Overweight, obesity and weight gain up to three years after liver transplantation

• Autor(a) principal: Anastácio, L. Rezende
• Data de Publicação: 2012
• Outros Autores: Ferreira, L. Garcia, Liboredo, J. Costa, Ribeiro, H. de Sena, Lima, A. Soares, Vilela, E. Garcia, Correia, Maria Isabel Toulson Davisson
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFLA
• Texto Completo: http://repositorio.ufla.br/jspui/handle/1/38769
• topic: Liver transplantation; Weight gain; Obesity; Trasplante de hígado; Aumento de peso; Obesidad

Introduction: Previous studies have shown that weight gain commonly occurs after liver transplantation (LTx). Few risk factors have been studied. Objectives: The aim of this study was to assess the weight changes and incidence excessive weight up to 3 years after surgery. Methods: Post-LTx patients were assessed for their weight changes and incidence of excessive weight before liver disease; on the first outpatient appointment after LTx; 3 and 6mo after LTx; 1; 2 and 3y after LTx. Demographic, socioeconomic, lifestyle and clinical variables were collected to assess risk factors for weight gain, overweight and obesity using linear and logistic regression analysis. Results: Eighty patients undergoing LTx between 1997/2006 were assessed. Patients lost an average of 9.1 kg during liver disease. This weight was recovered within 1 year after surgery; after 3 years, patients had gained an average of 11.6 kg. The incidence of excessive weight increased over the years, and 56.4% of patients were overweight in the 3 years after LTx; most of them were obese (30.0%). Risk factors for weight gain on the third year after LTx were greater BMI before liver disease (p < 0.01); former smoker (p < 0.01); family history of overweight (p = 0.04); being hosewife/unemployed/retired (p = 0.08); alcoholic indication for LTx (p = 0.02). Risk factors for incidence of excessive weight on the third year after LTx were being married (RR: 13.13; CI: 1.33-125.0); being former smoker (RR: 4.68; CI: 1.16-18.85); greater age at LTx (RR: 1.1; CI: 1.02-1.20). Conclusions: Post-LTx patients experienced weight gain after surgery, mainly during the 1 year after operation and increased progressive incidence up to 3 years, due to different risk factors, some of them can be prevented.