Avaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus)
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/4965 |
Resumo: | The neonatal development is stimulated by various hormonal interactions. Environmental pollutants that mimic steroid hormones, such as bisphenol A (BPA) can cause changes in the pattern of development of the prostate, leading to lifelong lesions. The objective of this study was to determine whether neonatal exposure to BPA affects the development of prostate gerbils males and females. For this, the newborns were exposed to environmental levels (LBPA - 40 μ / kg / day) and high dose (HBPA - 4 mg / kg / day) of BPA, from 1st to the 7th day of life. On the eighth day, the prostatic complexes were collected and processed for morphological analysis, stereological and immunohistochemistry. It was observed through the three-dimensional reconstruction that in males the prostatic buds have elongated in a "V" form towards the ventral condensed mesenchyme (VMP). The stereological data of males showed a significant increase in the relative frequency of the mesenchymal compartment in the LBPA group compared to other groups (p ≤ 0.05). The AR-positive cells became significantly more frequent in the periurethral mesenchyme (PEM), ventral epithelial buds (VB) and muscle layer (SM) in the BPA group. There was a reduction in the frequency of PCNA-positive cells in the periurethral buds (PeB) and in the SM of the LBPA group. In females, the three-dimensional reconstruction showed that PeBs can emerge from one or both sides of the urethra and it was also visible a significant paraurethral mesenchyme (MAP) reduction in the BPA group. Only females of the HBPA group apparently presented paraurethral buds (PAB) more developed. In the LBPA group it was observed an increase in the AR-positive cells frequency in the PeM and a decrease of these cells in the PeB and mesenchyme paraurethral (PaM). In the HBPA group the AR-positive cells were more frequent in the PeM and PaB and reduced in PeB and PaM. PCNA-positive cells became significantly less frequent in the PaB and PaM of LBPA and HBPA groups. Regarding the ER-α positive cells in the group LBPA females showed a reduction in the immunoblots of PeM and MS, whereas in the group HBPA this reduction occurred only in the PaM. This study revealed that the postnatal development of the prostate of female gerbils occurs earlier and are morphologically distinct from what occurs in males of the same species. Furthermore, it can be seen that the BPA exerted a proliferative effect on the prostate gland of males and females with eight days of postnatal life, though females being more susceptible to this environmental chemicals. |
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Santos, Fernanda Cristina Alcântara doshttp://lattes.cnpq.br/3025583084190459Marques, Mara Rúbiahttp://lattes.cnpq.br/4187443843319711Santos, Fernanda Cristina Alcantara dosBlanck, Lara Silvia Corradi OlhêArruda, Walquíriahttp://lattes.cnpq.br/1919842934251082Lima, Rodrigo Fernandes de2015-11-30T11:21:55Z2015-03-06LIMA, R. F. Avaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus). 2015. 52 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, 2015.http://repositorio.bc.ufg.br/tede/handle/tede/4965The neonatal development is stimulated by various hormonal interactions. Environmental pollutants that mimic steroid hormones, such as bisphenol A (BPA) can cause changes in the pattern of development of the prostate, leading to lifelong lesions. The objective of this study was to determine whether neonatal exposure to BPA affects the development of prostate gerbils males and females. For this, the newborns were exposed to environmental levels (LBPA - 40 μ / kg / day) and high dose (HBPA - 4 mg / kg / day) of BPA, from 1st to the 7th day of life. On the eighth day, the prostatic complexes were collected and processed for morphological analysis, stereological and immunohistochemistry. It was observed through the three-dimensional reconstruction that in males the prostatic buds have elongated in a "V" form towards the ventral condensed mesenchyme (VMP). The stereological data of males showed a significant increase in the relative frequency of the mesenchymal compartment in the LBPA group compared to other groups (p ≤ 0.05). The AR-positive cells became significantly more frequent in the periurethral mesenchyme (PEM), ventral epithelial buds (VB) and muscle layer (SM) in the BPA group. There was a reduction in the frequency of PCNA-positive cells in the periurethral buds (PeB) and in the SM of the LBPA group. In females, the three-dimensional reconstruction showed that PeBs can emerge from one or both sides of the urethra and it was also visible a significant paraurethral mesenchyme (MAP) reduction in the BPA group. Only females of the HBPA group apparently presented paraurethral buds (PAB) more developed. In the LBPA group it was observed an increase in the AR-positive cells frequency in the PeM and a decrease of these cells in the PeB and mesenchyme paraurethral (PaM). In the HBPA group the AR-positive cells were more frequent in the PeM and PaB and reduced in PeB and PaM. PCNA-positive cells became significantly less frequent in the PaB and PaM of LBPA and HBPA groups. Regarding the ER-α positive cells in the group LBPA females showed a reduction in the immunoblots of PeM and MS, whereas in the group HBPA this reduction occurred only in the PaM. This study revealed that the postnatal development of the prostate of female gerbils occurs earlier and are morphologically distinct from what occurs in males of the same species. Furthermore, it can be seen that the BPA exerted a proliferative effect on the prostate gland of males and females with eight days of postnatal life, though females being more susceptible to this environmental chemicals.O desenvolvimento neonatal é estimulado por diversas interações hormonais. Os poluentes ambientais que mimetizam hormônios esteróides, como o bisfenol-A (BPA), podem causar alterações no padrão de desenvolvimento da próstata, levando a lesões ao longo da vida. O objetivo deste estudo foi verificar se a exposição neonatal ao BPA afeta o desenvolvimento da próstata de gerbilos machos e fêmeas. Para isso, os recém-nascidos foram expostos a níveis ambientais (LBPA – 40 μ/kg/dia) e doses elevadas (HBPA – 4 mg/kg/dia) de BPA, do 1° ao 7º dia de vida. No oitavo dia, os complexos prostáticos foram coletados e processados para as análises morfológica, estereológica e imunohistoquímica. Com a reconstrução tridimensional observamos que nos machos os brotos prostáticos se alongaram em forma de “V” em direção ao mesênquima condensado ventral (VMP). Os dados estereológicos dos machos demonstraram um aumento significativo na frequência relativa do compartimento mesenquimal do grupo LBPA em relação aos demais grupos (p ≤ 0,05). As células AR-positivas tornaram-se significativamente mais frequentes no mesênquima periuretral (PeM), brotos epiteliais ventrais (VB) e camada muscular (SM) dos grupos tratados com BPA. Ocorreu uma redução na frequência de células PCNA-positivas nos brotos periuretrais (PeB) e na SM do grupo LBPA. Em fêmeas, a reconstrução tridimensional demonstrou que os PeBs podem emergir de um ou ambos os lados da uretra e também foi visível uma significativa redução do mesênquima parauretral (PaM) nos grupos tratados com BPA. Apenas as fêmeas do grupo HBPA apresentaram brotos parauretrais (PaB) aparentemente mais desenvolvidos. No grupo LBPA observou-se um aumento na frequência de células AR-positivas no PeM e uma diminuição destas células no PeB e mesênquima parauretral (PaM). No grupo HBPA as células AR-positivas tornaram-se mais frequentes no PeM e PaB, contudo sofreram redução no PeB e PaM. Células PCNA-positivas tornaram-se significativamente menos frequentes no PaB e PaM dos grupos LBPA e HBPA. Em relação às células ER-α positivas, nas fêmeas do grupo LBPA observou-se uma redução das imunomarcações no PeM e SM, enquanto que no grupo HBPA essa redução ocorreu apenas no PaM. Este estudo revelou que o desenvolvimento pós-natal da próstata de fêmeas de gerbilos é mais precoce e morfologicamente distinto do que ocorre nos machos da mesma espécie. Além disso, pode-se observar que o BPA exerceu um efeito antiproliferativo sobre a glândula prostática de machos e fêmeas com oito dias de vida pós-natal, sendo as fêmeas mais susceptíveis a este químico ambiental.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2015-11-30T11:20:19Z No. of bitstreams: 2 Dissertação - Rodrigo Fernandes de Lima - 2015.pdf: 2077886 bytes, checksum: 41cc0e061b83ff79f5098eb054d1fcda (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-11-30T11:21:55Z (GMT) No. of bitstreams: 2 Dissertação - Rodrigo Fernandes de Lima - 2015.pdf: 2077886 bytes, checksum: 41cc0e061b83ff79f5098eb054d1fcda (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2015-11-30T11:21:55Z (GMT). No. of bitstreams: 2 Dissertação - Rodrigo Fernandes de Lima - 2015.pdf: 2077886 bytes, checksum: 41cc0e061b83ff79f5098eb054d1fcda (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2015-03-06Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Biologia (ICB)UFGBrasilInstituto de Ciências Biológicas - ICB (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessPróstata ventralMorfogênese prostáticaBPAReceptores hormonaisProliferação celularVentral prostateProstate morphogenesisBPAHormone receptorsCell proliferationCIENCIAS BIOLOGICASAvaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus)Morphophysiological evaluation of the effects of bisphenol A on the development of neonatal prostate gerbilis (Meriones unguiculatus)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis6883982777473437920600600600600-3872772117827373404-34391788430682021612075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Avaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus) |
dc.title.alternative.eng.fl_str_mv |
Morphophysiological evaluation of the effects of bisphenol A on the development of neonatal prostate gerbilis (Meriones unguiculatus) |
title |
Avaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus) |
spellingShingle |
Avaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus) Lima, Rodrigo Fernandes de Próstata ventral Morfogênese prostática BPA Receptores hormonais Proliferação celular Ventral prostate Prostate morphogenesis BPA Hormone receptors Cell proliferation CIENCIAS BIOLOGICAS |
title_short |
Avaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus) |
title_full |
Avaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus) |
title_fullStr |
Avaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus) |
title_full_unstemmed |
Avaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus) |
title_sort |
Avaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus) |
author |
Lima, Rodrigo Fernandes de |
author_facet |
Lima, Rodrigo Fernandes de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Santos, Fernanda Cristina Alcântara dos |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3025583084190459 |
dc.contributor.advisor-co1.fl_str_mv |
Marques, Mara Rúbia |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/4187443843319711 |
dc.contributor.referee1.fl_str_mv |
Santos, Fernanda Cristina Alcantara dos |
dc.contributor.referee2.fl_str_mv |
Blanck, Lara Silvia Corradi Olhê |
dc.contributor.referee3.fl_str_mv |
Arruda, Walquíria |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1919842934251082 |
dc.contributor.author.fl_str_mv |
Lima, Rodrigo Fernandes de |
contributor_str_mv |
Santos, Fernanda Cristina Alcântara dos Marques, Mara Rúbia Santos, Fernanda Cristina Alcantara dos Blanck, Lara Silvia Corradi Olhê Arruda, Walquíria |
dc.subject.por.fl_str_mv |
Próstata ventral Morfogênese prostática BPA Receptores hormonais Proliferação celular |
topic |
Próstata ventral Morfogênese prostática BPA Receptores hormonais Proliferação celular Ventral prostate Prostate morphogenesis BPA Hormone receptors Cell proliferation CIENCIAS BIOLOGICAS |
dc.subject.eng.fl_str_mv |
Ventral prostate Prostate morphogenesis BPA Hormone receptors Cell proliferation |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS |
description |
The neonatal development is stimulated by various hormonal interactions. Environmental pollutants that mimic steroid hormones, such as bisphenol A (BPA) can cause changes in the pattern of development of the prostate, leading to lifelong lesions. The objective of this study was to determine whether neonatal exposure to BPA affects the development of prostate gerbils males and females. For this, the newborns were exposed to environmental levels (LBPA - 40 μ / kg / day) and high dose (HBPA - 4 mg / kg / day) of BPA, from 1st to the 7th day of life. On the eighth day, the prostatic complexes were collected and processed for morphological analysis, stereological and immunohistochemistry. It was observed through the three-dimensional reconstruction that in males the prostatic buds have elongated in a "V" form towards the ventral condensed mesenchyme (VMP). The stereological data of males showed a significant increase in the relative frequency of the mesenchymal compartment in the LBPA group compared to other groups (p ≤ 0.05). The AR-positive cells became significantly more frequent in the periurethral mesenchyme (PEM), ventral epithelial buds (VB) and muscle layer (SM) in the BPA group. There was a reduction in the frequency of PCNA-positive cells in the periurethral buds (PeB) and in the SM of the LBPA group. In females, the three-dimensional reconstruction showed that PeBs can emerge from one or both sides of the urethra and it was also visible a significant paraurethral mesenchyme (MAP) reduction in the BPA group. Only females of the HBPA group apparently presented paraurethral buds (PAB) more developed. In the LBPA group it was observed an increase in the AR-positive cells frequency in the PeM and a decrease of these cells in the PeB and mesenchyme paraurethral (PaM). In the HBPA group the AR-positive cells were more frequent in the PeM and PaB and reduced in PeB and PaM. PCNA-positive cells became significantly less frequent in the PaB and PaM of LBPA and HBPA groups. Regarding the ER-α positive cells in the group LBPA females showed a reduction in the immunoblots of PeM and MS, whereas in the group HBPA this reduction occurred only in the PaM. This study revealed that the postnatal development of the prostate of female gerbils occurs earlier and are morphologically distinct from what occurs in males of the same species. Furthermore, it can be seen that the BPA exerted a proliferative effect on the prostate gland of males and females with eight days of postnatal life, though females being more susceptible to this environmental chemicals. |
publishDate |
2015 |
dc.date.accessioned.fl_str_mv |
2015-11-30T11:21:55Z |
dc.date.issued.fl_str_mv |
2015-03-06 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LIMA, R. F. Avaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus). 2015. 52 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, 2015. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/4965 |
identifier_str_mv |
LIMA, R. F. Avaliação morfofisiológica dos efeitos do bisfenol-A sobre o desenvolvimento neonatal da próstata de gerbilos (Meriones unguiculatus). 2015. 52 f. Dissertação (Mestrado em Biologia) - Universidade Federal de Goiás, 2015. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/4965 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
6883982777473437920 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-3872772117827373404 |
dc.relation.cnpq.fl_str_mv |
-3439178843068202161 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
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