Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
dARK ID: | ark:/38995/0013000006j46 |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/4636 |
Resumo: | To verify the relationship between the polymorphisms rs18011282 in PPAR-gamma gene and rs429358 + rs7412 in apolipoprotein E gene and lipid profile of adolescents under cardiovascular risk factors. Material and methods: The study sample was composed of 115 adolescents aged 10-19 years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic and dietetic variables. ANOVA or Kruskal-Wallis tests were used in the analysis of ungrouped genotypes, while Student’s t-test or Mann-Whitney test were applied to the analysis of the grouped genotypes. Results: The overweight adolescents presented lower HDL-c concentrations (p=0.0016). Those carrying PPAR-gamma Ala allele showed higher serum TAG (p=0.0423) and VLDL-c (p=0.0410) levels when compared to those carrying the Pro allele. For the apolipoprotein E gene polymorphism, it was observed a tendency of higher TAG (p=0.0712) and VLDL-c (p=0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele. Conclusion: The polymorphisms PPAR-gama rs18011282 and apolipoprotein E rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents. |
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Cominetti, Cristianehttp://lattes.cnpq.br/3143023553465749Horst, Maria AderuzaSilva, Daniela de Melo eBotelho, Patrícia BorgesCominetti, Cristianehttp://lattes.cnpq.br/3767000097050314Alves, Maira Chiquito2015-10-15T12:46:45Z2015-03-20ALVES, M. C. Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular. 2015. 107 f. Dissertação (Mestrado em Nutrição e Saúde) - Universidade Federal de Goiás, Goiânia, 2015.http://repositorio.bc.ufg.br/tede/handle/tede/4636ark:/38995/0013000006j46To verify the relationship between the polymorphisms rs18011282 in PPAR-gamma gene and rs429358 + rs7412 in apolipoprotein E gene and lipid profile of adolescents under cardiovascular risk factors. Material and methods: The study sample was composed of 115 adolescents aged 10-19 years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic and dietetic variables. ANOVA or Kruskal-Wallis tests were used in the analysis of ungrouped genotypes, while Student’s t-test or Mann-Whitney test were applied to the analysis of the grouped genotypes. Results: The overweight adolescents presented lower HDL-c concentrations (p=0.0016). Those carrying PPAR-gamma Ala allele showed higher serum TAG (p=0.0423) and VLDL-c (p=0.0410) levels when compared to those carrying the Pro allele. For the apolipoprotein E gene polymorphism, it was observed a tendency of higher TAG (p=0.0712) and VLDL-c (p=0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele. Conclusion: The polymorphisms PPAR-gama rs18011282 and apolipoprotein E rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents.Verificar a relação dos polimorfismos rs18011282 no gene do PPAR-gama e rs429358 + rs7412 no gene da apolipoproteína E com o perfil lipídico de adolescentes com fatores de risco cardiovascular. Material e métodos: A amostra foi constituida por 115 adolescentes com idade entre 10-19 anos e com fatores de risco cardiovascular. Os estudantes foram avaliados quanto as variáveis socioeconômicas, antropométricas, bioquímicas, genéticas e dietéticas. Os testes ANOVA ou Kruskal-Wallis foram utilizados para os genótipos não agrupados, e as análises dos genótipos agrupados foram realizadas por meio dos testes t de Student e Mann-Whitney. Resultados: Os adolescentes com excesso de peso apresentaram concentrações inferiores de HDL-c (p=0,0016). Carreadores do alelo variante Ala (PPAR-gama) apresentaram concentrações séricas superiores de TG (p=0,0423) e de VLDL-c (p=0,0410) em relação ao carreadores do alelo selvagem Pro. Para o polimorfismo no gene da ApoE foram observadas concentrações séricas de TG (p=0,0712) e de VLDL-c (p=0,0758) marginalmente maiores nos carreadores do alelo E4 em relação aos não carreadores deste alelo. Conclusão: Os polimorfismos rs18011282 no gene que codifica o PPAR-gama e rs429358 + rs7412 no gene que codifica a ApoE podem estar relacionados ao desenvolvimento de dislipidemias em adolescentes.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2015-10-15T12:44:52Z No. of bitstreams: 2 Dissertação - Maira Chiquito Alves - 2015.pdf: 2795650 bytes, checksum: df30e15f25e56e8cea5234d554455c1b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-10-15T12:46:45Z (GMT) No. of bitstreams: 2 Dissertação - Maira Chiquito Alves - 2015.pdf: 2795650 bytes, checksum: df30e15f25e56e8cea5234d554455c1b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2015-10-15T12:46:45Z (GMT). No. of bitstreams: 2 Dissertação - Maira Chiquito Alves - 2015.pdf: 2795650 bytes, checksum: df30e15f25e56e8cea5234d554455c1b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) Previous issue date: 2015-03-20Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEGapplication/pdfhttp://repositorio.bc.ufg.br/tede/retrieve/20710/Disserta%c3%a7%c3%a3o%20-%20Maira%20Chiquito%20Alves%20-%202015.pdf.jpgporUniversidade Federal de GoiásPrograma de Pós-graduação em Nutrição e Saúde (FANUT)UFGBrasilFaculdade de Nutrição - FANUT (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessApolipoproteína EPPAR-gamaPolimorfismo genéticoDoenças cardiovascularesAlterações do peso corporalApolipoprotein EPPAR-gammaGenetic polymorphismDyslipidemiaCardiovascular diseasesCIENCIAS DA SAUDE::NUTRICAOPolimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascularPolymorphism in the PPAR-gamma and apolipoprotein e genes: relationships with lipid profile of adolescents with cardiovascular risk factorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-30109707181642501066006006006009028001981735587154-1073001350029933100-961409807440757778reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGTEXTDissertação - Maira Chiquito Alves - 2015.pdf.txtDissertação - Maira Chiquito Alves - 2015.pdf.txtExtracted Texttext/plain181761http://repositorio.bc.ufg.br/tede/bitstreams/a30ed1c7-fe63-4c5c-88db-106feb270922/downloade80a0f8b13be7734cdb3d306890e0087MD56THUMBNAILDissertação - Maira Chiquito Alves - 2015.pdf.jpgDissertação - Maira Chiquito Alves - 2015.pdf.jpgGenerated Thumbnailimage/jpeg1943http://repositorio.bc.ufg.br/tede/bitstreams/becd95f6-96e5-479d-b8ce-9ab5b7ac8645/downloadcc73c4c239a4c332d642ba1e7c7a9fb2MD57LICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular |
dc.title.alternative.eng.fl_str_mv |
Polymorphism in the PPAR-gamma and apolipoprotein e genes: relationships with lipid profile of adolescents with cardiovascular risk factors |
title |
Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular |
spellingShingle |
Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular Alves, Maira Chiquito Apolipoproteína E PPAR-gama Polimorfismo genético Doenças cardiovasculares Alterações do peso corporal Apolipoprotein E PPAR-gamma Genetic polymorphism Dyslipidemia Cardiovascular diseases CIENCIAS DA SAUDE::NUTRICAO |
title_short |
Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular |
title_full |
Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular |
title_fullStr |
Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular |
title_full_unstemmed |
Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular |
title_sort |
Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular |
author |
Alves, Maira Chiquito |
author_facet |
Alves, Maira Chiquito |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Cominetti, Cristiane |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3143023553465749 |
dc.contributor.advisor-co1.fl_str_mv |
Horst, Maria Aderuza |
dc.contributor.referee1.fl_str_mv |
Silva, Daniela de Melo e |
dc.contributor.referee2.fl_str_mv |
Botelho, Patrícia Borges |
dc.contributor.referee3.fl_str_mv |
Cominetti, Cristiane |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/3767000097050314 |
dc.contributor.author.fl_str_mv |
Alves, Maira Chiquito |
contributor_str_mv |
Cominetti, Cristiane Horst, Maria Aderuza Silva, Daniela de Melo e Botelho, Patrícia Borges Cominetti, Cristiane |
dc.subject.por.fl_str_mv |
Apolipoproteína E PPAR-gama Polimorfismo genético Doenças cardiovasculares Alterações do peso corporal |
topic |
Apolipoproteína E PPAR-gama Polimorfismo genético Doenças cardiovasculares Alterações do peso corporal Apolipoprotein E PPAR-gamma Genetic polymorphism Dyslipidemia Cardiovascular diseases CIENCIAS DA SAUDE::NUTRICAO |
dc.subject.eng.fl_str_mv |
Apolipoprotein E PPAR-gamma Genetic polymorphism Dyslipidemia Cardiovascular diseases |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::NUTRICAO |
description |
To verify the relationship between the polymorphisms rs18011282 in PPAR-gamma gene and rs429358 + rs7412 in apolipoprotein E gene and lipid profile of adolescents under cardiovascular risk factors. Material and methods: The study sample was composed of 115 adolescents aged 10-19 years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic and dietetic variables. ANOVA or Kruskal-Wallis tests were used in the analysis of ungrouped genotypes, while Student’s t-test or Mann-Whitney test were applied to the analysis of the grouped genotypes. Results: The overweight adolescents presented lower HDL-c concentrations (p=0.0016). Those carrying PPAR-gamma Ala allele showed higher serum TAG (p=0.0423) and VLDL-c (p=0.0410) levels when compared to those carrying the Pro allele. For the apolipoprotein E gene polymorphism, it was observed a tendency of higher TAG (p=0.0712) and VLDL-c (p=0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele. Conclusion: The polymorphisms PPAR-gama rs18011282 and apolipoprotein E rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents. |
publishDate |
2015 |
dc.date.accessioned.fl_str_mv |
2015-10-15T12:46:45Z |
dc.date.issued.fl_str_mv |
2015-03-20 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ALVES, M. C. Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular. 2015. 107 f. Dissertação (Mestrado em Nutrição e Saúde) - Universidade Federal de Goiás, Goiânia, 2015. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/4636 |
dc.identifier.dark.fl_str_mv |
ark:/38995/0013000006j46 |
identifier_str_mv |
ALVES, M. C. Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular. 2015. 107 f. Dissertação (Mestrado em Nutrição e Saúde) - Universidade Federal de Goiás, Goiânia, 2015. ark:/38995/0013000006j46 |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/4636 |
dc.language.iso.fl_str_mv |
por |
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por |
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600 600 600 600 |
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9028001981735587154 |
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-1073001350029933100 |
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-961409807440757778 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Nutrição e Saúde (FANUT) |
dc.publisher.initials.fl_str_mv |
UFG |
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Brasil |
dc.publisher.department.fl_str_mv |
Faculdade de Nutrição - FANUT (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
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