Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/8295 |
Resumo: | Schizophrenia (EQZ) is a chronic mental illness that affects about 1% of the world population and is characterized by behavioral domains such as positive symptoms characterized by hallucinations and delusions and negative symptoms that involve apathy, anhedonia and social blunting. The cause of EQZ remains unknown, but it is known to be a disease whose etiology involves environmental and genetic factors. Several studies seek to identify factors that clarify the etiology of the disease. The agent that causes toxoplasmosis, Toxoplasma gondii, seems to be related to the development and progression of the disease, evidenced by studies that argue that T. gondii infection may be a triggering factor for psychosis in some individuals, since the parasite has a certain tropism by the central nervous system. Furthermore, studies have reported parasite infection as a factor related to genotoxicity, including toxoplasma infection in an animal model. Based on the foregoing, the present study aimed to evaluate the seropositivity to T. gondii (IgM or IgG) and the avidity of IgG in a group of individuals diagnosed with EQZ in the city of Goiânia and to evaluate the occurrence of genotoxicity in these, of genotoxicity with exposure to xenobiotics such as tobacco, alcohol, especially drugs, and / or T. gondii infection. Seropositivity was observed above 70% among individuals diagnosed with EQZ in relation to the controls, with avidity above 50%, indicating that individuals had contact with T. gondii at some time prior to the survey. Despite the genotoxic damage found, there was no significant difference in genotoxic damage among the infected individuals evaluated. The present study did not demonstrate that T. gondii may be a contributing factor to the occurrence of DNA damage, and the use of antipsychotic drugs, tobacco and alcohol, despite being a risk factor for genotoxicity, did not demonstrate an influence significant difference in the present study. However, it is necessary to carry out other analyzes and investigate parameters such as the time of drug use and exposure to other xenobiotics. In order to know better the life habits of individuals, it may help to provide more information about this relationship between T. gondii and EQZ. |
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Parise, Michelle Rochahttp://lattes.cnpq.br/1256067662875050Avelar, Juliana Boaventurahttp://lattes.cnpq.br/2170858365257711Parise, Michelle RochaSilva, Daniela de Melo eRodrigues, Rosângela Mariahttp://lattes.cnpq.br/9631351971457445Oliveira, Nícolas Gustavo Matias de2018-04-04T13:24:34Z2018-03-01Oliveira, N. G. M. Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos. 2018. 86 f. Dissertação (Mestrado em Genética e Biologia Molecular) - Universidade Federal de Goiás, Goiânia, 2018.http://repositorio.bc.ufg.br/tede/handle/tede/8295Schizophrenia (EQZ) is a chronic mental illness that affects about 1% of the world population and is characterized by behavioral domains such as positive symptoms characterized by hallucinations and delusions and negative symptoms that involve apathy, anhedonia and social blunting. The cause of EQZ remains unknown, but it is known to be a disease whose etiology involves environmental and genetic factors. Several studies seek to identify factors that clarify the etiology of the disease. The agent that causes toxoplasmosis, Toxoplasma gondii, seems to be related to the development and progression of the disease, evidenced by studies that argue that T. gondii infection may be a triggering factor for psychosis in some individuals, since the parasite has a certain tropism by the central nervous system. Furthermore, studies have reported parasite infection as a factor related to genotoxicity, including toxoplasma infection in an animal model. Based on the foregoing, the present study aimed to evaluate the seropositivity to T. gondii (IgM or IgG) and the avidity of IgG in a group of individuals diagnosed with EQZ in the city of Goiânia and to evaluate the occurrence of genotoxicity in these, of genotoxicity with exposure to xenobiotics such as tobacco, alcohol, especially drugs, and / or T. gondii infection. Seropositivity was observed above 70% among individuals diagnosed with EQZ in relation to the controls, with avidity above 50%, indicating that individuals had contact with T. gondii at some time prior to the survey. Despite the genotoxic damage found, there was no significant difference in genotoxic damage among the infected individuals evaluated. The present study did not demonstrate that T. gondii may be a contributing factor to the occurrence of DNA damage, and the use of antipsychotic drugs, tobacco and alcohol, despite being a risk factor for genotoxicity, did not demonstrate an influence significant difference in the present study. However, it is necessary to carry out other analyzes and investigate parameters such as the time of drug use and exposure to other xenobiotics. In order to know better the life habits of individuals, it may help to provide more information about this relationship between T. gondii and EQZ.A esquizofrenia (EQZ) é uma doença mental crônica que afeta cerca de 1% da população mundial e se caracteriza por domínios comportamentais, como sintomas positivos, caracterizados por alucinações e delírios e sintomas negativos, que envolvem apatia, anedonia e embotamento social. A causa da EQZ ainda permanece desconhecida, mas sabe-se que se trata de uma doença que cuja etiologia envolve fatores ambientais e genéticos. Vários estudos buscam identificar fatores que esclareçam a etiologia da doença. O agente causador da toxoplasmose, Toxoplasma gondii, parece ter relação com o desenvolvimento e progressão da doença, evidenciado por estudos que defendem que a infecção por T. gondii pode ser um fator desencadeante de psicoses em alguns indivíduos, já que o parasito apresenta um certo tropismo pelo sistema nervoso central. Ainda, estudos tem reportado a infecção por parasitos como fator relacionado a genotoxicidade, incluindo a infecção pelo toxoplasma em um modelo animal. Com base no exposto, o presente trabalho teve por objetivo avaliar a soropositividade para T. gondii (IgM ou IgG) e a avidez da IgG em um grupo de indivíduos diagnosticados com EQZ do município de Goiânia e avaliar a ocorrência de genotoxicidade nestes, procurando relação da genotoxicidade com a exposição a xenobióticos como tabaco, álcool, especialmente medicamentos, e/ou com a infecção pelo T. gondii. Observou- se soropositividade acima de 70% entre os indivíduos diagnosticados com EQZ em relação aos controles, com avidez acima de 50%, indicando que os indivíduos tiveram contato com o T. gondii em algum momento anterior a pesquisa. Apesar do dano genotóxico encontrado, não houve diferença significativa no dano genotóxico entre os indivíduos infectados avaliados. O presente estudo não demonstrou que T. gondii pode ser um fator contribuinte para a ocorrência de danos ao DNA, e o uso de fármacos antipsicóticos, o fumo e o álcool, apesar de serem um fator de risco para a genotoxicidade, não demonstraram uma influência significativa no presente estudo. Entretanto, há a necessidade de realizar outras análises e investigar parâmetros como o tempo de uso dos fármacos, e de exposição a outros xenobióticos, enfim, o melhor conhecimento dos hábitos de vida dos indivíduos pode ajudar a trazer mais informações acerca dessa relação entre T. gondii e a EQZ.Submitted by Franciele Moreira (francielemoreyra@gmail.com) on 2018-04-04T11:49:33Z No. of bitstreams: 2 Dissertação - Nícolas Gustavo Matias de Oliveira - 2018.pdf: 1671663 bytes, checksum: 77209b17924ba8b6327e4442c9878a74 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-04-04T13:24:34Z (GMT) No. of bitstreams: 2 Dissertação - Nícolas Gustavo Matias de Oliveira - 2018.pdf: 1671663 bytes, checksum: 77209b17924ba8b6327e4442c9878a74 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2018-04-04T13:24:34Z (GMT). No. of bitstreams: 2 Dissertação - Nícolas Gustavo Matias de Oliveira - 2018.pdf: 1671663 bytes, checksum: 77209b17924ba8b6327e4442c9878a74 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2018-03-01Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Genética e Biologia MolecularUFGBrasilInstituto de Ciências Biológicas - ICB (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessEsquizofreniaToxoplasmoseMedicamentos antipsicóticosXenobióticosGenotoxicidadeAntipsychotic drugsSchizophreniaToxoplasmosisXenobioticsGenotoxicityCIENCIAS BIOLOGICAS::GENETICASoroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticosSoroprevalence of toxoplasmose and evaluation of genotoxicity in individuals diagnosed with schizophrenia exposed to xenobioticsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis7015780075895009588600600600600-3872772117827373404-55181442685852520512075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.eng.fl_str_mv |
Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos |
dc.title.alternative.eng.fl_str_mv |
Soroprevalence of toxoplasmose and evaluation of genotoxicity in individuals diagnosed with schizophrenia exposed to xenobiotics |
title |
Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos |
spellingShingle |
Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos Oliveira, Nícolas Gustavo Matias de Esquizofrenia Toxoplasmose Medicamentos antipsicóticos Xenobióticos Genotoxicidade Antipsychotic drugs Schizophrenia Toxoplasmosis Xenobiotics Genotoxicity CIENCIAS BIOLOGICAS::GENETICA |
title_short |
Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos |
title_full |
Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos |
title_fullStr |
Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos |
title_full_unstemmed |
Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos |
title_sort |
Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos |
author |
Oliveira, Nícolas Gustavo Matias de |
author_facet |
Oliveira, Nícolas Gustavo Matias de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Parise, Michelle Rocha |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1256067662875050 |
dc.contributor.advisor-co1.fl_str_mv |
Avelar, Juliana Boaventura |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/2170858365257711 |
dc.contributor.referee1.fl_str_mv |
Parise, Michelle Rocha |
dc.contributor.referee2.fl_str_mv |
Silva, Daniela de Melo e |
dc.contributor.referee3.fl_str_mv |
Rodrigues, Rosângela Maria |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9631351971457445 |
dc.contributor.author.fl_str_mv |
Oliveira, Nícolas Gustavo Matias de |
contributor_str_mv |
Parise, Michelle Rocha Avelar, Juliana Boaventura Parise, Michelle Rocha Silva, Daniela de Melo e Rodrigues, Rosângela Maria |
dc.subject.por.fl_str_mv |
Esquizofrenia Toxoplasmose Medicamentos antipsicóticos Xenobióticos Genotoxicidade Antipsychotic drugs |
topic |
Esquizofrenia Toxoplasmose Medicamentos antipsicóticos Xenobióticos Genotoxicidade Antipsychotic drugs Schizophrenia Toxoplasmosis Xenobiotics Genotoxicity CIENCIAS BIOLOGICAS::GENETICA |
dc.subject.eng.fl_str_mv |
Schizophrenia Toxoplasmosis Xenobiotics Genotoxicity |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::GENETICA |
description |
Schizophrenia (EQZ) is a chronic mental illness that affects about 1% of the world population and is characterized by behavioral domains such as positive symptoms characterized by hallucinations and delusions and negative symptoms that involve apathy, anhedonia and social blunting. The cause of EQZ remains unknown, but it is known to be a disease whose etiology involves environmental and genetic factors. Several studies seek to identify factors that clarify the etiology of the disease. The agent that causes toxoplasmosis, Toxoplasma gondii, seems to be related to the development and progression of the disease, evidenced by studies that argue that T. gondii infection may be a triggering factor for psychosis in some individuals, since the parasite has a certain tropism by the central nervous system. Furthermore, studies have reported parasite infection as a factor related to genotoxicity, including toxoplasma infection in an animal model. Based on the foregoing, the present study aimed to evaluate the seropositivity to T. gondii (IgM or IgG) and the avidity of IgG in a group of individuals diagnosed with EQZ in the city of Goiânia and to evaluate the occurrence of genotoxicity in these, of genotoxicity with exposure to xenobiotics such as tobacco, alcohol, especially drugs, and / or T. gondii infection. Seropositivity was observed above 70% among individuals diagnosed with EQZ in relation to the controls, with avidity above 50%, indicating that individuals had contact with T. gondii at some time prior to the survey. Despite the genotoxic damage found, there was no significant difference in genotoxic damage among the infected individuals evaluated. The present study did not demonstrate that T. gondii may be a contributing factor to the occurrence of DNA damage, and the use of antipsychotic drugs, tobacco and alcohol, despite being a risk factor for genotoxicity, did not demonstrate an influence significant difference in the present study. However, it is necessary to carry out other analyzes and investigate parameters such as the time of drug use and exposure to other xenobiotics. In order to know better the life habits of individuals, it may help to provide more information about this relationship between T. gondii and EQZ. |
publishDate |
2018 |
dc.date.accessioned.fl_str_mv |
2018-04-04T13:24:34Z |
dc.date.issued.fl_str_mv |
2018-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Oliveira, N. G. M. Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos. 2018. 86 f. Dissertação (Mestrado em Genética e Biologia Molecular) - Universidade Federal de Goiás, Goiânia, 2018. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/8295 |
identifier_str_mv |
Oliveira, N. G. M. Soroprevalência de toxoplasmose e avaliação de genotoxicidade em indivíduos diagnosticados com esquizofrenia expostos a xenobióticos. 2018. 86 f. Dissertação (Mestrado em Genética e Biologia Molecular) - Universidade Federal de Goiás, Goiânia, 2018. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/8295 |
dc.language.iso.fl_str_mv |
por |
language |
por |
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7015780075895009588 |
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600 600 600 600 |
dc.relation.department.fl_str_mv |
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dc.relation.cnpq.fl_str_mv |
-5518144268585252051 |
dc.relation.sponsorship.fl_str_mv |
2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
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dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Genética e Biologia Molecular |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Ciências Biológicas - ICB (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
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Universidade Federal de Goiás (UFG) |
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UFG |
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Repositório Institucional da UFG |
bitstream.url.fl_str_mv |
http://repositorio.bc.ufg.br/tede/bitstreams/a600ddb5-6ae6-42d7-9316-5e1c0dace503/download http://repositorio.bc.ufg.br/tede/bitstreams/197c4b1b-e5dc-41d8-874c-b1800889ff0d/download http://repositorio.bc.ufg.br/tede/bitstreams/37cff8ac-5401-49c4-88bf-3d5777a9772b/download http://repositorio.bc.ufg.br/tede/bitstreams/95f690bd-3c71-4dfa-ab74-8163ea77efe0/download http://repositorio.bc.ufg.br/tede/bitstreams/697d2cda-7824-4208-9d95-1d7354444536/download |
bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f d41d8cd98f00b204e9800998ecf8427e d41d8cd98f00b204e9800998ecf8427e 77209b17924ba8b6327e4442c9878a74 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1798044361282289664 |