Mechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targets
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.33590/emjgastroenterol/10310983. http://hdl.handle.net/1843/56322 https://orcid.org/0000-0002-1600-0289 https://orcid.org/0000-0003-3432-0769 |
Resumo: | Chemotherapy-induced mucositis is a common, often severe, side effect experienced by cancer patients during their treatment, which is a major challenge for successful anticancer therapy. As chemotherapy regimens evolve to include more efficacious agents, mucositis is increasingly becoming a major cause of dose-limiting toxicity and merits further investigation. This condition is characterised by both inflammation and loss of cells from the epithelial barrier of the gastrointestinal tract. This article reviews the current understanding of the inflammatory mechanisms behind chemotherapy’s toxic effect on the gastrointestinal tract and provides evidence that inflammation is a key factor behind gastrointestinal toxicity of chemotherapy. The authors discuss potential therapeutic targets that can contribute to mucositis treatment and prevention. |
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2023-07-14T22:28:55Z2023-07-14T22:28:55Z2018718291https://doi.org/10.33590/emjgastroenterol/10310983.2054-6203http://hdl.handle.net/1843/56322https://orcid.org/0000-0002-1600-0289https://orcid.org/0000-0003-3432-0769Chemotherapy-induced mucositis is a common, often severe, side effect experienced by cancer patients during their treatment, which is a major challenge for successful anticancer therapy. As chemotherapy regimens evolve to include more efficacious agents, mucositis is increasingly becoming a major cause of dose-limiting toxicity and merits further investigation. This condition is characterised by both inflammation and loss of cells from the epithelial barrier of the gastrointestinal tract. This article reviews the current understanding of the inflammatory mechanisms behind chemotherapy’s toxic effect on the gastrointestinal tract and provides evidence that inflammation is a key factor behind gastrointestinal toxicity of chemotherapy. The authors discuss potential therapeutic targets that can contribute to mucositis treatment and prevention.porUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAEuropean Medical Journal GastroenterologyQuimioterapiaSistema gastrointestinal - DoençasChemotherapyMucositisGastrointestinalMechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targetsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.emjreviews.com/gastroenterology/article/editors-pick-mechanisms-underlying-chemotherapy-associated-mucositis-the-role-of-inflammatory-mediators-and-potential-therapeutic-targets/Zelia Menezes GarciaRaquel Duque do Nascimento ArifaCaio Tavares FagundesDanielle da Glória de Souzainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56322/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALMechanisms Underlying Chemotherapy-Associated Mucositis The Role of Inflammatory Mediators and Potential Therapeutic Targets.pdfMechanisms Underlying Chemotherapy-Associated Mucositis The Role of Inflammatory Mediators and Potential Therapeutic Targets.pdfapplication/pdf1042793https://repositorio.ufmg.br/bitstream/1843/56322/2/Mechanisms%20Underlying%20Chemotherapy-Associated%20Mucositis%20The%20Role%20of%20Inflammatory%20Mediators%20and%20Potential%20Therapeutic%20Targets.pdff2aab477052db53696efa59b58aeb6ebMD521843/563222023-07-14 19:28:55.481oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-14T22:28:55Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Mechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targets |
title |
Mechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targets |
spellingShingle |
Mechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targets Zelia Menezes Garcia Chemotherapy Mucositis Gastrointestinal Quimioterapia Sistema gastrointestinal - Doenças |
title_short |
Mechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targets |
title_full |
Mechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targets |
title_fullStr |
Mechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targets |
title_full_unstemmed |
Mechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targets |
title_sort |
Mechanisms underlying chemotherapy-associated mucositis: the role of inflammatory mediators and potential therapeutic targets |
author |
Zelia Menezes Garcia |
author_facet |
Zelia Menezes Garcia Raquel Duque do Nascimento Arifa Caio Tavares Fagundes Danielle da Glória de Souza |
author_role |
author |
author2 |
Raquel Duque do Nascimento Arifa Caio Tavares Fagundes Danielle da Glória de Souza |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Zelia Menezes Garcia Raquel Duque do Nascimento Arifa Caio Tavares Fagundes Danielle da Glória de Souza |
dc.subject.por.fl_str_mv |
Chemotherapy Mucositis Gastrointestinal |
topic |
Chemotherapy Mucositis Gastrointestinal Quimioterapia Sistema gastrointestinal - Doenças |
dc.subject.other.pt_BR.fl_str_mv |
Quimioterapia Sistema gastrointestinal - Doenças |
description |
Chemotherapy-induced mucositis is a common, often severe, side effect experienced by cancer patients during their treatment, which is a major challenge for successful anticancer therapy. As chemotherapy regimens evolve to include more efficacious agents, mucositis is increasingly becoming a major cause of dose-limiting toxicity and merits further investigation. This condition is characterised by both inflammation and loss of cells from the epithelial barrier of the gastrointestinal tract. This article reviews the current understanding of the inflammatory mechanisms behind chemotherapy’s toxic effect on the gastrointestinal tract and provides evidence that inflammation is a key factor behind gastrointestinal toxicity of chemotherapy. The authors discuss potential therapeutic targets that can contribute to mucositis treatment and prevention. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2023-07-14T22:28:55Z |
dc.date.available.fl_str_mv |
2023-07-14T22:28:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56322 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.33590/emjgastroenterol/10310983. |
dc.identifier.issn.pt_BR.fl_str_mv |
2054-6203 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-1600-0289 https://orcid.org/0000-0003-3432-0769 |
url |
https://doi.org/10.33590/emjgastroenterol/10310983. http://hdl.handle.net/1843/56322 https://orcid.org/0000-0002-1600-0289 https://orcid.org/0000-0003-3432-0769 |
identifier_str_mv |
2054-6203 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.ispartof.pt_BR.fl_str_mv |
European Medical Journal Gastroenterology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ICB - DEPARTAMENTO DE MICROBIOLOGIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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