Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFLA |
Texto Completo: | http://repositorio.ufla.br/jspui/handle/1/40690 |
Resumo: | Resveratrol is an anti-inflammatory compound found in several foods. Periodontal disease (PD) is associated to other systemic diseases, and inflammation may be responsible for the association. Consequently, controlling inflammation not only may benefit oral health but also may assist with the management of other chronic inflammatory conditions. We aimed to investigate the effects of resveratrol administration on PD control in preclinical studies. A systematic search was performed for scientific articles using both electronic databases and a manual search using combinations of the following keywords: “resveratrol” OR “3,5,4′-trihydroxystilbene” AND “periodontal disease” OR “periodontitis” OR “gingivitis”. Only in vivo original studies investigating resveratrol treatment on experimental animal models of PD were selected. A quality assessment of the studies was performed using the Animal Research Reporting In Vivo Experiment (ARRIVE) guidelines, and the risk of bias was assessed using the Syrcle tool. The search returned 570 articles, and 11 matched the inclusion criteria. A meta-analysis showed that resveratrol treatment attenuated alveolar bone loss (τ2 = 0.0041; 95% CI: −0.14; −0.04). The ARRIVE criteria reported a good quality of studies in general (mean score 28.5 ± 2.5). However, five Syrcle domains indicated a high risk of bias or did not present information clearly. We concluded that, in preclinical studies, resveratrol treatment prevented PD progression. |
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Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies2,3,5,4'-tetrahydroxystilbene-2-O-β-glucosidePeriodontitisOral HealthMouth DiseasesFunctional FoodPeriodontiteSaúde OralDoenças da BocaAlimento funcionalPolifenóisResveratrol is an anti-inflammatory compound found in several foods. Periodontal disease (PD) is associated to other systemic diseases, and inflammation may be responsible for the association. Consequently, controlling inflammation not only may benefit oral health but also may assist with the management of other chronic inflammatory conditions. We aimed to investigate the effects of resveratrol administration on PD control in preclinical studies. A systematic search was performed for scientific articles using both electronic databases and a manual search using combinations of the following keywords: “resveratrol” OR “3,5,4′-trihydroxystilbene” AND “periodontal disease” OR “periodontitis” OR “gingivitis”. Only in vivo original studies investigating resveratrol treatment on experimental animal models of PD were selected. A quality assessment of the studies was performed using the Animal Research Reporting In Vivo Experiment (ARRIVE) guidelines, and the risk of bias was assessed using the Syrcle tool. The search returned 570 articles, and 11 matched the inclusion criteria. A meta-analysis showed that resveratrol treatment attenuated alveolar bone loss (τ2 = 0.0041; 95% CI: −0.14; −0.04). The ARRIVE criteria reported a good quality of studies in general (mean score 28.5 ± 2.5). However, five Syrcle domains indicated a high risk of bias or did not present information clearly. We concluded that, in preclinical studies, resveratrol treatment prevented PD progression.MDPI Journals2020-05-07T18:36:57Z2020-05-07T18:36:57Z2019-05info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfANDRADE, E. F. et al. Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies. Nutrients, Basel, v. 11, n. 5, May 2019. DOI: 10.3390/nu11050953.http://repositorio.ufla.br/jspui/handle/1/40690Nutrientsreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessAndrade, Eric FrancelinoOrlando, Débora RibeiroAraújo, Amanda Melo Sant’AnnaAndrade, James Newton Bizetto Meira deAzzi, Diana VilelaLima, Renato Ribeiro deLobo-Júnior, Adalfredo RochaPereira, Luciano Joséeng2020-07-04T14:55:49Zoai:localhost:1/40690Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2020-07-04T14:55:49Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false |
dc.title.none.fl_str_mv |
Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies |
title |
Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies |
spellingShingle |
Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies Andrade, Eric Francelino 2,3,5,4'-tetrahydroxystilbene-2-O-β-glucoside Periodontitis Oral Health Mouth Diseases Functional Food Periodontite Saúde Oral Doenças da Boca Alimento funcional Polifenóis |
title_short |
Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies |
title_full |
Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies |
title_fullStr |
Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies |
title_full_unstemmed |
Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies |
title_sort |
Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies |
author |
Andrade, Eric Francelino |
author_facet |
Andrade, Eric Francelino Orlando, Débora Ribeiro Araújo, Amanda Melo Sant’Anna Andrade, James Newton Bizetto Meira de Azzi, Diana Vilela Lima, Renato Ribeiro de Lobo-Júnior, Adalfredo Rocha Pereira, Luciano José |
author_role |
author |
author2 |
Orlando, Débora Ribeiro Araújo, Amanda Melo Sant’Anna Andrade, James Newton Bizetto Meira de Azzi, Diana Vilela Lima, Renato Ribeiro de Lobo-Júnior, Adalfredo Rocha Pereira, Luciano José |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Andrade, Eric Francelino Orlando, Débora Ribeiro Araújo, Amanda Melo Sant’Anna Andrade, James Newton Bizetto Meira de Azzi, Diana Vilela Lima, Renato Ribeiro de Lobo-Júnior, Adalfredo Rocha Pereira, Luciano José |
dc.subject.por.fl_str_mv |
2,3,5,4'-tetrahydroxystilbene-2-O-β-glucoside Periodontitis Oral Health Mouth Diseases Functional Food Periodontite Saúde Oral Doenças da Boca Alimento funcional Polifenóis |
topic |
2,3,5,4'-tetrahydroxystilbene-2-O-β-glucoside Periodontitis Oral Health Mouth Diseases Functional Food Periodontite Saúde Oral Doenças da Boca Alimento funcional Polifenóis |
description |
Resveratrol is an anti-inflammatory compound found in several foods. Periodontal disease (PD) is associated to other systemic diseases, and inflammation may be responsible for the association. Consequently, controlling inflammation not only may benefit oral health but also may assist with the management of other chronic inflammatory conditions. We aimed to investigate the effects of resveratrol administration on PD control in preclinical studies. A systematic search was performed for scientific articles using both electronic databases and a manual search using combinations of the following keywords: “resveratrol” OR “3,5,4′-trihydroxystilbene” AND “periodontal disease” OR “periodontitis” OR “gingivitis”. Only in vivo original studies investigating resveratrol treatment on experimental animal models of PD were selected. A quality assessment of the studies was performed using the Animal Research Reporting In Vivo Experiment (ARRIVE) guidelines, and the risk of bias was assessed using the Syrcle tool. The search returned 570 articles, and 11 matched the inclusion criteria. A meta-analysis showed that resveratrol treatment attenuated alveolar bone loss (τ2 = 0.0041; 95% CI: −0.14; −0.04). The ARRIVE criteria reported a good quality of studies in general (mean score 28.5 ± 2.5). However, five Syrcle domains indicated a high risk of bias or did not present information clearly. We concluded that, in preclinical studies, resveratrol treatment prevented PD progression. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-05 2020-05-07T18:36:57Z 2020-05-07T18:36:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
ANDRADE, E. F. et al. Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies. Nutrients, Basel, v. 11, n. 5, May 2019. DOI: 10.3390/nu11050953. http://repositorio.ufla.br/jspui/handle/1/40690 |
identifier_str_mv |
ANDRADE, E. F. et al. Can resveratrol treatment control the progression of induced periodontal disease? a systematic review and meta-analysis of preclinical studies. Nutrients, Basel, v. 11, n. 5, May 2019. DOI: 10.3390/nu11050953. |
url |
http://repositorio.ufla.br/jspui/handle/1/40690 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI Journals |
publisher.none.fl_str_mv |
MDPI Journals |
dc.source.none.fl_str_mv |
Nutrients reponame:Repositório Institucional da UFLA instname:Universidade Federal de Lavras (UFLA) instacron:UFLA |
instname_str |
Universidade Federal de Lavras (UFLA) |
instacron_str |
UFLA |
institution |
UFLA |
reponame_str |
Repositório Institucional da UFLA |
collection |
Repositório Institucional da UFLA |
repository.name.fl_str_mv |
Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA) |
repository.mail.fl_str_mv |
nivaldo@ufla.br || repositorio.biblioteca@ufla.br |
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1807835049620406272 |