUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em PatologiaUFCBRCIENCIAS DA SAUDEThe oral mucosa is one of the human body areas most frequently traumatized and usually presents traumatic ulcers. There are different treatment choices among which both professionals and patients may follow in order to treat oral ulcerations, for instance, formulations from plants extract among other natural products. The use of phytotherapics has a long history of success, however the associated use of substances still has poor scientific background. The aroeira-do-sertÃo (Myracrondruon urundeva AllemÃo) and Aloe vera (Aloe barbadensis Miller) have anti-ulcerogenic and anti-inflammatory proven activity when used as isolated substances and have been largely prescribed by health care professionals. The goal of this study was to evaluate the combined use of the aqueous extract of aroeira (10%) with the dry extract of aloe vera (40%) on the treatment of traumatic ulcers, as well as its toxicity. Traumatic ulcers were surgically created on the oral mucosa of Wistar rats and further exposed to the test solution containing both aroeira e aloe vera, twice a day. The animals from test and control grups were sacrificed by euthanasia after 01, 05 and 10 days. The oral ulcers were measured and histologically evaluated. Their corporeal mass were compared and a hematological analysis performed. Stomach, kidneys, liver and spleen were removed and microscopically investigated for signs of toxicity. According to the results, the combined solution of aroeira and aloe vera did not present systemic toxicity, neither had any influence on the ulcers healing performance, despite having reduced its initial growth.A mucosa bucal à uma das Ãreas mais traumatizadas do organismo, podendo apresentar Ãlceras traumÃticas com frequÃncia. SÃo muitos os diferentes tipos de tratamento aos quais ambos profissionais e pacientes recorrem para tratar as lesÃes ulceradas, como por exemplo, as formulaÃÃes à base de extratos de plantas e produtos naturais. A utilizaÃÃo de fitoterÃpicos tem uma longa histÃria de sucessos, porÃm, o uso combinado de substÃncias ainda apresenta escassa referÃncia cientÃfica. A aroeira-do-sertÃo (Myracrodruon urundeuva AllemÃo) e a Aloe vera (Aloe barbadensis Miller) tÃm comprovada aÃÃo antiulcerogÃnica e anti-inflamatÃria quando usados isoladamente e sÃo amplamente indicados por profissionais da saÃde. O objetivo desse estudo foi avaliar a aÃÃo conjugada do extrato aquoso de aroeira (10%) e extrato seco de Aloe vera (40%) no tratamento de Ãlceras traumÃticas e sua toxicidade. Ãlceras traumÃticas foram realizadas cirurgicamente em mucosa de ratos Wistar e expostas a uma soluÃÃo teste contendo aroeira e aloe, aplicadas duas vezes ao dia. Os animais dos grupos controle e teste sofreram eutanÃsia em 01, 05 e 10 dias e tiveram suas Ãlceras medidas e avaliadas histopatologicamente. Foi tambÃm realizada uma comparaÃÃo da massa corpÃrea e uma anÃlise hematolÃgica em todos os animais. EstÃmago, rins, fÃgado e baÃo foram analisados por microscopia Ãtica para avaliaÃÃo de parÃmetros de toxicidade. De acordo com os resultados, a soluÃÃo conjugada dos dois fitoterÃpicos nÃo apresentou toxicidade sistÃmica, nem influenciou na cicatrizaÃÃo das Ãlceras, apesar de ter reduzido o seu crescimento inicial.CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16434application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:29:37Zmail@mail.com -
dc.title.en.fl_str_mv The combined use of the aqueous extract of aroeira (40%) and aloe vera dry extract (10%)on treatment of traumatic ulcers of Wistar rats
dc.title.alternative.pt.fl_str_mv AvaliaÃÃo dos extratos conjugados de aroeira-do-sertÃo (myracrodruon urundeuva allemÃo) e aloe vera (aloe barbadensis miller) em modelo experimental de Ãlcera traumÃtica em ratos
title The combined use of the aqueous extract of aroeira (40%) and aloe vera dry extract (10%)on treatment of traumatic ulcers of Wistar rats
spellingShingle The combined use of the aqueous extract of aroeira (40%) and aloe vera dry extract (10%)on treatment of traumatic ulcers of Wistar rats
Guilherme Morais de Lima Mota
CIENCIAS DA SAUDE
title_short The combined use of the aqueous extract of aroeira (40%) and aloe vera dry extract (10%)on treatment of traumatic ulcers of Wistar rats
title_full The combined use of the aqueous extract of aroeira (40%) and aloe vera dry extract (10%)on treatment of traumatic ulcers of Wistar rats
title_fullStr The combined use of the aqueous extract of aroeira (40%) and aloe vera dry extract (10%)on treatment of traumatic ulcers of Wistar rats
title_full_unstemmed The combined use of the aqueous extract of aroeira (40%) and aloe vera dry extract (10%)on treatment of traumatic ulcers of Wistar rats
title_sort The combined use of the aqueous extract of aroeira (40%) and aloe vera dry extract (10%)on treatment of traumatic ulcers of Wistar rats
author Guilherme Morais de Lima Mota
author_facet Guilherme Morais de Lima Mota
author_role author
dc.contributor.advisor1.fl_str_mv Fernando Schemelzer de Moraes Bezerra
dc.contributor.advisor1ID.fl_str_mv 13419803320
dc.contributor.referee1.fl_str_mv Ana Paula Negreiros Nunes Alves
dc.contributor.referee1ID.fl_str_mv 19242662372
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/5522921433940881
dc.contributor.referee2.fl_str_mv FabrÃcio Bitu Sousa
dc.contributor.referee2ID.fl_str_mv 44079117353
dc.contributor.referee2Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.jsp?id=K4705026P9
dc.contributor.referee3.fl_str_mv SÃrgio Luis da Silva Pereira
dc.contributor.referee3ID.fl_str_mv 14967209890
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/3751400405175446
dc.contributor.authorID.fl_str_mv 54857015315
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/1267016502070557
dc.contributor.author.fl_str_mv Guilherme Morais de Lima Mota
contributor_str_mv Fernando Schemelzer de Moraes Bezerra
Ana Paula Negreiros Nunes Alves
FabrÃcio Bitu Sousa
SÃrgio Luis da Silva Pereira
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE
topic CIENCIAS DA SAUDE
dc.description.sponsorship.fl_txt_mv CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior
dc.description.abstract.por.fl_txt_mv The oral mucosa is one of the human body areas most frequently traumatized and usually presents traumatic ulcers. There are different treatment choices among which both professionals and patients may follow in order to treat oral ulcerations, for instance, formulations from plants extract among other natural products. The use of phytotherapics has a long history of success, however the associated use of substances still has poor scientific background. The aroeira-do-sertÃo (Myracrondruon urundeva AllemÃo) and Aloe vera (Aloe barbadensis Miller) have anti-ulcerogenic and anti-inflammatory proven activity when used as isolated substances and have been largely prescribed by health care professionals. The goal of this study was to evaluate the combined use of the aqueous extract of aroeira (10%) with the dry extract of aloe vera (40%) on the treatment of traumatic ulcers, as well as its toxicity. Traumatic ulcers were surgically created on the oral mucosa of Wistar rats and further exposed to the test solution containing both aroeira e aloe vera, twice a day. The animals from test and control grups were sacrificed by euthanasia after 01, 05 and 10 days. The oral ulcers were measured and histologically evaluated. Their corporeal mass were compared and a hematological analysis performed. Stomach, kidneys, liver and spleen were removed and microscopically investigated for signs of toxicity. According to the results, the combined solution of aroeira and aloe vera did not present systemic toxicity, neither had any influence on the ulcers healing performance, despite having reduced its initial growth.
A mucosa bucal à uma das Ãreas mais traumatizadas do organismo, podendo apresentar Ãlceras traumÃticas com frequÃncia. SÃo muitos os diferentes tipos de tratamento aos quais ambos profissionais e pacientes recorrem para tratar as lesÃes ulceradas, como por exemplo, as formulaÃÃes à base de extratos de plantas e produtos naturais. A utilizaÃÃo de fitoterÃpicos tem uma longa histÃria de sucessos, porÃm, o uso combinado de substÃncias ainda apresenta escassa referÃncia cientÃfica. A aroeira-do-sertÃo (Myracrodruon urundeuva AllemÃo) e a Aloe vera (Aloe barbadensis Miller) tÃm comprovada aÃÃo antiulcerogÃnica e anti-inflamatÃria quando usados isoladamente e sÃo amplamente indicados por profissionais da saÃde. O objetivo desse estudo foi avaliar a aÃÃo conjugada do extrato aquoso de aroeira (10%) e extrato seco de Aloe vera (40%) no tratamento de Ãlceras traumÃticas e sua toxicidade. Ãlceras traumÃticas foram realizadas cirurgicamente em mucosa de ratos Wistar e expostas a uma soluÃÃo teste contendo aroeira e aloe, aplicadas duas vezes ao dia. Os animais dos grupos controle e teste sofreram eutanÃsia em 01, 05 e 10 dias e tiveram suas Ãlceras medidas e avaliadas histopatologicamente. Foi tambÃm realizada uma comparaÃÃo da massa corpÃrea e uma anÃlise hematolÃgica em todos os animais. EstÃmago, rins, fÃgado e baÃo foram analisados por microscopia Ãtica para avaliaÃÃo de parÃmetros de toxicidade. De acordo com os resultados, a soluÃÃo conjugada dos dois fitoterÃpicos nÃo apresentou toxicidade sistÃmica, nem influenciou na cicatrizaÃÃo das Ãlceras, apesar de ter reduzido o seu crescimento inicial.
description The oral mucosa is one of the human body areas most frequently traumatized and usually presents traumatic ulcers. There are different treatment choices among which both professionals and patients may follow in order to treat oral ulcerations, for instance, formulations from plants extract among other natural products. The use of phytotherapics has a long history of success, however the associated use of substances still has poor scientific background. The aroeira-do-sertÃo (Myracrondruon urundeva AllemÃo) and Aloe vera (Aloe barbadensis Miller) have anti-ulcerogenic and anti-inflammatory proven activity when used as isolated substances and have been largely prescribed by health care professionals. The goal of this study was to evaluate the combined use of the aqueous extract of aroeira (10%) with the dry extract of aloe vera (40%) on the treatment of traumatic ulcers, as well as its toxicity. Traumatic ulcers were surgically created on the oral mucosa of Wistar rats and further exposed to the test solution containing both aroeira e aloe vera, twice a day. The animals from test and control grups were sacrificed by euthanasia after 01, 05 and 10 days. The oral ulcers were measured and histologically evaluated. Their corporeal mass were compared and a hematological analysis performed. Stomach, kidneys, liver and spleen were removed and microscopically investigated for signs of toxicity. According to the results, the combined solution of aroeira and aloe vera did not present systemic toxicity, neither had any influence on the ulcers healing performance, despite having reduced its initial growth.
publishDate 2015
dc.date.issued.fl_str_mv 2015-09-28
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
status_str publishedVersion
format masterThesis
dc.identifier.uri.fl_str_mv http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16434
url http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16434
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.publisher.program.fl_str_mv Programa de PÃs-GraduaÃÃo em Patologia
dc.publisher.initials.fl_str_mv UFC
dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFC
instname:Universidade Federal do Ceará
instacron:UFC
reponame_str Biblioteca Digital de Teses e Dissertações da UFC
collection Biblioteca Digital de Teses e Dissertações da UFC
instname_str Universidade Federal do Ceará
instacron_str UFC
institution UFC
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