Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas

Detalhes bibliográficos
Autor(a) principal: Oliveira, Relton Romeis de
Data de Publicação: 2013
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Repositório Institucional da UFG
dARK ID: ark:/38995/00130000051sn
Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/3108
Resumo: This work describes the development and characterization of magnetic solid lipid nanoparticles (SLNMP) containing paclitaxel for magnetohyperthermia applications. Magnetic nanoparticles were prepared by coprecipitation of Fe(II) and Fe(III) salts in an alkaline medium. SLNMP containing paclitaxel were prepared by emulsification – solvent diffusion. Characterization of the nanostructured system included morphology analysis, average diameter and size distribution, encapsulation efficiency for paclitaxel, stability and magnetic properties of magnetometry and magnetohyperthermia. Magnetic SLNMP containing paclitaxel exhibited an average diameter of 200nm with a polydispersity index of 0,189; which was confirmed by Atomic Force Microscopy. Stability studies conducted with lyophilized samples showed a decrease of approximately 15% in the amount of encapsulated paclitaxel in 30 days. Magnetometry data confirmed the superparamagnetic behavior of the nanocarriers and magnetohyperthermia effect was demonstrated by an increase of 25°C of the temperature of the nanocarrier. A three fold increase in the drug release rate was obtained when the temperature was raised from 25 to 43°C in the in vitro release assay. This indicated that temperature increase acts as a trigger mechanism for drug release, allowing the preparation of nanostructured controlled drug delivery systems controlled by magnetohyperthermia.
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spelling Lima, Eliana Martinshttp://lattes.cnpq.br/7248774319455970Bakuzis, Andris FigueiroaLima, Eliana MartinsAlonso, AntonioTaveira, Stephânia Fleuryhttp://lattes.cnpq.br/4031577881091710Oliveira, Relton Romeis de2014-09-19T19:33:51Z2013-02-28Oliveira, Relton Romeis de. Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas. 2013. 62 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Programa de Pós-graduação em Ciências Farmacêuticas (FF) - Universidade Federal de Goiás, Goiânia, 2013.http://repositorio.bc.ufg.br/tede/handle/tede/3108ark:/38995/00130000051snThis work describes the development and characterization of magnetic solid lipid nanoparticles (SLNMP) containing paclitaxel for magnetohyperthermia applications. Magnetic nanoparticles were prepared by coprecipitation of Fe(II) and Fe(III) salts in an alkaline medium. SLNMP containing paclitaxel were prepared by emulsification – solvent diffusion. Characterization of the nanostructured system included morphology analysis, average diameter and size distribution, encapsulation efficiency for paclitaxel, stability and magnetic properties of magnetometry and magnetohyperthermia. Magnetic SLNMP containing paclitaxel exhibited an average diameter of 200nm with a polydispersity index of 0,189; which was confirmed by Atomic Force Microscopy. Stability studies conducted with lyophilized samples showed a decrease of approximately 15% in the amount of encapsulated paclitaxel in 30 days. Magnetometry data confirmed the superparamagnetic behavior of the nanocarriers and magnetohyperthermia effect was demonstrated by an increase of 25°C of the temperature of the nanocarrier. A three fold increase in the drug release rate was obtained when the temperature was raised from 25 to 43°C in the in vitro release assay. This indicated that temperature increase acts as a trigger mechanism for drug release, allowing the preparation of nanostructured controlled drug delivery systems controlled by magnetohyperthermia.Este trabalho descreve o desenvolvimento e caracterização de nanopartículas lipídicas sólidas magnéticas contendo paclitaxel para aplicação em magnetohipertermia. Nanopartículas magnéticas foram obtidas pelo método de coprecipitação de sais de Fe(II) e Fe(III) em meio alcalino. Nanopartículas lipídicas sólidas magnéticas contendo paclitaxel foram preparadas pelo método de emulsificação-difusão de solvente. O sistema nanoestruturado foi caracterizado quanto à morfologia, diâmetro médio e distribuição de tamanho, eficiência de encapsulação do paclitaxel, estabilidade e propriedades magnéticas de magnetometria e magnetohipertermia. As nanopartículas lipídicas sólidas magnéticas contendo paclitaxel apresentaram diâmetro médio de aproximadamente 200nm com índice de polidispersão de 0,189 e 67% de eficiência de encapsulação do PTX. O estudo de estabilidade realizado em amostras liofilizadas mostrou redução de aproximadamente 15% do paclitaxel encapsulado no período de 30 dias. Pelo estudo de magnetometria os nanocarreadores apresentaram curva de magnetização condizente com material em regime perparamagnético e o efeito de magnetohipertermia foi verificado pelo aumento da temperatura de aproximadamente 25ºC do nanocarreador.A taxa de liberação do paclitaxel foi aumentada em 3 vezes quando a temperatura foi elevada de 25ºC para 43ºC no ensaio de liberação in vitro indicando que o aquecimento dos nanocarreadores pode representar um mecanismo desencadeador do processo de liberação do fármaco, possibilitando a obtenção de sistemas de liberação controlada por magnetohipertermia.Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2014-09-18T21:14:48Z No. of bitstreams: 2 DISSERTAÇÃO REVISÃO FINAL.pdf: 1776163 bytes, checksum: 9cc893b53fed44267523efd8f741e790 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)Rejected by Luciana Ferreira (lucgeral@gmail.com), reason: Há problema na citação, a qual foi registrada assim: Oliveira, Relton Romeis de - Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas - 2013 - 62 f. - Dissertação - Programa de Pós-graduação em Ciências Farmacêuticas (FF) - Universidade Federal de Goiás - Goiânia, 2013. Deve-se seguir a NBR 6023. Ex.: ALCÂNTARA, Guizelle Aparecida de. Caracterização farmacognostica e atividade antimicrobiana da folha e casca do caule da myrciarostratadc.(myrtaceae). 2012. 41 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Federal de Goiás, Goiânia, 2012. Ou seja, terá que alterar o que aparece nesse campo já registrado automático pelo programa, como: pontuação o sobrenome todo em maiúsculo, etc. on 2014-09-19T13:22:35Z (GMT)Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2014-09-19T19:22:41Z No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) DISSERTAÇÃO REVISÃO FINAL.pdf: 1776163 bytes, checksum: 9cc893b53fed44267523efd8f741e790 (MD5)Approved for entry into archive by Jaqueline Silva (jtas29@gmail.com) on 2014-09-19T19:33:51Z (GMT) No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) DISSERTAÇÃO REVISÃO FINAL.pdf: 1776163 bytes, checksum: 9cc893b53fed44267523efd8f741e790 (MD5)Made available in DSpace on 2014-09-19T19:33:51Z (GMT). No. of bitstreams: 2 license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5) DISSERTAÇÃO REVISÃO FINAL.pdf: 1776163 bytes, checksum: 9cc893b53fed44267523efd8f741e790 (MD5) Previous issue date: 2013-02-28Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfhttp://repositorio.bc.ufg.br/tede/retrieve/8077/DISSERTA%c3%87%c3%83O%20REVIS%c3%83O%20FINAL.pdf.jpgporUniversidade Federal de GoiásPrograma de Pós-graduação em Ciências Farmacêuticas (FF)UFGBrasilFaculdade Farmácia - FF (RG)ARIAS, F.; OTERO, J. M.; GUERRERO, C.; CARDONA, A. F.; VARGAS, C. A.; CARRANZA, H.; CASTRO, C.; MORA, M.; GUERRA, B.; OJEDA, K.; RAMÍREZ, H.; REVEIZ, L.; BIJELIC, L.; ZAPPA, L.; SUGARBAKER, P. Pseudomixoma peritoneal: primeros casos tratados en Colombia con peritonectomía radical y quimioterapia intraperitoneal hipertérmica. Revista Colombiana de Cirugía, v. 24, p. 184-194, 2009. 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dc.title.por.fl_str_mv Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas
dc.title.alternative.por.fl_str_mv Magnetically triggered controlled release of paclitaxel from solid lipid nanoparticles
title Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas
spellingShingle Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas
Oliveira, Relton Romeis de
Paclitaxel
Nanopartículas lipídicas sólidas magnéticas
Hipertermia magnética
Paclitaxel
Solid Lipid nanoparaticles
Magnetic hyperthermia
FARMACIA::ANALISE E CONTROLE E MEDICAMENTOS
title_short Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas
title_full Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas
title_fullStr Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas
title_full_unstemmed Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas
title_sort Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas
author Oliveira, Relton Romeis de
author_facet Oliveira, Relton Romeis de
author_role author
dc.contributor.advisor1.fl_str_mv Lima, Eliana Martins
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/7248774319455970
dc.contributor.advisor-co1.fl_str_mv Bakuzis, Andris Figueiroa
dc.contributor.referee1.fl_str_mv Lima, Eliana Martins
dc.contributor.referee2.fl_str_mv Alonso, Antonio
dc.contributor.referee3.fl_str_mv Taveira, Stephânia Fleury
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/4031577881091710
dc.contributor.author.fl_str_mv Oliveira, Relton Romeis de
contributor_str_mv Lima, Eliana Martins
Bakuzis, Andris Figueiroa
Lima, Eliana Martins
Alonso, Antonio
Taveira, Stephânia Fleury
dc.subject.por.fl_str_mv Paclitaxel
Nanopartículas lipídicas sólidas magnéticas
Hipertermia magnética
Paclitaxel
Solid Lipid nanoparaticles
Magnetic hyperthermia
topic Paclitaxel
Nanopartículas lipídicas sólidas magnéticas
Hipertermia magnética
Paclitaxel
Solid Lipid nanoparaticles
Magnetic hyperthermia
FARMACIA::ANALISE E CONTROLE E MEDICAMENTOS
dc.subject.cnpq.fl_str_mv FARMACIA::ANALISE E CONTROLE E MEDICAMENTOS
description This work describes the development and characterization of magnetic solid lipid nanoparticles (SLNMP) containing paclitaxel for magnetohyperthermia applications. Magnetic nanoparticles were prepared by coprecipitation of Fe(II) and Fe(III) salts in an alkaline medium. SLNMP containing paclitaxel were prepared by emulsification – solvent diffusion. Characterization of the nanostructured system included morphology analysis, average diameter and size distribution, encapsulation efficiency for paclitaxel, stability and magnetic properties of magnetometry and magnetohyperthermia. Magnetic SLNMP containing paclitaxel exhibited an average diameter of 200nm with a polydispersity index of 0,189; which was confirmed by Atomic Force Microscopy. Stability studies conducted with lyophilized samples showed a decrease of approximately 15% in the amount of encapsulated paclitaxel in 30 days. Magnetometry data confirmed the superparamagnetic behavior of the nanocarriers and magnetohyperthermia effect was demonstrated by an increase of 25°C of the temperature of the nanocarrier. A three fold increase in the drug release rate was obtained when the temperature was raised from 25 to 43°C in the in vitro release assay. This indicated that temperature increase acts as a trigger mechanism for drug release, allowing the preparation of nanostructured controlled drug delivery systems controlled by magnetohyperthermia.
publishDate 2013
dc.date.issued.fl_str_mv 2013-02-28
dc.date.accessioned.fl_str_mv 2014-09-19T19:33:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.citation.fl_str_mv Oliveira, Relton Romeis de. Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas. 2013. 62 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Programa de Pós-graduação em Ciências Farmacêuticas (FF) - Universidade Federal de Goiás, Goiânia, 2013.
dc.identifier.uri.fl_str_mv http://repositorio.bc.ufg.br/tede/handle/tede/3108
dc.identifier.dark.fl_str_mv ark:/38995/00130000051sn
identifier_str_mv Oliveira, Relton Romeis de. Desenvolvimento, caracterização e estudo de liberação in vitro por magnetohipertermia de paclitaxel em nanopartículas lipídicas sólidas magnéticas. 2013. 62 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Programa de Pós-graduação em Ciências Farmacêuticas (FF) - Universidade Federal de Goiás, Goiânia, 2013.
ark:/38995/00130000051sn
url http://repositorio.bc.ufg.br/tede/handle/tede/3108
dc.language.iso.fl_str_mv por
language por
dc.relation.program.fl_str_mv 824936988196152412
dc.relation.confidence.fl_str_mv 600
600
600
600
dc.relation.department.fl_str_mv 6010281161524209375
dc.relation.cnpq.fl_str_mv 6216025074656932336
dc.relation.sponsorship.fl_str_mv 2075167498588264571
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