THE ROLE OF Nicotiana glauca GRAHAM (PARAGUAYAN HERBS) AS AN ADJUVANT IN IMMUNOMODULATION OF NEWCASTLE DISEASE VACCINE FOR BROILERS

• Autor(a) principal: Cleff, Marlete Brum
• Data de Publicação: 2008
• Outros Autores: Fischer, Geferson, Quincozes, Caren Gularte, Anciuti, Marcos Antônio, Freitag, Rogério, Vidor, Telmo, Gentilini, Fabiane Pereira, Nogueira, Carlos Eduardo
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Ciência animal brasileira (Online)
• Texto Completo: https://revistas.ufg.br/vet/article/view/1086

The Nicotiana glauca is a native plant species from Argentina, but found all over South América, being used against headaches, rheumatism, injuries, ulcers, and so on. Researchers have considered it as having immunomodulation effect. This study was conducted to investigate the use of a aqueous extract of Nicotiana glauca Graham as an immunomodulator (adjuvant) of a Newcastle disease vaccine.. A total of 56 broilers were distributed into 4 experimental groups. Each one of them received 3 dosages of this vaccine with or without the addition of different concentrations of the extract Using hemmoaglutination inhibition techniques , the results have shown differences (P<0.05) in the third sera collection. An increase in the antibody titer with the inclusion of 5 mg/dosage of the extract (Treatment 3) as compared to 1 mg/dosage (Treatment 2) and 10 mg/dosage of the extract (Treatment 4) was observed, However, birds from Treatment 3 did not differ (P> 0.05) from Treatment 1. These results indicated that further investigations are required, including the use of cytotoxicity tests in vitro, to evaluate the immunomodulation effect of this extract.  KEY WORDS: Immunomodulation effect, Nicotiana glauca Graham, vaccine.