ProduÃÃo de Biocimentos de Apatitas NanomÃtricas Aplicadas como Sistema de LiberaÃÃo Controlada de Drogas

Detalhes bibliográficos
Autor(a) principal: Josà Silvio Veras Albuquerque
Data de Publicação: 2012
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFC
Texto Completo: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7151
Resumo: Calcium phosphate biocements have been object of intense study in recent years due to their potential utility in biomedical applications. They can be used to liberate active substances in the human body, as antibiotic or anticancer drugs. In this work, calcium phosphate biocements under the pure or combined form with calcium sulphate had been investigated as to their potential to liberate ampicillin. Mechanical behavior, the time of handling, pH and the porosity of the biocements were evaluated using samples in the shape of cylinders with 6 mm of height and 12 mm of diameter. Test results were submitted to a statistical treatment to determine whether the arithmetic means of the different additive levels are statistically significant or not. It was demonstrated that the adittion of sulphate to conventional biocement DCPD produces a significant increase in the mechanical resistance. This increase is probably due to the formation of needle-like crystals, that strengthen the crystalline matrix of the biocement. Ampicillin incorporated to the biocements was released in a buffer solution of phosphate (PBS) at the physiological temperature and in different times of immersion. The amounts of drug released were estimated from UV/VIS absorbance measurements of systems (samples) BCF-00 and BCF-10. Comparison of the release profiles indicate that in 120 minutes of experiment 3.85% of the drug were released from sample BCF-10, while sample BCF-00 liberates practically three times as much, that is, 9.37%. This decrease in the release tax probably occurs due to the amount of porosity of the samples.
id UFC_8c1f330762895a0cc394b186a5158add
oai_identifier_str oai:www.teses.ufc.br:5004
network_acronym_str UFC
network_name_str Biblioteca Digital de Teses e Dissertações da UFC
spelling info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisProduÃÃo de Biocimentos de Apatitas NanomÃtricas Aplicadas como Sistema de LiberaÃÃo Controlada de DrogasProductio of a Nanometric Apatite Biocement Applied as a Drug Release Controlled System2012-02-03Ricardo EmÃlio Ferreira Quevedo Nogueira20333560353http://lattes.cnpq.br/6064127323404237AntÃnio SÃrgio Bezerra Sombra11420618334http://lattes.cnpq.br/6034251420222926 Ãnio Pontes de Deus24220396349CecÃlia AmÃlia de Carvalho Zavaglia 62792520868http://lattes.cnpq.br/9726544779319467 Marcelo Henrique Prado da Silva87019183700http://lattes.cnpq.br/3027347445652264 24744590386http://lattes.cnpq.br/4019981851710163Josà Silvio Veras AlbuquerqueUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em Engenharia e CiÃncia de MateriaisUFCBRcalcium phosphate biomaterials biocement, drugCiÃncia dos materiaisMateriais biomÃdicosBIOMATERIAIS E MATERIAIS BIOCOMPATIVEISCalcium phosphate biocements have been object of intense study in recent years due to their potential utility in biomedical applications. They can be used to liberate active substances in the human body, as antibiotic or anticancer drugs. In this work, calcium phosphate biocements under the pure or combined form with calcium sulphate had been investigated as to their potential to liberate ampicillin. Mechanical behavior, the time of handling, pH and the porosity of the biocements were evaluated using samples in the shape of cylinders with 6 mm of height and 12 mm of diameter. Test results were submitted to a statistical treatment to determine whether the arithmetic means of the different additive levels are statistically significant or not. It was demonstrated that the adittion of sulphate to conventional biocement DCPD produces a significant increase in the mechanical resistance. This increase is probably due to the formation of needle-like crystals, that strengthen the crystalline matrix of the biocement. Ampicillin incorporated to the biocements was released in a buffer solution of phosphate (PBS) at the physiological temperature and in different times of immersion. The amounts of drug released were estimated from UV/VIS absorbance measurements of systems (samples) BCF-00 and BCF-10. Comparison of the release profiles indicate that in 120 minutes of experiment 3.85% of the drug were released from sample BCF-10, while sample BCF-00 liberates practically three times as much, that is, 9.37%. This decrease in the release tax probably occurs due to the amount of porosity of the samples.Os biocimentos de fosfatos de cÃlcio tÃm sido objeto de intenso estudo nos Ãltimos anos devido à sua potencial utilidade em aplicaÃÃes biomÃdicas. Entre outras aplicaÃÃes, os biocimentos podem ser utilizados para liberar substÃncias ativas no corpo humano, como antibiÃticos ou drogas anticÃncer. Neste trabalho, biocimentos de fosfato de cÃlcio, sob a forma pura ou combinada com sulfato de cÃlcio di-hidratado, foram investigados como matrizes em potencial para liberar ampicilina. O comportamento mecÃnico, o tempo de pega, o pH e a porosidade dos biocimentos foram avaliados utilizando amostras em formato de cilindros com 6 mm de altura e 12 mm de diÃmetro. Os dados obtidos foram sujeitos a tratamento estatÃstico para comparar se as mÃdias aritmÃticas entre os nÃveis de aditivos sÃo estatisticamente significantes. Foi demonstrado que a aditivaÃÃo do biocimento convencional DCPD produz um aumento significativo na resistÃncia mecÃnica. Este aumento à devido à formaÃÃo de cristais em forma de agulhas, que reforÃam a matriz cristalina do biocimento. Ampicilina incorporada aos biocimentos foi liberada em soluÃÃo tampÃo de fosfatos (PBS) à temperatura fisiolÃgica e em diferentes tempos de imersÃo. As quantidades de fÃrmaco liberadas foram estimadas a partir de medidas de absorbÃncia no UV-VisÃvel. Comparando os perfis de liberaÃÃo, os resultados indicam que, em 120 minutos de experimento, 3,85% do fÃrmaco sÃo liberados da amostra BCF-10, enquanto a amostra BCF-00 libera praticamente o triplo, ou seja, 9,37%. Este decrÃscimo na taxa de liberaÃÃo provavelmente ocorre em funÃÃo da quantidade de poros presentes nas amostras. CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superiorhttp://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7151application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:20:13Zmail@mail.com -
dc.title.pt.fl_str_mv ProduÃÃo de Biocimentos de Apatitas NanomÃtricas Aplicadas como Sistema de LiberaÃÃo Controlada de Drogas
dc.title.alternative..fl_str_mv Productio of a Nanometric Apatite Biocement Applied as a Drug Release Controlled System
title ProduÃÃo de Biocimentos de Apatitas NanomÃtricas Aplicadas como Sistema de LiberaÃÃo Controlada de Drogas
spellingShingle ProduÃÃo de Biocimentos de Apatitas NanomÃtricas Aplicadas como Sistema de LiberaÃÃo Controlada de Drogas
Josà Silvio Veras Albuquerque
CiÃncia dos materiais
Materiais biomÃdicos
BIOMATERIAIS E MATERIAIS BIOCOMPATIVEIS
title_short ProduÃÃo de Biocimentos de Apatitas NanomÃtricas Aplicadas como Sistema de LiberaÃÃo Controlada de Drogas
title_full ProduÃÃo de Biocimentos de Apatitas NanomÃtricas Aplicadas como Sistema de LiberaÃÃo Controlada de Drogas
title_fullStr ProduÃÃo de Biocimentos de Apatitas NanomÃtricas Aplicadas como Sistema de LiberaÃÃo Controlada de Drogas
title_full_unstemmed ProduÃÃo de Biocimentos de Apatitas NanomÃtricas Aplicadas como Sistema de LiberaÃÃo Controlada de Drogas
title_sort ProduÃÃo de Biocimentos de Apatitas NanomÃtricas Aplicadas como Sistema de LiberaÃÃo Controlada de Drogas
author Josà Silvio Veras Albuquerque
author_facet Josà Silvio Veras Albuquerque
author_role author
dc.contributor.advisor1.fl_str_mv Ricardo EmÃlio Ferreira Quevedo Nogueira
dc.contributor.advisor1ID.fl_str_mv 20333560353
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/6064127323404237
dc.contributor.referee1.fl_str_mv AntÃnio SÃrgio Bezerra Sombra
dc.contributor.referee1ID.fl_str_mv 11420618334
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/6034251420222926
dc.contributor.referee2.fl_str_mv Ãnio Pontes de Deus
dc.contributor.referee2ID.fl_str_mv 24220396349
dc.contributor.referee3.fl_str_mv CecÃlia AmÃlia de Carvalho Zavaglia
dc.contributor.referee3ID.fl_str_mv 62792520868
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/9726544779319467
dc.contributor.referee4.fl_str_mv Marcelo Henrique Prado da Silva
dc.contributor.referee4ID.fl_str_mv 87019183700
dc.contributor.referee4Lattes.fl_str_mv http://lattes.cnpq.br/3027347445652264
dc.contributor.authorID.fl_str_mv 24744590386
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/4019981851710163
dc.contributor.author.fl_str_mv Josà Silvio Veras Albuquerque
contributor_str_mv Ricardo EmÃlio Ferreira Quevedo Nogueira
AntÃnio SÃrgio Bezerra Sombra
Ãnio Pontes de Deus
CecÃlia AmÃlia de Carvalho Zavaglia
Marcelo Henrique Prado da Silva
dc.subject.por.fl_str_mv CiÃncia dos materiais
Materiais biomÃdicos
topic CiÃncia dos materiais
Materiais biomÃdicos
BIOMATERIAIS E MATERIAIS BIOCOMPATIVEIS
dc.subject.cnpq.fl_str_mv BIOMATERIAIS E MATERIAIS BIOCOMPATIVEIS
dc.description.sponsorship.fl_txt_mv CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior
dc.description.abstract..fl_txt_mv Calcium phosphate biocements have been object of intense study in recent years due to their potential utility in biomedical applications. They can be used to liberate active substances in the human body, as antibiotic or anticancer drugs. In this work, calcium phosphate biocements under the pure or combined form with calcium sulphate had been investigated as to their potential to liberate ampicillin. Mechanical behavior, the time of handling, pH and the porosity of the biocements were evaluated using samples in the shape of cylinders with 6 mm of height and 12 mm of diameter. Test results were submitted to a statistical treatment to determine whether the arithmetic means of the different additive levels are statistically significant or not. It was demonstrated that the adittion of sulphate to conventional biocement DCPD produces a significant increase in the mechanical resistance. This increase is probably due to the formation of needle-like crystals, that strengthen the crystalline matrix of the biocement. Ampicillin incorporated to the biocements was released in a buffer solution of phosphate (PBS) at the physiological temperature and in different times of immersion. The amounts of drug released were estimated from UV/VIS absorbance measurements of systems (samples) BCF-00 and BCF-10. Comparison of the release profiles indicate that in 120 minutes of experiment 3.85% of the drug were released from sample BCF-10, while sample BCF-00 liberates practically three times as much, that is, 9.37%. This decrease in the release tax probably occurs due to the amount of porosity of the samples.
dc.description.abstract.por.fl_txt_mv Os biocimentos de fosfatos de cÃlcio tÃm sido objeto de intenso estudo nos Ãltimos anos devido à sua potencial utilidade em aplicaÃÃes biomÃdicas. Entre outras aplicaÃÃes, os biocimentos podem ser utilizados para liberar substÃncias ativas no corpo humano, como antibiÃticos ou drogas anticÃncer. Neste trabalho, biocimentos de fosfato de cÃlcio, sob a forma pura ou combinada com sulfato de cÃlcio di-hidratado, foram investigados como matrizes em potencial para liberar ampicilina. O comportamento mecÃnico, o tempo de pega, o pH e a porosidade dos biocimentos foram avaliados utilizando amostras em formato de cilindros com 6 mm de altura e 12 mm de diÃmetro. Os dados obtidos foram sujeitos a tratamento estatÃstico para comparar se as mÃdias aritmÃticas entre os nÃveis de aditivos sÃo estatisticamente significantes. Foi demonstrado que a aditivaÃÃo do biocimento convencional DCPD produz um aumento significativo na resistÃncia mecÃnica. Este aumento à devido à formaÃÃo de cristais em forma de agulhas, que reforÃam a matriz cristalina do biocimento. Ampicilina incorporada aos biocimentos foi liberada em soluÃÃo tampÃo de fosfatos (PBS) à temperatura fisiolÃgica e em diferentes tempos de imersÃo. As quantidades de fÃrmaco liberadas foram estimadas a partir de medidas de absorbÃncia no UV-VisÃvel. Comparando os perfis de liberaÃÃo, os resultados indicam que, em 120 minutos de experimento, 3,85% do fÃrmaco sÃo liberados da amostra BCF-10, enquanto a amostra BCF-00 libera praticamente o triplo, ou seja, 9,37%. Este decrÃscimo na taxa de liberaÃÃo provavelmente ocorre em funÃÃo da quantidade de poros presentes nas amostras.
description Calcium phosphate biocements have been object of intense study in recent years due to their potential utility in biomedical applications. They can be used to liberate active substances in the human body, as antibiotic or anticancer drugs. In this work, calcium phosphate biocements under the pure or combined form with calcium sulphate had been investigated as to their potential to liberate ampicillin. Mechanical behavior, the time of handling, pH and the porosity of the biocements were evaluated using samples in the shape of cylinders with 6 mm of height and 12 mm of diameter. Test results were submitted to a statistical treatment to determine whether the arithmetic means of the different additive levels are statistically significant or not. It was demonstrated that the adittion of sulphate to conventional biocement DCPD produces a significant increase in the mechanical resistance. This increase is probably due to the formation of needle-like crystals, that strengthen the crystalline matrix of the biocement. Ampicillin incorporated to the biocements was released in a buffer solution of phosphate (PBS) at the physiological temperature and in different times of immersion. The amounts of drug released were estimated from UV/VIS absorbance measurements of systems (samples) BCF-00 and BCF-10. Comparison of the release profiles indicate that in 120 minutes of experiment 3.85% of the drug were released from sample BCF-10, while sample BCF-00 liberates practically three times as much, that is, 9.37%. This decrease in the release tax probably occurs due to the amount of porosity of the samples.
publishDate 2012
dc.date.issued.fl_str_mv 2012-02-03
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
status_str publishedVersion
format doctoralThesis
dc.identifier.uri.fl_str_mv http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7151
url http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7151
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.publisher.program.fl_str_mv Programa de PÃs-GraduaÃÃo em Engenharia e CiÃncia de Materiais
dc.publisher.initials.fl_str_mv UFC
dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFC
instname:Universidade Federal do Ceará
instacron:UFC
reponame_str Biblioteca Digital de Teses e Dissertações da UFC
collection Biblioteca Digital de Teses e Dissertações da UFC
instname_str Universidade Federal do Ceará
instacron_str UFC
institution UFC
repository.name.fl_str_mv -
repository.mail.fl_str_mv mail@mail.com
_version_ 1643295155394969600

Registros relacionados