Locoregional adverse effects of cancer therapy in women with advanced breast cancer: An integrative review
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por eng |
| Título da fonte: | Reme (Online) |
| Texto Completo: | https://periodicos.ufmg.br/index.php/reme/article/view/40564 |
Resumo: | Objective: to identify the locoregional adverse effects of administering intravenous oncologic therapy in women with advanced breast cancer. Method: this was an integrative literature review using the PubMed/MEDLINE, CINAHL, LILACS, and EMBASE databases, without a time cut, in addition to a reverse search of the selected articles updated until May 2022. The population included women with advanced breast cancer undergoing intervention with intravenous oncologic therapy with chemotherapy, hormone therapy, or monoclonal antibody, and the outcome assessed locoregional adverse effects. Results: 2,789 studies were identified, and the final sample consisted of 8 clinical trials and 1 retrospective observational study, all of which were international studies published from 1986 to 2018. Predominantly, patients with stage IV breast cancer, were aged 50 years or older, and had multiple metastases. Locoregional adverse effects were phlebitis, ulceration and/or necrosis, pain, erythema, and unspecified injection site reaction. The studies did not detail the type of venous catheter, the osmolarity of the drugs, and preventive care to reduce these adverse effects. Conclusion: The evidence from these articles showed that locoregional adverse effects are present in efficacy research of oncologic drugs in women with advanced breast cancer. Nonetheless, the safety of administering cancer drugs is not elucidated in this review, indicating the need for follow-up studies of adverse effects. |
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Locoregional adverse effects of cancer therapy in women with advanced breast cancer: An integrative reviewEfectos adversos locorregionales de la terapia oncológica en mujeres con cáncer de mama avanzado: Una revisión integradoraEfeitos adversos locorregionais da terapêutica oncológica em mulheres com câncer de mama avançado: Revisão integrativaNeoplasias da MamaEfeitos Colaterais e Reações Adversas Relacionados a MedicamentosAntineoplásicosPrática Clínica Baseada em EvidênciasEnfermagemNeoplasias de la MamaEfectos Colaterales y Reacciones Adversas Relacionados con MedicamentosAntineoplásicosPráctica Clínica Basada en la EvidenciaEnfermeríaBreast NeoplasmsDrug-Related Side Effects and Adverse ReactionsAntineoplastic AgentsEvidence-Based PracticeNursingObjective: to identify the locoregional adverse effects of administering intravenous oncologic therapy in women with advanced breast cancer. Method: this was an integrative literature review using the PubMed/MEDLINE, CINAHL, LILACS, and EMBASE databases, without a time cut, in addition to a reverse search of the selected articles updated until May 2022. The population included women with advanced breast cancer undergoing intervention with intravenous oncologic therapy with chemotherapy, hormone therapy, or monoclonal antibody, and the outcome assessed locoregional adverse effects. Results: 2,789 studies were identified, and the final sample consisted of 8 clinical trials and 1 retrospective observational study, all of which were international studies published from 1986 to 2018. Predominantly, patients with stage IV breast cancer, were aged 50 years or older, and had multiple metastases. Locoregional adverse effects were phlebitis, ulceration and/or necrosis, pain, erythema, and unspecified injection site reaction. The studies did not detail the type of venous catheter, the osmolarity of the drugs, and preventive care to reduce these adverse effects. Conclusion: The evidence from these articles showed that locoregional adverse effects are present in efficacy research of oncologic drugs in women with advanced breast cancer. Nonetheless, the safety of administering cancer drugs is not elucidated in this review, indicating the need for follow-up studies of adverse effects.Objetivo: identificación de los efectos adversos locorregionales de la administración de la terapia oncológica intravenosa en mujeres con cáncer de mama avanzado. Método: revisión bibliográfica integradora, que utilizó las bases de datos PubMed/MEDLINE, CINAHL, LILACS y EMBASE, sin corte de tiempo, además de una búsqueda inversa de los artículos seleccionados, actualizada hasta mayo de 2022 La población incluyó mujeres con cáncer de mama avanzado, sometidas a intervención con terapia oncológica endovenosa con quimioterapia u hormonoterapia o anticuerpo monoclonal y el resultado evaluó los efectos adversos locorregionales Resultados: se identificaron 2.789 estudios y la muestra final se compuso de ocho ensayos clínicos, un estudio observacional retrospectivo, todos estudios internacionales, publicados desde 1986 hasta 2018. Predominantemente, las pacientes tenían cáncer de mama en estadio IV, edad de 50 años o más y metástasis múltiples. Los efectos adversos locorregionales fueron flebitis, ulceración y/o necrosis, dolor, eritema y reacción en el lugar de la inyección no especificada. Los estudios no detallan el tipo de catéter venoso, la osmolaridad de los fármacos y los cuidados preventivos para reducir estos efectos adversos. Conclusión: las pruebas de estos artículos mostraron que los efectos adversos locorregionales están presentes en los estudios de eficacia de los fármacos oncológicos en mujeres con cáncer de mama avanzado. Sin embargo, cabe destacar que la seguridad de la administración de los fármacos contra el cáncer no se dilucida en esta revisión, lo que indica la necesidad de realizar estudios de seguimiento sobre los efectos adversos.Objetivo: identificar os efeitos adversos locorregionais da administração da terapêutica oncológica endovenosa em mulheres com câncer de mama avançado. Método: revisão integrativa da literatura, que utilizou as bases de dados PubMed/MEDLINE, CINAHL, LILACS e EMBASE, sem recorte temporal, além de busca reversa dos artigos selecionados, atualizada até maio de 2022 A população contemplou mulheres com câncer de mama avançado submetidas à intervenção com terapêutica oncológica endovenosa com quimioterapia ou hormonioterapia ou anticorpo monoclonal, e o desfecho avaliou efeitos adversos locorregionais Resultados: identificaram-se 2.789 estudos, e a amostra final foi composta por 8 ensaios clínicos e 1 estudo observacional retrospectivo, sendo todos estudos internacionais e publicados no período de 1986 a 2018. Predominantemente, as pacientes tinham câncer de mama em estádio IV, idade de 50 anos ou mais e múltiplas metástases. Os efeitos adversos locorregionais foram: flebite, ulceração e/ou necrose, dor, eritema e reação no local da injeção não especificada. Os estudos não trazem detalhamento do tipo de cateter venoso, osmolaridade dos fármacos e cuidados preventivos para diminuição desses efeitos adversos. Conclusão: as evidências desses artigos mostraram que os efeitos adversos locorregionais estão presentes em estudos de eficácia dos fármacos oncológicos em mulheres com câncer de mama avançado. No entanto, destaca-se que a segurança da administração dos fármacos oncológicos não se apresenta elucidada nessa revisão, indicando necessidade de estudos de acompanhamento dos efeitos adversos.Universidade Federal de Minas Gerais2022-12-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://periodicos.ufmg.br/index.php/reme/article/view/4056410.35699/2316-9389.2022.40564REME-Revista Mineira de Enfermagem; Vol. 26 (2022)REME-Revista Mineira de Enfermagem; Vol. 26 (2022)REME-Revista Mineira de Enfermagem; v. 26 (2022)2316-93891415-2762reponame:Reme (Online)instname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGporenghttps://periodicos.ufmg.br/index.php/reme/article/view/40564/31990https://periodicos.ufmg.br/index.php/reme/article/view/40564/31992Copyright (c) 2022 REME-Revista Mineira de Enfermagemhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBarros , Laylla Lara Enderson Natale , Priscilla de Donoso , Miguir Terezinha Mendoza , Isabel Yovana Quispe Souza , Amanda Damasceno de Ercole , Flávia Falci Simino, Giovana Paula Rezende 2023-03-30T17:09:02Zoai:periodicos.ufmg.br:article/40564Revistaremeufmg@gmail.comPUBhttps://periodicos.ufmg.br/index.php/reme/oairemeufmg@gmail.com2316-93891415-2762opendoar:2023-03-30T17:09:02Reme (Online) - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.none.fl_str_mv |
Locoregional adverse effects of cancer therapy in women with advanced breast cancer: An integrative review Efectos adversos locorregionales de la terapia oncológica en mujeres con cáncer de mama avanzado: Una revisión integradora Efeitos adversos locorregionais da terapêutica oncológica em mulheres com câncer de mama avançado: Revisão integrativa |
| title |
Locoregional adverse effects of cancer therapy in women with advanced breast cancer: An integrative review |
| spellingShingle |
Locoregional adverse effects of cancer therapy in women with advanced breast cancer: An integrative review Barros , Laylla Lara Enderson Neoplasias da Mama Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Antineoplásicos Prática Clínica Baseada em Evidências Enfermagem Neoplasias de la Mama Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos Antineoplásicos Práctica Clínica Basada en la Evidencia Enfermería Breast Neoplasms Drug-Related Side Effects and Adverse Reactions Antineoplastic Agents Evidence-Based Practice Nursing |
| title_short |
Locoregional adverse effects of cancer therapy in women with advanced breast cancer: An integrative review |
| title_full |
Locoregional adverse effects of cancer therapy in women with advanced breast cancer: An integrative review |
| title_fullStr |
Locoregional adverse effects of cancer therapy in women with advanced breast cancer: An integrative review |
| title_full_unstemmed |
Locoregional adverse effects of cancer therapy in women with advanced breast cancer: An integrative review |
| title_sort |
Locoregional adverse effects of cancer therapy in women with advanced breast cancer: An integrative review |
| author |
Barros , Laylla Lara Enderson |
| author_facet |
Barros , Laylla Lara Enderson Natale , Priscilla de Donoso , Miguir Terezinha Mendoza , Isabel Yovana Quispe Souza , Amanda Damasceno de Ercole , Flávia Falci Simino, Giovana Paula Rezende |
| author_role |
author |
| author2 |
Natale , Priscilla de Donoso , Miguir Terezinha Mendoza , Isabel Yovana Quispe Souza , Amanda Damasceno de Ercole , Flávia Falci Simino, Giovana Paula Rezende |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Barros , Laylla Lara Enderson Natale , Priscilla de Donoso , Miguir Terezinha Mendoza , Isabel Yovana Quispe Souza , Amanda Damasceno de Ercole , Flávia Falci Simino, Giovana Paula Rezende |
| dc.subject.por.fl_str_mv |
Neoplasias da Mama Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Antineoplásicos Prática Clínica Baseada em Evidências Enfermagem Neoplasias de la Mama Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos Antineoplásicos Práctica Clínica Basada en la Evidencia Enfermería Breast Neoplasms Drug-Related Side Effects and Adverse Reactions Antineoplastic Agents Evidence-Based Practice Nursing |
| topic |
Neoplasias da Mama Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Antineoplásicos Prática Clínica Baseada em Evidências Enfermagem Neoplasias de la Mama Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos Antineoplásicos Práctica Clínica Basada en la Evidencia Enfermería Breast Neoplasms Drug-Related Side Effects and Adverse Reactions Antineoplastic Agents Evidence-Based Practice Nursing |
| description |
Objective: to identify the locoregional adverse effects of administering intravenous oncologic therapy in women with advanced breast cancer. Method: this was an integrative literature review using the PubMed/MEDLINE, CINAHL, LILACS, and EMBASE databases, without a time cut, in addition to a reverse search of the selected articles updated until May 2022. The population included women with advanced breast cancer undergoing intervention with intravenous oncologic therapy with chemotherapy, hormone therapy, or monoclonal antibody, and the outcome assessed locoregional adverse effects. Results: 2,789 studies were identified, and the final sample consisted of 8 clinical trials and 1 retrospective observational study, all of which were international studies published from 1986 to 2018. Predominantly, patients with stage IV breast cancer, were aged 50 years or older, and had multiple metastases. Locoregional adverse effects were phlebitis, ulceration and/or necrosis, pain, erythema, and unspecified injection site reaction. The studies did not detail the type of venous catheter, the osmolarity of the drugs, and preventive care to reduce these adverse effects. Conclusion: The evidence from these articles showed that locoregional adverse effects are present in efficacy research of oncologic drugs in women with advanced breast cancer. Nonetheless, the safety of administering cancer drugs is not elucidated in this review, indicating the need for follow-up studies of adverse effects. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-12-02 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://periodicos.ufmg.br/index.php/reme/article/view/40564 10.35699/2316-9389.2022.40564 |
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https://periodicos.ufmg.br/index.php/reme/article/view/40564 |
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10.35699/2316-9389.2022.40564 |
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por eng |
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por eng |
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https://periodicos.ufmg.br/index.php/reme/article/view/40564/31990 https://periodicos.ufmg.br/index.php/reme/article/view/40564/31992 |
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Copyright (c) 2022 REME-Revista Mineira de Enfermagem https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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Copyright (c) 2022 REME-Revista Mineira de Enfermagem https://creativecommons.org/licenses/by/4.0 |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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Universidade Federal de Minas Gerais |
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REME-Revista Mineira de Enfermagem; Vol. 26 (2022) REME-Revista Mineira de Enfermagem; Vol. 26 (2022) REME-Revista Mineira de Enfermagem; v. 26 (2022) 2316-9389 1415-2762 reponame:Reme (Online) instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Reme (Online) |
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Reme (Online) |
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Reme (Online) - Universidade Federal de Minas Gerais (UFMG) |
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remeufmg@gmail.com |
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