A influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
dARK ID: | ark:/38995/0013000009pqr |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/6746 |
Resumo: | Abstract: Toxoplasma gondii is a pathogenic agente capable o causing both local and systemic disease in immunocompetent and immunocompromised individuals. It can be agressive inducing lesions in the central nervous system, viscera, eye globe and/or lymohatic ganglia. Neurocysticercosis is the most severe form of cysticercosis. It is the one of the main helminthiasis of the central nervous system leasing to varied symptoms. During toxoplasmosis infection the inflammatory response is typically pro-inflammatory. When there is co-infection between these two agents, this typical pro-inflammatory response may lead to the death of the parasites resulting in the release of antigens. Therefore an experimental model using T. gondii cysts and T. crassiceps antigens was developed. The aim of this study was to evaluate the influence of T. crassiceps cysticerci antigens in the modulation of the inflammatory response of the experimental neurotoxoplasmosis. BALB/c mice were inoculated with T. gondii cysts and/or T. crassiceps cysticerci antigens. The animals were euthanized 60 or 90 days after the inoculation. The histopathologic analysis and the cytokine dosage from spleen cell culture were performed. The animals from the neurotoxoplasmosis group at 90 DAI (NT90) presented greater intensity of the lesions such as vasculitis, meningitis and microgliosis alongside with a Th1 immune profile with high dosages of IFNγ. While in the neurocysticercosis group at 60 DAI (NCC60) the lesions were more discrete with high dosages of IL4 displaying a Th2 immune profile. In the co-infected group the parenchyma lesions were more discrete. Also in the co-infected group there were lower dosages of IFNγ and higher dosages of IL4 in comparison to the NT90 group. It is possible to conclude that the T. crassiceps cysticerci antigens decreased the intensity of the lesions caused by the T. gondii infection inducing a Th2 immune response. |
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Lino Júnior, Ruy de Souzahttp://lattes.cnpq.br/0372118837748010Castro, Ana Maria dehttp://lattes.cnpq.br/9232309971000621Lino Júnior, Ruy de SouzaOliveira, Milton Adriano Pelli deFreitas, Aline de Araújohttp://lattes.cnpq.br/8306518909544923Souza, Amanda Juliana Soaris de2017-01-16T13:10:24Z2016-12-12SOUZA, A. J. S. A influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental. 2016. 57 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2016.http://repositorio.bc.ufg.br/tede/handle/tede/6746ark:/38995/0013000009pqrAbstract: Toxoplasma gondii is a pathogenic agente capable o causing both local and systemic disease in immunocompetent and immunocompromised individuals. It can be agressive inducing lesions in the central nervous system, viscera, eye globe and/or lymohatic ganglia. Neurocysticercosis is the most severe form of cysticercosis. It is the one of the main helminthiasis of the central nervous system leasing to varied symptoms. During toxoplasmosis infection the inflammatory response is typically pro-inflammatory. When there is co-infection between these two agents, this typical pro-inflammatory response may lead to the death of the parasites resulting in the release of antigens. Therefore an experimental model using T. gondii cysts and T. crassiceps antigens was developed. The aim of this study was to evaluate the influence of T. crassiceps cysticerci antigens in the modulation of the inflammatory response of the experimental neurotoxoplasmosis. BALB/c mice were inoculated with T. gondii cysts and/or T. crassiceps cysticerci antigens. The animals were euthanized 60 or 90 days after the inoculation. The histopathologic analysis and the cytokine dosage from spleen cell culture were performed. The animals from the neurotoxoplasmosis group at 90 DAI (NT90) presented greater intensity of the lesions such as vasculitis, meningitis and microgliosis alongside with a Th1 immune profile with high dosages of IFNγ. While in the neurocysticercosis group at 60 DAI (NCC60) the lesions were more discrete with high dosages of IL4 displaying a Th2 immune profile. In the co-infected group the parenchyma lesions were more discrete. Also in the co-infected group there were lower dosages of IFNγ and higher dosages of IL4 in comparison to the NT90 group. It is possible to conclude that the T. crassiceps cysticerci antigens decreased the intensity of the lesions caused by the T. gondii infection inducing a Th2 immune response.Resumo: O Toxoplasma gondii é um agente patogênico que pode causar doença sistêmica e local em indivíduos imunocompetentes e imunossuprimidos, podendo se mostrar agressivo, causando lesões no sistema nervoso central, órgãos viscerais, olhos e/ou gânglios linfáticos. A Neurocisticercose é a forma mais grave de cisticercose, sendo uma das principais helmintoses do sistema nervoso central, e podendo causar sintomas variados. Na infecção pela toxoplasmose, a resposta imunológica é tipicamente pró-inflamatória. Durante a coinfecção, este tipo de resposta pode causar a morte do parasito, causando a liberação dos antígenos. Desta forma, tornou-se necessário o desenvolvimento de um modelo experimental utilizando o T. gondii e os antígenos de cisticerco de T. crassiceps. O objetivo deste trabalho foi avaliar influência dos antígenos do cisticerco de Taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental. Para isso camundongos BALB/c foram inoculados com cistos de T. gondii e/ou antígenos de cisticercos e eutanasiados aos 60 ou 90 dias após a inoculação. Foi realizada análise histopatológica dos encéfalos e dosagem de citocinas a partir de cultura de células do baço. Os animais do grupo neurotoxoplasmose aos 90DAI (NT90) apresentaram maior intensidade de lesões, como vasculite, meningite e microgliose e perfil imune do tipo Th1, com dosagens elevadas de IFNγ, enquanto que o grupo neurocisticercose aos 60DAI (NCC60), as lesões foram mais discretas e dosagens elevadas de IL4, revelando perfil imune do tipo Th2. No grupo de animais coinfectados as lesões no parênquima foram mais discretas. Além disso, o grupo co-inoculado NT e NCC (COINF) apresentou dosagens baixas de IFNγ e aumentadas de IL4 em relação ao grupo NT90. Conclui-se que a inoculação de antígenos de T. crassiceps amenizou as lesões causadas pelo T. gondii induzindo uma resposta imunológica do tipo Th2.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2017-01-16T13:07:10Z No. of bitstreams: 2 Dissertação - Amanda Juliana Soaris de Souza - 2016.pdf: 2234438 bytes, checksum: 7ea39739a499e174ae4502af4bafbfaa (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-01-16T13:10:24Z (GMT) No. of bitstreams: 2 Dissertação - Amanda Juliana Soaris de Souza - 2016.pdf: 2234438 bytes, checksum: 7ea39739a499e174ae4502af4bafbfaa (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2017-01-16T13:10:24Z (GMT). No. of bitstreams: 2 Dissertação - Amanda Juliana Soaris de Souza - 2016.pdf: 2234438 bytes, checksum: 7ea39739a499e174ae4502af4bafbfaa (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-12-12Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Biologia das Interações Parasito-Hospedeiro (IPTSP)UFGBrasilInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessNeurocisticercoseNeurotoxoplasmoseTaenia crassicepsToxoplasma gondiiCoinfecção palavrasNeurocysticercosisNeurotoxoplasmosisTaenia crassicepsToxoplasma gondiiCoinfectionMEDICINA::ANATOMIA PATOLOGICA E PATOLOGIA CLINICAA influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimentalThe influence of taenia crassiceps cysticercus antigens on modulation of inflammatory response in experimental neurotoxoplasmosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis5228863982809406209600600600600-776901144456455628873375774538195024532075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
A influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental |
dc.title.alternative.eng.fl_str_mv |
The influence of taenia crassiceps cysticercus antigens on modulation of inflammatory response in experimental neurotoxoplasmosis |
title |
A influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental |
spellingShingle |
A influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental Souza, Amanda Juliana Soaris de Neurocisticercose Neurotoxoplasmose Taenia crassiceps Toxoplasma gondii Coinfecção palavras Neurocysticercosis Neurotoxoplasmosis Taenia crassiceps Toxoplasma gondii Coinfection MEDICINA::ANATOMIA PATOLOGICA E PATOLOGIA CLINICA |
title_short |
A influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental |
title_full |
A influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental |
title_fullStr |
A influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental |
title_full_unstemmed |
A influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental |
title_sort |
A influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental |
author |
Souza, Amanda Juliana Soaris de |
author_facet |
Souza, Amanda Juliana Soaris de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Lino Júnior, Ruy de Souza |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/0372118837748010 |
dc.contributor.advisor-co1.fl_str_mv |
Castro, Ana Maria de |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/9232309971000621 |
dc.contributor.referee1.fl_str_mv |
Lino Júnior, Ruy de Souza |
dc.contributor.referee2.fl_str_mv |
Oliveira, Milton Adriano Pelli de |
dc.contributor.referee3.fl_str_mv |
Freitas, Aline de Araújo |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8306518909544923 |
dc.contributor.author.fl_str_mv |
Souza, Amanda Juliana Soaris de |
contributor_str_mv |
Lino Júnior, Ruy de Souza Castro, Ana Maria de Lino Júnior, Ruy de Souza Oliveira, Milton Adriano Pelli de Freitas, Aline de Araújo |
dc.subject.por.fl_str_mv |
Neurocisticercose Neurotoxoplasmose Taenia crassiceps Toxoplasma gondii Coinfecção palavras |
topic |
Neurocisticercose Neurotoxoplasmose Taenia crassiceps Toxoplasma gondii Coinfecção palavras Neurocysticercosis Neurotoxoplasmosis Taenia crassiceps Toxoplasma gondii Coinfection MEDICINA::ANATOMIA PATOLOGICA E PATOLOGIA CLINICA |
dc.subject.eng.fl_str_mv |
Neurocysticercosis Neurotoxoplasmosis Taenia crassiceps Toxoplasma gondii Coinfection |
dc.subject.cnpq.fl_str_mv |
MEDICINA::ANATOMIA PATOLOGICA E PATOLOGIA CLINICA |
description |
Abstract: Toxoplasma gondii is a pathogenic agente capable o causing both local and systemic disease in immunocompetent and immunocompromised individuals. It can be agressive inducing lesions in the central nervous system, viscera, eye globe and/or lymohatic ganglia. Neurocysticercosis is the most severe form of cysticercosis. It is the one of the main helminthiasis of the central nervous system leasing to varied symptoms. During toxoplasmosis infection the inflammatory response is typically pro-inflammatory. When there is co-infection between these two agents, this typical pro-inflammatory response may lead to the death of the parasites resulting in the release of antigens. Therefore an experimental model using T. gondii cysts and T. crassiceps antigens was developed. The aim of this study was to evaluate the influence of T. crassiceps cysticerci antigens in the modulation of the inflammatory response of the experimental neurotoxoplasmosis. BALB/c mice were inoculated with T. gondii cysts and/or T. crassiceps cysticerci antigens. The animals were euthanized 60 or 90 days after the inoculation. The histopathologic analysis and the cytokine dosage from spleen cell culture were performed. The animals from the neurotoxoplasmosis group at 90 DAI (NT90) presented greater intensity of the lesions such as vasculitis, meningitis and microgliosis alongside with a Th1 immune profile with high dosages of IFNγ. While in the neurocysticercosis group at 60 DAI (NCC60) the lesions were more discrete with high dosages of IL4 displaying a Th2 immune profile. In the co-infected group the parenchyma lesions were more discrete. Also in the co-infected group there were lower dosages of IFNγ and higher dosages of IL4 in comparison to the NT90 group. It is possible to conclude that the T. crassiceps cysticerci antigens decreased the intensity of the lesions caused by the T. gondii infection inducing a Th2 immune response. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-12-12 |
dc.date.accessioned.fl_str_mv |
2017-01-16T13:10:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUZA, A. J. S. A influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental. 2016. 57 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2016. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/6746 |
dc.identifier.dark.fl_str_mv |
ark:/38995/0013000009pqr |
identifier_str_mv |
SOUZA, A. J. S. A influência dos antígenos do cisticerco de taenia crassiceps na modulação da resposta inflamatória na neurotoxoplasmose experimental. 2016. 57 f. Dissertação (Mestrado em Biologia da Relação Parasito-Hospedeiro) - Universidade Federal de Goiás, Goiânia, 2016. ark:/38995/0013000009pqr |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/6746 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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5228863982809406209 |
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600 600 600 600 |
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dc.relation.cnpq.fl_str_mv |
7337577453819502453 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Biologia das Interações Parasito-Hospedeiro (IPTSP) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
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bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f d41d8cd98f00b204e9800998ecf8427e d41d8cd98f00b204e9800998ecf8427e 7ea39739a499e174ae4502af4bafbfaa |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1815172613580783616 |