Atividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratório
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/7527 |
Resumo: | Feeding mosquitoes and disease vectors have been considered a major threat to global public health. The mosquito Aedes aegypti (Diptera, Culicidae) is the main vector of the four serotypes of dengue and urban yellow fever. Dengues is a viral human disease that is gradually becoming endemic in Central America and several South American countries. Nowadays, there is no specific antiviral drug for treatment and no vaccine available for prevention. The only available measure to interrupt transmission is vector control, which is done when potential breeding are eliminated with larvicides application in water recipients, and, in case of adult vectors, with insecticides dispersion though the air. However, the increasing resistance of populations of Ae. aegypti to current insecticides has made effective control hard to achieve. Besides, other serious problems have arisen because of their continued use, such as environmental and human toxicity, which, consequently, have encouraged the development of alternative mosquito control methods, less aggressive to humans and other living beings. Thus, compounds derived from plants have been considered good choice to be used as effective tools in controlling the vector, also as environmentally safe agents. After collecting and heating Anacardium occidentale L. fruits 40 ° C, the liquid obtained was tested to confirm its larvicidal activity. Then, it was fractionated by silica gel column. The fractionation resulted in eight fractions, which were coded as AO1 to AO8. In this paper, the Cashew Nut Shell Liquid (CNSL) and its fractions were evaluated for their biological activity in third instars’ larvae of Ae. aegypti. The residual effect of CNSL and its toxicity in laboratory animals (Rattus novergicos) were evaluated. Considering the CNSL, LC50 and LC90 of 6.55 and 10.98 ppm, respectively, were found in the laboratory. The active fractions, AO2 and AO3, presented LC50 and LC90 of 3.18 and of 7.80 ppm, and 3.57 and 10.47 ppm, respectively. The CNSL had residual effects until the 6th day and was shown to be nontoxic after oral subacute treatment in rats. |
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Silva, Heloisa Helena Garcia dahttp://lattes.cnpq.br/3761550565958179Silva, Heloisa Helena Garcia daSantos, Adelair Helena dosSilva, Ionizete Garcia daArruda, Valquiriahttp://lattes.cnpq.br/1755619421141133Guissoni, Ana Carla Peixoto2017-07-10T11:35:51Z2011-02-18GUISSONI, A. C. P. Atividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratório. 2011. 69 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2011.http://repositorio.bc.ufg.br/tede/handle/tede/7527Feeding mosquitoes and disease vectors have been considered a major threat to global public health. The mosquito Aedes aegypti (Diptera, Culicidae) is the main vector of the four serotypes of dengue and urban yellow fever. Dengues is a viral human disease that is gradually becoming endemic in Central America and several South American countries. Nowadays, there is no specific antiviral drug for treatment and no vaccine available for prevention. The only available measure to interrupt transmission is vector control, which is done when potential breeding are eliminated with larvicides application in water recipients, and, in case of adult vectors, with insecticides dispersion though the air. However, the increasing resistance of populations of Ae. aegypti to current insecticides has made effective control hard to achieve. Besides, other serious problems have arisen because of their continued use, such as environmental and human toxicity, which, consequently, have encouraged the development of alternative mosquito control methods, less aggressive to humans and other living beings. Thus, compounds derived from plants have been considered good choice to be used as effective tools in controlling the vector, also as environmentally safe agents. After collecting and heating Anacardium occidentale L. fruits 40 ° C, the liquid obtained was tested to confirm its larvicidal activity. Then, it was fractionated by silica gel column. The fractionation resulted in eight fractions, which were coded as AO1 to AO8. In this paper, the Cashew Nut Shell Liquid (CNSL) and its fractions were evaluated for their biological activity in third instars’ larvae of Ae. aegypti. The residual effect of CNSL and its toxicity in laboratory animals (Rattus novergicos) were evaluated. Considering the CNSL, LC50 and LC90 of 6.55 and 10.98 ppm, respectively, were found in the laboratory. The active fractions, AO2 and AO3, presented LC50 and LC90 of 3.18 and of 7.80 ppm, and 3.57 and 10.47 ppm, respectively. The CNSL had residual effects until the 6th day and was shown to be nontoxic after oral subacute treatment in rats.Mosquitos hematófagos, vetores de doenças, representam uma grande ameaça à saúde pública global. O mosquito Aedes aegypti (Diptera, Culicidae) é o principal vetor dos quatro sorotipos do vírus da dengue e da febre amarela urbana. A dengue é uma doença humana viral que está, gradualmente,tornando-se endêmica na América Central e em vários países sul-americanos. No momento não existem medicamentos antivirais específicos para seu tratamento e nenhuma vacina está disponível para prevenção. A única medida disponível para interromper a transmissão é o controle do vetor. Este é feito através da eliminação dos criadouros potenciais, aplicação de larvicidas em coleções de água e, para os adultos, aplicações espaciais de inseticidas. No entanto, a crescente resistência das populações de Ae. aegypti aos atuais inseticidas tem dificultado um eficiente controle. Além disso, outros problemas graves surgiram por seu uso contínuo, tais como a toxicidade ambiental e humana. Isto, consequentemente, aumentou a demanda pelo desenvolvimento de métodos alternativos para o controle do mosquito, que sejam menos agresivos para os humanos e outros seres vivos. Assim, os compostos derivados de plantas têm surgido como bons candidatos, não só como ferramentas eficazes no controle do vetor, mas também como agentes ambientalmente seguros. Após a coleta e aquecimento dos frutos de Anacardium occidentale L. a 40° C, obteve-se um líquido, conhecido como Líquido da Castanha do Caju (LCC), que depois de testado quanto à sua atividade larvicida em laboratório, foi fracionado em coluna de sílica gel. O fracionamento deu origem a oito frações, as quais foram codificadas como AO1 a AO8. Neste trabalho, o LCC, e suas frações foram avaliados quanto a sua atividade biológica em larvas de 3° estádio de Ae. aegypti Foi avaliado também o efeito residual do LCC e sua toxicidade em animais de laboratório (Rattus novergicos). Para o LCC foram encontradas CL50 e CL90 de 6,55 e 10,98 ppm, respectivamente. Já as frações ativas, AO2 e AO3, apresentaram CL50 e CL90 de 3,18 e 7,80 ppm, e 3,57 e 10,47ppm, respectivamente. O LCC apresentou efeito residual até o 6º dia e mostrou ser atóxico após tratamento subagudo via oral em ratos.Submitted by Cássia Santos (cassia.bcufg@gmail.com) on 2017-07-03T12:10:07Z No. of bitstreams: 2 Dissertação - Ana Carla Peixoto Guissoni - 2011.pdf: 1922127 bytes, checksum: 8ffe25b15ad2e7a9e502e8d12a607d26 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-07-10T11:35:51Z (GMT) No. of bitstreams: 2 Dissertação - Ana Carla Peixoto Guissoni - 2011.pdf: 1922127 bytes, checksum: 8ffe25b15ad2e7a9e502e8d12a607d26 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2017-07-10T11:35:51Z (GMT). No. of bitstreams: 2 Dissertação - Ana Carla Peixoto Guissoni - 2011.pdf: 1922127 bytes, checksum: 8ffe25b15ad2e7a9e502e8d12a607d26 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2011-02-18Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP)UFGBrasilInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAedes aegyptiDengueAnacardium occidentaleAedes aegyptiDengueAnacardium occidentaleCIENCIAS BIOLOGICAS::PARASITOLOGIAAtividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratórioActivity larvicide of Anacardium Occidentale as a control alternative for Aedes aegypti and its toxicity in laboratory animalsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis6085308344741430434600600600600-7769011444564556288-45445767472715743062075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.eng.fl_str_mv |
Atividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratório |
dc.title.alternative.eng.fl_str_mv |
Activity larvicide of Anacardium Occidentale as a control alternative for Aedes aegypti and its toxicity in laboratory animals |
title |
Atividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratório |
spellingShingle |
Atividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratório Guissoni, Ana Carla Peixoto Aedes aegypti Dengue Anacardium occidentale Aedes aegypti Dengue Anacardium occidentale CIENCIAS BIOLOGICAS::PARASITOLOGIA |
title_short |
Atividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratório |
title_full |
Atividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratório |
title_fullStr |
Atividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratório |
title_full_unstemmed |
Atividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratório |
title_sort |
Atividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratório |
author |
Guissoni, Ana Carla Peixoto |
author_facet |
Guissoni, Ana Carla Peixoto |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Silva, Heloisa Helena Garcia da |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3761550565958179 |
dc.contributor.referee1.fl_str_mv |
Silva, Heloisa Helena Garcia da |
dc.contributor.referee2.fl_str_mv |
Santos, Adelair Helena dos |
dc.contributor.referee3.fl_str_mv |
Silva, Ionizete Garcia da |
dc.contributor.referee4.fl_str_mv |
Arruda, Valquiria |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1755619421141133 |
dc.contributor.author.fl_str_mv |
Guissoni, Ana Carla Peixoto |
contributor_str_mv |
Silva, Heloisa Helena Garcia da Silva, Heloisa Helena Garcia da Santos, Adelair Helena dos Silva, Ionizete Garcia da Arruda, Valquiria |
dc.subject.por.fl_str_mv |
Aedes aegypti Dengue Anacardium occidentale |
topic |
Aedes aegypti Dengue Anacardium occidentale Aedes aegypti Dengue Anacardium occidentale CIENCIAS BIOLOGICAS::PARASITOLOGIA |
dc.subject.eng.fl_str_mv |
Aedes aegypti Dengue Anacardium occidentale |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::PARASITOLOGIA |
description |
Feeding mosquitoes and disease vectors have been considered a major threat to global public health. The mosquito Aedes aegypti (Diptera, Culicidae) is the main vector of the four serotypes of dengue and urban yellow fever. Dengues is a viral human disease that is gradually becoming endemic in Central America and several South American countries. Nowadays, there is no specific antiviral drug for treatment and no vaccine available for prevention. The only available measure to interrupt transmission is vector control, which is done when potential breeding are eliminated with larvicides application in water recipients, and, in case of adult vectors, with insecticides dispersion though the air. However, the increasing resistance of populations of Ae. aegypti to current insecticides has made effective control hard to achieve. Besides, other serious problems have arisen because of their continued use, such as environmental and human toxicity, which, consequently, have encouraged the development of alternative mosquito control methods, less aggressive to humans and other living beings. Thus, compounds derived from plants have been considered good choice to be used as effective tools in controlling the vector, also as environmentally safe agents. After collecting and heating Anacardium occidentale L. fruits 40 ° C, the liquid obtained was tested to confirm its larvicidal activity. Then, it was fractionated by silica gel column. The fractionation resulted in eight fractions, which were coded as AO1 to AO8. In this paper, the Cashew Nut Shell Liquid (CNSL) and its fractions were evaluated for their biological activity in third instars’ larvae of Ae. aegypti. The residual effect of CNSL and its toxicity in laboratory animals (Rattus novergicos) were evaluated. Considering the CNSL, LC50 and LC90 of 6.55 and 10.98 ppm, respectively, were found in the laboratory. The active fractions, AO2 and AO3, presented LC50 and LC90 of 3.18 and of 7.80 ppm, and 3.57 and 10.47 ppm, respectively. The CNSL had residual effects until the 6th day and was shown to be nontoxic after oral subacute treatment in rats. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-02-18 |
dc.date.accessioned.fl_str_mv |
2017-07-10T11:35:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GUISSONI, A. C. P. Atividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratório. 2011. 69 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/7527 |
identifier_str_mv |
GUISSONI, A. C. P. Atividade larvicida de Anacardium Occidentale como alternativa de controle para Aedes aegypti e sua toxicidade em animais de laboratório. 2011. 69 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2011. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/7527 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
6085308344741430434 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-7769011444564556288 |
dc.relation.cnpq.fl_str_mv |
-4544576747271574306 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
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UFG |
institution |
UFG |
reponame_str |
Repositório Institucional da UFG |
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Repositório Institucional da UFG |
bitstream.url.fl_str_mv |
http://repositorio.bc.ufg.br/tede/bitstreams/e86d441c-9ef7-40ef-9671-9ac0503f0e5d/download http://repositorio.bc.ufg.br/tede/bitstreams/5a4dd767-67c7-46df-8bf0-a3826b8c9367/download http://repositorio.bc.ufg.br/tede/bitstreams/a16bcc1f-3378-4999-ae16-786ca0cc6ff7/download http://repositorio.bc.ufg.br/tede/bitstreams/0042ed7b-989c-4d2d-80c1-ec07953f72de/download http://repositorio.bc.ufg.br/tede/bitstreams/b3e8c1d1-ee32-4ccd-88b9-9b9602d58b9b/download |
bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f d41d8cd98f00b204e9800998ecf8427e d41d8cd98f00b204e9800998ecf8427e 8ffe25b15ad2e7a9e502e8d12a607d26 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1798044365884489728 |