Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFJF |
| Texto Completo: | http://dx.doi.org/10.1590/0004-282x20180083 https://repositorio.ufjf.br/jspui/handle/ufjf/9232 |
Resumo: | As opções terapêuticas para esclerose múltipla (EM) modificaram-se ao longo dos últimos anos, trazendo uma nova categoria de drogas com melhor perfil de eficácia. No entanto, estas drogas vieram com um novo perfil de potenciais eventos adversos que exigem que o neurologista os reconheça bem e rapidamente. Uma das complicações mais temidas destes tratamentos para a EM é a leucoencefalopatia multifocal progressiva (LEMP), causada pela reativação do vírus John Cunningham (JCV). Objetivo: Identificar o perfil sorológico de JCV em pacientes com EM. Métodos: Dados sorológicos de JCV foram obtidos através do ensaio por enzimas imuno-adsorvidas (ELISA) fornecido pelo programa STRATIFY-JCV. Resultados: Um total de 1.501 testes sanguíneos foram obtidos de 1.102 pacientes com EM. O grupo teve 633 pacientes (57,1%) soropositivos para anticorpos anti-JCV e 469 pacientes negativos (42,9%). Vinte e três pacientes se tornaram posivitos após resultados iniciais negativos para anticorpos anti-JCV. A taxa de soroconversão foi 18,5% em 22 meses. Conclusão: O perfil sorológico do JCV e a soroconversão nos pacientes brasileiros foi semelhante àquela descrita em outros países. |
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2019-02-27T15:01:45Z2019-02-262019-02-27T15:01:45Z2018-09769588591http://dx.doi.org/10.1590/0004-282x20180083https://repositorio.ufjf.br/jspui/handle/ufjf/9232As opções terapêuticas para esclerose múltipla (EM) modificaram-se ao longo dos últimos anos, trazendo uma nova categoria de drogas com melhor perfil de eficácia. No entanto, estas drogas vieram com um novo perfil de potenciais eventos adversos que exigem que o neurologista os reconheça bem e rapidamente. Uma das complicações mais temidas destes tratamentos para a EM é a leucoencefalopatia multifocal progressiva (LEMP), causada pela reativação do vírus John Cunningham (JCV). Objetivo: Identificar o perfil sorológico de JCV em pacientes com EM. Métodos: Dados sorológicos de JCV foram obtidos através do ensaio por enzimas imuno-adsorvidas (ELISA) fornecido pelo programa STRATIFY-JCV. Resultados: Um total de 1.501 testes sanguíneos foram obtidos de 1.102 pacientes com EM. O grupo teve 633 pacientes (57,1%) soropositivos para anticorpos anti-JCV e 469 pacientes negativos (42,9%). Vinte e três pacientes se tornaram posivitos após resultados iniciais negativos para anticorpos anti-JCV. A taxa de soroconversão foi 18,5% em 22 meses. Conclusão: O perfil sorológico do JCV e a soroconversão nos pacientes brasileiros foi semelhante àquela descrita em outros países.Treatment options for multiple sclerosis (MS) have changed over the last few years, bringing about a new category of drugs with more efficient profiles. However, these drugs have come with a whole new profile of potential adverse events that neurologists have to learn well and quickly. One of the most feared complications of these MS treatments is progressive multifocal leukoencephalopathy caused by the reactivation of the John Cunningham virus (JCV). Objective: To identify the serologic profile of JCV in patients with MS. Methods: Data on serum antibodies for JCV were obtained using the enzyme-linked immunosorbent assay provided by the STRATIFY-JCV program. Results: A total of 1,501 blood tests were obtained from 1,102 patients with MS. There were 633 patients (57.1%) who were positive for antibodies for JCV and 469 patients who were negative (42.9%). Twenty-three patients became positive after initially having negative JCV antibody status. The rate of seroconversion was 18.5% over 22 months. Conclusion: The JCV serologic profile and seroconversion in Brazilian patients were similar to those described in other countries.eng--BrasilArquivos de Neuro-Psiquiatria-Esclerose múltiplaLeucoencefalopatia multifocal progressivaVírus JCNatalizumabMultiple sclerosisLeukoencephalopathyProgressive multifocalJC virusNatalizumabSerological profile of John Cunningham virus (JCV) in patients with multiple sclerosisPerfil sorológico do vírus John Cunningham (JCV) em pacientes com esclerose múltiplainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBranco, Luciana PratsAdoni, TarsoApostolos-Pereira, Samira LuisaBrooks, Joseph Bruno BidinCorrea, Eber CastroDamasceno, Carlos AugustoEboni, Audred Cristina BiondoFezer, LeticiaGama, Paulo Diniz daGoncalves, Marcus Vinicius MagnoGomes, SidneyGrzesiuk, Anderson KuntzMendes, Maria FernandaMorales, Rogerio RizoMuniz, AndreParolin, Monica Fiuza KonckePimentel, Maria Lucia VellutiniRibeiro, Marlise de CastroSantos, Gutemberg Augusto Cruz dosSato, Henry KoitiScherpenhuijzen, Simone BatistaScorcine, ClaudioSiquineli, FabioSousa, Nise Alexandra de CarvalhoVarela, Daniel LimaWinckler, Tereza Cristina AvilaFragoso, Yara Dadaltiinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILSerological profile of John Cunningham virus (JCV) in patients with multiple sclerosis.pdf.jpgSerological profile of John Cunningham virus (JCV) in patients with multiple sclerosis.pdf.jpgGenerated Thumbnailimage/jpeg1584https://repositorio.ufjf.br/jspui/bitstream/ufjf/9232/4/Serological%20profile%20of%20John%20Cunningham%20virus%20%28JCV%29%20in%20patients%20with%20multiple%20sclerosis.pdf.jpgce2a48bb5e083254c41f109cc3b427f7MD54ORIGINALSerological profile of John Cunningham virus (JCV) in patients with multiple sclerosis.pdfSerological profile of John Cunningham virus (JCV) in patients with multiple sclerosis.pdfapplication/pdf96610https://repositorio.ufjf.br/jspui/bitstream/ufjf/9232/1/Serological%20profile%20of%20John%20Cunningham%20virus%20%28JCV%29%20in%20patients%20with%20multiple%20sclerosis.pdf1cd244b965c4cbf08c62cf6231929edbMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82197https://repositorio.ufjf.br/jspui/bitstream/ufjf/9232/2/license.txt000e18a5aee6ca21bb5811ddf55fc37bMD52TEXTSerological profile of John Cunningham virus (JCV) in patients with multiple sclerosis.pdf.txtSerological profile of John Cunningham virus (JCV) in patients with multiple sclerosis.pdf.txtExtracted texttext/plain18648https://repositorio.ufjf.br/jspui/bitstream/ufjf/9232/3/Serological%20profile%20of%20John%20Cunningham%20virus%20%28JCV%29%20in%20patients%20with%20multiple%20sclerosis.pdf.txt43f780731353ee4475ebe6eea53c7ad2MD53ufjf/92322019-06-16 12:46:05.177oai:hermes.cpd.ufjf.br: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Repositório InstitucionalPUBhttps://repositorio.ufjf.br/oai/requestopendoar:2019-06-16T15:46:05Repositório Institucional da UFJF - Universidade Federal de Juiz de Fora (UFJF)false |
| dc.title.pt_BR.fl_str_mv |
Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis |
| dc.title.alternative.pt_BR.fl_str_mv |
Perfil sorológico do vírus John Cunningham (JCV) em pacientes com esclerose múltipla |
| title |
Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis |
| spellingShingle |
Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis Branco, Luciana Prats - Esclerose múltipla Leucoencefalopatia multifocal progressiva Vírus JC Natalizumab Multiple sclerosis Leukoencephalopathy Progressive multifocal JC virus Natalizumab |
| title_short |
Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis |
| title_full |
Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis |
| title_fullStr |
Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis |
| title_full_unstemmed |
Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis |
| title_sort |
Serological profile of John Cunningham virus (JCV) in patients with multiple sclerosis |
| author |
Branco, Luciana Prats |
| author_facet |
Branco, Luciana Prats Adoni, Tarso Apostolos-Pereira, Samira Luisa Brooks, Joseph Bruno Bidin Correa, Eber Castro Damasceno, Carlos Augusto Eboni, Audred Cristina Biondo Fezer, Leticia Gama, Paulo Diniz da Goncalves, Marcus Vinicius Magno Gomes, Sidney Grzesiuk, Anderson Kuntz Mendes, Maria Fernanda Morales, Rogerio Rizo Muniz, Andre Parolin, Monica Fiuza Koncke Pimentel, Maria Lucia Vellutini Ribeiro, Marlise de Castro Santos, Gutemberg Augusto Cruz dos Sato, Henry Koiti Scherpenhuijzen, Simone Batista Scorcine, Claudio Siquineli, Fabio Sousa, Nise Alexandra de Carvalho Varela, Daniel Lima Winckler, Tereza Cristina Avila Fragoso, Yara Dadalti |
| author_role |
author |
| author2 |
Adoni, Tarso Apostolos-Pereira, Samira Luisa Brooks, Joseph Bruno Bidin Correa, Eber Castro Damasceno, Carlos Augusto Eboni, Audred Cristina Biondo Fezer, Leticia Gama, Paulo Diniz da Goncalves, Marcus Vinicius Magno Gomes, Sidney Grzesiuk, Anderson Kuntz Mendes, Maria Fernanda Morales, Rogerio Rizo Muniz, Andre Parolin, Monica Fiuza Koncke Pimentel, Maria Lucia Vellutini Ribeiro, Marlise de Castro Santos, Gutemberg Augusto Cruz dos Sato, Henry Koiti Scherpenhuijzen, Simone Batista Scorcine, Claudio Siquineli, Fabio Sousa, Nise Alexandra de Carvalho Varela, Daniel Lima Winckler, Tereza Cristina Avila Fragoso, Yara Dadalti |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Branco, Luciana Prats Adoni, Tarso Apostolos-Pereira, Samira Luisa Brooks, Joseph Bruno Bidin Correa, Eber Castro Damasceno, Carlos Augusto Eboni, Audred Cristina Biondo Fezer, Leticia Gama, Paulo Diniz da Goncalves, Marcus Vinicius Magno Gomes, Sidney Grzesiuk, Anderson Kuntz Mendes, Maria Fernanda Morales, Rogerio Rizo Muniz, Andre Parolin, Monica Fiuza Koncke Pimentel, Maria Lucia Vellutini Ribeiro, Marlise de Castro Santos, Gutemberg Augusto Cruz dos Sato, Henry Koiti Scherpenhuijzen, Simone Batista Scorcine, Claudio Siquineli, Fabio Sousa, Nise Alexandra de Carvalho Varela, Daniel Lima Winckler, Tereza Cristina Avila Fragoso, Yara Dadalti |
| dc.subject.cnpq.fl_str_mv |
- |
| topic |
- Esclerose múltipla Leucoencefalopatia multifocal progressiva Vírus JC Natalizumab Multiple sclerosis Leukoencephalopathy Progressive multifocal JC virus Natalizumab |
| dc.subject.por.fl_str_mv |
Esclerose múltipla Leucoencefalopatia multifocal progressiva Vírus JC Natalizumab Multiple sclerosis Leukoencephalopathy Progressive multifocal JC virus Natalizumab |
| description |
As opções terapêuticas para esclerose múltipla (EM) modificaram-se ao longo dos últimos anos, trazendo uma nova categoria de drogas com melhor perfil de eficácia. No entanto, estas drogas vieram com um novo perfil de potenciais eventos adversos que exigem que o neurologista os reconheça bem e rapidamente. Uma das complicações mais temidas destes tratamentos para a EM é a leucoencefalopatia multifocal progressiva (LEMP), causada pela reativação do vírus John Cunningham (JCV). Objetivo: Identificar o perfil sorológico de JCV em pacientes com EM. Métodos: Dados sorológicos de JCV foram obtidos através do ensaio por enzimas imuno-adsorvidas (ELISA) fornecido pelo programa STRATIFY-JCV. Resultados: Um total de 1.501 testes sanguíneos foram obtidos de 1.102 pacientes com EM. O grupo teve 633 pacientes (57,1%) soropositivos para anticorpos anti-JCV e 469 pacientes negativos (42,9%). Vinte e três pacientes se tornaram posivitos após resultados iniciais negativos para anticorpos anti-JCV. A taxa de soroconversão foi 18,5% em 22 meses. Conclusão: O perfil sorológico do JCV e a soroconversão nos pacientes brasileiros foi semelhante àquela descrita em outros países. |
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2018 |
| dc.date.issued.fl_str_mv |
2018-09 |
| dc.date.accessioned.fl_str_mv |
2019-02-27T15:01:45Z |
| dc.date.available.fl_str_mv |
2019-02-26 2019-02-27T15:01:45Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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https://repositorio.ufjf.br/jspui/handle/ufjf/9232 |
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http://dx.doi.org/10.1590/0004-282x20180083 |
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http://dx.doi.org/10.1590/0004-282x20180083 https://repositorio.ufjf.br/jspui/handle/ufjf/9232 |
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eng |
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eng |
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Arquivos de Neuro-Psiquiatria |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Brasil |
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