Avaliação da produção de citocinas, quimiocinas e fatores de crescimento nas fases aguda e convalescente da infecção pelo vírus Zika em área endêmica

• Autor(a) principal: Silva, Paulo Alex Neves da
• Data de Publicação: 2017
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/9278
• topic: Vírus Zika; Inflamação; Citocinas; Zika virus; Cytokine; Inflammation; CIENCIAS BIOLOGICAS::IMUNOLOGIA

The Zika virus (ZIKV) is transmitted by the bite of the mosquito, mainly of the genus Aedes. The virus was first isolated in nonhuman primates in Zika forest in Uganda in 1947. Between 1953-2006, there were sporadic cases of ZIKV infection in humans in Africa, Asia and Oceania, and it was considered benign. In 2007, there was the first outbreak of the ZIKV and from that time, began to emerge complications such as microcephaly and Guillain-Barre syndrome. Approximately 80% of ZIKV infection cases are asymptomatic, but when symptoms do occur are usually mild and nonspecific. The objective of this study was to evaluate plasma levels of cytokines, chemokines and growth factors for infection ZIKV in acute and convalescente phases. Few immune mediators had significantly higher levels in the acute phase, namely IFN-γ, IP-10 and RANTES when compared to healthy donors. In addition, plasma levels of IP-10 were also significantly higher in the acute phase of infection when compared to the convalescent phase. No associations were observed between cytokine, chemokines and growth factor levels that were evaluated, and the number of symptoms or viremia. Together, our data indicate that the Zika virus infection during acute phase, in endemic areas, is able to stimulate the immune system in a subtle way and with a markedly pro-inflammatory profile, and it may not be able to eliminate the viral infection efficiently, collaborating for the immunopathogenesis of the infection and favoring viral dissemination.