Anti-candida activity of cinnamon inhibition of virulence factors of clinical strains of Candida albicans by essential oil of Cinnamomum zeylanicum
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/40919 |
Resumo: | Essential oil of cinnamon (Cinnamomum zeylanicum) has been used in medicine and food additives. In the present work, we examined the antifungal activity of essential oil extracted from C. zeylanicum bark against oral opportunistic strains of Candida albicans. In addition, we verified the capability of this essential oil to inhibit fungal adhesion to buccal epithelial cells (BECs), germ tube formation, and proteinase activities. Cinnamon oil presented minimum inhibitory concentration (MIC) values that ranged from 31.2 to 125 µg mL-1 against the isolates of the tested C. albicans strains. Cinnamon essential oil could inhibit the adhesion of C. albicans to BECs for all of the isolates tested in present study. The C. albicans strains showed inhibited proteinase production after treatment with cinnamon oil, based on the MIC values determined for each C. albicans strain. Cinnamon oil was also able to inhibit the germ tube formation of all isolates of C. albicans, with the percentage of inhibition ranging from 44.7 to 82.9%. Our results showed that cinnamon oil presented potent antifungal activity and the ability to inhibit virulence factors of oral pathogenic strains of C. albicans. |
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2022-04-08T00:30:12Z2022-04-08T00:30:12Z2018314122518-3834http://hdl.handle.net/1843/40919Essential oil of cinnamon (Cinnamomum zeylanicum) has been used in medicine and food additives. In the present work, we examined the antifungal activity of essential oil extracted from C. zeylanicum bark against oral opportunistic strains of Candida albicans. In addition, we verified the capability of this essential oil to inhibit fungal adhesion to buccal epithelial cells (BECs), germ tube formation, and proteinase activities. Cinnamon oil presented minimum inhibitory concentration (MIC) values that ranged from 31.2 to 125 µg mL-1 against the isolates of the tested C. albicans strains. Cinnamon essential oil could inhibit the adhesion of C. albicans to BECs for all of the isolates tested in present study. The C. albicans strains showed inhibited proteinase production after treatment with cinnamon oil, based on the MIC values determined for each C. albicans strain. Cinnamon oil was also able to inhibit the germ tube formation of all isolates of C. albicans, with the percentage of inhibition ranging from 44.7 to 82.9%. Our results showed that cinnamon oil presented potent antifungal activity and the ability to inhibit virulence factors of oral pathogenic strains of C. albicans.engUniversidade Federal de Minas GeraisUFMGBrasilFAR - DEPARTAMENTO DE ALIMENTOSICB - DEPARTAMENTO DE MICROBIOLOGIAPSM MicrobiologyPlantas medicinaisCanelaCinnamomum zeylanicumÓleo essencialCandida albicansAdhesionCinnamon oilGerm tubeProteinaseAnti-candida activity of cinnamon inhibition of virulence factors of clinical strains of Candida albicans by essential oil of Cinnamomum zeylanicuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://psmpublishers.org/issues/anti-candida-activity-of-cinnamon-inhibition-of-virulence-factors-of-clinical-strains-of-candida-albicans-by-essential-oil-of-cinnamomum-zeylanicum/Priscila Codeiro de Lima CarvalhoNívea Pereira de SáInayara Cristina Alves LacerdaCarla PataroLuiz Henrique RosaRodrigo Silva AlvesJuliana Pereira LyonCarlos Augusto RosaSusana Johannapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/40919/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALAnti-Candida Activity of Cinnamon Inhibition of Virulence Factors of Clinical Strains of Candida albicans by Essential Oil of Cinnamomum zeylanicum.pdfAnti-Candida Activity of Cinnamon Inhibition of Virulence Factors of Clinical Strains of Candida albicans by Essential Oil of Cinnamomum zeylanicum.pdfapplication/pdf447906https://repositorio.ufmg.br/bitstream/1843/40919/2/Anti-Candida%20Activity%20of%20Cinnamon%20Inhibition%20of%20Virulence%20Factors%20of%20Clinical%20Strains%20of%20Candida%20albicans%20by%20Essential%20Oil%20of%20Cinnamomum%20zeylanicum.pdf1b30e175bd6ff5f592ebc5a57de1f99fMD521843/409192022-04-07 21:30:12.532oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-04-08T00:30:12Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Anti-candida activity of cinnamon inhibition of virulence factors of clinical strains of Candida albicans by essential oil of Cinnamomum zeylanicum |
title |
Anti-candida activity of cinnamon inhibition of virulence factors of clinical strains of Candida albicans by essential oil of Cinnamomum zeylanicum |
spellingShingle |
Anti-candida activity of cinnamon inhibition of virulence factors of clinical strains of Candida albicans by essential oil of Cinnamomum zeylanicum Priscila Codeiro de Lima Carvalho Adhesion Cinnamon oil Germ tube Proteinase Plantas medicinais Canela Cinnamomum zeylanicum Óleo essencial Candida albicans |
title_short |
Anti-candida activity of cinnamon inhibition of virulence factors of clinical strains of Candida albicans by essential oil of Cinnamomum zeylanicum |
title_full |
Anti-candida activity of cinnamon inhibition of virulence factors of clinical strains of Candida albicans by essential oil of Cinnamomum zeylanicum |
title_fullStr |
Anti-candida activity of cinnamon inhibition of virulence factors of clinical strains of Candida albicans by essential oil of Cinnamomum zeylanicum |
title_full_unstemmed |
Anti-candida activity of cinnamon inhibition of virulence factors of clinical strains of Candida albicans by essential oil of Cinnamomum zeylanicum |
title_sort |
Anti-candida activity of cinnamon inhibition of virulence factors of clinical strains of Candida albicans by essential oil of Cinnamomum zeylanicum |
author |
Priscila Codeiro de Lima Carvalho |
author_facet |
Priscila Codeiro de Lima Carvalho Nívea Pereira de Sá Inayara Cristina Alves Lacerda Carla Pataro Luiz Henrique Rosa Rodrigo Silva Alves Juliana Pereira Lyon Carlos Augusto Rosa Susana Johann |
author_role |
author |
author2 |
Nívea Pereira de Sá Inayara Cristina Alves Lacerda Carla Pataro Luiz Henrique Rosa Rodrigo Silva Alves Juliana Pereira Lyon Carlos Augusto Rosa Susana Johann |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Priscila Codeiro de Lima Carvalho Nívea Pereira de Sá Inayara Cristina Alves Lacerda Carla Pataro Luiz Henrique Rosa Rodrigo Silva Alves Juliana Pereira Lyon Carlos Augusto Rosa Susana Johann |
dc.subject.por.fl_str_mv |
Adhesion Cinnamon oil Germ tube Proteinase |
topic |
Adhesion Cinnamon oil Germ tube Proteinase Plantas medicinais Canela Cinnamomum zeylanicum Óleo essencial Candida albicans |
dc.subject.other.pt_BR.fl_str_mv |
Plantas medicinais Canela Cinnamomum zeylanicum Óleo essencial Candida albicans |
description |
Essential oil of cinnamon (Cinnamomum zeylanicum) has been used in medicine and food additives. In the present work, we examined the antifungal activity of essential oil extracted from C. zeylanicum bark against oral opportunistic strains of Candida albicans. In addition, we verified the capability of this essential oil to inhibit fungal adhesion to buccal epithelial cells (BECs), germ tube formation, and proteinase activities. Cinnamon oil presented minimum inhibitory concentration (MIC) values that ranged from 31.2 to 125 µg mL-1 against the isolates of the tested C. albicans strains. Cinnamon essential oil could inhibit the adhesion of C. albicans to BECs for all of the isolates tested in present study. The C. albicans strains showed inhibited proteinase production after treatment with cinnamon oil, based on the MIC values determined for each C. albicans strain. Cinnamon oil was also able to inhibit the germ tube formation of all isolates of C. albicans, with the percentage of inhibition ranging from 44.7 to 82.9%. Our results showed that cinnamon oil presented potent antifungal activity and the ability to inhibit virulence factors of oral pathogenic strains of C. albicans. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2022-04-08T00:30:12Z |
dc.date.available.fl_str_mv |
2022-04-08T00:30:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/40919 |
dc.identifier.issn.pt_BR.fl_str_mv |
2518-3834 |
identifier_str_mv |
2518-3834 |
url |
http://hdl.handle.net/1843/40919 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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PSM Microbiology |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
FAR - DEPARTAMENTO DE ALIMENTOS ICB - DEPARTAMENTO DE MICROBIOLOGIA |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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