Location of injected polymethylmethacrylate microspheres influences the onset of late adverse effects : an experimental and histopathologic study
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/130223 |
Resumo: | Polymethylmethacrylate (PMMA) has been widely used in the correction of wrinkles because of its long-lasting cosmetic improvements. However, side effects and complications may occur, and its clinical appearance on the oral mucosa can be similar to that of inflammatory or neoplastic disease. The aim of this research was to compare the clinical and histopathologic responses to PMMA injected by two different methods. Twenty-two rats received an injection of PMMA using the tunneling technique (gold standard), with subcutaneous deposition of the filler in the face, or a variation of the technique with transcutaneous submucosal deposition of the filler in the cheek. The tissue reaction was analyzed clinically every 24 hours during the first week, then once a week for the following 3 months. Histologic evaluation was based on the local inflammatory response to the filler. No clinical changes were observed during the initial evaluation period (0–14 days). After 14 days, only the submucosal group showed extra-oral enlargement (n=4, 18.2%). Histopathologic analysis revealed nodule formation in four animals (18.2%) in the submucosal group, with no nodules observed in the subcutaneous group. The data obtained in this study demonstrate that the technique used to deliver the filler may influence the risk of adverse reactions. |
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Jesus, Luciano Henrique deHildebrand, Laura de CamposMartins, Manoela DominguesRosa, Francinne Miranda daDanilevicz, Chris KrebsSant'Ana Filho, Manoel2015-11-25T02:39:53Z20151178-7015http://hdl.handle.net/10183/130223000974170Polymethylmethacrylate (PMMA) has been widely used in the correction of wrinkles because of its long-lasting cosmetic improvements. However, side effects and complications may occur, and its clinical appearance on the oral mucosa can be similar to that of inflammatory or neoplastic disease. The aim of this research was to compare the clinical and histopathologic responses to PMMA injected by two different methods. Twenty-two rats received an injection of PMMA using the tunneling technique (gold standard), with subcutaneous deposition of the filler in the face, or a variation of the technique with transcutaneous submucosal deposition of the filler in the cheek. The tissue reaction was analyzed clinically every 24 hours during the first week, then once a week for the following 3 months. Histologic evaluation was based on the local inflammatory response to the filler. No clinical changes were observed during the initial evaluation period (0–14 days). After 14 days, only the submucosal group showed extra-oral enlargement (n=4, 18.2%). Histopathologic analysis revealed nodule formation in four animals (18.2%) in the submucosal group, with no nodules observed in the subcutaneous group. The data obtained in this study demonstrate that the technique used to deliver the filler may influence the risk of adverse reactions.application/pdfengClinical, cosmetic and investigational dermatology. Auckland, NZ. Vol. 8 (Aug. 2015), p. 431-436Polimetil metacrilatoEfeitos adversosMateriais odontológicosDermal fillerPolymethylmethacrylateAdverse reactionsLocation of injected polymethylmethacrylate microspheres influences the onset of late adverse effects : an experimental and histopathologic studyEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000974170.pdf000974170.pdfTexto completo (inglês)application/pdf1876039http://www.lume.ufrgs.br/bitstream/10183/130223/1/000974170.pdfd20b108c48ca8b9ce4e7e55a0cbd11a4MD51TEXT000974170.pdf.txt000974170.pdf.txtExtracted Texttext/plain28979http://www.lume.ufrgs.br/bitstream/10183/130223/2/000974170.pdf.txtb7706c2b96044497e7edc95c702baa2aMD52THUMBNAIL000974170.pdf.jpg000974170.pdf.jpgGenerated Thumbnailimage/jpeg1982http://www.lume.ufrgs.br/bitstream/10183/130223/3/000974170.pdf.jpgea83683c03530d91519b37efc5fb6015MD5310183/1302232022-02-22 05:09:41.071304oai:www.lume.ufrgs.br:10183/130223Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-02-22T08:09:41Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Location of injected polymethylmethacrylate microspheres influences the onset of late adverse effects : an experimental and histopathologic study |
title |
Location of injected polymethylmethacrylate microspheres influences the onset of late adverse effects : an experimental and histopathologic study |
spellingShingle |
Location of injected polymethylmethacrylate microspheres influences the onset of late adverse effects : an experimental and histopathologic study Jesus, Luciano Henrique de Polimetil metacrilato Efeitos adversos Materiais odontológicos Dermal filler Polymethylmethacrylate Adverse reactions |
title_short |
Location of injected polymethylmethacrylate microspheres influences the onset of late adverse effects : an experimental and histopathologic study |
title_full |
Location of injected polymethylmethacrylate microspheres influences the onset of late adverse effects : an experimental and histopathologic study |
title_fullStr |
Location of injected polymethylmethacrylate microspheres influences the onset of late adverse effects : an experimental and histopathologic study |
title_full_unstemmed |
Location of injected polymethylmethacrylate microspheres influences the onset of late adverse effects : an experimental and histopathologic study |
title_sort |
Location of injected polymethylmethacrylate microspheres influences the onset of late adverse effects : an experimental and histopathologic study |
author |
Jesus, Luciano Henrique de |
author_facet |
Jesus, Luciano Henrique de Hildebrand, Laura de Campos Martins, Manoela Domingues Rosa, Francinne Miranda da Danilevicz, Chris Krebs Sant'Ana Filho, Manoel |
author_role |
author |
author2 |
Hildebrand, Laura de Campos Martins, Manoela Domingues Rosa, Francinne Miranda da Danilevicz, Chris Krebs Sant'Ana Filho, Manoel |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Jesus, Luciano Henrique de Hildebrand, Laura de Campos Martins, Manoela Domingues Rosa, Francinne Miranda da Danilevicz, Chris Krebs Sant'Ana Filho, Manoel |
dc.subject.por.fl_str_mv |
Polimetil metacrilato Efeitos adversos Materiais odontológicos |
topic |
Polimetil metacrilato Efeitos adversos Materiais odontológicos Dermal filler Polymethylmethacrylate Adverse reactions |
dc.subject.eng.fl_str_mv |
Dermal filler Polymethylmethacrylate Adverse reactions |
description |
Polymethylmethacrylate (PMMA) has been widely used in the correction of wrinkles because of its long-lasting cosmetic improvements. However, side effects and complications may occur, and its clinical appearance on the oral mucosa can be similar to that of inflammatory or neoplastic disease. The aim of this research was to compare the clinical and histopathologic responses to PMMA injected by two different methods. Twenty-two rats received an injection of PMMA using the tunneling technique (gold standard), with subcutaneous deposition of the filler in the face, or a variation of the technique with transcutaneous submucosal deposition of the filler in the cheek. The tissue reaction was analyzed clinically every 24 hours during the first week, then once a week for the following 3 months. Histologic evaluation was based on the local inflammatory response to the filler. No clinical changes were observed during the initial evaluation period (0–14 days). After 14 days, only the submucosal group showed extra-oral enlargement (n=4, 18.2%). Histopathologic analysis revealed nodule formation in four animals (18.2%) in the submucosal group, with no nodules observed in the subcutaneous group. The data obtained in this study demonstrate that the technique used to deliver the filler may influence the risk of adverse reactions. |
publishDate |
2015 |
dc.date.accessioned.fl_str_mv |
2015-11-25T02:39:53Z |
dc.date.issued.fl_str_mv |
2015 |
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Estrangeiro info:eu-repo/semantics/article |
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http://hdl.handle.net/10183/130223 |
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1178-7015 |
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000974170 |
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http://hdl.handle.net/10183/130223 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Clinical, cosmetic and investigational dermatology. Auckland, NZ. Vol. 8 (Aug. 2015), p. 431-436 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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