Analysis of the association of markers caT, LEC and oipA functional and non functional of Helicobacter pylori in gastric disorders
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFC |
Texto Completo: | http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18757 |
Resumo: | The Helicobacter pylori is a bacterium that colonizes the gastric mucosa of human beings. The chronic infection caused by this pathogen is strongly associated with an increased risk for gastric illnesses different, ranging from chronic gastritis and peptic ulcer for two types of gastric cancer, adenocarcinoma and lymphoma of the lymphoid tissue associated to mucosa. The aim of this study was to evaluate the association of cagT markers, LEC, functional and nonfunctional oipA in patients with disorders of gastritis, ulcers and stomach cancer. Genotyping of the strains was performed by PCR. Were evaluated 181 patients attended at the University Hospital Walter CantÃdio, 87 (48.1%) men, 94 (51.9%) women, with ages ranging from 18-90 years, mean age of 53 + 17.8 years, with a positive diagnosis for H. pylori infection, these 48 carriers of gastric cancer, 69 patients with peptic ulcer and 64 with gastritis. The prevalence of the genotypes studied was: 145/181 (80.1%) cagT, 83/181 (45.9%) LEC 81/181 (44.7%) oipA and oipA"on"34/81.In the group of patients with gastric cancer was observed that the most frequent genotype was the cagT 43/48 (89,5%), followed by the oipA gene "on" 10/18 (55.6%) and LEC 17/48 (35.4%). In the group of patients with peptic ulcer genotype was the most frequent cagT 62/69 (89.8%), followed by gene LEC, 34/69 (49.3%) and the oipA"on" 13/31 (41.9%). In the group of patients with the most frequent genotype gastritis was cagT 40/64 (62.5%), followed by gene LEC 32/64 (50.0%) and the oipA "on" 11/32 (34.4%). Furthermore, by the presented data there is no association of H. pylori and gender and or age of the patients.The genetic study of the markers of H. pylori infection and its relationship with the gastric disorders is essential to establish the profile of virulence of strains and thus elucidate the clinical outcomes variables involved with this infection. |
id |
UFC_6b9ef56bb05735c4bdd166d59da41d04 |
---|---|
oai_identifier_str |
oai:www.teses.ufc.br:11995 |
network_acronym_str |
UFC |
network_name_str |
Biblioteca Digital de Teses e Dissertações da UFC |
spelling |
info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisAnalysis of the association of markers caT, LEC and oipA functional and non functional of Helicobacter pylori in gastric disordersAnÃlise da associaÃÃo dos marcadores cagT, LEC e oipA funcional e nÃo funcional do Helicobacter pylori em afecÃÃes gÃstricas2015-12-15LÃcia LibanÃz Bessa Campelo Braga20891342320http://lattes.cnpq.br/6795261152083416Regina FÃtima GonÃalves Feitosa12334812315http://lattes.cnpq.br/2351181311408985Marta Maria das Chagas Medeiros11255579315http://buscatextual.cnpq.br/buscatextual/visualizacv.jsp?id=K4785814E6Cicero Igor Simoes Moura Silva86400851372http://lattes.cnpq.br/0320679522017318Orleancio Gomes Ripardo de Azevedo01023337347http://lattes.cnpq.br/956384416446291885304697391Maria Helane Rocha Batista GonÃalvesUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em CirurgiaUFCBRENFERMAGEMThe Helicobacter pylori is a bacterium that colonizes the gastric mucosa of human beings. The chronic infection caused by this pathogen is strongly associated with an increased risk for gastric illnesses different, ranging from chronic gastritis and peptic ulcer for two types of gastric cancer, adenocarcinoma and lymphoma of the lymphoid tissue associated to mucosa. The aim of this study was to evaluate the association of cagT markers, LEC, functional and nonfunctional oipA in patients with disorders of gastritis, ulcers and stomach cancer. Genotyping of the strains was performed by PCR. Were evaluated 181 patients attended at the University Hospital Walter CantÃdio, 87 (48.1%) men, 94 (51.9%) women, with ages ranging from 18-90 years, mean age of 53 + 17.8 years, with a positive diagnosis for H. pylori infection, these 48 carriers of gastric cancer, 69 patients with peptic ulcer and 64 with gastritis. The prevalence of the genotypes studied was: 145/181 (80.1%) cagT, 83/181 (45.9%) LEC 81/181 (44.7%) oipA and oipA"on"34/81.In the group of patients with gastric cancer was observed that the most frequent genotype was the cagT 43/48 (89,5%), followed by the oipA gene "on" 10/18 (55.6%) and LEC 17/48 (35.4%). In the group of patients with peptic ulcer genotype was the most frequent cagT 62/69 (89.8%), followed by gene LEC, 34/69 (49.3%) and the oipA"on" 13/31 (41.9%). In the group of patients with the most frequent genotype gastritis was cagT 40/64 (62.5%), followed by gene LEC 32/64 (50.0%) and the oipA "on" 11/32 (34.4%). Furthermore, by the presented data there is no association of H. pylori and gender and or age of the patients.The genetic study of the markers of H. pylori infection and its relationship with the gastric disorders is essential to establish the profile of virulence of strains and thus elucidate the clinical outcomes variables involved with this infection. O Helicobacter pylori à uma bactÃria que coloniza a mucosa gÃstrica de seres humanos. A infecÃÃo crÃnica causada por este patÃgeno està fortemente associada a um risco aumentado de doenÃas gÃstricas diferentes, variando de gastrite crÃnica e Ãlcera pÃptica para dois tipos de cÃncer gÃstrico, adenocarcinoma e linfoma do tecido linfÃide associado à mucosa. O objetivo do presente estudo foi avaliar a associaÃÃo dos marcadores cagT, LEC e oipA funcional e nÃo funcional em pacientes portadores das afecÃÃes gastrite, Ãlcera e cÃncer gÃstrico.Foi realizada a genotipagem das cepas por meio da tÃcnica de PCR. Foram avaliados 181 pacientes, atendidos no Hospital UniversitÃrio Walter CantÃdio, sendo 87(48,1%) homens, 94(51,9%) mulheres, com idade variando de 18-90 anos, com mÃdia de 53 + 17,8 anos, com diagnÃstico positivo para a infecÃÃo por H. pylori. Destes, 48 portadores de cÃncer gÃstrico, 69 pacientes com âÃlcera pÃptica e 64 com gastrite. A prevalÃncia dos genÃtipos estudados foi: 145/181 (80,1%) cagT, 83/181 (45,9%) LEC, 81/181 (44,7%) oipA, e oipAâonâ34/81 (41,9%).No grupo dos pacientes com cÃncer gÃstrico observou-se que o genÃtipo mais frequente foi o cagT 43/48 (89,6%), seguido do gene oipA âonâ 10/18 (55,6%) e LEC 17/48 (35,4%). No grupo dos pacientes com Ãlcera pÃptica o genÃtipo mais frequente foi o cagT 62/69 (89,8%), seguido do gene LEC; 34/69 (49,3%) e oipAâonâ 13/31 (41,9%). No grupo dos pacientes com gastrite o genÃtipo mais frequente foi cagT 40/64 (62,5%), seguido do gene LEC 32/64 (50,0%) e oipA âonâ 11/32 (34,4%). NÃo houve associaÃÃo significativa dos genÃtipos do H. pylori com gÃnero, nem com faixa etÃria dos pacientes. O estudo genÃtico dos marcadores de H. pylori e sua relaÃÃo com as afecÃÃes gÃstricas à fundamental para se estabelecer o perfil de virulÃncia das cepas e assim elucidar os variÃveis desfechos clÃnicos envolvidos com essa infecÃÃo. FundaÃÃo de Amparo à Pesquisa do Estado do CearÃhttp://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18757application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:31:35Zmail@mail.com - |
dc.title.en.fl_str_mv |
Analysis of the association of markers caT, LEC and oipA functional and non functional of Helicobacter pylori in gastric disorders |
dc.title.alternative.pt.fl_str_mv |
AnÃlise da associaÃÃo dos marcadores cagT, LEC e oipA funcional e nÃo funcional do Helicobacter pylori em afecÃÃes gÃstricas |
title |
Analysis of the association of markers caT, LEC and oipA functional and non functional of Helicobacter pylori in gastric disorders |
spellingShingle |
Analysis of the association of markers caT, LEC and oipA functional and non functional of Helicobacter pylori in gastric disorders Maria Helane Rocha Batista GonÃalves ENFERMAGEM |
title_short |
Analysis of the association of markers caT, LEC and oipA functional and non functional of Helicobacter pylori in gastric disorders |
title_full |
Analysis of the association of markers caT, LEC and oipA functional and non functional of Helicobacter pylori in gastric disorders |
title_fullStr |
Analysis of the association of markers caT, LEC and oipA functional and non functional of Helicobacter pylori in gastric disorders |
title_full_unstemmed |
Analysis of the association of markers caT, LEC and oipA functional and non functional of Helicobacter pylori in gastric disorders |
title_sort |
Analysis of the association of markers caT, LEC and oipA functional and non functional of Helicobacter pylori in gastric disorders |
author |
Maria Helane Rocha Batista GonÃalves |
author_facet |
Maria Helane Rocha Batista GonÃalves |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
LÃcia LibanÃz Bessa Campelo Braga |
dc.contributor.advisor1ID.fl_str_mv |
20891342320 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6795261152083416 |
dc.contributor.referee1.fl_str_mv |
Regina FÃtima GonÃalves Feitosa |
dc.contributor.referee1ID.fl_str_mv |
12334812315 |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/2351181311408985 |
dc.contributor.referee2.fl_str_mv |
Marta Maria das Chagas Medeiros |
dc.contributor.referee2ID.fl_str_mv |
11255579315 |
dc.contributor.referee2Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.jsp?id=K4785814E6 |
dc.contributor.referee3.fl_str_mv |
Cicero Igor Simoes Moura Silva |
dc.contributor.referee3ID.fl_str_mv |
86400851372 |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/0320679522017318 |
dc.contributor.referee4.fl_str_mv |
Orleancio Gomes Ripardo de Azevedo |
dc.contributor.referee4ID.fl_str_mv |
01023337347 |
dc.contributor.referee4Lattes.fl_str_mv |
http://lattes.cnpq.br/9563844164462918 |
dc.contributor.authorID.fl_str_mv |
85304697391 |
dc.contributor.author.fl_str_mv |
Maria Helane Rocha Batista GonÃalves |
contributor_str_mv |
LÃcia LibanÃz Bessa Campelo Braga Regina FÃtima GonÃalves Feitosa Marta Maria das Chagas Medeiros Cicero Igor Simoes Moura Silva Orleancio Gomes Ripardo de Azevedo |
dc.subject.cnpq.fl_str_mv |
ENFERMAGEM |
topic |
ENFERMAGEM |
dc.description.sponsorship.fl_txt_mv |
FundaÃÃo de Amparo à Pesquisa do Estado do Cearà |
dc.description.abstract.por.fl_txt_mv |
The Helicobacter pylori is a bacterium that colonizes the gastric mucosa of human beings. The chronic infection caused by this pathogen is strongly associated with an increased risk for gastric illnesses different, ranging from chronic gastritis and peptic ulcer for two types of gastric cancer, adenocarcinoma and lymphoma of the lymphoid tissue associated to mucosa. The aim of this study was to evaluate the association of cagT markers, LEC, functional and nonfunctional oipA in patients with disorders of gastritis, ulcers and stomach cancer. Genotyping of the strains was performed by PCR. Were evaluated 181 patients attended at the University Hospital Walter CantÃdio, 87 (48.1%) men, 94 (51.9%) women, with ages ranging from 18-90 years, mean age of 53 + 17.8 years, with a positive diagnosis for H. pylori infection, these 48 carriers of gastric cancer, 69 patients with peptic ulcer and 64 with gastritis. The prevalence of the genotypes studied was: 145/181 (80.1%) cagT, 83/181 (45.9%) LEC 81/181 (44.7%) oipA and oipA"on"34/81.In the group of patients with gastric cancer was observed that the most frequent genotype was the cagT 43/48 (89,5%), followed by the oipA gene "on" 10/18 (55.6%) and LEC 17/48 (35.4%). In the group of patients with peptic ulcer genotype was the most frequent cagT 62/69 (89.8%), followed by gene LEC, 34/69 (49.3%) and the oipA"on" 13/31 (41.9%). In the group of patients with the most frequent genotype gastritis was cagT 40/64 (62.5%), followed by gene LEC 32/64 (50.0%) and the oipA "on" 11/32 (34.4%). Furthermore, by the presented data there is no association of H. pylori and gender and or age of the patients.The genetic study of the markers of H. pylori infection and its relationship with the gastric disorders is essential to establish the profile of virulence of strains and thus elucidate the clinical outcomes variables involved with this infection. O Helicobacter pylori à uma bactÃria que coloniza a mucosa gÃstrica de seres humanos. A infecÃÃo crÃnica causada por este patÃgeno està fortemente associada a um risco aumentado de doenÃas gÃstricas diferentes, variando de gastrite crÃnica e Ãlcera pÃptica para dois tipos de cÃncer gÃstrico, adenocarcinoma e linfoma do tecido linfÃide associado à mucosa. O objetivo do presente estudo foi avaliar a associaÃÃo dos marcadores cagT, LEC e oipA funcional e nÃo funcional em pacientes portadores das afecÃÃes gastrite, Ãlcera e cÃncer gÃstrico.Foi realizada a genotipagem das cepas por meio da tÃcnica de PCR. Foram avaliados 181 pacientes, atendidos no Hospital UniversitÃrio Walter CantÃdio, sendo 87(48,1%) homens, 94(51,9%) mulheres, com idade variando de 18-90 anos, com mÃdia de 53 + 17,8 anos, com diagnÃstico positivo para a infecÃÃo por H. pylori. Destes, 48 portadores de cÃncer gÃstrico, 69 pacientes com âÃlcera pÃptica e 64 com gastrite. A prevalÃncia dos genÃtipos estudados foi: 145/181 (80,1%) cagT, 83/181 (45,9%) LEC, 81/181 (44,7%) oipA, e oipAâonâ34/81 (41,9%).No grupo dos pacientes com cÃncer gÃstrico observou-se que o genÃtipo mais frequente foi o cagT 43/48 (89,6%), seguido do gene oipA âonâ 10/18 (55,6%) e LEC 17/48 (35,4%). No grupo dos pacientes com Ãlcera pÃptica o genÃtipo mais frequente foi o cagT 62/69 (89,8%), seguido do gene LEC; 34/69 (49,3%) e oipAâonâ 13/31 (41,9%). No grupo dos pacientes com gastrite o genÃtipo mais frequente foi cagT 40/64 (62,5%), seguido do gene LEC 32/64 (50,0%) e oipA âonâ 11/32 (34,4%). NÃo houve associaÃÃo significativa dos genÃtipos do H. pylori com gÃnero, nem com faixa etÃria dos pacientes. O estudo genÃtico dos marcadores de H. pylori e sua relaÃÃo com as afecÃÃes gÃstricas à fundamental para se estabelecer o perfil de virulÃncia das cepas e assim elucidar os variÃveis desfechos clÃnicos envolvidos com essa infecÃÃo. |
description |
The Helicobacter pylori is a bacterium that colonizes the gastric mucosa of human beings. The chronic infection caused by this pathogen is strongly associated with an increased risk for gastric illnesses different, ranging from chronic gastritis and peptic ulcer for two types of gastric cancer, adenocarcinoma and lymphoma of the lymphoid tissue associated to mucosa. The aim of this study was to evaluate the association of cagT markers, LEC, functional and nonfunctional oipA in patients with disorders of gastritis, ulcers and stomach cancer. Genotyping of the strains was performed by PCR. Were evaluated 181 patients attended at the University Hospital Walter CantÃdio, 87 (48.1%) men, 94 (51.9%) women, with ages ranging from 18-90 years, mean age of 53 + 17.8 years, with a positive diagnosis for H. pylori infection, these 48 carriers of gastric cancer, 69 patients with peptic ulcer and 64 with gastritis. The prevalence of the genotypes studied was: 145/181 (80.1%) cagT, 83/181 (45.9%) LEC 81/181 (44.7%) oipA and oipA"on"34/81.In the group of patients with gastric cancer was observed that the most frequent genotype was the cagT 43/48 (89,5%), followed by the oipA gene "on" 10/18 (55.6%) and LEC 17/48 (35.4%). In the group of patients with peptic ulcer genotype was the most frequent cagT 62/69 (89.8%), followed by gene LEC, 34/69 (49.3%) and the oipA"on" 13/31 (41.9%). In the group of patients with the most frequent genotype gastritis was cagT 40/64 (62.5%), followed by gene LEC 32/64 (50.0%) and the oipA "on" 11/32 (34.4%). Furthermore, by the presented data there is no association of H. pylori and gender and or age of the patients.The genetic study of the markers of H. pylori infection and its relationship with the gastric disorders is essential to establish the profile of virulence of strains and thus elucidate the clinical outcomes variables involved with this infection. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-12-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
status_str |
publishedVersion |
format |
doctoralThesis |
dc.identifier.uri.fl_str_mv |
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18757 |
url |
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18757 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal do Cearà |
dc.publisher.program.fl_str_mv |
Programa de PÃs-GraduaÃÃo em Cirurgia |
dc.publisher.initials.fl_str_mv |
UFC |
dc.publisher.country.fl_str_mv |
BR |
publisher.none.fl_str_mv |
Universidade Federal do Cearà |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações da UFC instname:Universidade Federal do Ceará instacron:UFC |
reponame_str |
Biblioteca Digital de Teses e Dissertações da UFC |
collection |
Biblioteca Digital de Teses e Dissertações da UFC |
instname_str |
Universidade Federal do Ceará |
instacron_str |
UFC |
institution |
UFC |
repository.name.fl_str_mv |
-
|
repository.mail.fl_str_mv |
mail@mail.com |
_version_ |
1643295232015466496 |