Prognosis of chronic chagas heart disease and other pending clinical challenges

• Autor(a) principal: Rosália Morais Torres
• Data de Publicação: 2021
• Outros Autores: Cristiano Pisani, Maria da Consolacao Vieira Moreira, Dilma do Socorro Moraes de Souza, Wilson de Oliveira Junior, Silvia Marinho Martins, João Carlos Pinto Dias, Dalmo Correia Filho, Maria do Carmo Pereira Nunes, Walderez Dutra, Andre Talvani, Andrea Silvestre Sousa, Fernanda de Souza Nogueira, Sardinha Mendes, Maurício Ibrahim Scanavacca
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: http://hdl.handle.net/1843/61930
• topic: Chagas disease; Prognosis; Chagas cardiomyopathy; Evolution markers; Public health; Public health; Prognosis; Chagas Disease; Chagas Cardiomyopathy

In this chapter, the main prognostic markers of Chagas heart disease are addressed, with an emphasis on the most recent findings and questions, establishing the basis for a broad discussion of recommendations and new approaches to managing Chagas cardiopathy. The main biological and genetic markers and the contribution of the electrocardiogram, echocardiogram and cardiac magnetic resonance are presented. We also discuss the most recent therapeutic proposals for heart failure, thromboembolism and arrhythmias, as well as current experience in heart transplantation in patients suffering from severe Chagas cardiomyopathy. The clinical and epidemiological challenges introduced by acute Chagas disease due to oral contamination are discussed. In addition, we highlight the importance of ageing and comorbidities in influencing the outcome of chronic Chagas heart disease. Finally, we discuss the importance of public policies, the vital role of funding agencies, universities, the scientific community and health professionals, and the application of new technologies in finding solutions for better management of Chagas heart disease.