Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFLA |
Texto Completo: | http://repositorio.ufla.br/jspui/handle/1/55212 |
Resumo: | Low endogenous estrogen action causes several injuries. Medicinal plants, such as flaxseed and mulberry, contain substances that have been shown to be effective to the organism. The aim was to verify the effects of flaxseed and/or mulberry extracts on ovariectomized Wistar rats. The animals received supplements of extracts and estrogen or saline by gavage for 60 days and were weighed weekly. Vaginal wash, blood, pituitary, uterus, liver, and kidneys were collected. Phenolic compounds and the antioxidant activity of the extracts, lipid profile, uric acid, liver enzymes, and pituitary weight were measured. Histomorphometric for uterine wall and histopathological analyses for liver and kidney were performed. Flaxseed and mulberry extracts showed great antioxidant activity and large amounts of phenolic compounds. The treatment with extracts had less weight gain, increased pituitary weight, the predominance of vaginal epithelial cells, and reduced TC, LDL-c and lipase activity, similar to estrogen animals. Estrogen or flaxseed + mulberry animals reduced VLDL-c and TAG. HDL-c, uric acid, and liver enzymes did not differ. Estrogen or extracts demonstrated trophic action on the endometrial thickness and have not shown hepatotoxicity or nephrotoxicity. We suggested the beneficial effects of flaxseed and mulberry extract as an alternative to reduce and/or prevent the negative effects caused by low estrogenic action. |
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Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar ratsPhytoestrogensAntioxidantsEstrogenCompound phenolicsMetabolismBody weightFitoestrógenosAntioxidantesEstrogênioCompostos fenólicosMetabolismoPeso corporalRatas - OvariectomiaLow endogenous estrogen action causes several injuries. Medicinal plants, such as flaxseed and mulberry, contain substances that have been shown to be effective to the organism. The aim was to verify the effects of flaxseed and/or mulberry extracts on ovariectomized Wistar rats. The animals received supplements of extracts and estrogen or saline by gavage for 60 days and were weighed weekly. Vaginal wash, blood, pituitary, uterus, liver, and kidneys were collected. Phenolic compounds and the antioxidant activity of the extracts, lipid profile, uric acid, liver enzymes, and pituitary weight were measured. Histomorphometric for uterine wall and histopathological analyses for liver and kidney were performed. Flaxseed and mulberry extracts showed great antioxidant activity and large amounts of phenolic compounds. The treatment with extracts had less weight gain, increased pituitary weight, the predominance of vaginal epithelial cells, and reduced TC, LDL-c and lipase activity, similar to estrogen animals. Estrogen or flaxseed + mulberry animals reduced VLDL-c and TAG. HDL-c, uric acid, and liver enzymes did not differ. Estrogen or extracts demonstrated trophic action on the endometrial thickness and have not shown hepatotoxicity or nephrotoxicity. We suggested the beneficial effects of flaxseed and mulberry extract as an alternative to reduce and/or prevent the negative effects caused by low estrogenic action.Multidisciplinary Digital Publishing Institute (MDPI)2022-09-27T17:42:27Z2022-09-27T17:42:27Z2022-08info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPEREIRA, J. P. C. et al. Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats. Nutrients, Basel, v. 14, n. 15, 3238, 2022. DOI: 10.3390/nu14153238.http://repositorio.ufla.br/jspui/handle/1/55212Nutrientsreponame:Repositório Institucional da UFLAinstname:Universidade Federal de Lavras (UFLA)instacron:UFLAAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessPereira, Jéssica Petrine CastroOliveira, Erika AparecidaPereira, Fernanda Aparecida CastroSeixas, Josilene NascimentoGuimaraes, Camila Souza de OliveiraBorges, Bruno Del Biancoeng2022-09-27T17:43:26Zoai:localhost:1/55212Repositório InstitucionalPUBhttp://repositorio.ufla.br/oai/requestnivaldo@ufla.br || repositorio.biblioteca@ufla.bropendoar:2022-09-27T17:43:26Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA)false |
dc.title.none.fl_str_mv |
Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats |
title |
Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats |
spellingShingle |
Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats Pereira, Jéssica Petrine Castro Phytoestrogens Antioxidants Estrogen Compound phenolics Metabolism Body weight Fitoestrógenos Antioxidantes Estrogênio Compostos fenólicos Metabolismo Peso corporal Ratas - Ovariectomia |
title_short |
Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats |
title_full |
Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats |
title_fullStr |
Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats |
title_full_unstemmed |
Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats |
title_sort |
Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats |
author |
Pereira, Jéssica Petrine Castro |
author_facet |
Pereira, Jéssica Petrine Castro Oliveira, Erika Aparecida Pereira, Fernanda Aparecida Castro Seixas, Josilene Nascimento Guimaraes, Camila Souza de Oliveira Borges, Bruno Del Bianco |
author_role |
author |
author2 |
Oliveira, Erika Aparecida Pereira, Fernanda Aparecida Castro Seixas, Josilene Nascimento Guimaraes, Camila Souza de Oliveira Borges, Bruno Del Bianco |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Pereira, Jéssica Petrine Castro Oliveira, Erika Aparecida Pereira, Fernanda Aparecida Castro Seixas, Josilene Nascimento Guimaraes, Camila Souza de Oliveira Borges, Bruno Del Bianco |
dc.subject.por.fl_str_mv |
Phytoestrogens Antioxidants Estrogen Compound phenolics Metabolism Body weight Fitoestrógenos Antioxidantes Estrogênio Compostos fenólicos Metabolismo Peso corporal Ratas - Ovariectomia |
topic |
Phytoestrogens Antioxidants Estrogen Compound phenolics Metabolism Body weight Fitoestrógenos Antioxidantes Estrogênio Compostos fenólicos Metabolismo Peso corporal Ratas - Ovariectomia |
description |
Low endogenous estrogen action causes several injuries. Medicinal plants, such as flaxseed and mulberry, contain substances that have been shown to be effective to the organism. The aim was to verify the effects of flaxseed and/or mulberry extracts on ovariectomized Wistar rats. The animals received supplements of extracts and estrogen or saline by gavage for 60 days and were weighed weekly. Vaginal wash, blood, pituitary, uterus, liver, and kidneys were collected. Phenolic compounds and the antioxidant activity of the extracts, lipid profile, uric acid, liver enzymes, and pituitary weight were measured. Histomorphometric for uterine wall and histopathological analyses for liver and kidney were performed. Flaxseed and mulberry extracts showed great antioxidant activity and large amounts of phenolic compounds. The treatment with extracts had less weight gain, increased pituitary weight, the predominance of vaginal epithelial cells, and reduced TC, LDL-c and lipase activity, similar to estrogen animals. Estrogen or flaxseed + mulberry animals reduced VLDL-c and TAG. HDL-c, uric acid, and liver enzymes did not differ. Estrogen or extracts demonstrated trophic action on the endometrial thickness and have not shown hepatotoxicity or nephrotoxicity. We suggested the beneficial effects of flaxseed and mulberry extract as an alternative to reduce and/or prevent the negative effects caused by low estrogenic action. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-27T17:42:27Z 2022-09-27T17:42:27Z 2022-08 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
PEREIRA, J. P. C. et al. Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats. Nutrients, Basel, v. 14, n. 15, 3238, 2022. DOI: 10.3390/nu14153238. http://repositorio.ufla.br/jspui/handle/1/55212 |
identifier_str_mv |
PEREIRA, J. P. C. et al. Beneficial effects of flaxseed and/or mulberry extracts supplementation in ovariectomized wistar rats. Nutrients, Basel, v. 14, n. 15, 3238, 2022. DOI: 10.3390/nu14153238. |
url |
http://repositorio.ufla.br/jspui/handle/1/55212 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute (MDPI) |
dc.source.none.fl_str_mv |
Nutrients reponame:Repositório Institucional da UFLA instname:Universidade Federal de Lavras (UFLA) instacron:UFLA |
instname_str |
Universidade Federal de Lavras (UFLA) |
instacron_str |
UFLA |
institution |
UFLA |
reponame_str |
Repositório Institucional da UFLA |
collection |
Repositório Institucional da UFLA |
repository.name.fl_str_mv |
Repositório Institucional da UFLA - Universidade Federal de Lavras (UFLA) |
repository.mail.fl_str_mv |
nivaldo@ufla.br || repositorio.biblioteca@ufla.br |
_version_ |
1784550142945263616 |