Double blinded randomized clinical trial to assess the effectiveness of several preparations for colonoscopy

• Autor(a) principal: Bruno Giusti Werneckcortes
• Data de Publicação: 2018
• Outros Autores: Raquel Martins Cabral, Guilherme Augusto Alves do Carmo, Fábio Lopes de Queiroz, Sinara Mônica de Oliveira Leite, Amanda Cristina de Souza Andrade, Alexandre Silluzio Ferreira, Marta Eugênia Alcici, Maria da Conceição Juste Werneck Côrtes
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: https://doi.org/10.1016/j.jcol.2018.07.001V; http://hdl.handle.net/1843/40318
• topic: Colonoscopia; Preparação do intestino; Picossulfato sódico; Manitol; Lactulose; Lactitol

Introduction Colonoscopy is the screening gold standard to investigate several conditions in the colon. The excellence of preparation is a determining factor for a quality colonoscopy. Objective Compare the quality of colon preparations for colonoscopy with different kinds of laxative medications in a public hospital of Belo Horizonte, Brazil. Method A prospective double blind randomized clinical trial was conducted from June 2016 to March 2017. A total of 117 Patients were randomised in four groups to receive a type of preparation (Sodium picosulfate, Mannitol, Lactitol, Lactulose). The patients answered a questionnaire and peripheral blood samples were collected before and after the preparation.The quality of the cleansing was accessed according to the Boston Bowel Preparation Scale. Results 99.1% of patients have taken the recommended dose and 79.5% reported a good tolerability. Endoscopists performed complete colonoscopy in 89.7%, with an polipectomy rate of 47%. The total effectiveness rate of the solutions were 88%. There were no statistically significant differences between groups (p = 0.271). Regarding the laboratory parameters, differences were seen in the pre- and post-test values of sodium, chlorine and creatinine but without exceeding reference values. Conclusion The four preparations were effective for colon cleansing, with good acceptance, differing only as for costs.