Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFJF |
| Texto Completo: | http://dx.doi.org/10.1016/j.htct.2017.10.002 https://repositorio.ufjf.br/jspui/handle/ufjf/7459 |
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2018-09-13T14:42:53Z2018-09-132018-09-13T14:42:53Z2018-04402132135http://dx.doi.org/10.1016/j.htct.2017.10.002https://repositorio.ufjf.br/jspui/handle/ufjf/7459-Background: Diarrhea is frequently seen in autologous stem cell transplantation. Although toxicity related to conditioning is the most common cause, infectious pathogens can play a distinctive role particularly in certain regions and environments. Methods: The role of enteropathogens was investigated in 47 patients submitted to autologous stem cell transplantation at a Brazilian center between May 2011 and May 2013. All patients who presented with diarrhea consented to stool sample analysis to identify the etiological agents including coccidia, Strongyloides sp., Clostridium difficile and other pathogenic bacteria. Results: Thirty-nine patients (83%) had diarrhea, among whom seven (17.5%) presented with coccidia, three (7.5%) with Candida sp., one (2.5%) with C. difficile, and one (2.5%) with Giardia lamblia. There was a tendency toward a higher incidence of diarrhea in older patients (p-value = 0.09) and those who received conditioning with lomustine, etoposide, cytarabine, and melphalan (p-value = 0.083). Furthermore, the number of days of neutropenia was higher in patients with diarrhea (p-value = 0.06). Conclusions: The high frequency of diarrhea caused by coccidia shows the importance of investigating and correctly identifying etiological agents and highlights the possible varieties of intestinal infections in patients who undergo autologous stem cell transplantation.eng--BrasilHematology, Transfusion and Cell Therapy-Stem cell transplantDiarrheaEtiological agentCoccidiaInfectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American centerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCastro, Marcelo Dias deChebli, Julio MariaCosta, Luciano JoséAlves, Katia Regina LopesAtalla, AngeloHallack Neto, Abrahao E.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFJFinstname:Universidade Federal de Juiz de Fora (UFJF)instacron:UFJFTHUMBNAILInfectious diarrhea in autologous stem cell transplantation.pdf.jpgInfectious diarrhea in autologous stem cell transplantation.pdf.jpgGenerated Thumbnailimage/jpeg1744https://repositorio.ufjf.br/jspui/bitstream/ufjf/7459/4/Infectious%20diarrhea%20in%20autologous%20stem%20cell%20transplantation.pdf.jpgba0bb7bec6fb777601101458cc76f604MD54ORIGINALInfectious diarrhea in autologous stem cell transplantation.pdfInfectious diarrhea in autologous stem cell transplantation.pdfapplication/pdf191948https://repositorio.ufjf.br/jspui/bitstream/ufjf/7459/1/Infectious%20diarrhea%20in%20autologous%20stem%20cell%20transplantation.pdf1ed0017af2b08d3ebe0d823241889f60MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82197https://repositorio.ufjf.br/jspui/bitstream/ufjf/7459/2/license.txt000e18a5aee6ca21bb5811ddf55fc37bMD52TEXTInfectious diarrhea in autologous stem cell transplantation.pdf.txtInfectious diarrhea in autologous stem cell transplantation.pdf.txtExtracted texttext/plain16638https://repositorio.ufjf.br/jspui/bitstream/ufjf/7459/3/Infectious%20diarrhea%20in%20autologous%20stem%20cell%20transplantation.pdf.txt17a6588b0d354c54a778acb04c14a11bMD53ufjf/74592019-06-16 11:13:04.848oai:hermes.cpd.ufjf.br:ufjf/7459TElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBCgpDb20gYSBhcHJlc2VudGHvv73vv71vIGRlc3RhIGxpY2Vu77+9YSwgdm9j77+9IChvIGF1dG9yIChlcykgb3UgbyB0aXR1bGFyIGRvcyBkaXJlaXRvcyBkZSBhdXRvcikgY29uY2VkZSBhbyBSZXBvc2l077+9cmlvIApJbnN0aXR1Y2lvbmFsIGRhIFVuaXZlcnNpZGFkZSBGZWRlcmFsIGRlIEp1aXogZGUgRm9yYSBvIGRpcmVpdG8gbu+/vW8tZXhjbHVzaXZvIGRlIHJlcHJvZHV6aXIsIHRyYWR1emlyIChjb25mb3JtZSBkZWZpbmlkbyBhYmFpeG8pLCBlL291IGRpc3RyaWJ1aXIgYSBzdWEgcHVibGljYe+/ve+/vW8gKGluY2x1aW5kbyBvIHJlc3VtbykgcG9yIHRvZG8gbyBtdW5kbyBubyBmb3JtYXRvIGltcHJlc3NvIGUgZWxldHLvv71uaWNvIGUgZW0gcXVhbHF1ZXIgbWVpbywgaW5jbHVpbmRvIG9zIGZvcm1hdG9zIO+/vXVkaW8gb3Ugdu+/vWRlby4KClZvY++/vSBjb25jb3JkYSBxdWUgbyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZGUgSnVpeiBkZSBGb3JhIHBvZGUsIHNlbSBhbHRlcmFyIG8gY29udGXvv71kbywgdHJhbnNwb3IgYSBzdWEgcHVibGljYe+/ve+/vW8gcGFyYSBxdWFscXVlciBtZWlvIG91IGZvcm1hdG8gcGFyYSBmaW5zIGRlIHByZXNlcnZh77+977+9by4gVm9j77+9IHRhbWLvv71tIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkZSBKdWl6IGRlIEZvcmEgcG9kZSBtYW50ZXIgbWFpcyBkZSB1bWEgY++/vXBpYSBkZSBzdWEgcHVibGljYe+/ve+/vW8gcGFyYSBmaW5zIGRlIHNlZ3VyYW7vv71hLCBiYWNrLXVwIGUgcHJlc2VydmHvv73vv71vLiBWb2Pvv70gZGVjbGFyYSBxdWUgYSBzdWEgcHVibGljYe+/ve+/vW8g77+9IG9yaWdpbmFsIGUgcXVlIHZvY++/vSB0ZW0gbyBwb2RlciBkZSBjb25jZWRlciBvcyBkaXJlaXRvcyBjb250aWRvcyBuZXN0YSBsaWNlbu+/vWEuIFZvY++/vSB0YW1i77+9bSBkZWNsYXJhIHF1ZSBvIGRlcO+/vXNpdG8gZGEgc3VhIHB1YmxpY2Hvv73vv71vIG7vv71vLCBxdWUgc2VqYSBkZSBzZXUgY29uaGVjaW1lbnRvLCBpbmZyaW5nZSBkaXJlaXRvcyBhdXRvcmFpcyBkZSBuaW5nde+/vW0uCgpDYXNvIGEgc3VhIHB1YmxpY2Hvv73vv71vIGNvbnRlbmhhIG1hdGVyaWFsIHF1ZSB2b2Pvv70gbu+/vW8gcG9zc3VpIGEgdGl0dWxhcmlkYWRlIGRvcyBkaXJlaXRvcyBhdXRvcmFpcywgdm9j77+9IGRlY2xhcmEgcXVlIG9idGV2ZSBhIHBlcm1pc3Pvv71vIGlycmVzdHJpdGEgZG8gZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzIHBhcmEgY29uY2VkZXIgYW8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVuaXZlcnNpZGFkZSBGZWRlcmFsIGRlIEp1aXogZGUgRm9yYSBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7vv71hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Tvv70gY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250Ze+/vWRvIGRhIHB1YmxpY2Hvv73vv71vIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFBVQkxJQ0Hvv73vv71PIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ++/vU5JTyBPVSBBUE9JTyBERSBVTUEgQUfvv71OQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0Pvv70gREVDTEFSQSBRVUUgUkVTUEVJVE9VIFRPRE9TIEUgUVVBSVNRVUVSIERJUkVJVE9TIERFIFJFVklT77+9TyBDT01PIFRBTULvv71NIEFTIERFTUFJUyBPQlJJR0Hvv73vv71FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKTyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZGUgSnVpeiBkZSBGb3JhIHNlIGNvbXByb21ldGUgYSBpZGVudGlmaWNhciBjbGFyYW1lbnRlIG8gc2V1IG5vbWUgKHMpIG91IG8ocykgbm9tZShzKSBkbyhzKSBkZXRlbnRvcihlcykgZG9zIGRpcmVpdG9zIGF1dG9yYWlzIGRhIHB1YmxpY2Hvv73vv71vLCBlIG7vv71vIGZhcu+/vSBxdWFscXVlciBhbHRlcmHvv73vv71vLCBhbO+/vW0gZGFxdWVsYXMgY29uY2VkaWRhcyBwb3IgZXN0YSBsaWNlbu+/vWEuCg==Repositório InstitucionalPUBhttps://repositorio.ufjf.br/oai/requestopendoar:2019-06-16T14:13:04Repositório Institucional da UFJF - Universidade Federal de Juiz de Fora (UFJF)false |
| dc.title.pt_BR.fl_str_mv |
Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center |
| title |
Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center |
| spellingShingle |
Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center Castro, Marcelo Dias de - Stem cell transplant Diarrhea Etiological agent Coccidia |
| title_short |
Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center |
| title_full |
Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center |
| title_fullStr |
Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center |
| title_full_unstemmed |
Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center |
| title_sort |
Infectious diarrhea in autologous stem cell transplantation: high prevalence of coccidia in a South American center |
| author |
Castro, Marcelo Dias de |
| author_facet |
Castro, Marcelo Dias de Chebli, Julio Maria Costa, Luciano José Alves, Katia Regina Lopes Atalla, Angelo Hallack Neto, Abrahao E. |
| author_role |
author |
| author2 |
Chebli, Julio Maria Costa, Luciano José Alves, Katia Regina Lopes Atalla, Angelo Hallack Neto, Abrahao E. |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Castro, Marcelo Dias de Chebli, Julio Maria Costa, Luciano José Alves, Katia Regina Lopes Atalla, Angelo Hallack Neto, Abrahao E. |
| dc.subject.cnpq.fl_str_mv |
- |
| topic |
- Stem cell transplant Diarrhea Etiological agent Coccidia |
| dc.subject.por.fl_str_mv |
Stem cell transplant Diarrhea Etiological agent Coccidia |
| description |
- |
| publishDate |
2018 |
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2018-09-13T14:42:53Z |
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2018-09-13 2018-09-13T14:42:53Z |
| dc.date.issued.fl_str_mv |
2018-04 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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https://repositorio.ufjf.br/jspui/handle/ufjf/7459 |
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http://dx.doi.org/10.1016/j.htct.2017.10.002 |
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http://dx.doi.org/10.1016/j.htct.2017.10.002 https://repositorio.ufjf.br/jspui/handle/ufjf/7459 |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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Hematology, Transfusion and Cell Therapy |
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info:eu-repo/semantics/openAccess |
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openAccess |
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- |
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Brasil |
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reponame:Repositório Institucional da UFJF instname:Universidade Federal de Juiz de Fora (UFJF) instacron:UFJF |
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