A avaliação do efeito de antissépticos na superfície ocular e o papel da gentamicina no controle microbiano de córneas doadas
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/8115 |
Resumo: | Decontamination of the surface of the donor eyeballs is part of the operational norms that eye banks advocate before preservation, and antisepsis procedures are effective, ensuring greater transplantation safety. The objective of the present study was to evaluate the antiseptic effect in reducing the microbiota of the ocular globe of donors of corneas prior to enucleation, with 5% povidone-iodine (PVP-I) and 0.05% chlorhexidine gluconate (GC), In the action times of 5, 10 and 15 minutes, as well as the susceptibility profile of the microbiota isolated from gentamicin. Thirty pairs of corneas received antiseptics, with PVP-I in the right eye and GC in the left, and for each time of action 10 pairs of eyeballs were used. Swabs were collected from the ocular surface before application of the solutions, after and at the time of preservation of the corneal tissue, to evaluate the reduction of the microbiota. After identification of the microbiota, an antibiogram test was performed with gentamicin. The data were computed and evaluated by Chi-square or Fisher's exact test, T-test and McNemar test paired, and the statistical significance level was 5% (p <0.05). In the second collection, after antisepsis, there was a reduction of 39,5% in the total of gram positive bacteria (G +), and of 76,5% in the gram negative (G-) bacteria, with no statistically significant difference (p = 0.183), which demonstrated that the bacterial elimination capacity of the antiseptics was similar. It was observed that, in the second collection, both were more effective for G-, with a statistically significant difference (p <0.001), than for G +, with no statistically significant difference (p = 0.494). In the third collection, after the residual effect of the antiseptics, there was a reduction of 99.1% of all the microorganisms. In the antibiogram test, 88% of the isolated microorganisms were sensitive to gentamicin. It was concluded that the use of antiseptics is essential for the effective decontamination of donated corneas prior to preservation. The residual time of the antiseptics increased the decontamination power of PVP-I and GC, being similar in reducing the microbiota of the ocular globe of the donor of corneas. Gentamycin contained in the cornea preservation medium complements the antisepsis of the donated tissues. |
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Ávila, Marcos Pereirahttp://lattes.cnpq.br/3335187297522447Braga, Carla Afonso da Silva Bitencourthttp://lattes.cnpq.br/7673897995590123Ávila, Marcos PereiraBarbosa, Mônica SantiagoBeniz Neto, Joséhttp://lattes.cnpq.br/9606116470418199Ito, Célia Regina Malveste2018-01-18T14:29:20Z2017-09-26ITO, Célia Regina Malveste. A avaliação do efeito de antissépticos na superfície ocular e o papel da gentamicina no controle microbiano de córneas doadas. 2017. 55 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2017.http://repositorio.bc.ufg.br/tede/handle/tede/8115Decontamination of the surface of the donor eyeballs is part of the operational norms that eye banks advocate before preservation, and antisepsis procedures are effective, ensuring greater transplantation safety. The objective of the present study was to evaluate the antiseptic effect in reducing the microbiota of the ocular globe of donors of corneas prior to enucleation, with 5% povidone-iodine (PVP-I) and 0.05% chlorhexidine gluconate (GC), In the action times of 5, 10 and 15 minutes, as well as the susceptibility profile of the microbiota isolated from gentamicin. Thirty pairs of corneas received antiseptics, with PVP-I in the right eye and GC in the left, and for each time of action 10 pairs of eyeballs were used. Swabs were collected from the ocular surface before application of the solutions, after and at the time of preservation of the corneal tissue, to evaluate the reduction of the microbiota. After identification of the microbiota, an antibiogram test was performed with gentamicin. The data were computed and evaluated by Chi-square or Fisher's exact test, T-test and McNemar test paired, and the statistical significance level was 5% (p <0.05). In the second collection, after antisepsis, there was a reduction of 39,5% in the total of gram positive bacteria (G +), and of 76,5% in the gram negative (G-) bacteria, with no statistically significant difference (p = 0.183), which demonstrated that the bacterial elimination capacity of the antiseptics was similar. It was observed that, in the second collection, both were more effective for G-, with a statistically significant difference (p <0.001), than for G +, with no statistically significant difference (p = 0.494). In the third collection, after the residual effect of the antiseptics, there was a reduction of 99.1% of all the microorganisms. In the antibiogram test, 88% of the isolated microorganisms were sensitive to gentamicin. It was concluded that the use of antiseptics is essential for the effective decontamination of donated corneas prior to preservation. The residual time of the antiseptics increased the decontamination power of PVP-I and GC, being similar in reducing the microbiota of the ocular globe of the donor of corneas. Gentamycin contained in the cornea preservation medium complements the antisepsis of the donated tissues.A descontaminação da superfície dos globos oculares doados são normas operacionais que os bancos de olhos preconizam antes da preservação e os procedimentos de antissepsia são eficazes, garantindo uma maior segurança ao transplante. O objetivo do presente estudo foi avaliar o efeito antisséptico na redução da microbiota do globo ocular de doadores de córneas antes da enucleação, com o povidona-iodo (PVP-I) a 5% e gluconato de clorexidina (GC) a 0,05%, nos tempos de ação de 5, 10 e 15 minutos, bem como o perfil de susceptibilidade da microbiota isolada à gentamicina. Trinta pares de córneas receberam antissépticos, sendo o PVP-I no olho direito e o GC no esquerdo, e para cada tempo de ação foram utilizados 10 pares de globos oculares. Foram colhidos swabs da superfície ocular antes da aplicação das soluções, após e no momento da preservação do tecido corneano, para avaliar a redução da microbiota. Após identificação da microbiota, foi realizado teste de antibiograma com gentamicina. Os dados foram computados e avaliados pelos testes Qui-Quadrado ou Exato de Fisher, teste T e Teste McNemar pareado, e o nível de significância estatística foi (p<0,05). Com relação aos dados obtidos na segunda coleta, após o uso de antissépticos, houve uma redução de 39,5% no total de bactérias gram positivas (G+) e de 76,5% nas gram negativas (G-), não havendo diferença estatística significativa (p=0,183), sendo semelhante a capacidade de eliminação bacteriana dos antissépticos. Observa-se que, na segunda coleta, ambos foram mais eficazes para as G-, com diferença estatisticamente significativa (p<0,001), do que para as G+, sem diferença estatisticamente significativa (p=0,494). Na terceira coleta, após o efeito residual dos antissépticos, houve redução de 99,1% de todos os micro-organismos. No teste de antibiograma, 88% dos micro-organismos isolados foram sensíveis à gentamicina. Concluiu-se que o uso de antissépticos é essencial para a efetiva descontaminação das córneas doadas antes da preservação. O tempo residual dos antissépticos aumentou o poder de descontaminação do PVP-I e GC, sendo semelhantes na redução da microbiota do globo ocular do doador de córneas. A gentamicina contida no meio de preservação de córnea complementa a antissepsia dos tecidos doados.Submitted by Franciele Moreira (francielemoreyra@gmail.com) on 2018-01-18T14:06:02Z No. of bitstreams: 2 Dissertação - Célia Regina Malveste Ito - 2017.pdf: 2187840 bytes, checksum: ce24431d5cefc9c1e1356d4d3763413d (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-01-18T14:29:20Z (GMT) No. of bitstreams: 2 Dissertação - Célia Regina Malveste Ito - 2017.pdf: 2187840 bytes, checksum: ce24431d5cefc9c1e1356d4d3763413d (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2018-01-18T14:29:20Z (GMT). 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dc.title.eng.fl_str_mv |
A avaliação do efeito de antissépticos na superfície ocular e o papel da gentamicina no controle microbiano de córneas doadas |
dc.title.alternative.eng.fl_str_mv |
Evaluation of antisseptic effects on the eye surface and the role of gentamicin in microbial control of donated corneas |
title |
A avaliação do efeito de antissépticos na superfície ocular e o papel da gentamicina no controle microbiano de córneas doadas |
spellingShingle |
A avaliação do efeito de antissépticos na superfície ocular e o papel da gentamicina no controle microbiano de córneas doadas Ito, Célia Regina Malveste Banco de olhos Enucleação Povidona-iodo Gluconato de clorexidina Transplante Eye bank Enucleation Povidone-iodine Chlorhexidine gluconate Transplantation CIENCIAS BIOLOGICAS::MICROBIOLOGIA |
title_short |
A avaliação do efeito de antissépticos na superfície ocular e o papel da gentamicina no controle microbiano de córneas doadas |
title_full |
A avaliação do efeito de antissépticos na superfície ocular e o papel da gentamicina no controle microbiano de córneas doadas |
title_fullStr |
A avaliação do efeito de antissépticos na superfície ocular e o papel da gentamicina no controle microbiano de córneas doadas |
title_full_unstemmed |
A avaliação do efeito de antissépticos na superfície ocular e o papel da gentamicina no controle microbiano de córneas doadas |
title_sort |
A avaliação do efeito de antissépticos na superfície ocular e o papel da gentamicina no controle microbiano de córneas doadas |
author |
Ito, Célia Regina Malveste |
author_facet |
Ito, Célia Regina Malveste |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Ávila, Marcos Pereira |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/3335187297522447 |
dc.contributor.advisor-co1.fl_str_mv |
Braga, Carla Afonso da Silva Bitencourt |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/7673897995590123 |
dc.contributor.referee1.fl_str_mv |
Ávila, Marcos Pereira |
dc.contributor.referee2.fl_str_mv |
Barbosa, Mônica Santiago |
dc.contributor.referee3.fl_str_mv |
Beniz Neto, José |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9606116470418199 |
dc.contributor.author.fl_str_mv |
Ito, Célia Regina Malveste |
contributor_str_mv |
Ávila, Marcos Pereira Braga, Carla Afonso da Silva Bitencourt Ávila, Marcos Pereira Barbosa, Mônica Santiago Beniz Neto, José |
dc.subject.por.fl_str_mv |
Banco de olhos Enucleação Povidona-iodo Gluconato de clorexidina Transplante |
topic |
Banco de olhos Enucleação Povidona-iodo Gluconato de clorexidina Transplante Eye bank Enucleation Povidone-iodine Chlorhexidine gluconate Transplantation CIENCIAS BIOLOGICAS::MICROBIOLOGIA |
dc.subject.eng.fl_str_mv |
Eye bank Enucleation Povidone-iodine Chlorhexidine gluconate Transplantation |
dc.subject.cnpq.fl_str_mv |
CIENCIAS BIOLOGICAS::MICROBIOLOGIA |
description |
Decontamination of the surface of the donor eyeballs is part of the operational norms that eye banks advocate before preservation, and antisepsis procedures are effective, ensuring greater transplantation safety. The objective of the present study was to evaluate the antiseptic effect in reducing the microbiota of the ocular globe of donors of corneas prior to enucleation, with 5% povidone-iodine (PVP-I) and 0.05% chlorhexidine gluconate (GC), In the action times of 5, 10 and 15 minutes, as well as the susceptibility profile of the microbiota isolated from gentamicin. Thirty pairs of corneas received antiseptics, with PVP-I in the right eye and GC in the left, and for each time of action 10 pairs of eyeballs were used. Swabs were collected from the ocular surface before application of the solutions, after and at the time of preservation of the corneal tissue, to evaluate the reduction of the microbiota. After identification of the microbiota, an antibiogram test was performed with gentamicin. The data were computed and evaluated by Chi-square or Fisher's exact test, T-test and McNemar test paired, and the statistical significance level was 5% (p <0.05). In the second collection, after antisepsis, there was a reduction of 39,5% in the total of gram positive bacteria (G +), and of 76,5% in the gram negative (G-) bacteria, with no statistically significant difference (p = 0.183), which demonstrated that the bacterial elimination capacity of the antiseptics was similar. It was observed that, in the second collection, both were more effective for G-, with a statistically significant difference (p <0.001), than for G +, with no statistically significant difference (p = 0.494). In the third collection, after the residual effect of the antiseptics, there was a reduction of 99.1% of all the microorganisms. In the antibiogram test, 88% of the isolated microorganisms were sensitive to gentamicin. It was concluded that the use of antiseptics is essential for the effective decontamination of donated corneas prior to preservation. The residual time of the antiseptics increased the decontamination power of PVP-I and GC, being similar in reducing the microbiota of the ocular globe of the donor of corneas. Gentamycin contained in the cornea preservation medium complements the antisepsis of the donated tissues. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-09-26 |
dc.date.accessioned.fl_str_mv |
2018-01-18T14:29:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ITO, Célia Regina Malveste. A avaliação do efeito de antissépticos na superfície ocular e o papel da gentamicina no controle microbiano de córneas doadas. 2017. 55 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2017. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/8115 |
identifier_str_mv |
ITO, Célia Regina Malveste. A avaliação do efeito de antissépticos na superfície ocular e o papel da gentamicina no controle microbiano de córneas doadas. 2017. 55 f. Dissertação (Mestrado em Ciências da Saúde) - Universidade Federal de Goiás, Goiânia, 2017. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/8115 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
-1006864312617745310 |
dc.relation.confidence.fl_str_mv |
600 600 600 |
dc.relation.department.fl_str_mv |
1545772475950486338 |
dc.relation.cnpq.fl_str_mv |
-3854583469976220812 |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Ciências da Saúde (FM) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Faculdade de Medicina - FM (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Repositório Institucional da UFG |
collection |
Repositório Institucional da UFG |
bitstream.url.fl_str_mv |
http://repositorio.bc.ufg.br/tede/bitstreams/3088806e-bbb6-418e-bef6-4d2524bda19a/download http://repositorio.bc.ufg.br/tede/bitstreams/eeb1c3e8-0db5-431c-837e-3aab0c1b79b4/download http://repositorio.bc.ufg.br/tede/bitstreams/3b3b6370-51ba-4d54-9e81-6d944d022142/download http://repositorio.bc.ufg.br/tede/bitstreams/c5b44ada-47b9-42fb-a147-d020f80cd688/download http://repositorio.bc.ufg.br/tede/bitstreams/2423e543-24e1-4e2e-8501-31f4d19612a7/download |
bitstream.checksum.fl_str_mv |
bd3efa91386c1718a7f26a329fdcb468 4afdbb8c545fd630ea7db775da747b2f d41d8cd98f00b204e9800998ecf8427e d41d8cd98f00b204e9800998ecf8427e ce24431d5cefc9c1e1356d4d3763413d |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFG - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
tasesdissertacoes.bc@ufg.br |
_version_ |
1798044366821916672 |