Spray de quitosana na cicatrização de feridas cutâneas em ratas diabéticas
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/7056 |
Resumo: | The healing is a complex and dynamic event aimed at the restoration of tissue integrity. However, some factors, such as diabetes, can harm this physiological event. Chitosan, a derivative of chitin, has been considered as a versatile and effective option for the treatment of wounds. This study aimed to evaluate and compare the effect of chitosan 2% gel and chitosan spray based on secondary intention healing of skin wounds in diabetic rats. 54 rats were used, divided randomly into three groups: control group (CG), chitosan 2% gel group (GG), and Chitosan spray group (GS) with 18 animals each. The rats in GC, GG, and GS had their wounds treated daily with saline solution 0.9%, chitosan 2% gel, and chitosan spray, respectively. The groups were divided into three subgroups (n = 6) according to the times of histological analysis of wound (third, seventh, and 14th day). The induction of diabetes in the rats took place by intraperitoneal application of alloxan (120 mg/kg). After confirming the state of diabetes, the animals were anesthetized and the wounds made with the aid of a punch 9.0mm in the dorsal region. Macroscopic and microscopic analyzes were performed. Macroscopic analysis showed that after 14 days, the chitosan 2% gel and chitosan spray gave a contraction rate of 100% and 99%, respectively. At the histological level, there was the anticipated recruitment of mononuclear cells, fibroblasia, and deposition of dense fibrovascular tissue and marked fibrosis in the wounds of GG and GS, emphasizing the ability of this biopolymer to optimize the healing of diabetics. It can therefore be a therapeutic option for the development of other formulations that provide wound repair in diabetic patients. |
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Paulo, Neusa Margaridahttp://lattes.cnpq.br/7949273598509043Menezes, Liliana Borges dehttp://lattes.cnpq.br/2012543423092393Paulo, Neusa Margaridahttp://lattes.cnpq.br/7949273598509043Damasceno, Adilson DonizetiSilva, Luciano Scheneider dahttp://lattes.cnpq.br/1362290523224562Santos, Thamiza Carla Costa dos2017-04-03T12:02:47Z2016-08-02SANTOS, T. C. C. Spray de quitosana na cicatrização de feridas cutâneas em ratas diabéticas. 2016. 49 f. Dissertação (Mestrado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2016.http://repositorio.bc.ufg.br/tede/handle/tede/7056The healing is a complex and dynamic event aimed at the restoration of tissue integrity. However, some factors, such as diabetes, can harm this physiological event. Chitosan, a derivative of chitin, has been considered as a versatile and effective option for the treatment of wounds. This study aimed to evaluate and compare the effect of chitosan 2% gel and chitosan spray based on secondary intention healing of skin wounds in diabetic rats. 54 rats were used, divided randomly into three groups: control group (CG), chitosan 2% gel group (GG), and Chitosan spray group (GS) with 18 animals each. The rats in GC, GG, and GS had their wounds treated daily with saline solution 0.9%, chitosan 2% gel, and chitosan spray, respectively. The groups were divided into three subgroups (n = 6) according to the times of histological analysis of wound (third, seventh, and 14th day). The induction of diabetes in the rats took place by intraperitoneal application of alloxan (120 mg/kg). After confirming the state of diabetes, the animals were anesthetized and the wounds made with the aid of a punch 9.0mm in the dorsal region. Macroscopic and microscopic analyzes were performed. Macroscopic analysis showed that after 14 days, the chitosan 2% gel and chitosan spray gave a contraction rate of 100% and 99%, respectively. At the histological level, there was the anticipated recruitment of mononuclear cells, fibroblasia, and deposition of dense fibrovascular tissue and marked fibrosis in the wounds of GG and GS, emphasizing the ability of this biopolymer to optimize the healing of diabetics. It can therefore be a therapeutic option for the development of other formulations that provide wound repair in diabetic patients.A cicatrização é um evento complexo e dinâmico que visa a restauração da integridade tecidual. No entanto, alguns fatores, como o diabetes, podem prejudicar este evento fisiológico. A quitosana, um derivado da quitina, tem sido cogitada como uma opção versátil e eficaz para o tratamento de feridas. O presente estudo teve como objetivo avaliar e comparar o efeito do gel de quitosana a 2% e spray à base de quitosana na cicatrização por segunda intenção de feridas cutâneas em ratas diabéticas. Foram utilizadas 54 ratas, divididas, aleatoriamente, em três grupos: grupo controle (GC) grupo gel de quitosana a 2% (GG) e grupo spray de quitosan (GS) com 18 animais, cada. As ratas dos grupos GC, GG e GS tiveram suas feridas tratadas diariamente com solução fisiológica 0,9%, gel de quitosana a 2% e spray à base de quitosana, respectivamente. Os grupos foram subdivididos em três subgrupos (n=6) conforme os tempos de análise histológica da ferida (terceiro, sétimo e 14º dia). A indução do diabetes mellitus, nas ratas, ocorreu por meio da aplicação intraperitoneal da aloxana (120mg/kg). Após a confirmação do estado de diabetes, os animais foram anestesiados e as feridas confeccionadas com auxílio de um punch de 9,0mm na região dorsal. Foram realizadas análises macroscópicas e microscópicas. As análises macroscópicas mostraram que ao 14º dia, o gel de quitosana 2% e o spray de quitosana proporcionaram uma taxa de contração de 100% e 99%, respectivamente. A nível histológico, observou-se o recrutamento antecipado de células mononucleares, fibroblasia e deposição de tecido fibrovascular denso acentuados e fibrose nas feridas dos GG e GS, enfatizando a capacidade deste biopolímero em otimizar a cicatrização de diabéticos. Podendo, portanto, ser uma opção terapêutica como também a base para o desenvolvimento de outras formulações que proporcionem a reparação de feridas em pacientes diabéticos.Submitted by JÚLIO HEBER SILVA (julioheber@yahoo.com.br) on 2017-03-31T17:23:22Z No. of bitstreams: 2 Dissertação - Thamiza Carla Costa dos Santos - 2016.pdf: 1439728 bytes, checksum: 19a51f9a39cdb7d376515edd24484335 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-04-03T12:02:47Z (GMT) No. of bitstreams: 2 Dissertação - Thamiza Carla Costa dos Santos - 2016.pdf: 1439728 bytes, checksum: 19a51f9a39cdb7d376515edd24484335 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2017-04-03T12:02:47Z (GMT). No. of bitstreams: 2 Dissertação - Thamiza Carla Costa dos Santos - 2016.pdf: 1439728 bytes, checksum: 19a51f9a39cdb7d376515edd24484335 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-08-02Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciência Animal (EVZ)UFGBrasilEscola de Veterinária e Zootecnia - EVZ (RG)http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessCurativoDiabetesHidrogelPolissacarídeoQuitinaCurativeDiabetesHydrogelPolysaccharideChitinCLINICA E CIRURGIA ANIMAL::CLINICA CIRURGICA ANIMALSpray de quitosana na cicatrização de feridas cutâneas em ratas diabéticasChitosan spray on the healing of skin wounds in diabetic ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis4581960685150189167600600600600-621755211424909458257108190664311514372075167498588264571reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; 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dc.title.por.fl_str_mv |
Spray de quitosana na cicatrização de feridas cutâneas em ratas diabéticas |
dc.title.alternative.eng.fl_str_mv |
Chitosan spray on the healing of skin wounds in diabetic rats |
title |
Spray de quitosana na cicatrização de feridas cutâneas em ratas diabéticas |
spellingShingle |
Spray de quitosana na cicatrização de feridas cutâneas em ratas diabéticas Santos, Thamiza Carla Costa dos Curativo Diabetes Hidrogel Polissacarídeo Quitina Curative Diabetes Hydrogel Polysaccharide Chitin CLINICA E CIRURGIA ANIMAL::CLINICA CIRURGICA ANIMAL |
title_short |
Spray de quitosana na cicatrização de feridas cutâneas em ratas diabéticas |
title_full |
Spray de quitosana na cicatrização de feridas cutâneas em ratas diabéticas |
title_fullStr |
Spray de quitosana na cicatrização de feridas cutâneas em ratas diabéticas |
title_full_unstemmed |
Spray de quitosana na cicatrização de feridas cutâneas em ratas diabéticas |
title_sort |
Spray de quitosana na cicatrização de feridas cutâneas em ratas diabéticas |
author |
Santos, Thamiza Carla Costa dos |
author_facet |
Santos, Thamiza Carla Costa dos |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Paulo, Neusa Margarida |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/7949273598509043 |
dc.contributor.advisor-co1.fl_str_mv |
Menezes, Liliana Borges de |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/2012543423092393 |
dc.contributor.referee1.fl_str_mv |
Paulo, Neusa Margarida |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/7949273598509043 |
dc.contributor.referee2.fl_str_mv |
Damasceno, Adilson Donizeti |
dc.contributor.referee3.fl_str_mv |
Silva, Luciano Scheneider da |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/1362290523224562 |
dc.contributor.author.fl_str_mv |
Santos, Thamiza Carla Costa dos |
contributor_str_mv |
Paulo, Neusa Margarida Menezes, Liliana Borges de Paulo, Neusa Margarida Damasceno, Adilson Donizeti Silva, Luciano Scheneider da |
dc.subject.por.fl_str_mv |
Curativo Diabetes Hidrogel Polissacarídeo Quitina |
topic |
Curativo Diabetes Hidrogel Polissacarídeo Quitina Curative Diabetes Hydrogel Polysaccharide Chitin CLINICA E CIRURGIA ANIMAL::CLINICA CIRURGICA ANIMAL |
dc.subject.eng.fl_str_mv |
Curative Diabetes Hydrogel Polysaccharide Chitin |
dc.subject.cnpq.fl_str_mv |
CLINICA E CIRURGIA ANIMAL::CLINICA CIRURGICA ANIMAL |
description |
The healing is a complex and dynamic event aimed at the restoration of tissue integrity. However, some factors, such as diabetes, can harm this physiological event. Chitosan, a derivative of chitin, has been considered as a versatile and effective option for the treatment of wounds. This study aimed to evaluate and compare the effect of chitosan 2% gel and chitosan spray based on secondary intention healing of skin wounds in diabetic rats. 54 rats were used, divided randomly into three groups: control group (CG), chitosan 2% gel group (GG), and Chitosan spray group (GS) with 18 animals each. The rats in GC, GG, and GS had their wounds treated daily with saline solution 0.9%, chitosan 2% gel, and chitosan spray, respectively. The groups were divided into three subgroups (n = 6) according to the times of histological analysis of wound (third, seventh, and 14th day). The induction of diabetes in the rats took place by intraperitoneal application of alloxan (120 mg/kg). After confirming the state of diabetes, the animals were anesthetized and the wounds made with the aid of a punch 9.0mm in the dorsal region. Macroscopic and microscopic analyzes were performed. Macroscopic analysis showed that after 14 days, the chitosan 2% gel and chitosan spray gave a contraction rate of 100% and 99%, respectively. At the histological level, there was the anticipated recruitment of mononuclear cells, fibroblasia, and deposition of dense fibrovascular tissue and marked fibrosis in the wounds of GG and GS, emphasizing the ability of this biopolymer to optimize the healing of diabetics. It can therefore be a therapeutic option for the development of other formulations that provide wound repair in diabetic patients. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016-08-02 |
dc.date.accessioned.fl_str_mv |
2017-04-03T12:02:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, T. C. C. Spray de quitosana na cicatrização de feridas cutâneas em ratas diabéticas. 2016. 49 f. Dissertação (Mestrado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2016. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/7056 |
identifier_str_mv |
SANTOS, T. C. C. Spray de quitosana na cicatrização de feridas cutâneas em ratas diabéticas. 2016. 49 f. Dissertação (Mestrado em Ciência Animal) - Universidade Federal de Goiás, Goiânia, 2016. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/7056 |
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por |
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por |
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4581960685150189167 |
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600 600 600 600 |
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dc.relation.cnpq.fl_str_mv |
5710819066431151437 |
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2075167498588264571 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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Universidade Federal de Goiás |
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Programa de Pós-graduação em Ciência Animal (EVZ) |
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UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Escola de Veterinária e Zootecnia - EVZ (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
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