A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma

Detalhes bibliográficos
Autor(a) principal: Abreu, Fernanda Cruvinel de
Data de Publicação: 2016
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFG
dARK ID: ark:/38995/0013000005jc0
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/6610
Resumo: The main goal of asthma treatment is to achieve and maintain clinical control of the disease. The exhaled fraction nitric oxide (FeNO) level is considered a biomarker of airways inflammation and its important to conduct researches involving this measured and its relationship in evaluation of asthma control.Objective: To determine whether the FeNO level can be used to discriminate between patients with controlled, partially controlled and uncontrolled asthma. Materials and methods: The FeNO level and asthma control were evaluated in a retrospective and analytic cross– sectional study through data collected from asthmatic patients who were assessed by clinical history, asthma control, physical examination, spirometry, and FeNO level. Asthma control was determined by the criteria of the Global Initiative for Asthma, and classified as controlled asthma, partially controlled asthma, and uncontrolled asthma. The FeNO values were classified as low (<25 ppb) or intermediate/high (≥25 ppb), based on the American Thoracic Society recommendations. Results: The symptoms of 81 asthmatic patients were classified as controlled (34 [42%] patients), partially controlled (27 [33,3%] patients), and uncontrolled (20 [24.7%] patients). The FeNO level discriminated between the uncontrolled and controlled groups (p = 0,01) and between the uncontrolled and partially controlled groups (p = 0,01), but not between the controlled and partially controlled groups (p = 0,98). An FeNO level >30 ppb was associated with uncontrolled asthma (p < 0,01) with an area under the receiver operating characteristic curve of 0,78 (95% confidence interval, 0,65-0,89). Conclusions: The FeNO level aided the identification of uncontrolled asthma. This measurement may can be helpful in determining asthma control.
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spelling Rabahi, Marcelo Fouadhttp://lattes.cnpq.br/1489771770609266Rabahi, Marcelo FouadCosta, Lusmaia Damaceno CamargoMoreira, Maria Auxiliadora Carmohttp://lattes.cnpq.br/9156103928318415Abreu, Fernanda Cruvinel de2016-12-16T16:48:59Z2016-11-16ABREU, F. C. A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma. 2016. 78 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2016.http://repositorio.bc.ufg.br/tede/handle/tede/6610ark:/38995/0013000005jc0The main goal of asthma treatment is to achieve and maintain clinical control of the disease. The exhaled fraction nitric oxide (FeNO) level is considered a biomarker of airways inflammation and its important to conduct researches involving this measured and its relationship in evaluation of asthma control.Objective: To determine whether the FeNO level can be used to discriminate between patients with controlled, partially controlled and uncontrolled asthma. Materials and methods: The FeNO level and asthma control were evaluated in a retrospective and analytic cross– sectional study through data collected from asthmatic patients who were assessed by clinical history, asthma control, physical examination, spirometry, and FeNO level. Asthma control was determined by the criteria of the Global Initiative for Asthma, and classified as controlled asthma, partially controlled asthma, and uncontrolled asthma. The FeNO values were classified as low (<25 ppb) or intermediate/high (≥25 ppb), based on the American Thoracic Society recommendations. Results: The symptoms of 81 asthmatic patients were classified as controlled (34 [42%] patients), partially controlled (27 [33,3%] patients), and uncontrolled (20 [24.7%] patients). The FeNO level discriminated between the uncontrolled and controlled groups (p = 0,01) and between the uncontrolled and partially controlled groups (p = 0,01), but not between the controlled and partially controlled groups (p = 0,98). An FeNO level >30 ppb was associated with uncontrolled asthma (p < 0,01) with an area under the receiver operating characteristic curve of 0,78 (95% confidence interval, 0,65-0,89). Conclusions: The FeNO level aided the identification of uncontrolled asthma. This measurement may can be helpful in determining asthma control.O principal objetivo do tratamento da asma é alcançar e manter o controle clínico da doença. A medida da Fração Exalada do Óxido Nítrico (FeNO) é considerada um biomarcador da inflamação das vias aéreas sendo de extrema importância a realização de pesquisas envolvendo essa medida e a avaliação do nível de controle da asma. Objetivo: Verificar se a medida da FeNO discrimina pacientes com asma controlada, parcialmente controlada e não controlada. Materiais e métodos: Realizou-se um estudo restrospectivo, transversal analítico por meio da coleta de dados de pacientes asmáticos que foram avaliados em relação a sua história clínica, nível de controle da asma, exame físico, espirometria e FeNO. O nível de controle da asma foi determinado conforme critério da Global Initiative for Asthma (GINA), classificados como controlados, parcialmente controlados e não controlados. Os valores da FeNO foram classificados em baixo ou intermediário/alto (baixo <25 ppb e intermediário/elevado ≥ 25 ppb), de acordo com as recomendações da American Thoracic Society (ATS). Resultados: Foram incluídos 81 pacientes asmáticos classificados em controlados 34 (42%), parcialmente controlados 27 (33,3%) e não controlados 20 (24,7%). A medida da FeNO discriminou o grupo não controlado dos grupos controlado (p = 0,01) e parcialmente controlado (p = 0,01), mas não discriminou os grupos controlado e parcialmente controlado (p = 0,98). FENO >30 estava associado a asma não controlada (p <0,01) com área sob a curva ROC de 0,78 (Intervalo de Confiança 95%, 0.65- 0.89).Conclusão: A FeNO foi capaz de identificar asmáticos não controlados. 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dc.title.por.fl_str_mv A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma
dc.title.alternative.eng.fl_str_mv The Fraction Exhaled Nitric Oxide (FeNO) as a biomarker of asthma control
title A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma
spellingShingle A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma
Abreu, Fernanda Cruvinel de
Asma
FeNO
Óxido nítrico
Controle da asma
Asthma
FeNO
Nitric oxide
Asthma control
CIENCIAS DA SAUDE
title_short A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma
title_full A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma
title_fullStr A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma
title_full_unstemmed A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma
title_sort A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma
author Abreu, Fernanda Cruvinel de
author_facet Abreu, Fernanda Cruvinel de
author_role author
dc.contributor.advisor1.fl_str_mv Rabahi, Marcelo Fouad
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/1489771770609266
dc.contributor.referee1.fl_str_mv Rabahi, Marcelo Fouad
dc.contributor.referee2.fl_str_mv Costa, Lusmaia Damaceno Camargo
dc.contributor.referee3.fl_str_mv Moreira, Maria Auxiliadora Carmo
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/9156103928318415
dc.contributor.author.fl_str_mv Abreu, Fernanda Cruvinel de
contributor_str_mv Rabahi, Marcelo Fouad
Rabahi, Marcelo Fouad
Costa, Lusmaia Damaceno Camargo
Moreira, Maria Auxiliadora Carmo
dc.subject.por.fl_str_mv Asma
FeNO
Óxido nítrico
Controle da asma
topic Asma
FeNO
Óxido nítrico
Controle da asma
Asthma
FeNO
Nitric oxide
Asthma control
CIENCIAS DA SAUDE
dc.subject.eng.fl_str_mv Asthma
FeNO
Nitric oxide
Asthma control
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE
description The main goal of asthma treatment is to achieve and maintain clinical control of the disease. The exhaled fraction nitric oxide (FeNO) level is considered a biomarker of airways inflammation and its important to conduct researches involving this measured and its relationship in evaluation of asthma control.Objective: To determine whether the FeNO level can be used to discriminate between patients with controlled, partially controlled and uncontrolled asthma. Materials and methods: The FeNO level and asthma control were evaluated in a retrospective and analytic cross– sectional study through data collected from asthmatic patients who were assessed by clinical history, asthma control, physical examination, spirometry, and FeNO level. Asthma control was determined by the criteria of the Global Initiative for Asthma, and classified as controlled asthma, partially controlled asthma, and uncontrolled asthma. The FeNO values were classified as low (<25 ppb) or intermediate/high (≥25 ppb), based on the American Thoracic Society recommendations. Results: The symptoms of 81 asthmatic patients were classified as controlled (34 [42%] patients), partially controlled (27 [33,3%] patients), and uncontrolled (20 [24.7%] patients). The FeNO level discriminated between the uncontrolled and controlled groups (p = 0,01) and between the uncontrolled and partially controlled groups (p = 0,01), but not between the controlled and partially controlled groups (p = 0,98). An FeNO level >30 ppb was associated with uncontrolled asthma (p < 0,01) with an area under the receiver operating characteristic curve of 0,78 (95% confidence interval, 0,65-0,89). Conclusions: The FeNO level aided the identification of uncontrolled asthma. This measurement may can be helpful in determining asthma control.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-16T16:48:59Z
dc.date.issued.fl_str_mv 2016-11-16
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv ABREU, F. C. A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma. 2016. 78 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2016.
dc.identifier.uri.fl_str_mv http://repositorio.bc.ufg.br/tede/handle/tede/6610
dc.identifier.dark.fl_str_mv ark:/38995/0013000005jc0
identifier_str_mv ABREU, F. C. A medida da Fração Exalada do Óxido Nítrico (FeNO) como marcador do nível de controle da asma. 2016. 78 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2016.
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