Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)

Detalhes bibliográficos
Autor(a) principal: Porsani, Mariana Y. H.
Data de Publicação: 2017
Outros Autores: Paludetti, Monique, Orlando, Débora R., Peconick, Ana Paula, Costa, Rafael C., Oliveira, Luiz E. D., Zangeronimo, Márcio G., Sousa, Raimundo V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFLA
Texto Completo: http://repositorio.ufla.br/jspui/handle/1/29755
Resumo: Recently, glutamine and β-glucan have been demonstrated to play an important role in modulation of the immune system and in promoting intestinal health benefits. The aim of this study was to investigate the effect of this intervention on inflammatory responses and intestinal health in mice orally pretreated with soluble Saccharomyces cerevisiae derived 1,3/1,6-β-glucan (80mg/kg) with or without glutamine (150mg/kg) and then challenged with cytarabine (Ara-C) (15mg/kg). Improvements in villi and crypts were not observed in the β-glucan group. The intestinal morphometry in the glutamine group showed the best results. β-glucan in combination with glutamine presented the highest values of IL-1β and IL-10 and lowest values for leukocytes and INF-γ. Based on these results, combined β-glucan and glutamine pretreatment reduced intestinal inflammation and improved the immune response after Ara-C challenge.
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spelling Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)Efeito protetor do β-glucano e glutamina em lesões intestinais e imunológicas induzidas por ciratabina (Ara-C) em camundongosβ-glucanGlutamineIntestineImmunologyMiceCytarabineAra-CChemotherapyYeastIntestinal healthImmunomodulatorsβ-glucanoGlutaminaIntestinoImunologiaCiratabinaCamundongoQuimioterapiaLeveduraSaúde intestinalImunomoduladoresRecently, glutamine and β-glucan have been demonstrated to play an important role in modulation of the immune system and in promoting intestinal health benefits. The aim of this study was to investigate the effect of this intervention on inflammatory responses and intestinal health in mice orally pretreated with soluble Saccharomyces cerevisiae derived 1,3/1,6-β-glucan (80mg/kg) with or without glutamine (150mg/kg) and then challenged with cytarabine (Ara-C) (15mg/kg). Improvements in villi and crypts were not observed in the β-glucan group. The intestinal morphometry in the glutamine group showed the best results. β-glucan in combination with glutamine presented the highest values of IL-1β and IL-10 and lowest values for leukocytes and INF-γ. Based on these results, combined β-glucan and glutamine pretreatment reduced intestinal inflammation and improved the immune response after Ara-C challenge.Recentemente, glutamina e β-glucano têm demonstrado desempenhar um papel importante na modulação do sistema imune e na promoção de benefícios para a saúde intestinal. O objetivo deste estudo foi investigar o efeito dessa intervenção sobre as respostas inflamatórias e saúde intestinal de camundongos pré- tratados por via oral com 1,3/1,6-β-glucano (80mg/kg) derivado de Saccharomyces cerevisiae com ou sem glutamina (150mg/kg) e posteriormente desafiados com citarabina (Ara-C) (15mg/kg). Melhoras em vilosidades e criptas não foram observadas no grupo de tratamento com β-glucano. A morfometria intestinal no grupo de tratamento com glutamina apresentou os melhores resultados. O grupo em que foi utilizado β-glucano em combinação com glutamina apresentou os maiores valores de IL-1β e IL -10 e valores mais baixos para os leucócitos e INF-γ. Com base nestes resultados, o pré-tratamento de β-glucano combinado com glutamina reduziu a inflamação intestinal e melhorou a resposta imune após o desafio com Ara-C.Colégio Brasileiro de Patologia Animal - CBPA. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)2018-07-25T20:37:12Z2018-07-25T20:37:12Z2017-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPORSANI, M. Y. B. et al. Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C). Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 9, Sept. 2017.http://repositorio.ufla.br/jspui/handle/1/29755Pesquisa Veterinária Brasileirareponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessPorsani, Mariana Y. H.Paludetti, MoniqueOrlando, Débora R.Peconick, Ana PaulaCosta, Rafael C.Oliveira, Luiz E. D.Zangeronimo, Márcio G.Sousa, Raimundo V.eng2018-07-25T20:37:12Zoai:localhost:1/29755Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2018-07-25T20:37:12Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false
dc.title.none.fl_str_mv Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
Efeito protetor do β-glucano e glutamina em lesões intestinais e imunológicas induzidas por ciratabina (Ara-C) em camundongos
title Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
spellingShingle Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
Porsani, Mariana Y. H.
β-glucan
Glutamine
Intestine
Immunology
Mice
Cytarabine
Ara-C
Chemotherapy
Yeast
Intestinal health
Immunomodulators
β-glucano
Glutamina
Intestino
Imunologia
Ciratabina
Camundongo
Quimioterapia
Levedura
Saúde intestinal
Imunomoduladores
title_short Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
title_full Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
title_fullStr Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
title_full_unstemmed Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
title_sort Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
author Porsani, Mariana Y. H.
author_facet Porsani, Mariana Y. H.
Paludetti, Monique
Orlando, Débora R.
Peconick, Ana Paula
Costa, Rafael C.
Oliveira, Luiz E. D.
Zangeronimo, Márcio G.
Sousa, Raimundo V.
author_role author
author2 Paludetti, Monique
Orlando, Débora R.
Peconick, Ana Paula
Costa, Rafael C.
Oliveira, Luiz E. D.
Zangeronimo, Márcio G.
Sousa, Raimundo V.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Porsani, Mariana Y. H.
Paludetti, Monique
Orlando, Débora R.
Peconick, Ana Paula
Costa, Rafael C.
Oliveira, Luiz E. D.
Zangeronimo, Márcio G.
Sousa, Raimundo V.
dc.subject.por.fl_str_mv β-glucan
Glutamine
Intestine
Immunology
Mice
Cytarabine
Ara-C
Chemotherapy
Yeast
Intestinal health
Immunomodulators
β-glucano
Glutamina
Intestino
Imunologia
Ciratabina
Camundongo
Quimioterapia
Levedura
Saúde intestinal
Imunomoduladores
topic β-glucan
Glutamine
Intestine
Immunology
Mice
Cytarabine
Ara-C
Chemotherapy
Yeast
Intestinal health
Immunomodulators
β-glucano
Glutamina
Intestino
Imunologia
Ciratabina
Camundongo
Quimioterapia
Levedura
Saúde intestinal
Imunomoduladores
description Recently, glutamine and β-glucan have been demonstrated to play an important role in modulation of the immune system and in promoting intestinal health benefits. The aim of this study was to investigate the effect of this intervention on inflammatory responses and intestinal health in mice orally pretreated with soluble Saccharomyces cerevisiae derived 1,3/1,6-β-glucan (80mg/kg) with or without glutamine (150mg/kg) and then challenged with cytarabine (Ara-C) (15mg/kg). Improvements in villi and crypts were not observed in the β-glucan group. The intestinal morphometry in the glutamine group showed the best results. β-glucan in combination with glutamine presented the highest values of IL-1β and IL-10 and lowest values for leukocytes and INF-γ. Based on these results, combined β-glucan and glutamine pretreatment reduced intestinal inflammation and improved the immune response after Ara-C challenge.
publishDate 2017
dc.date.none.fl_str_mv 2017-09
2018-07-25T20:37:12Z
2018-07-25T20:37:12Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv PORSANI, M. Y. B. et al. Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C). Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 9, Sept. 2017.
http://repositorio.ufla.br/jspui/handle/1/29755
identifier_str_mv PORSANI, M. Y. B. et al. Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C). Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 37, n. 9, Sept. 2017.
url http://repositorio.ufla.br/jspui/handle/1/29755
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.source.none.fl_str_mv Pesquisa Veterinária Brasileira
reponame:Repositório Institucional da UFLA
instname:Universidade Federal de Lavras (UFLA)
instacron:UFLA
instname_str Universidade Federal de Lavras (UFLA)
instacron_str UFLA
institution UFLA
reponame_str Repositório Institucional da UFLA
collection Repositório Institucional da UFLA
repository.name.fl_str_mv Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)
repository.mail.fl_str_mv nivaldo@ufla.br || repositorio.biblioteca@ufla.br
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