Perfil genotípico e epidemiológico do carcinoma de células escamosas de laringe

• Autor(a) principal: Vasconcelos , Paulo Marcelo de Faria
• Data de Publicação: 2016
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• dARK ID: ark:/38995/0013000007v7w
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/6996
• topic: Polimorfismo; Câncer; Perfil; Laringe; Carcinoma de células escamosas; Genótipo; Molecular; Epidemiológico; Polymorphism; Cancer; Profile; Larynx; Squamous cell carcinoma; Genotypic; Molecular; Epidemiological; CIENCIAS DA SAUDE

The larynx has important functions in the body, such as speech and breath. A particular pathology that affects this anatomical site will bring serious physiological problems, having a significant impact on quality of life of the patient. The aim of this study was to evaluate the clinical and epidemiological data, social-demographic and molecular patients diagnosed with squamous cell carcinoma (SCC) of the larynx of the Registro de Câncer de Base Populacional of Goiania (RCBP) of the Associação de Combate ao Câncer in Goiás (ACCG), analyzing the data of 63 patients followed over a period of 6 years. This study was conducted at the Núcleo de Pesquisa Replicon (PUC-GO) and LaGene (SES-GO), in order to evaluate the clinical and epidemiological characteristics and molecular related to cancer of the larynx. This study found no association between biometabolism genes of xenobiotics (CYP1A1, GSTM1 and GSTT1) and susceptibility to SCC of the larynx. Additionally, the study of polymorphism in codon 72 of TP53 revealed that individuals Pro/Pro develop cancer of the larynx later than the Arg/Arg and Arg/Pro patients. Comparing the case and control groups were observed an increased risk of developing cancer of the larynx in the presence of the Arg/Pro genotype 2.7 times. The HPV genome rate was 3% of analyzed samples (HPV16/45 and HPV11), all for Arg/Arg individuals. The SCC larynx, in this study, occurred 3.5 times more men than women. Patients with tobacco habits and chronic alcoholic and concomitant feature a significantly lower survival compared to patients without such habits at an interval of six years. Additionally, the overall survival of the larynx was approximately 66% in six years. This observation is directly related to smoking and concomitant alcoholic habits, strengthening the participation of these factors in the initiation and progression of SSC larynx. Additional changes in previously studied areas and the investigation of other factors associated with laryngeal carcinomas can be important tools in estimating the prognosis of tumor progression and hence improving the quality of life of patients.