Complications and management of polymethylmethacrylate (pmma) injections to the midface
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://hdl.handle.net/1843/54522 https://orcid.org/0000-0002-7569-986X |
Resumo: | Background: Polymethylmethacrylate (PMMA) has been used as an injectable filler to treat hollows and reduce rhytids. PMMA injections have been associated with several side effects, however, the literature is scarce on periorbital complications and their treatments.Objectives: The purpose of this study is to report a series of complications after periorbital PMMA injections to the midface and to describe their management.Methods: Retrospective chart review, including photography and histopathology when available. Results: The authors identified 11 cases of complications of PMMA injections to the midface. Patient ages ranged from 36 to 62 years (mean, 47 years;median, 44 years). Two (18%) were males and 9 (82%) were females. Adverse effects began between 2 to 24 months after injection (mean, 7.2 months;median, 6 months). All patients had edema, erythema, and contour irregularity. Seven (64%) patients had nodules, 4 (36%) had yellow, xanthomatousskin changes, and 2 (18%) had eyelid malposition. Histopathology demonstrated a giant cell inflammation in 5 of 6 cases. Corticosteroid injection was tried in 6 cases but was associated with minimal clinical improvement. Surgical debulking of the implanted material was performed in 9 (82%) cases and was effective in improving edema, erythema, and nodularity.Conclusions: PMMA injection to the midface may be associated with chronic inflammation, fibrotic nodules, yellowing of the skin, and eyelid malposition. Intralesional corticosteroid injections yielded minimal or no improvement; surgical debulking achieved favorable results. |
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2023-06-05T19:50:48Z2023-06-05T19:50:48Z201636213213510.1093/asj/sjv1951090820Xhttp://hdl.handle.net/1843/54522https://orcid.org/0000-0002-7569-986XBackground: Polymethylmethacrylate (PMMA) has been used as an injectable filler to treat hollows and reduce rhytids. PMMA injections have been associated with several side effects, however, the literature is scarce on periorbital complications and their treatments.Objectives: The purpose of this study is to report a series of complications after periorbital PMMA injections to the midface and to describe their management.Methods: Retrospective chart review, including photography and histopathology when available. Results: The authors identified 11 cases of complications of PMMA injections to the midface. Patient ages ranged from 36 to 62 years (mean, 47 years;median, 44 years). Two (18%) were males and 9 (82%) were females. Adverse effects began between 2 to 24 months after injection (mean, 7.2 months;median, 6 months). All patients had edema, erythema, and contour irregularity. Seven (64%) patients had nodules, 4 (36%) had yellow, xanthomatousskin changes, and 2 (18%) had eyelid malposition. Histopathology demonstrated a giant cell inflammation in 5 of 6 cases. Corticosteroid injection was tried in 6 cases but was associated with minimal clinical improvement. Surgical debulking of the implanted material was performed in 9 (82%) cases and was effective in improving edema, erythema, and nodularity.Conclusions: PMMA injection to the midface may be associated with chronic inflammation, fibrotic nodules, yellowing of the skin, and eyelid malposition. Intralesional corticosteroid injections yielded minimal or no improvement; surgical debulking achieved favorable results.engUniversidade Federal de Minas GeraisUFMGBrasilMED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIAAesthetic Surgery JournalPolimetil MetacrilatoEfeitos Colaterais e Reações Adversas Relacionados a MedicamentosInjeçõesPolymethylmethacrylateAdverse effectsInjectionsComplications and management of polymethylmethacrylate (pmma) injections to the midfaceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi:10.1093/asj/sjv195Roberto MurillolimongiJeremiah TaoAndré BorbaFilipe PereiraAna Rosa Pimentel de FigueiredoPatrícia AkaishiAntônio Augusto Velasco e Cruzapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/54522/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALComplications and Management of Polymethylemethacrylate PMMA Injections to the Midface pdfa.pdfComplications and Management of Polymethylemethacrylate PMMA Injections to the Midface pdfa.pdfapplication/pdf3337918https://repositorio.ufmg.br/bitstream/1843/54522/2/Complications%20and%20Management%20of%20Polymethylemethacrylate%20PMMA%20Injections%20to%20the%20Midface%20pdfa.pdf296e5d018b9a64ed75503111b1d23aefMD521843/545222023-06-05 16:52:52.689oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-06-05T19:52:52Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Complications and management of polymethylmethacrylate (pmma) injections to the midface |
title |
Complications and management of polymethylmethacrylate (pmma) injections to the midface |
spellingShingle |
Complications and management of polymethylmethacrylate (pmma) injections to the midface Roberto Murillolimongi Polymethylmethacrylate Adverse effects Injections Polimetil Metacrilato Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Injeções |
title_short |
Complications and management of polymethylmethacrylate (pmma) injections to the midface |
title_full |
Complications and management of polymethylmethacrylate (pmma) injections to the midface |
title_fullStr |
Complications and management of polymethylmethacrylate (pmma) injections to the midface |
title_full_unstemmed |
Complications and management of polymethylmethacrylate (pmma) injections to the midface |
title_sort |
Complications and management of polymethylmethacrylate (pmma) injections to the midface |
author |
Roberto Murillolimongi |
author_facet |
Roberto Murillolimongi Jeremiah Tao André Borba Filipe Pereira Ana Rosa Pimentel de Figueiredo Patrícia Akaishi Antônio Augusto Velasco e Cruz |
author_role |
author |
author2 |
Jeremiah Tao André Borba Filipe Pereira Ana Rosa Pimentel de Figueiredo Patrícia Akaishi Antônio Augusto Velasco e Cruz |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Roberto Murillolimongi Jeremiah Tao André Borba Filipe Pereira Ana Rosa Pimentel de Figueiredo Patrícia Akaishi Antônio Augusto Velasco e Cruz |
dc.subject.por.fl_str_mv |
Polymethylmethacrylate Adverse effects Injections |
topic |
Polymethylmethacrylate Adverse effects Injections Polimetil Metacrilato Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Injeções |
dc.subject.other.pt_BR.fl_str_mv |
Polimetil Metacrilato Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Injeções |
description |
Background: Polymethylmethacrylate (PMMA) has been used as an injectable filler to treat hollows and reduce rhytids. PMMA injections have been associated with several side effects, however, the literature is scarce on periorbital complications and their treatments.Objectives: The purpose of this study is to report a series of complications after periorbital PMMA injections to the midface and to describe their management.Methods: Retrospective chart review, including photography and histopathology when available. Results: The authors identified 11 cases of complications of PMMA injections to the midface. Patient ages ranged from 36 to 62 years (mean, 47 years;median, 44 years). Two (18%) were males and 9 (82%) were females. Adverse effects began between 2 to 24 months after injection (mean, 7.2 months;median, 6 months). All patients had edema, erythema, and contour irregularity. Seven (64%) patients had nodules, 4 (36%) had yellow, xanthomatousskin changes, and 2 (18%) had eyelid malposition. Histopathology demonstrated a giant cell inflammation in 5 of 6 cases. Corticosteroid injection was tried in 6 cases but was associated with minimal clinical improvement. Surgical debulking of the implanted material was performed in 9 (82%) cases and was effective in improving edema, erythema, and nodularity.Conclusions: PMMA injection to the midface may be associated with chronic inflammation, fibrotic nodules, yellowing of the skin, and eyelid malposition. Intralesional corticosteroid injections yielded minimal or no improvement; surgical debulking achieved favorable results. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2023-06-05T19:50:48Z |
dc.date.available.fl_str_mv |
2023-06-05T19:50:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/54522 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1093/asj/sjv195 |
dc.identifier.issn.pt_BR.fl_str_mv |
1090820X |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-7569-986X |
identifier_str_mv |
10.1093/asj/sjv195 1090820X |
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http://hdl.handle.net/1843/54522 https://orcid.org/0000-0002-7569-986X |
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eng |
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eng |
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Aesthetic Surgery Journal |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
dc.publisher.department.fl_str_mv |
MED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA |
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Universidade Federal de Minas Gerais |
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