Double blinded randomized clinical trial to assess the effectiveness of several preparations for colonoscopy

• Autor(a) principal: Cortes,Bruno Giusti Werneck
• Data de Publicação: 2018
• Outros Autores: Cabral,Raquel Martins, Carmo,Guilherme Augusto Alves do, Queiroz,Fábio Lopes de, Leite,Sinara Mônica de Oliveira, Andrade,Amanda Cristina de Souza, Ferreira,Alexandre Silluzio, Alcici,Marta Eugênia, Cortes,Maria da Conceição Juste Werneck
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Journal of Coloproctology (Rio de Janeiro. Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2237-93632018000400302
• topic: Colonoscopy; Quality; Bowel preparation; Sodium picosulfate; Mannitol; Lactitol; Lactulose

ABSTRACT Introduction: Colonoscopy is the screening gold standard to investigate several conditions in the colon. The excellence of preparation is a determining factor for a quality colonoscopy. Objective: Compare the quality of colon preparations for colonoscopy with different kinds of laxative medications in a public hospital of Belo Horizonte, Brazil. Method: A prospective double blind randomized clinical trial was conducted from June 2016 to March 2017. A total of 117 Patients were randomised in four groups to receive a type of preparation (Sodium picosulfate, Mannitol, Lactitol, Lactulose). The patients answered a questionnaire and peripheral blood samples were collected before and after the preparation.The quality of the cleansing was accessed according to the Boston Bowel Preparation Scale. Results: 99.1% of patients have taken the recommended dose and 79.5% reported a good tolerability. Endoscopists performed complete colonoscopy in 89.7%, with an polipectomy rate of 47%. The total effectiveness rate of the solutions were 88%. There were no statistically significant differences between groups (p = 0.271). Regarding the laboratory parameters, differences were seen in the pre- and post-test values of sodium, chlorine and creatinine but without exceeding reference values. Conclusion: The four preparations were effective for colon cleansing, with good acceptance, differing only as for costs.