Obtaining of derivatives lithocholic acid and antimicrobial activity

Detalhes bibliográficos
Autor(a) principal: PatrÃcia Georgina Garcia do Nascimento
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da UFC
Texto Completo: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16720
Resumo: This paper describes obtaining eight lithocholic acid derivatives, as well as inhibitory activity. Interest in the use of lithocholic acid as starting material for the preparation of derivatives arose because of it being widely studied in order to discover new biological activities and such studies have shown good results. In this work it was used for the synthesis of a series of derivatives with modifications at the C-3 and/or C-24 of the steroid skeleton. The series was prepared using simple chemical and showed good yields. Aiming to investigate the antibacterial activity of the same and its derivatives, aiming to structure-activity relationships, tests were performed with bacteria Escherichia coli, Staphylococcus aureus, Bacillus cereus and Pseudomonas aeruginosa, try some of them presented significant results. And lithocholic acid derivatives were characterized by spectroscopic IR, 1H NMR, 13C-BB NMR and 13C-DEPT NMR and mass spectrometry as well as comparison with data in the literature and described constitute the body of the dissertation.
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spelling info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisObtaining of derivatives lithocholic acid and antimicrobial activityObtenÃÃo de derivados do Ãcido litocÃlico e suas atividades antimicrobianas2012-10-31Telma Leda Gomes de Lemos04511700320http://buscatextual.cnpq.br/buscatextual/visualizacv.jsp?id=K4783204Z7Gilvandete Maria Pinheiro Santiago11776650344JoÃo Carlos da Costa AssunÃÃo78977770300http://lattes.cnpq.br/8873683560219910 01583371311CV: http://lattes.cnpq.br/7244554044381270PatrÃcia Georgina Garcia do NascimentoUniversidade Federal do CearÃPrograma de PÃs-GraduaÃÃo em QuÃmica UFCBRÃcidos biliaresÃcido litocÃlicoDerivadosAtividade antimicrobianaBile acidsLithocholic acidDerivativesAntimicrobial activityQUIMICA DOS PRODUTOS NATURAISThis paper describes obtaining eight lithocholic acid derivatives, as well as inhibitory activity. Interest in the use of lithocholic acid as starting material for the preparation of derivatives arose because of it being widely studied in order to discover new biological activities and such studies have shown good results. In this work it was used for the synthesis of a series of derivatives with modifications at the C-3 and/or C-24 of the steroid skeleton. The series was prepared using simple chemical and showed good yields. Aiming to investigate the antibacterial activity of the same and its derivatives, aiming to structure-activity relationships, tests were performed with bacteria Escherichia coli, Staphylococcus aureus, Bacillus cereus and Pseudomonas aeruginosa, try some of them presented significant results. And lithocholic acid derivatives were characterized by spectroscopic IR, 1H NMR, 13C-BB NMR and 13C-DEPT NMR and mass spectrometry as well as comparison with data in the literature and described constitute the body of the dissertation.Esse trabalho descreve a obtenÃÃo de oito derivados do Ãcido litocÃlico, bem como, suas atividades antimicrobianas. O interesse pela utilizaÃÃo do Ãcido litocÃlico como material de partida na preparaÃÃo de derivados surgiu pelo fato do mesmo sendo bastante estudado com o objetivo de descobrir novas atividades biolÃgicas e tais estudos terem apresentado bons resultados. Nesse trabalho, o Ãcido litocÃlico foi submetido a modificaÃÃes moleculares nas posiÃÃes C-3 e/ou C-24 do esqueleto esteroidal. A sÃrie foi preparada utilizando quÃmica convencional e apresentando bons rendimentos. Com o objetivo de investigar a atividade antimicrobiana dos compostos, foram realizados testes com as bactÃrias Escherichia coli, Staphylococcus aureus, Bacillus cereus e Pseudomonas aeruginosa, tento alguns deles apresentado resultados bastante significativos. O Ãcido litocÃlico e seus derivados foram caracterizados por mÃtodos espectroscÃpicos de IV, RMN 1H, RMN 13C-BB e RMN 13C-DEPT e por espectrometria de massa, bem como comparaÃÃo com dados descritos na literatura.CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16720application/pdfinfo:eu-repo/semantics/openAccessporreponame:Biblioteca Digital de Teses e Dissertações da UFCinstname:Universidade Federal do Cearáinstacron:UFC2019-01-21T11:30:07Zmail@mail.com -
dc.title.en.fl_str_mv Obtaining of derivatives lithocholic acid and antimicrobial activity
dc.title.alternative.pt.fl_str_mv ObtenÃÃo de derivados do Ãcido litocÃlico e suas atividades antimicrobianas
title Obtaining of derivatives lithocholic acid and antimicrobial activity
spellingShingle Obtaining of derivatives lithocholic acid and antimicrobial activity
PatrÃcia Georgina Garcia do Nascimento
Ãcidos biliares
Ãcido litocÃlico
Derivados
Atividade antimicrobiana
Bile acids
Lithocholic acid
Derivatives
Antimicrobial activity
QUIMICA DOS PRODUTOS NATURAIS
title_short Obtaining of derivatives lithocholic acid and antimicrobial activity
title_full Obtaining of derivatives lithocholic acid and antimicrobial activity
title_fullStr Obtaining of derivatives lithocholic acid and antimicrobial activity
title_full_unstemmed Obtaining of derivatives lithocholic acid and antimicrobial activity
title_sort Obtaining of derivatives lithocholic acid and antimicrobial activity
author PatrÃcia Georgina Garcia do Nascimento
author_facet PatrÃcia Georgina Garcia do Nascimento
author_role author
dc.contributor.advisor1.fl_str_mv Telma Leda Gomes de Lemos
dc.contributor.advisor1ID.fl_str_mv 04511700320
dc.contributor.advisor1Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.jsp?id=K4783204Z7
dc.contributor.advisor-co1.fl_str_mv Gilvandete Maria Pinheiro Santiago
dc.contributor.advisor-co1ID.fl_str_mv 11776650344
dc.contributor.referee1.fl_str_mv JoÃo Carlos da Costa AssunÃÃo
dc.contributor.referee1ID.fl_str_mv 78977770300
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/8873683560219910
dc.contributor.authorID.fl_str_mv 01583371311
dc.contributor.authorLattes.fl_str_mv CV: http://lattes.cnpq.br/7244554044381270
dc.contributor.author.fl_str_mv PatrÃcia Georgina Garcia do Nascimento
contributor_str_mv Telma Leda Gomes de Lemos
Gilvandete Maria Pinheiro Santiago
JoÃo Carlos da Costa AssunÃÃo
dc.subject.por.fl_str_mv Ãcidos biliares
Ãcido litocÃlico
Derivados
Atividade antimicrobiana
topic Ãcidos biliares
Ãcido litocÃlico
Derivados
Atividade antimicrobiana
Bile acids
Lithocholic acid
Derivatives
Antimicrobial activity
QUIMICA DOS PRODUTOS NATURAIS
dc.subject.eng.fl_str_mv Bile acids
Lithocholic acid
Derivatives
Antimicrobial activity
dc.subject.cnpq.fl_str_mv QUIMICA DOS PRODUTOS NATURAIS
dc.description.sponsorship.fl_txt_mv CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior
dc.description.abstract.por.fl_txt_mv This paper describes obtaining eight lithocholic acid derivatives, as well as inhibitory activity. Interest in the use of lithocholic acid as starting material for the preparation of derivatives arose because of it being widely studied in order to discover new biological activities and such studies have shown good results. In this work it was used for the synthesis of a series of derivatives with modifications at the C-3 and/or C-24 of the steroid skeleton. The series was prepared using simple chemical and showed good yields. Aiming to investigate the antibacterial activity of the same and its derivatives, aiming to structure-activity relationships, tests were performed with bacteria Escherichia coli, Staphylococcus aureus, Bacillus cereus and Pseudomonas aeruginosa, try some of them presented significant results. And lithocholic acid derivatives were characterized by spectroscopic IR, 1H NMR, 13C-BB NMR and 13C-DEPT NMR and mass spectrometry as well as comparison with data in the literature and described constitute the body of the dissertation.
Esse trabalho descreve a obtenÃÃo de oito derivados do Ãcido litocÃlico, bem como, suas atividades antimicrobianas. O interesse pela utilizaÃÃo do Ãcido litocÃlico como material de partida na preparaÃÃo de derivados surgiu pelo fato do mesmo sendo bastante estudado com o objetivo de descobrir novas atividades biolÃgicas e tais estudos terem apresentado bons resultados. Nesse trabalho, o Ãcido litocÃlico foi submetido a modificaÃÃes moleculares nas posiÃÃes C-3 e/ou C-24 do esqueleto esteroidal. A sÃrie foi preparada utilizando quÃmica convencional e apresentando bons rendimentos. Com o objetivo de investigar a atividade antimicrobiana dos compostos, foram realizados testes com as bactÃrias Escherichia coli, Staphylococcus aureus, Bacillus cereus e Pseudomonas aeruginosa, tento alguns deles apresentado resultados bastante significativos. O Ãcido litocÃlico e seus derivados foram caracterizados por mÃtodos espectroscÃpicos de IV, RMN 1H, RMN 13C-BB e RMN 13C-DEPT e por espectrometria de massa, bem como comparaÃÃo com dados descritos na literatura.
description This paper describes obtaining eight lithocholic acid derivatives, as well as inhibitory activity. Interest in the use of lithocholic acid as starting material for the preparation of derivatives arose because of it being widely studied in order to discover new biological activities and such studies have shown good results. In this work it was used for the synthesis of a series of derivatives with modifications at the C-3 and/or C-24 of the steroid skeleton. The series was prepared using simple chemical and showed good yields. Aiming to investigate the antibacterial activity of the same and its derivatives, aiming to structure-activity relationships, tests were performed with bacteria Escherichia coli, Staphylococcus aureus, Bacillus cereus and Pseudomonas aeruginosa, try some of them presented significant results. And lithocholic acid derivatives were characterized by spectroscopic IR, 1H NMR, 13C-BB NMR and 13C-DEPT NMR and mass spectrometry as well as comparison with data in the literature and described constitute the body of the dissertation.
publishDate 2012
dc.date.issued.fl_str_mv 2012-10-31
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
status_str publishedVersion
format masterThesis
dc.identifier.uri.fl_str_mv http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16720
url http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16720
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.publisher.program.fl_str_mv Programa de PÃs-GraduaÃÃo em QuÃmica
dc.publisher.initials.fl_str_mv UFC
dc.publisher.country.fl_str_mv BR
publisher.none.fl_str_mv Universidade Federal do CearÃ
dc.source.none.fl_str_mv reponame:Biblioteca Digital de Teses e Dissertações da UFC
instname:Universidade Federal do Ceará
instacron:UFC
reponame_str Biblioteca Digital de Teses e Dissertações da UFC
collection Biblioteca Digital de Teses e Dissertações da UFC
instname_str Universidade Federal do Ceará
instacron_str UFC
institution UFC
repository.name.fl_str_mv -
repository.mail.fl_str_mv mail@mail.com
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