3D implant of copolyamide associated with thermoplastic elastomer (PCTPE) for tracheal repair in rabbits (Oryctolagus cuniculus): preliminary study
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Ciência animal brasileira (Online) |
Texto Completo: | https://revistas.ufg.br/vet/article/view/76225 |
Resumo: | Large segmental tracheal defects can pose a serious clinical challenge owing to the lack of suitable substitutes for reconstructive surgery. Polymeric biomaterials are widely used in medicine. However, the implantation of biomaterials triggers a series of biological events, and material biocompatibility is of paramount importance in regenerative medicine. The objective of this study was to evaluate the use of a copolyamide associated with thermoplastic elastomer (PCTPE) in 3D-printed prostheses for repairing partial tracheal defects in rabbits. Sixteen male New Zealand White rabbits were used, and partial tracheal defects were created in the ventral region from the 4th to the 8th tracheal ring. The animals were subdivided into groups (n=4) based on the time of euthanasia, scheduled at seven days (G7), 15 days (G15), 30 days (G30), and 60 days (G60). Histopathological analysis with hematoxylin and eosin staining revealed that the 3D implant of PCTPE exhibited a foreign body reaction, and inflammation persisted for up to 60 days. Histochemistry with picrosirius red revealed a tendency for a greater amount of type I collagen to accumulate in the early stages of inflammation, whereas type III collagen was predominant in later evaluation periods. These findings suggest an exacerbated and inadequate tissue-material interface reaction and perpetuation of the inflammatory process. |
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3D implant of copolyamide associated with thermoplastic elastomer (PCTPE) for tracheal repair in rabbits (Oryctolagus cuniculus): preliminary studyImplante 3D de copoliamida associada à elastômero termoplástico (PCTPE) para reparação traqueal de coelhos (Oryctolagus cuniculus): estudo preliminarLarge segmental tracheal defects can pose a serious clinical challenge owing to the lack of suitable substitutes for reconstructive surgery. Polymeric biomaterials are widely used in medicine. However, the implantation of biomaterials triggers a series of biological events, and material biocompatibility is of paramount importance in regenerative medicine. The objective of this study was to evaluate the use of a copolyamide associated with thermoplastic elastomer (PCTPE) in 3D-printed prostheses for repairing partial tracheal defects in rabbits. Sixteen male New Zealand White rabbits were used, and partial tracheal defects were created in the ventral region from the 4th to the 8th tracheal ring. The animals were subdivided into groups (n=4) based on the time of euthanasia, scheduled at seven days (G7), 15 days (G15), 30 days (G30), and 60 days (G60). Histopathological analysis with hematoxylin and eosin staining revealed that the 3D implant of PCTPE exhibited a foreign body reaction, and inflammation persisted for up to 60 days. Histochemistry with picrosirius red revealed a tendency for a greater amount of type I collagen to accumulate in the early stages of inflammation, whereas type III collagen was predominant in later evaluation periods. These findings suggest an exacerbated and inadequate tissue-material interface reaction and perpetuation of the inflammatory process. Defeitos de grandes segmentos traqueais podem apresentar sério problema clínico, devido à ausência de substitutos na cirurgia reconstrutiva. Os biomateriais poliméricos estão entre os mais utilizados na medicina. Entretanto, a implantação de um biomaterial desencadeia uma série de eventos biológicos e a biocompatibilidade do material é de extrema importância para a medicina regenerativa. Objetivou-se com este estudo avaliar o uso da copoliamida associada ao elastômero termoplástico (PCTPE) em próteses impressas em 3D para reparação de defeitos parciais da traqueia de coelhos. Foram utilizados 16 coelhos machos da raça Nova Zelândia Branco, submetidos à criação de um defeito parcial de traqueia na região ventral do 4º ao 8º anel traqueal. Os animais foram subdivididos (n=4) de acordo com o momento das eutanásias, programadas com intervalo de sete (G7), quinze (G15), trinta (G30) e sessenta dias (G60). A análise histopatológica por hematoxilina e eosina (HE) revelou que o implante 3D de PCTPE apresentou reação do tipo corpo estranho e a inflamação persistiu até os 60 dias de avaliação. A histoquímica de picrosirius vermelho revelou tendência de maior quantidade de colágeno tipo I nos tempos iniciais de inflamação, enquanto o colágeno tipo III foi predominante nos períodos tardios de avaliação. Pode- se sugerir reação exacerbada e não adequada da interface tecido-material e perpetuação do processo inflamatório.Universidade Federal de Goiás2024-01-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://revistas.ufg.br/vet/article/view/76225Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 25 (2024): Publicação continuaCiência Animal Brasileira / Brazilian Animal Science; v. 25 (2024): Publicação continua1809-68911518-2797reponame:Ciência animal brasileira (Online)instname:Universidade Federal de Goiás (UFG)instacron:UFGporenghttps://revistas.ufg.br/vet/article/view/76225/40745https://revistas.ufg.br/vet/article/view/76225/40746https://revistas.ufg.br/vet/article/view/76225/40864https://revistas.ufg.br/vet/article/view/76225/40865Copyright (c) 2024 Ciência Animal Brasileira / Brazilian Animal Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRein, AriadneCarrijo da Costa, MarceloMontanhin, GabrielFernandes, GustavoDall’ Agnol Leite, MarcellaSalvitti de Sá Rocha, Thiago AndréUnger Carra, Gabriel Joãode Oliveira Vasconcelos, RosemeriGosuen Gonçalves Dias, Luís GustavoCastro Moraes, Paola2024-03-27T21:43:47Zoai:ojs.revistas.ufg.br:article/76225Revistahttps://revistas.ufg.br/vetPUBhttps://revistas.ufg.br/vet/oai||revistacab@gmail.com1809-68911518-2797opendoar:2024-05-21T19:56:37.434668Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG)true |
dc.title.none.fl_str_mv |
3D implant of copolyamide associated with thermoplastic elastomer (PCTPE) for tracheal repair in rabbits (Oryctolagus cuniculus): preliminary study Implante 3D de copoliamida associada à elastômero termoplástico (PCTPE) para reparação traqueal de coelhos (Oryctolagus cuniculus): estudo preliminar |
title |
3D implant of copolyamide associated with thermoplastic elastomer (PCTPE) for tracheal repair in rabbits (Oryctolagus cuniculus): preliminary study |
spellingShingle |
3D implant of copolyamide associated with thermoplastic elastomer (PCTPE) for tracheal repair in rabbits (Oryctolagus cuniculus): preliminary study Rein, Ariadne |
title_short |
3D implant of copolyamide associated with thermoplastic elastomer (PCTPE) for tracheal repair in rabbits (Oryctolagus cuniculus): preliminary study |
title_full |
3D implant of copolyamide associated with thermoplastic elastomer (PCTPE) for tracheal repair in rabbits (Oryctolagus cuniculus): preliminary study |
title_fullStr |
3D implant of copolyamide associated with thermoplastic elastomer (PCTPE) for tracheal repair in rabbits (Oryctolagus cuniculus): preliminary study |
title_full_unstemmed |
3D implant of copolyamide associated with thermoplastic elastomer (PCTPE) for tracheal repair in rabbits (Oryctolagus cuniculus): preliminary study |
title_sort |
3D implant of copolyamide associated with thermoplastic elastomer (PCTPE) for tracheal repair in rabbits (Oryctolagus cuniculus): preliminary study |
author |
Rein, Ariadne |
author_facet |
Rein, Ariadne Carrijo da Costa, Marcelo Montanhin, Gabriel Fernandes, Gustavo Dall’ Agnol Leite, Marcella Salvitti de Sá Rocha, Thiago André Unger Carra, Gabriel João de Oliveira Vasconcelos, Rosemeri Gosuen Gonçalves Dias, Luís Gustavo Castro Moraes, Paola |
author_role |
author |
author2 |
Carrijo da Costa, Marcelo Montanhin, Gabriel Fernandes, Gustavo Dall’ Agnol Leite, Marcella Salvitti de Sá Rocha, Thiago André Unger Carra, Gabriel João de Oliveira Vasconcelos, Rosemeri Gosuen Gonçalves Dias, Luís Gustavo Castro Moraes, Paola |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rein, Ariadne Carrijo da Costa, Marcelo Montanhin, Gabriel Fernandes, Gustavo Dall’ Agnol Leite, Marcella Salvitti de Sá Rocha, Thiago André Unger Carra, Gabriel João de Oliveira Vasconcelos, Rosemeri Gosuen Gonçalves Dias, Luís Gustavo Castro Moraes, Paola |
description |
Large segmental tracheal defects can pose a serious clinical challenge owing to the lack of suitable substitutes for reconstructive surgery. Polymeric biomaterials are widely used in medicine. However, the implantation of biomaterials triggers a series of biological events, and material biocompatibility is of paramount importance in regenerative medicine. The objective of this study was to evaluate the use of a copolyamide associated with thermoplastic elastomer (PCTPE) in 3D-printed prostheses for repairing partial tracheal defects in rabbits. Sixteen male New Zealand White rabbits were used, and partial tracheal defects were created in the ventral region from the 4th to the 8th tracheal ring. The animals were subdivided into groups (n=4) based on the time of euthanasia, scheduled at seven days (G7), 15 days (G15), 30 days (G30), and 60 days (G60). Histopathological analysis with hematoxylin and eosin staining revealed that the 3D implant of PCTPE exhibited a foreign body reaction, and inflammation persisted for up to 60 days. Histochemistry with picrosirius red revealed a tendency for a greater amount of type I collagen to accumulate in the early stages of inflammation, whereas type III collagen was predominant in later evaluation periods. These findings suggest an exacerbated and inadequate tissue-material interface reaction and perpetuation of the inflammatory process. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-01-15 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistas.ufg.br/vet/article/view/76225 |
url |
https://revistas.ufg.br/vet/article/view/76225 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://revistas.ufg.br/vet/article/view/76225/40745 https://revistas.ufg.br/vet/article/view/76225/40746 https://revistas.ufg.br/vet/article/view/76225/40864 https://revistas.ufg.br/vet/article/view/76225/40865 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2024 Ciência Animal Brasileira / Brazilian Animal Science http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2024 Ciência Animal Brasileira / Brazilian Animal Science http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 25 (2024): Publicação continua Ciência Animal Brasileira / Brazilian Animal Science; v. 25 (2024): Publicação continua 1809-6891 1518-2797 reponame:Ciência animal brasileira (Online) instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Ciência animal brasileira (Online) |
collection |
Ciência animal brasileira (Online) |
repository.name.fl_str_mv |
Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
||revistacab@gmail.com |
_version_ |
1799874791293845504 |