Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por eng |
Título da fonte: | Ciência animal brasileira (Online) |
Texto Completo: | https://revistas.ufg.br/vet/article/view/72911 |
Resumo: | Natural bioactive compounds obtained from microorganisms have awakened particular interest in the industry in recent years. This attention comes when the depletion of natural resources is pronounced, and the acquisition of new inputs and bioactive products of plant origin represents a challenge for the next generations. In this sense, prospecting for the large-scale production and use of bacterial pigments has represented a necessary strategy for the development of novel products. A wide variety of properties have been attributed to these substances, among them, the therapeutic potential against important diseases, such as cancer. There is consensus that available chemotherapy protocols are known to detrimentally affect the fertility of cancer patients. A considerable part of the deleterious effects of chemotherapy is related to the cytotoxicity of the drugs used for this purpose, which, in addition to cancer cells, affect normal cells. In this sense, the intrinsic properties attributed to bacterial pigments associated with low cytotoxicity and relevant cell selectivity certified them as potential anticancer drugs. However, little information is available about the reproductive toxicity of these new and promising compounds. Thus, the present review aims to address the main bacterial pigments, their potential uses as anticancer drugs, and their possible toxic effects, especially on the female gonad.Keywords: cancer; chemotherapy; fertility; bioactive compounds; bacteria |
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Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a reviewUso potencial de pigmentos bacterianos como drogas anticâncer e toxicidade reprodutiva feminina: uma revisãoNatural bioactive compounds obtained from microorganisms have awakened particular interest in the industry in recent years. This attention comes when the depletion of natural resources is pronounced, and the acquisition of new inputs and bioactive products of plant origin represents a challenge for the next generations. In this sense, prospecting for the large-scale production and use of bacterial pigments has represented a necessary strategy for the development of novel products. A wide variety of properties have been attributed to these substances, among them, the therapeutic potential against important diseases, such as cancer. There is consensus that available chemotherapy protocols are known to detrimentally affect the fertility of cancer patients. A considerable part of the deleterious effects of chemotherapy is related to the cytotoxicity of the drugs used for this purpose, which, in addition to cancer cells, affect normal cells. In this sense, the intrinsic properties attributed to bacterial pigments associated with low cytotoxicity and relevant cell selectivity certified them as potential anticancer drugs. However, little information is available about the reproductive toxicity of these new and promising compounds. Thus, the present review aims to address the main bacterial pigments, their potential uses as anticancer drugs, and their possible toxic effects, especially on the female gonad.Keywords: cancer; chemotherapy; fertility; bioactive compounds; bacteriaOs compostos bioativos naturais obtidos de microrganismos têm despertado especial interesse da indústria nos últimos anos. Esta atenção ocorre em um momento em que o esgotamento de recursos naturais é pronunciado, e a aquisição de novos insumos e produtos bioativos de origem vegetal representa um desafio para as próximas gerações. Neste sentido, a prospecção para a produção e uso em larga escala dos pigmentos bacterianos tem representado uma importante estratégia para o desenvolvimento de novos produtos. Uma grande variedade de propriedades foi atribuída a estas substâncias, entre elas, o potencial terapêutico contra doenças importantes, como o câncer. Existe um consenso de que os protocolos quimioterápicos disponíveis são conhecidos por afetarem negativamente a fertilidade de pacientes com câncer. Grande parte dos efeitos deletérios da quimioterapia está relacionado à citotoxicidade das drogas usadas para este fim, que além das células cancerosas, afetam as células normais. Nesse sentido, as propriedades naturais atribuídas aos pigmentos bacterianos associadas à baixa citotoxicidade e relevante seletividade, os qualificaram como potenciais drogas anticâncer. No entanto, pouco se tem de informação a respeito da toxicidade reprodutiva destes novos e promissores compostos. Dessa forma, a presente revisão tem o objetivo de abordar os principais pigmentos bacterianos, suas utilizações potenciais como drogas anticâncer, bem como os seus possíveis efeitos tóxicos, sobretudo, sobre a gônada feminina.Palavras-chave: câncer; quimioterapia; fertilidade; compostos bioativos; bactériaUniversidade Federal de Goiás2022-09-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://revistas.ufg.br/vet/article/view/72911Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 23 (2022): Continuous publicationCiência Animal Brasileira / Brazilian Animal Science; v. 23 (2022): Publicação contínua1809-68911518-2797reponame:Ciência animal brasileira (Online)instname:Universidade Federal de Goiás (UFG)instacron:UFGporenghttps://revistas.ufg.br/vet/article/view/72911/38765https://revistas.ufg.br/vet/article/view/72911/38910https://revistas.ufg.br/vet/article/view/72911/38766https://revistas.ufg.br/vet/article/view/72911/38911Copyright (c) 2022 Ciência Animal Brasileira / Brazilian Animal Sciencehttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, André Luiz da ConceiçãoFerreira, Anna Clara Accioly Figueiredo, José Ricardo de 2023-03-23T18:43:54Zoai:ojs.revistas.ufg.br:article/72911Revistahttps://revistas.ufg.br/vetPUBhttps://revistas.ufg.br/vet/oai||revistacab@gmail.com1809-68911518-2797opendoar:2024-05-21T19:56:31.820955Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG)true |
dc.title.none.fl_str_mv |
Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review Uso potencial de pigmentos bacterianos como drogas anticâncer e toxicidade reprodutiva feminina: uma revisão |
title |
Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review |
spellingShingle |
Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review Santos, André Luiz da Conceição |
title_short |
Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review |
title_full |
Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review |
title_fullStr |
Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review |
title_full_unstemmed |
Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review |
title_sort |
Potential use of bacterial pigments as anticancer drugs and female reproductive toxicity: a review |
author |
Santos, André Luiz da Conceição |
author_facet |
Santos, André Luiz da Conceição Ferreira, Anna Clara Accioly Figueiredo, José Ricardo de |
author_role |
author |
author2 |
Ferreira, Anna Clara Accioly Figueiredo, José Ricardo de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Santos, André Luiz da Conceição Ferreira, Anna Clara Accioly Figueiredo, José Ricardo de |
description |
Natural bioactive compounds obtained from microorganisms have awakened particular interest in the industry in recent years. This attention comes when the depletion of natural resources is pronounced, and the acquisition of new inputs and bioactive products of plant origin represents a challenge for the next generations. In this sense, prospecting for the large-scale production and use of bacterial pigments has represented a necessary strategy for the development of novel products. A wide variety of properties have been attributed to these substances, among them, the therapeutic potential against important diseases, such as cancer. There is consensus that available chemotherapy protocols are known to detrimentally affect the fertility of cancer patients. A considerable part of the deleterious effects of chemotherapy is related to the cytotoxicity of the drugs used for this purpose, which, in addition to cancer cells, affect normal cells. In this sense, the intrinsic properties attributed to bacterial pigments associated with low cytotoxicity and relevant cell selectivity certified them as potential anticancer drugs. However, little information is available about the reproductive toxicity of these new and promising compounds. Thus, the present review aims to address the main bacterial pigments, their potential uses as anticancer drugs, and their possible toxic effects, especially on the female gonad.Keywords: cancer; chemotherapy; fertility; bioactive compounds; bacteria |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistas.ufg.br/vet/article/view/72911 |
url |
https://revistas.ufg.br/vet/article/view/72911 |
dc.language.iso.fl_str_mv |
por eng |
language |
por eng |
dc.relation.none.fl_str_mv |
https://revistas.ufg.br/vet/article/view/72911/38765 https://revistas.ufg.br/vet/article/view/72911/38910 https://revistas.ufg.br/vet/article/view/72911/38766 https://revistas.ufg.br/vet/article/view/72911/38911 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Ciência Animal Brasileira / Brazilian Animal Science http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Ciência Animal Brasileira / Brazilian Animal Science http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
Brazilian Animal Science/ Ciência Animal Brasileira; Vol. 23 (2022): Continuous publication Ciência Animal Brasileira / Brazilian Animal Science; v. 23 (2022): Publicação contínua 1809-6891 1518-2797 reponame:Ciência animal brasileira (Online) instname:Universidade Federal de Goiás (UFG) instacron:UFG |
instname_str |
Universidade Federal de Goiás (UFG) |
instacron_str |
UFG |
institution |
UFG |
reponame_str |
Ciência animal brasileira (Online) |
collection |
Ciência animal brasileira (Online) |
repository.name.fl_str_mv |
Ciência animal brasileira (Online) - Universidade Federal de Goiás (UFG) |
repository.mail.fl_str_mv |
||revistacab@gmail.com |
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1799874790708740096 |