Identificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp.
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/6371 |
Resumo: | Approximately one third of all proteins have been estimated to contain at least one metal cofactor, being named metalloproteins. These represent one of the most diverse classes of proteins, containing metal ions provide catalytic, regulatory and structural functions. Bioinformatic tools have been developed to predict metalloproteins encoded by an organism based only on its genome sequence. Paracoccidioides complex includes termodimorphic pathogenic fungi that are found as saprobiotic mycelia in the environment and as yeast in host tissues. They are the etiologic agents of Paracoccidioidomycosis, a prevalent systemic mycosis in Latin America. It is known that many metalloproteins are important for virulence of several pathogenic microorganisms. On this way, the present work aimed to predict the cooper, iron and zinc proteins encoded by the genomes of three phylogenetic species of Paracoccidioides spp. (Pb01, Pb03 and Pb18). Cu-, Fe- and Zn-proteins represents 7% of the total proteins encoded by Paracoccidioides spp genomes. Zinc-proteins were the most abundant metalloproteins representing 5.7% of the fungus proteome, while copper and iron proteins represent 0.3% and 1.2% respectively. Functional classification revealed that metalloproteins are related to many cellular processes. Furthermore it was observed that many of these metalloproteins play roles as virulence factors, in the biology of the fungus, and an analysis of the protein interactions revealed that many of them depend on each other to perform their functions. Thus, it is concluded that the Cu-, Feand Zn- metalloproteome of Paracoccidioides is of utmost importance for biology and virulence |
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Bailão, Alexandre Melohttp://lattes.cnpq.br/5415221996976886Bailão, Alexandre MeloSoares, Célia Maria de AlmeidaStaats, Charley Cristian: http://lattes.cnpq.br/4879784913946661Tristão, Gabriel Brum2016-10-10T15:42:14Z2014-03-11TRISTÃO, G. B. Identificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp. 2014. 94 f. Dissertação (Mestrado em Genética e Biologia Molecular) - Universidade Federal de Goiás, Goiânia, 2014.http://repositorio.bc.ufg.br/tede/handle/tede/6371Approximately one third of all proteins have been estimated to contain at least one metal cofactor, being named metalloproteins. These represent one of the most diverse classes of proteins, containing metal ions provide catalytic, regulatory and structural functions. Bioinformatic tools have been developed to predict metalloproteins encoded by an organism based only on its genome sequence. Paracoccidioides complex includes termodimorphic pathogenic fungi that are found as saprobiotic mycelia in the environment and as yeast in host tissues. They are the etiologic agents of Paracoccidioidomycosis, a prevalent systemic mycosis in Latin America. It is known that many metalloproteins are important for virulence of several pathogenic microorganisms. On this way, the present work aimed to predict the cooper, iron and zinc proteins encoded by the genomes of three phylogenetic species of Paracoccidioides spp. (Pb01, Pb03 and Pb18). Cu-, Fe- and Zn-proteins represents 7% of the total proteins encoded by Paracoccidioides spp genomes. Zinc-proteins were the most abundant metalloproteins representing 5.7% of the fungus proteome, while copper and iron proteins represent 0.3% and 1.2% respectively. Functional classification revealed that metalloproteins are related to many cellular processes. Furthermore it was observed that many of these metalloproteins play roles as virulence factors, in the biology of the fungus, and an analysis of the protein interactions revealed that many of them depend on each other to perform their functions. Thus, it is concluded that the Cu-, Feand Zn- metalloproteome of Paracoccidioides is of utmost importance for biology and virulenceÉ estimado que por volta de um terço de todas as proteínas já conhecidas contém pelo menos um cofator metálico, sendo chamadas de metaloproteínas. Estas representam uma das mais diversas classes de proteínas, contendo íons metálicos que fornecem função catalítica, regulatória e estrutural. Atualmente ferramentas bioinformáticas tem sido desenvolvidas no intuito de prever metaloproteinas codificadas por um dado organismo tendo como base apenas a sua sequência genômica. O complexo Paracoccidioides inclui fungos termodimórficos, patogênicos que são encontrados como micélio saprobiótico no meio ambiente e como levedura nos tecidos de indivíduos infectados. Estes fungos são os agentes etiológicos da Paracoccidioidomicose (PCM), uma micose sistêmica prevalente na América Latina. Sabe-se que muitas metaloproteínas são importantes para a virulência de vários microorganismos patogênicos. Desta forma, o presente trabalho teve como objetivo prever as cobre, ferro e zinco proteínas codificadas pelos genomas de três espécies filogenéticas de Paracoccidioides spp. (Pb01, Pb03 e Pb18). As Cu, Fe e Zn- proteínas representam 7% do total de metaloproteínas codificadas pelos genomas de Paracoccidioides spp. As zinco proteínas foram as mais abundantes, representando 5,7% do metaloproteoma dos fungos, enquanto que as proteínas de cobre e ferro representam 0,3% e 1,2% respectivamente. A classificação funcional revelou que essas metaloproteínas estão relacionadas com muitos processos celulares. Além disso, observou-se que muitas destas metaloproteínas atuam como fatores de virulência na biologia do fungo, e uma análise da interação destas metaloproteínas revelou que muitas dependem uma da outra para exercer suas funções. Assim, conclui-se que o metaloproteoma de Cu, Fe e Zn de Paracoccidioides spp. é de extrema importância para a biologia e virulência deste patógeno humano.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-10-10T15:41:50Z No. of bitstreams: 2 Dissertação - Gabriel Brum Tristão - 2014.pdf: 2758860 bytes, checksum: 2422850e561b8d6f9f4cfd50487ebf4c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-10-10T15:42:14Z (GMT) No. of bitstreams: 2 Dissertação - Gabriel Brum Tristão - 2014.pdf: 2758860 bytes, checksum: 2422850e561b8d6f9f4cfd50487ebf4c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2016-10-10T15:42:14Z (GMT). No. of bitstreams: 2 Dissertação - Gabriel Brum Tristão - 2014.pdf: 2758860 bytes, checksum: 2422850e561b8d6f9f4cfd50487ebf4c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2014-03-11Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEGapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Genética e Biologia MolecularUFGBrasilInstituto de Ciências Biológicas - ICB (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessParacoccidioidesGenomasIdentificaçãoBioinformáticaProteínasMetaisParacoccidioidesGenomesIdentificationBioinformaticsProteinsMetalsCIENCIAS BIOLOGICAS::GENETICAIdentificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp.Identification of copper, iron and zinc metalloproteins coded by Paracoccoidioides spp. genomesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis7015780075895009588600600600600-3872772117827373404-5518144268585252051-961409807440757778reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Identificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp. |
dc.title.alternative.eng.fl_str_mv |
Identification of copper, iron and zinc metalloproteins coded by Paracoccoidioides spp. genomes |
title |
Identificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp. |
spellingShingle |
Identificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp. Tristão, Gabriel Brum Paracoccidioides Genomas Identificação Bioinformática Proteínas Metais Paracoccidioides Genomes Identification Bioinformatics Proteins Metals CIENCIAS BIOLOGICAS::GENETICA |
title_short |
Identificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp. |
title_full |
Identificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp. |
title_fullStr |
Identificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp. |
title_full_unstemmed |
Identificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp. |
title_sort |
Identificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp. |
author |
Tristão, Gabriel Brum |
author_facet |
Tristão, Gabriel Brum |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Bailão, Alexandre Melo |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/5415221996976886 |
dc.contributor.referee1.fl_str_mv |
Bailão, Alexandre Melo |
dc.contributor.referee2.fl_str_mv |
Soares, Célia Maria de Almeida |
dc.contributor.referee3.fl_str_mv |
Staats, Charley Cristian |
dc.contributor.authorLattes.fl_str_mv |
: http://lattes.cnpq.br/4879784913946661 |
dc.contributor.author.fl_str_mv |
Tristão, Gabriel Brum |
contributor_str_mv |
Bailão, Alexandre Melo Bailão, Alexandre Melo Soares, Célia Maria de Almeida Staats, Charley Cristian |
dc.subject.por.fl_str_mv |
Paracoccidioides Genomas Identificação Bioinformática Proteínas Metais |
topic |
Paracoccidioides Genomas Identificação Bioinformática Proteínas Metais Paracoccidioides Genomes Identification Bioinformatics Proteins Metals CIENCIAS BIOLOGICAS::GENETICA |
dc.subject.eng.fl_str_mv |
Paracoccidioides Genomes Identification Bioinformatics Proteins Metals |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::GENETICA |
description |
Approximately one third of all proteins have been estimated to contain at least one metal cofactor, being named metalloproteins. These represent one of the most diverse classes of proteins, containing metal ions provide catalytic, regulatory and structural functions. Bioinformatic tools have been developed to predict metalloproteins encoded by an organism based only on its genome sequence. Paracoccidioides complex includes termodimorphic pathogenic fungi that are found as saprobiotic mycelia in the environment and as yeast in host tissues. They are the etiologic agents of Paracoccidioidomycosis, a prevalent systemic mycosis in Latin America. It is known that many metalloproteins are important for virulence of several pathogenic microorganisms. On this way, the present work aimed to predict the cooper, iron and zinc proteins encoded by the genomes of three phylogenetic species of Paracoccidioides spp. (Pb01, Pb03 and Pb18). Cu-, Fe- and Zn-proteins represents 7% of the total proteins encoded by Paracoccidioides spp genomes. Zinc-proteins were the most abundant metalloproteins representing 5.7% of the fungus proteome, while copper and iron proteins represent 0.3% and 1.2% respectively. Functional classification revealed that metalloproteins are related to many cellular processes. Furthermore it was observed that many of these metalloproteins play roles as virulence factors, in the biology of the fungus, and an analysis of the protein interactions revealed that many of them depend on each other to perform their functions. Thus, it is concluded that the Cu-, Feand Zn- metalloproteome of Paracoccidioides is of utmost importance for biology and virulence |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-03-11 |
dc.date.accessioned.fl_str_mv |
2016-10-10T15:42:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
TRISTÃO, G. B. Identificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp. 2014. 94 f. Dissertação (Mestrado em Genética e Biologia Molecular) - Universidade Federal de Goiás, Goiânia, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/6371 |
identifier_str_mv |
TRISTÃO, G. B. Identificação de metaloproteínas associadas a cobre, ferro e zinco codificadas pelos genomas de Paracoccidioides spp. 2014. 94 f. Dissertação (Mestrado em Genética e Biologia Molecular) - Universidade Federal de Goiás, Goiânia, 2014. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/6371 |
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por |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Universidade Federal de Goiás |
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UFG |
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Brasil |
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Instituto de Ciências Biológicas - ICB (RG) |
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Universidade Federal de Goiás |
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