SIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | http://hdl.handle.net/1843/50729 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2023-03-08T11:59:49Z2023-03-08T11:59:49Z2019-0767909810.22161/ijaers.67122456-1908http://hdl.handle.net/1843/50729CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorThe current study evaluated the proliferation index and immunohistochemical expression of SIRT1 on normal skin and cutaneous melanocytic nevi (CMN) and cutaneous malignant melanoma (CMM). Formalin-fixed paraffin-embedded tissue samples from 43 CMN, 22 CMM and 10 normal skin were obtained and clinical data were abstracted from the electronic medicalrecord.SIRT1 and Ki67 proteins expressions were evaluated regarding to clinic pathological behavior in CMM. The level of significance was set at α = 5% (p < 0.05).Our findings showed that SIRT1 positivity was significantly higher in benign melanocytic nevi than that in cutaneous malignant melanoma (p=0.002). As expected, the proliferation index was significantly higher in samples of cutaneous malignant melanoma as compared to the normal skin and melanocytic nevi (p=0.001). However, the expression of Ki67 protein was not also significantly related to the expression of SIRT1 (p > 0.05). In conclusion, low expression of SIRT1 and high proliferation index may play an important role in progression of cutaneous melanoma.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASInternational Journal of Advanced Engineering Research and Science (IJAERS)Pele - CâncerMelanomaNevoSIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://ijaers.com/detail/sirt1-and-ki67-immunohistochemical-expression-in-progression-of-cutaneous-malignant-melanoma/Camila Santos PereiraMarcos Vinícius Macedo de OliveiraLudmilla Regina de SouzaOtávio Cardoso FilhoValéria Couto QuintãoAndréia Brito de SouzaMarcos Vinícius Mendes BarrosoLuiz Henrique da SilveiraAndré Luiz Sena GuimarãesAlfredo Maurício Batista de PaulaSérgio Henrique Sousa Santosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/50729/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALSIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma.pdfSIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma.pdfapplication/pdf282603https://repositorio.ufmg.br/bitstream/1843/50729/2/SIRT1%20and%20Ki67%20immunohistochemical%20expression%20in%20progression%20of%20cutaneous%20malignant%20melanoma.pdf0b5078279e9c330dbdb784b27e50c9f1MD521843/507292023-03-08 17:05:36.601oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-03-08T20:05:36Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
SIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma |
| title |
SIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma |
| spellingShingle |
SIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma Camila Santos Pereira Pele - Câncer Melanoma Nevo |
| title_short |
SIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma |
| title_full |
SIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma |
| title_fullStr |
SIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma |
| title_full_unstemmed |
SIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma |
| title_sort |
SIRT1 and Ki67 immunohistochemical expression in progression of cutaneous malignant melanoma |
| author |
Camila Santos Pereira |
| author_facet |
Camila Santos Pereira Marcos Vinícius Macedo de Oliveira Ludmilla Regina de Souza Otávio Cardoso Filho Valéria Couto Quintão Andréia Brito de Souza Marcos Vinícius Mendes Barroso Luiz Henrique da Silveira André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Sérgio Henrique Sousa Santos |
| author_role |
author |
| author2 |
Marcos Vinícius Macedo de Oliveira Ludmilla Regina de Souza Otávio Cardoso Filho Valéria Couto Quintão Andréia Brito de Souza Marcos Vinícius Mendes Barroso Luiz Henrique da Silveira André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Sérgio Henrique Sousa Santos |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Camila Santos Pereira Marcos Vinícius Macedo de Oliveira Ludmilla Regina de Souza Otávio Cardoso Filho Valéria Couto Quintão Andréia Brito de Souza Marcos Vinícius Mendes Barroso Luiz Henrique da Silveira André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Sérgio Henrique Sousa Santos |
| dc.subject.other.pt_BR.fl_str_mv |
Pele - Câncer Melanoma Nevo |
| topic |
Pele - Câncer Melanoma Nevo |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2019 |
| dc.date.issued.fl_str_mv |
2019-07 |
| dc.date.accessioned.fl_str_mv |
2023-03-08T11:59:49Z |
| dc.date.available.fl_str_mv |
2023-03-08T11:59:49Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/50729 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.22161/ijaers.6712 |
| dc.identifier.issn.pt_BR.fl_str_mv |
2456-1908 |
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10.22161/ijaers.6712 2456-1908 |
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http://hdl.handle.net/1843/50729 |
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eng |
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eng |
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International Journal of Advanced Engineering Research and Science (IJAERS) |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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