Infecção pelo vírus da hepatite B em pacientes com tuberculose em hospital de referência em Goiânia-GO

• Autor(a) principal: Aires, Rodrigo Sebba
• Data de Publicação: 2011
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Repositório Institucional da UFG
• dARK ID: ark:/38995/0013000004kq7
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/3646
• topic: Hepatite B (vírus); Tuberculose; Pacientes; Goiânia; CLINICA MEDICA::DOENCAS INFECCIOSAS E PARASITARIAS

Hepatitis B and tuberculosis (TB) are important public health problems. This study aimed to investigate the epidemiological and molecular profile of the hepatitis B virus (HBV) infection among patients with TB who were attended at the reference hospital for infectious diseases in Goiânia, Goiás. A total of 402 patients were interviewed for socio-demographic characteristics, risk factors for HBV infection and previous hepatitis B vaccination. Blood samples were collected and sera were tested for HBsAg, anti-HBc, and anti-HBs markers by an enzyme-linked immunosorbent assay (ELISA). HBsAg reactive samples were tested for HBeAg e anti-HBe markers by ELISA. HBV DNA was detected in HBsAg and anti-HBc reactive samples by polymerase chain reaction (PCR). HBV DNA positive samples were genotyped by restriction fragment length polymorphism (RFLP) and sequencing of the Pre-S/S region. The overall HBV prevalence infection was 25.6% (95% CI: 21.5-30.2). Age higher or equal 50 years old and injecting or non-injecting drug use were risk factors associated with HBV infection. HBV DNA was detected in ten (76.9%) HBsAg reactive samples. Of these, eight were genotyped as genotypes A (n = 7) and D (n=1). HBV occult infection rate of 14.4% was found among anti-HBc reactive patients. Only 10.9% had serological evidence of previous HBV vaccination. The high prevalence and risk factors such as injecting or non-injecting drug use, in addition to the low HBV vaccine coverage found, should indicate that there is a need for interventions aimed at improving hepatitis B prevention and control in patients with tuberculosis.