Cognitive deficits in euthymic children and adolescents: systematic review and meta-analysis.
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFC |
Texto Completo: | http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18550 |
Resumo: | This work consists of a systematic review with meta-analysis of studies investigating neuropsychological functions in youth up to the age of 18 diagnosed with Bipolar Disorder (BD) in euthymic phase compared to healthy controls (HC). The study aims to to clarify the cognitive functioning of pediatric bipolar patients by investigating a representative sample and controlling potential sources of heterogeneity. A systematic search in the literature was performed in the Pubmed/MEDLINE, PsycInfo and EMBASE databases from inception until March 23rd, 2016 to select original peer-reviewed studies that investigated neuropsychological functions in youths diagnosed with TB in the euthymic phase compared to HC. Effect sizes were extracted for each of the neuropsychological tests used. In addition, the results were grouped according to the following cognitive domains: attention and vigilance, verbal learning, verbal memory, working memory, visual learning, visual memory, executive functions, processing speed and general cognition. The PRISMA Statement protocol was followed. The study synthesized data from twenty-four studies that met the inclusion criteria (N = 1146, 510 in the BD group and 636 in the control group). In general, euthymic bipolar youngsters had significant deficits in the domains of verbal learning, verbal memory, working memory, visual learning and visual memory with moderate to large effect sizes (Hedgesâs g between 0.76 and 0.99). No significant deficits were observed in the domains of attention/vigilance, executive functions, and processing speed. The heterogeneity was moderate to large (I2 ≥ 50%) for most ES estimates. Differences in the definition of euthymia between the studies explained the heterogeneity in the ES estimation for verbal learning and memory. Evidence was also found for other potential sources of heterogeneity in various estimates of ES that included comorbidity with ADHD and anxiety disorders, as well as madication use. In addition, the use of different neuropsychological tests seemed to contribute to the heterogeneity of some estimates (e.g. in the attention/vigilance domain). At the end, it can be concluded that youths with euthymic BD present significant cognitive dysfunction encompassing the domains verbal learning, visual learning, verbal memory, visual memory and working memory. The results also suggest that, for a subset of individuals with BD, neurodevelopmental factors may contribute to cognitive dysfunction. |
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Biblioteca Digital de Teses e Dissertações da UFC |
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info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisCognitive deficits in euthymic children and adolescents: systematic review and meta-analysis.DÃficit cognitivo em crianÃas e adolescentes com transtorno bipolar em eutimia: revisÃo sistemÃtica e meta-anÃlise2016-12-27Andrà FÃrrer Carvalho62626922315http://lattes.cnpq.br/4167422383882509Cristiano Andre Kohler83018107004http://lattes.cnpq.br/5198822041947354Renan MagalhÃes Montenegro JÃnior35865326368http://lattes.cnpq.br/7492450432942397AluÃsio Ferreira de Lima19267164856http://lattes.cnpq.br/3925673395634061 Denise de Lima Oliveira Vilas Boas26980390864http://lattes.cnpq.br/2242445571095877Felipe Lustosa Leite 9670882435361888443391http://lattes.cnpq.br/2887301247861009Liana Rosa EliasUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em CiÃncias MÃdicasUFCBRPSICOLOGIAThis work consists of a systematic review with meta-analysis of studies investigating neuropsychological functions in youth up to the age of 18 diagnosed with Bipolar Disorder (BD) in euthymic phase compared to healthy controls (HC). The study aims to to clarify the cognitive functioning of pediatric bipolar patients by investigating a representative sample and controlling potential sources of heterogeneity. A systematic search in the literature was performed in the Pubmed/MEDLINE, PsycInfo and EMBASE databases from inception until March 23rd, 2016 to select original peer-reviewed studies that investigated neuropsychological functions in youths diagnosed with TB in the euthymic phase compared to HC. Effect sizes were extracted for each of the neuropsychological tests used. In addition, the results were grouped according to the following cognitive domains: attention and vigilance, verbal learning, verbal memory, working memory, visual learning, visual memory, executive functions, processing speed and general cognition. The PRISMA Statement protocol was followed. The study synthesized data from twenty-four studies that met the inclusion criteria (N = 1146, 510 in the BD group and 636 in the control group). In general, euthymic bipolar youngsters had significant deficits in the domains of verbal learning, verbal memory, working memory, visual learning and visual memory with moderate to large effect sizes (Hedgesâs g between 0.76 and 0.99). No significant deficits were observed in the domains of attention/vigilance, executive functions, and processing speed. The heterogeneity was moderate to large (I2 ≥ 50%) for most ES estimates. Differences in the definition of euthymia between the studies explained the heterogeneity in the ES estimation for verbal learning and memory. Evidence was also found for other potential sources of heterogeneity in various estimates of ES that included comorbidity with ADHD and anxiety disorders, as well as madication use. In addition, the use of different neuropsychological tests seemed to contribute to the heterogeneity of some estimates (e.g. in the attention/vigilance domain). At the end, it can be concluded that youths with euthymic BD present significant cognitive dysfunction encompassing the domains verbal learning, visual learning, verbal memory, visual memory and working memory. The results also suggest that, for a subset of individuals with BD, neurodevelopmental factors may contribute to cognitive dysfunction.Este trabalho consiste em uma revisÃo sistemÃtica com meta-anÃlise de estudos investigando funÃÃes neuropsicolÃgicas em jovens atà 18 anos diagnosticados com Transtorno Bipolar (TB) em fase eutÃmica em comparaÃÃo com controles saudÃveis (CS). Desta forma, espera-se esclarecer o funcionamento cognitivo de pacientes bipolares pediÃtricos com uma amostra representativa e com controle das potenciais fontes de heterogeneidade. Para o alcance dos objetivos, uma busca sistemÃtica na literatura foi realizada nas bases de dados Pubmed / MEDLINE, PsycInfo e EMBASE, desde o primeiro periÃdico veiculado à base, atà 23 de marÃo de 2016 em estudos originais revisados por pares (peer-review) que investigaram funÃÃes neuropsicolÃgicas de jovens eutÃmicos com TB em comparaÃÃo com CS. Foram extraÃdos os tamanhos de efeito (TE) para cada um dos testes neuropsicolÃgicos utilizados. Adicionalmente, os resultados foram agrupados de acordo com os seguintes domÃnios cognitivos: atenÃÃo/vigilÃncia, aprendizagem verbal, memÃria verbal, memÃria de trabalho, aprendizagem visual, memÃria visual, funÃÃes executivas, velocidade de processamento e cogniÃÃo geral. Foram seguidos os protocolos do PRISMA Statement. Como resultado, este estudo sintetizou dados de vinte e quatro estudos que preencheram os critÃrios de inclusÃo (N = 1146; sendo 510 no grupo TB e 636 no grupo controle). Em geral, os jovens bipolares eutÃmicos apresentaram dÃficits significativos nos domÃnios de: aprendizagem verbal, memÃria verbal, memÃria de trabalho, aprendizagem visual e memÃria visual, com tamanhos de efeito de moderado a grande (g de Hedge entre 0,76 a 0,99). NÃo foram observados dÃficits significativos nos domÃnios de atenÃÃo e vigilÃncia, funÃÃes executivas, e velocidade de processamento. A heterogeneidade foi alta (I2 ≥ 50%) para a maioria das estimativas de TE. DiferenÃas na definiÃÃo de eutimia entre os estudos explicaram a heterogeneidade na estimativa do TE para aprendizagem verbal e memÃria. TambÃm foram encontradas evidÃncias para outras fontes potenciais de heterogeneidade em vÃrias estimativas do TE, que incluiam comorbidade com TDA/H e transtornos de ansiedade, bem como o uso de medicamentos. AlÃm disso, o uso de diferentes testes neuropsicolÃgicos pareceu contribuir para a heterogeneidade de algumas estimativas (como por exemplo, no domÃnio atenÃÃo/vigilÃncia). Ao final, foi possÃvel concluir que jovens bipolares eutÃmicos apresentam disfunÃÃo cognitiva significativa abrangendo os domÃnios aprendizagem verbal, aprendizagem visual, memÃria verbal, memÃria visual e memÃria de trabalho. Estes dados sugerem que, para um subconjunto de indivÃduos com TB, os fatores do neurodesenvolvimento podem contribuir para a disfunÃÃo cognitiva.nÃo hÃFundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgicohttp://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18550application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:31:28Zmail@mail.com - |
dc.title.en.fl_str_mv |
Cognitive deficits in euthymic children and adolescents: systematic review and meta-analysis. |
dc.title.alternative.pt.fl_str_mv |
DÃficit cognitivo em crianÃas e adolescentes com transtorno bipolar em eutimia: revisÃo sistemÃtica e meta-anÃlise |
title |
Cognitive deficits in euthymic children and adolescents: systematic review and meta-analysis. |
spellingShingle |
Cognitive deficits in euthymic children and adolescents: systematic review and meta-analysis. Liana Rosa Elias PSICOLOGIA |
title_short |
Cognitive deficits in euthymic children and adolescents: systematic review and meta-analysis. |
title_full |
Cognitive deficits in euthymic children and adolescents: systematic review and meta-analysis. |
title_fullStr |
Cognitive deficits in euthymic children and adolescents: systematic review and meta-analysis. |
title_full_unstemmed |
Cognitive deficits in euthymic children and adolescents: systematic review and meta-analysis. |
title_sort |
Cognitive deficits in euthymic children and adolescents: systematic review and meta-analysis. |
author |
Liana Rosa Elias |
author_facet |
Liana Rosa Elias |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Andrà FÃrrer Carvalho |
dc.contributor.advisor1ID.fl_str_mv |
62626922315 |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/4167422383882509 |
dc.contributor.advisor-co1.fl_str_mv |
Cristiano Andre Kohler |
dc.contributor.advisor-co1ID.fl_str_mv |
83018107004 |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/5198822041947354 |
dc.contributor.referee1.fl_str_mv |
Renan MagalhÃes Montenegro JÃnior |
dc.contributor.referee1ID.fl_str_mv |
35865326368 |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/7492450432942397 |
dc.contributor.referee2.fl_str_mv |
AluÃsio Ferreira de Lima |
dc.contributor.referee2ID.fl_str_mv |
19267164856 |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/3925673395634061 |
dc.contributor.referee3.fl_str_mv |
Denise de Lima Oliveira Vilas Boas |
dc.contributor.referee3ID.fl_str_mv |
26980390864 |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/2242445571095877 |
dc.contributor.referee4.fl_str_mv |
Felipe Lustosa Leite |
dc.contributor.referee4ID.fl_str_mv |
96708824353 |
dc.contributor.authorID.fl_str_mv |
61888443391 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/2887301247861009 |
dc.contributor.author.fl_str_mv |
Liana Rosa Elias |
contributor_str_mv |
Andrà FÃrrer Carvalho Cristiano Andre Kohler Renan MagalhÃes Montenegro JÃnior AluÃsio Ferreira de Lima Denise de Lima Oliveira Vilas Boas Felipe Lustosa Leite |
dc.subject.cnpq.fl_str_mv |
PSICOLOGIA |
topic |
PSICOLOGIA |
dc.description.sponsorship.fl_txt_mv |
nÃo hà FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico |
dc.description.abstract.por.fl_txt_mv |
This work consists of a systematic review with meta-analysis of studies investigating neuropsychological functions in youth up to the age of 18 diagnosed with Bipolar Disorder (BD) in euthymic phase compared to healthy controls (HC). The study aims to to clarify the cognitive functioning of pediatric bipolar patients by investigating a representative sample and controlling potential sources of heterogeneity. A systematic search in the literature was performed in the Pubmed/MEDLINE, PsycInfo and EMBASE databases from inception until March 23rd, 2016 to select original peer-reviewed studies that investigated neuropsychological functions in youths diagnosed with TB in the euthymic phase compared to HC. Effect sizes were extracted for each of the neuropsychological tests used. In addition, the results were grouped according to the following cognitive domains: attention and vigilance, verbal learning, verbal memory, working memory, visual learning, visual memory, executive functions, processing speed and general cognition. The PRISMA Statement protocol was followed. The study synthesized data from twenty-four studies that met the inclusion criteria (N = 1146, 510 in the BD group and 636 in the control group). In general, euthymic bipolar youngsters had significant deficits in the domains of verbal learning, verbal memory, working memory, visual learning and visual memory with moderate to large effect sizes (Hedgesâs g between 0.76 and 0.99). No significant deficits were observed in the domains of attention/vigilance, executive functions, and processing speed. The heterogeneity was moderate to large (I2 ≥ 50%) for most ES estimates. Differences in the definition of euthymia between the studies explained the heterogeneity in the ES estimation for verbal learning and memory. Evidence was also found for other potential sources of heterogeneity in various estimates of ES that included comorbidity with ADHD and anxiety disorders, as well as madication use. In addition, the use of different neuropsychological tests seemed to contribute to the heterogeneity of some estimates (e.g. in the attention/vigilance domain). At the end, it can be concluded that youths with euthymic BD present significant cognitive dysfunction encompassing the domains verbal learning, visual learning, verbal memory, visual memory and working memory. The results also suggest that, for a subset of individuals with BD, neurodevelopmental factors may contribute to cognitive dysfunction. Este trabalho consiste em uma revisÃo sistemÃtica com meta-anÃlise de estudos investigando funÃÃes neuropsicolÃgicas em jovens atà 18 anos diagnosticados com Transtorno Bipolar (TB) em fase eutÃmica em comparaÃÃo com controles saudÃveis (CS). Desta forma, espera-se esclarecer o funcionamento cognitivo de pacientes bipolares pediÃtricos com uma amostra representativa e com controle das potenciais fontes de heterogeneidade. Para o alcance dos objetivos, uma busca sistemÃtica na literatura foi realizada nas bases de dados Pubmed / MEDLINE, PsycInfo e EMBASE, desde o primeiro periÃdico veiculado à base, atà 23 de marÃo de 2016 em estudos originais revisados por pares (peer-review) que investigaram funÃÃes neuropsicolÃgicas de jovens eutÃmicos com TB em comparaÃÃo com CS. Foram extraÃdos os tamanhos de efeito (TE) para cada um dos testes neuropsicolÃgicos utilizados. Adicionalmente, os resultados foram agrupados de acordo com os seguintes domÃnios cognitivos: atenÃÃo/vigilÃncia, aprendizagem verbal, memÃria verbal, memÃria de trabalho, aprendizagem visual, memÃria visual, funÃÃes executivas, velocidade de processamento e cogniÃÃo geral. Foram seguidos os protocolos do PRISMA Statement. Como resultado, este estudo sintetizou dados de vinte e quatro estudos que preencheram os critÃrios de inclusÃo (N = 1146; sendo 510 no grupo TB e 636 no grupo controle). Em geral, os jovens bipolares eutÃmicos apresentaram dÃficits significativos nos domÃnios de: aprendizagem verbal, memÃria verbal, memÃria de trabalho, aprendizagem visual e memÃria visual, com tamanhos de efeito de moderado a grande (g de Hedge entre 0,76 a 0,99). NÃo foram observados dÃficits significativos nos domÃnios de atenÃÃo e vigilÃncia, funÃÃes executivas, e velocidade de processamento. A heterogeneidade foi alta (I2 ≥ 50%) para a maioria das estimativas de TE. DiferenÃas na definiÃÃo de eutimia entre os estudos explicaram a heterogeneidade na estimativa do TE para aprendizagem verbal e memÃria. TambÃm foram encontradas evidÃncias para outras fontes potenciais de heterogeneidade em vÃrias estimativas do TE, que incluiam comorbidade com TDA/H e transtornos de ansiedade, bem como o uso de medicamentos. AlÃm disso, o uso de diferentes testes neuropsicolÃgicos pareceu contribuir para a heterogeneidade de algumas estimativas (como por exemplo, no domÃnio atenÃÃo/vigilÃncia). Ao final, foi possÃvel concluir que jovens bipolares eutÃmicos apresentam disfunÃÃo cognitiva significativa abrangendo os domÃnios aprendizagem verbal, aprendizagem visual, memÃria verbal, memÃria visual e memÃria de trabalho. Estes dados sugerem que, para um subconjunto de indivÃduos com TB, os fatores do neurodesenvolvimento podem contribuir para a disfunÃÃo cognitiva. |
description |
This work consists of a systematic review with meta-analysis of studies investigating neuropsychological functions in youth up to the age of 18 diagnosed with Bipolar Disorder (BD) in euthymic phase compared to healthy controls (HC). The study aims to to clarify the cognitive functioning of pediatric bipolar patients by investigating a representative sample and controlling potential sources of heterogeneity. A systematic search in the literature was performed in the Pubmed/MEDLINE, PsycInfo and EMBASE databases from inception until March 23rd, 2016 to select original peer-reviewed studies that investigated neuropsychological functions in youths diagnosed with TB in the euthymic phase compared to HC. Effect sizes were extracted for each of the neuropsychological tests used. In addition, the results were grouped according to the following cognitive domains: attention and vigilance, verbal learning, verbal memory, working memory, visual learning, visual memory, executive functions, processing speed and general cognition. The PRISMA Statement protocol was followed. The study synthesized data from twenty-four studies that met the inclusion criteria (N = 1146, 510 in the BD group and 636 in the control group). In general, euthymic bipolar youngsters had significant deficits in the domains of verbal learning, verbal memory, working memory, visual learning and visual memory with moderate to large effect sizes (Hedgesâs g between 0.76 and 0.99). No significant deficits were observed in the domains of attention/vigilance, executive functions, and processing speed. The heterogeneity was moderate to large (I2 ≥ 50%) for most ES estimates. Differences in the definition of euthymia between the studies explained the heterogeneity in the ES estimation for verbal learning and memory. Evidence was also found for other potential sources of heterogeneity in various estimates of ES that included comorbidity with ADHD and anxiety disorders, as well as madication use. In addition, the use of different neuropsychological tests seemed to contribute to the heterogeneity of some estimates (e.g. in the attention/vigilance domain). At the end, it can be concluded that youths with euthymic BD present significant cognitive dysfunction encompassing the domains verbal learning, visual learning, verbal memory, visual memory and working memory. The results also suggest that, for a subset of individuals with BD, neurodevelopmental factors may contribute to cognitive dysfunction. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-12-27 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
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publishedVersion |
format |
doctoralThesis |
dc.identifier.uri.fl_str_mv |
http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18550 |
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http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=18550 |
dc.language.iso.fl_str_mv |
por |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal do Cearà |
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Programa de PÃs-GraduaÃÃo em CiÃncias MÃdicas |
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UFC |
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BR |
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Universidade Federal do Cearà |
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Universidade Federal do Ceará |
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