Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/7821 |
Resumo: | Chagas disease is a parasitic disease caused by the Protozoan Trypanosoma cruzi. Approximately 30% of infected individuals develop cardiac manifestations. Among the factors involved in this evolution highlights the role of inflammation. Evidence points to an important relationship of adipokines with the cellular immune response and inflammation. The present study is objective is to evaluate the role of cytokines and leptin on immunopathology of acute phase of experimental infection by T. cruzi. For this we used C57Bl/6 WT mice, C57Bl/6 WT KO IFN-γ, Balb-c WT and Balb-c KO IL-4 100 infected with of Colombian strain forms of T. cruzi and non-infected controls was analyzed in the hearts the presence of T. cruzi, fibrosis, inflammatory infiltrate, production of cytokines in situ and serum levels of leptin, TNF-α and IL-10. Noted greater tissue parasitism in C57Bl/6 animals KO IFN-γ, but no difference in the intensity of the inflammatory infiltrate and percentage of fibrosis. Regarding cytokines C57Bl/6 mice IFN-γ KO infected showed increased TNF-α in situ, as well as the Balbc KO IL-4. Despite greater expression in situ, systemically animals Balb-c KO IL-4 have shown to be good producers of TNF-α and IL-10 as well as the C57Bl/6 KO IFNγ. However, these last have shown to be good producers of serum leptin, as well as the Balb-c. Thus, our results indicate that in the absence of IFN-γ mice infected can' not control the tissue parasitism. However, feature increased in situ of TNF-α and serum leptin as a compensatory mechanism of the Th1 response deficiency. |
id |
UFG-2_8b781488157449b7e04d00e9c7bc543b |
---|---|
oai_identifier_str |
oai:repositorio.bc.ufg.br:tede/7821 |
network_acronym_str |
UFG-2 |
network_name_str |
Repositório Institucional da UFG |
repository_id_str |
|
spelling |
Machado, Juliana Reishttp://lattes.cnpq.br/5289363102869037Lino Júnior, Ruy de SouzaCeles, Mara Rúbia Nuneshttp://lattes.cnpq.br/1234213665964187Machado, Juliana ReisOliveira, Flávia Aparecida deCastro, Ana Maria dehttp://lattes.cnpq.br/6312958481831238Almeida, Vera Lucia Lima de2017-10-02T13:43:34Z2017-04-07ALMEIDA, V. L. L. Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ. 2017. 66 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2017.http://repositorio.bc.ufg.br/tede/handle/tede/7821ark:/38995/0013000009f43Chagas disease is a parasitic disease caused by the Protozoan Trypanosoma cruzi. Approximately 30% of infected individuals develop cardiac manifestations. Among the factors involved in this evolution highlights the role of inflammation. Evidence points to an important relationship of adipokines with the cellular immune response and inflammation. The present study is objective is to evaluate the role of cytokines and leptin on immunopathology of acute phase of experimental infection by T. cruzi. For this we used C57Bl/6 WT mice, C57Bl/6 WT KO IFN-γ, Balb-c WT and Balb-c KO IL-4 100 infected with of Colombian strain forms of T. cruzi and non-infected controls was analyzed in the hearts the presence of T. cruzi, fibrosis, inflammatory infiltrate, production of cytokines in situ and serum levels of leptin, TNF-α and IL-10. Noted greater tissue parasitism in C57Bl/6 animals KO IFN-γ, but no difference in the intensity of the inflammatory infiltrate and percentage of fibrosis. Regarding cytokines C57Bl/6 mice IFN-γ KO infected showed increased TNF-α in situ, as well as the Balbc KO IL-4. Despite greater expression in situ, systemically animals Balb-c KO IL-4 have shown to be good producers of TNF-α and IL-10 as well as the C57Bl/6 KO IFNγ. However, these last have shown to be good producers of serum leptin, as well as the Balb-c. Thus, our results indicate that in the absence of IFN-γ mice infected can' not control the tissue parasitism. However, feature increased in situ of TNF-α and serum leptin as a compensatory mechanism of the Th1 response deficiency.A doença de Chagas é uma doença parasitária causada pelo protozoário Trypanosoma cruzi. Aproximadamente 30% dos indivíduos infectados desenvolvem a manifestação cardíaca. Dentre os fatores envolvidos nesta evolução destaca-se o papel da inflamação. Evidências apontam uma importante relação das adipocitocinas com a resposta imune celular e inflamação. O presente estudo objetivou avaliar o papel de citocinas e da leptina na imunopatologia da fase aguda da infecção experimental pelo T. cruzi. Para isso foram utilizados camundongos C57Bl/6 WT, C57Bl/6 KO IFN-γ, Balb-c WT e Balb-c KO IL-4 infectados com 100 formas tripomastigotas de cepa Colombiana de T. cruzi e controles não infectados. Foi analisado nos corações a presença ninhos de T. cruzi, infiltrado inflamatório, fibrose, produção de citocinas in situ e níveis séricos de leptina, TNF-α e IL-10. Foi observado maior parasitismo tissular nos animais C57Bl/6 KO IFN-γ, mas sem diferença na intensidade do infiltrado inflamatório e percentual de fibrose. Em relação as citocinas os camundongos C57Bl/6 KO IFN-γ infectados apresentaram aumento de TNF-α in situ, assim como os Balb-c KO IL-4. Apesar de maior expressão in situ, sistemicamente os animais Balb-c KO IL-4 não mostram ser bons produtores de TNF-α e IL-10 assim como os C57Bl/6 KO IFN-γ, entretanto esses últimos mostraram ser bons produtores de leptina sérica, assim como os Balb-c. Dessa forma, nossos resultados apontam que na ausência de IFN-γ os camundongos infectados não conseguem controlar o parasitismo tissular. Entretanto apresentam aumento in situ de TNF-α e leptina sérica como mecanismo compensatório da deficiência de resposta Th1, representado pela ausência de IFN-γ.Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2017-09-26T18:09:59Z No. of bitstreams: 2 Dissertação - Vera Lúcia Lima de Almeida - 2017.pdf: 4171276 bytes, checksum: 87f3a46f53c09bbba2b757e69ce2c7d8 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Rejected by Luciana Ferreira (lucgeral@gmail.com), reason: A citação apresenta problemas : Almeida, V. L. L. Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ. 2017. 66 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás,Goiânia,2017. CORRETO: ALMEIDA, V. L. L. Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ. 2017. 66 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2017. on 2017-09-27T11:28:48Z (GMT)Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2017-09-27T17:46:52Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertação - Vera Lúcia Lima de Almeida - 2017.pdf: 4171276 bytes, checksum: 87f3a46f53c09bbba2b757e69ce2c7d8 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-10-02T13:43:34Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertação - Vera Lúcia Lima de Almeida - 2017.pdf: 4171276 bytes, checksum: 87f3a46f53c09bbba2b757e69ce2c7d8 (MD5)Made available in DSpace on 2017-10-02T13:43:34Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertação - Vera Lúcia Lima de Almeida - 2017.pdf: 4171276 bytes, checksum: 87f3a46f53c09bbba2b757e69ce2c7d8 (MD5) Previous issue date: 2017-04-07Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPqapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP)UFGBrasilInstituto de Patologia Tropical e Saúde Pública - IPTSP (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessTrypanosoma cruziResposta imune celularCoraçãoAdipocitocinasNocauteCellular immune responseHeartAdipocytokinesKnockoutsCIENCIAS DA SAUDE::MEDICINAPapel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γThe role of cytokines and leptin in immunopathology of acute phase in experimental infection of Trypanosoma cruzi in knockout mice for IL-4 and IFN-γinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis6085308344741430434600600600600-7769011444564556288-969369452308786627-2555911436985713659reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGORIGINALDissertação - Vera Lúcia Lima de Almeida - 2017.pdfDissertação - Vera Lúcia Lima de Almeida - 2017.pdfapplication/pdf4171276http://repositorio.bc.ufg.br/tede/bitstreams/4a04aa26-4fbc-46ee-962a-3edd55bd6687/download87f3a46f53c09bbba2b757e69ce2c7d8MD55LICENSElicense.txtlicense.txttext/plain; charset=utf-82165http://repositorio.bc.ufg.br/tede/bitstreams/c0716644-2792-432d-ab11-4bec9d5dadf8/downloadbd3efa91386c1718a7f26a329fdcb468MD56CC-LICENSElicense_urllicense_urltext/plain; charset=utf-849http://repositorio.bc.ufg.br/tede/bitstreams/f6184172-b0aa-45bb-8803-dc9f00b95938/download4afdbb8c545fd630ea7db775da747b2fMD57license_textlicense_texttext/html; charset=utf-80http://repositorio.bc.ufg.br/tede/bitstreams/d0a766e2-06c0-4dcc-bd3d-c6cf2b066b79/downloadd41d8cd98f00b204e9800998ecf8427eMD58license_rdflicense_rdfapplication/rdf+xml; charset=utf-80http://repositorio.bc.ufg.br/tede/bitstreams/2d4d2c1f-4a6f-494f-b3e4-a59d29bb5bf6/downloadd41d8cd98f00b204e9800998ecf8427eMD59tede/78212017-10-02 10:43:34.599http://creativecommons.org/licenses/by-nc-nd/4.0/Acesso Abertoopen.accessoai:repositorio.bc.ufg.br:tede/7821http://repositorio.bc.ufg.br/tedeRepositório InstitucionalPUBhttp://repositorio.bc.ufg.br/oai/requesttasesdissertacoes.bc@ufg.bropendoar:2017-10-02T13:43:34Repositório Institucional da UFG - Universidade Federal de Goiás (UFG)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 |
dc.title.eng.fl_str_mv |
Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ |
dc.title.alternative.eng.fl_str_mv |
The role of cytokines and leptin in immunopathology of acute phase in experimental infection of Trypanosoma cruzi in knockout mice for IL-4 and IFN-γ |
title |
Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ |
spellingShingle |
Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ Almeida, Vera Lucia Lima de Trypanosoma cruzi Resposta imune celular Coração Adipocitocinas Nocaute Cellular immune response Heart Adipocytokines Knockouts CIENCIAS DA SAUDE::MEDICINA |
title_short |
Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ |
title_full |
Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ |
title_fullStr |
Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ |
title_full_unstemmed |
Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ |
title_sort |
Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ |
author |
Almeida, Vera Lucia Lima de |
author_facet |
Almeida, Vera Lucia Lima de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Machado, Juliana Reis |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/5289363102869037 |
dc.contributor.advisor-co1.fl_str_mv |
Lino Júnior, Ruy de Souza |
dc.contributor.advisor-co2.fl_str_mv |
Celes, Mara Rúbia Nunes |
dc.contributor.advisor-co2Lattes.fl_str_mv |
http://lattes.cnpq.br/1234213665964187 |
dc.contributor.referee1.fl_str_mv |
Machado, Juliana Reis |
dc.contributor.referee2.fl_str_mv |
Oliveira, Flávia Aparecida de |
dc.contributor.referee3.fl_str_mv |
Castro, Ana Maria de |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6312958481831238 |
dc.contributor.author.fl_str_mv |
Almeida, Vera Lucia Lima de |
contributor_str_mv |
Machado, Juliana Reis Lino Júnior, Ruy de Souza Celes, Mara Rúbia Nunes Machado, Juliana Reis Oliveira, Flávia Aparecida de Castro, Ana Maria de |
dc.subject.por.fl_str_mv |
Trypanosoma cruzi Resposta imune celular Coração Adipocitocinas Nocaute |
topic |
Trypanosoma cruzi Resposta imune celular Coração Adipocitocinas Nocaute Cellular immune response Heart Adipocytokines Knockouts CIENCIAS DA SAUDE::MEDICINA |
dc.subject.eng.fl_str_mv |
Cellular immune response Heart Adipocytokines Knockouts |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::MEDICINA |
description |
Chagas disease is a parasitic disease caused by the Protozoan Trypanosoma cruzi. Approximately 30% of infected individuals develop cardiac manifestations. Among the factors involved in this evolution highlights the role of inflammation. Evidence points to an important relationship of adipokines with the cellular immune response and inflammation. The present study is objective is to evaluate the role of cytokines and leptin on immunopathology of acute phase of experimental infection by T. cruzi. For this we used C57Bl/6 WT mice, C57Bl/6 WT KO IFN-γ, Balb-c WT and Balb-c KO IL-4 100 infected with of Colombian strain forms of T. cruzi and non-infected controls was analyzed in the hearts the presence of T. cruzi, fibrosis, inflammatory infiltrate, production of cytokines in situ and serum levels of leptin, TNF-α and IL-10. Noted greater tissue parasitism in C57Bl/6 animals KO IFN-γ, but no difference in the intensity of the inflammatory infiltrate and percentage of fibrosis. Regarding cytokines C57Bl/6 mice IFN-γ KO infected showed increased TNF-α in situ, as well as the Balbc KO IL-4. Despite greater expression in situ, systemically animals Balb-c KO IL-4 have shown to be good producers of TNF-α and IL-10 as well as the C57Bl/6 KO IFNγ. However, these last have shown to be good producers of serum leptin, as well as the Balb-c. Thus, our results indicate that in the absence of IFN-γ mice infected can' not control the tissue parasitism. However, feature increased in situ of TNF-α and serum leptin as a compensatory mechanism of the Th1 response deficiency. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-10-02T13:43:34Z |
dc.date.issued.fl_str_mv |
2017-04-07 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ALMEIDA, V. L. L. Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ. 2017. 66 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2017. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/7821 |
dc.identifier.dark.fl_str_mv |
ark:/38995/0013000009f43 |
identifier_str_mv |
ALMEIDA, V. L. L. Papel de citocinas e da leptina na imunopatologia da fase aguda na infecção experimental pelo trypanosoma cruzi em camundongos nocautes para IL-4 e IFN-γ. 2017. 66 f. Dissertação (Mestrado em Medicina Tropical e Saúde Publica) - Universidade Federal de Goiás, Goiânia, 2017. ark:/38995/0013000009f43 |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/7821 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
6085308344741430434 |
dc.relation.confidence.fl_str_mv |
600 600 600 600 |
dc.relation.department.fl_str_mv |
-7769011444564556288 |
dc.relation.cnpq.fl_str_mv |
-969369452308786627 |
dc.relation.sponsorship.fl_str_mv |
-2555911436985713659 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Medicina Tropical e Saúde Publica (IPTSP) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Patologia Tropical e Saúde Pública - IPTSP (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Repositório Institucional da UFG |
collection |
Repositório Institucional da UFG |
bitstream.url.fl_str_mv |
http://repositorio.bc.ufg.br/tede/bitstreams/4a04aa26-4fbc-46ee-962a-3edd55bd6687/download http://repositorio.bc.ufg.br/tede/bitstreams/c0716644-2792-432d-ab11-4bec9d5dadf8/download http://repositorio.bc.ufg.br/tede/bitstreams/f6184172-b0aa-45bb-8803-dc9f00b95938/download http://repositorio.bc.ufg.br/tede/bitstreams/d0a766e2-06c0-4dcc-bd3d-c6cf2b066b79/download http://repositorio.bc.ufg.br/tede/bitstreams/2d4d2c1f-4a6f-494f-b3e4-a59d29bb5bf6/download |
bitstream.checksum.fl_str_mv |
87f3a46f53c09bbba2b757e69ce2c7d8 bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f d41d8cd98f00b204e9800998ecf8427e d41d8cd98f00b204e9800998ecf8427e |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1811721467809759232 |