Sulfato de vincristina no tratamento do tumor venéreo transmissível frente à caracterização citomorfológica

• Autor(a) principal: SIMERMANN, Nívia Faria Silva
• Data de Publicação: 2009
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• dARK ID: ark:/38995/0013000002bzc
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tde/832
• topic: cão; citomorfologia; exame citológico; vincristina; 1.Tumor Venéreo Transmissível - Canino 2. Sulfato de Vincristina Resistência Quimioterápica; dog; cytomorphology; cytologic test; vincristine; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL::CLINICA CIRURGICA ANIMAL

The transmissible venereal tumor (TVT) is among the most common cancers in dogs in Brazil. This is a sexually transmitted cancer through a mechanism of transplantation of viable tumor cells, it has high incidence among dogs of both sexes in reproductive age, with high occurrence in areas of high concentration of dogs with poor control of reproduction. The diagnosis made in the routine of clinical medicine is usually based only on clinical symptoms and the chemotherapy of choice has been the vincristine sulfate. This drug has been shown in most cases a good response to treatment with complete regression of the tumor, but there are also cases where the tumor appears resistant to treatment. This study aimed to demonstrate the practicality of using fine needle aspiration cytology as a method of diagnosis and cytomorphologic classification, being effective and safe as well as measuring the response of different cytomorphologic groups forward to treatment with vincristine sulfate. Also evaluating the clinical response, hematologic and biochemical tests using serum liver function (ALT) and renal (creatinine), in the therapy instituted. Were evaluated and treated 18 dogs of both sexes, carrying TVT, which received six consecutive weeks during the administration of vincristine sulfate in the dosage of 0.03 mg / kg administered intravenously. The animals underwent weekly prior to medication, clinical assessment, haematological and biochemical. It was observed in this study that cytological examination is a simple technique, minimally invasive and painless, and a safe method that provides no risk to the patient's life and does not require the use of sophisticated equipment, sedation or anesthesia for their achievement. Animals carrying the TVT plasmacytoid type, had higher rate of tumor resistance to treatment in relation to established groups and linfocytic mixed, showing a greater resistance to treatment with this group of vincristine sulfate. The efficiency of response to treatment was presented by the linfocytic group. The vincristine sulfate showed few side effects, low hematological, hepatic and renal toxicity, it is therefore an effective option in the control of transmissible venereal tumor in not resistant cases.