Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular

Detalhes bibliográficos
Autor(a) principal: Alves, Maira Chiquito
Data de Publicação: 2015
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFG
dARK ID: ark:/38995/0013000006j46
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/4636
Resumo: To verify the relationship between the polymorphisms rs18011282 in PPAR-gamma gene and rs429358 + rs7412 in apolipoprotein E gene and lipid profile of adolescents under cardiovascular risk factors. Material and methods: The study sample was composed of 115 adolescents aged 10-19 years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic and dietetic variables. ANOVA or Kruskal-Wallis tests were used in the analysis of ungrouped genotypes, while Student’s t-test or Mann-Whitney test were applied to the analysis of the grouped genotypes. Results: The overweight adolescents presented lower HDL-c concentrations (p=0.0016). Those carrying PPAR-gamma Ala allele showed higher serum TAG (p=0.0423) and VLDL-c (p=0.0410) levels when compared to those carrying the Pro allele. For the apolipoprotein E gene polymorphism, it was observed a tendency of higher TAG (p=0.0712) and VLDL-c (p=0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele. Conclusion: The polymorphisms PPAR-gama rs18011282 and apolipoprotein E rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents.
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spelling Cominetti, Cristianehttp://lattes.cnpq.br/3143023553465749Horst, Maria AderuzaSilva, Daniela de Melo eBotelho, Patrícia BorgesCominetti, Cristianehttp://lattes.cnpq.br/3767000097050314Alves, Maira Chiquito2015-10-15T12:46:45Z2015-03-20ALVES, M. C. Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular. 2015. 107 f. Dissertação (Mestrado em Nutrição e Saúde) - Universidade Federal de Goiás, Goiânia, 2015.http://repositorio.bc.ufg.br/tede/handle/tede/4636ark:/38995/0013000006j46To verify the relationship between the polymorphisms rs18011282 in PPAR-gamma gene and rs429358 + rs7412 in apolipoprotein E gene and lipid profile of adolescents under cardiovascular risk factors. Material and methods: The study sample was composed of 115 adolescents aged 10-19 years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic and dietetic variables. ANOVA or Kruskal-Wallis tests were used in the analysis of ungrouped genotypes, while Student’s t-test or Mann-Whitney test were applied to the analysis of the grouped genotypes. Results: The overweight adolescents presented lower HDL-c concentrations (p=0.0016). Those carrying PPAR-gamma Ala allele showed higher serum TAG (p=0.0423) and VLDL-c (p=0.0410) levels when compared to those carrying the Pro allele. For the apolipoprotein E gene polymorphism, it was observed a tendency of higher TAG (p=0.0712) and VLDL-c (p=0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele. Conclusion: The polymorphisms PPAR-gama rs18011282 and apolipoprotein E rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents.Verificar a relação dos polimorfismos rs18011282 no gene do PPAR-gama e rs429358 + rs7412 no gene da apolipoproteína E com o perfil lipídico de adolescentes com fatores de risco cardiovascular. Material e métodos: A amostra foi constituida por 115 adolescentes com idade entre 10-19 anos e com fatores de risco cardiovascular. Os estudantes foram avaliados quanto as variáveis socioeconômicas, antropométricas, bioquímicas, genéticas e dietéticas. Os testes ANOVA ou Kruskal-Wallis foram utilizados para os genótipos não agrupados, e as análises dos genótipos agrupados foram realizadas por meio dos testes t de Student e Mann-Whitney. Resultados: Os adolescentes com excesso de peso apresentaram concentrações inferiores de HDL-c (p=0,0016). Carreadores do alelo variante Ala (PPAR-gama) apresentaram concentrações séricas superiores de TG (p=0,0423) e de VLDL-c (p=0,0410) em relação ao carreadores do alelo selvagem Pro. Para o polimorfismo no gene da ApoE foram observadas concentrações séricas de TG (p=0,0712) e de VLDL-c (p=0,0758) marginalmente maiores nos carreadores do alelo E4 em relação aos não carreadores deste alelo. Conclusão: Os polimorfismos rs18011282 no gene que codifica o PPAR-gama e rs429358 + rs7412 no gene que codifica a ApoE podem estar relacionados ao desenvolvimento de dislipidemias em adolescentes.Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2015-10-15T12:44:52Z No. of bitstreams: 2 Dissertação - Maira Chiquito Alves - 2015.pdf: 2795650 bytes, checksum: df30e15f25e56e8cea5234d554455c1b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-10-15T12:46:45Z (GMT) No. of bitstreams: 2 Dissertação - Maira Chiquito Alves - 2015.pdf: 2795650 bytes, checksum: df30e15f25e56e8cea5234d554455c1b (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Made available in DSpace on 2015-10-15T12:46:45Z (GMT). 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dc.title.por.fl_str_mv Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular
dc.title.alternative.eng.fl_str_mv Polymorphism in the PPAR-gamma and apolipoprotein e genes: relationships with lipid profile of adolescents with cardiovascular risk factors
title Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular
spellingShingle Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular
Alves, Maira Chiquito
Apolipoproteína E
PPAR-gama
Polimorfismo genético
Doenças cardiovasculares
Alterações do peso corporal
Apolipoprotein E
PPAR-gamma
Genetic polymorphism
Dyslipidemia
Cardiovascular diseases
CIENCIAS DA SAUDE::NUTRICAO
title_short Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular
title_full Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular
title_fullStr Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular
title_full_unstemmed Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular
title_sort Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular
author Alves, Maira Chiquito
author_facet Alves, Maira Chiquito
author_role author
dc.contributor.advisor1.fl_str_mv Cominetti, Cristiane
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3143023553465749
dc.contributor.advisor-co1.fl_str_mv Horst, Maria Aderuza
dc.contributor.referee1.fl_str_mv Silva, Daniela de Melo e
dc.contributor.referee2.fl_str_mv Botelho, Patrícia Borges
dc.contributor.referee3.fl_str_mv Cominetti, Cristiane
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/3767000097050314
dc.contributor.author.fl_str_mv Alves, Maira Chiquito
contributor_str_mv Cominetti, Cristiane
Horst, Maria Aderuza
Silva, Daniela de Melo e
Botelho, Patrícia Borges
Cominetti, Cristiane
dc.subject.por.fl_str_mv Apolipoproteína E
PPAR-gama
Polimorfismo genético
Doenças cardiovasculares
Alterações do peso corporal
topic Apolipoproteína E
PPAR-gama
Polimorfismo genético
Doenças cardiovasculares
Alterações do peso corporal
Apolipoprotein E
PPAR-gamma
Genetic polymorphism
Dyslipidemia
Cardiovascular diseases
CIENCIAS DA SAUDE::NUTRICAO
dc.subject.eng.fl_str_mv Apolipoprotein E
PPAR-gamma
Genetic polymorphism
Dyslipidemia
Cardiovascular diseases
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE::NUTRICAO
description To verify the relationship between the polymorphisms rs18011282 in PPAR-gamma gene and rs429358 + rs7412 in apolipoprotein E gene and lipid profile of adolescents under cardiovascular risk factors. Material and methods: The study sample was composed of 115 adolescents aged 10-19 years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic and dietetic variables. ANOVA or Kruskal-Wallis tests were used in the analysis of ungrouped genotypes, while Student’s t-test or Mann-Whitney test were applied to the analysis of the grouped genotypes. Results: The overweight adolescents presented lower HDL-c concentrations (p=0.0016). Those carrying PPAR-gamma Ala allele showed higher serum TAG (p=0.0423) and VLDL-c (p=0.0410) levels when compared to those carrying the Pro allele. For the apolipoprotein E gene polymorphism, it was observed a tendency of higher TAG (p=0.0712) and VLDL-c (p=0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele. Conclusion: The polymorphisms PPAR-gama rs18011282 and apolipoprotein E rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-10-15T12:46:45Z
dc.date.issued.fl_str_mv 2015-03-20
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dc.identifier.citation.fl_str_mv ALVES, M. C. Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular. 2015. 107 f. Dissertação (Mestrado em Nutrição e Saúde) - Universidade Federal de Goiás, Goiânia, 2015.
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identifier_str_mv ALVES, M. C. Polimorfismos nos genes do PPAR-gama e da apolipoproteína e: relações com o perfil lipídico de adolescentes com fatores de risco cardiovascular. 2015. 107 f. Dissertação (Mestrado em Nutrição e Saúde) - Universidade Federal de Goiás, Goiânia, 2015.
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