Hierarchical analysis of hypertension with the polymorphic variant of the ACE gene and other risk factors in the elderly
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.5935/2359-4802.20170031 http://hdl.handle.net/1843/44381 |
Resumo: | Background: hypertension is a clinical condition of multifactorial etiology that imposes serious harm to the health of elderly individuals. Despite the fact that cardiovascular disorders influence the development of hypertension in this age group, several other genetic and environmental factors have been described in the literature, including the polymorphic variant of the angiotensin-converting enzyme (ACE) gene and the distribution of body fat. Objective: to assess the prevalence of hypertension among elderly individuals and its possible correlation with the I/D polymorphic variant of the ACE gene and other associated risk factors. Methods: population-based study using a hierarchical model and including 387 elderly individuals residing in the urban area of Ibiaí (Minas Gerais, Brazil). Results: on statistical analysis, the polymorphic variant of the ACE gene was not associated with hypertension (p = 0.316). On the other hand, there was a significant association between hypertension and the variables female sex, absence of a partner, consumption of more than one portion of salt per day, and changes in body mass index and waist-to-hip ratio. Conclusion: although the polymorphic variant of the ACE gene showed no influence on the prevalence of hypertension in elderly individuals, some variables such as individual, socioeconomic, metabolic, and behavioral habits were associated with this condition. |
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2022-08-19T12:10:04Z2022-08-19T12:10:04Z20173015260https://doi.org/10.5935/2359-4802.201700312359-5647http://hdl.handle.net/1843/44381Background: hypertension is a clinical condition of multifactorial etiology that imposes serious harm to the health of elderly individuals. Despite the fact that cardiovascular disorders influence the development of hypertension in this age group, several other genetic and environmental factors have been described in the literature, including the polymorphic variant of the angiotensin-converting enzyme (ACE) gene and the distribution of body fat. Objective: to assess the prevalence of hypertension among elderly individuals and its possible correlation with the I/D polymorphic variant of the ACE gene and other associated risk factors. Methods: population-based study using a hierarchical model and including 387 elderly individuals residing in the urban area of Ibiaí (Minas Gerais, Brazil). Results: on statistical analysis, the polymorphic variant of the ACE gene was not associated with hypertension (p = 0.316). On the other hand, there was a significant association between hypertension and the variables female sex, absence of a partner, consumption of more than one portion of salt per day, and changes in body mass index and waist-to-hip ratio. Conclusion: although the polymorphic variant of the ACE gene showed no influence on the prevalence of hypertension in elderly individuals, some variables such as individual, socioeconomic, metabolic, and behavioral habits were associated with this condition.Fundamento: a hipertensão arterial sistêmica (HAS) é uma condição clínica de etiologia multifatorial e de sério agravo à saúde do idoso. Apesar das alterações cardiovasculares influenciarem o desenvolvimento da HAS nesta faixa etária, vários outros fatores genéticos e ambientais têm sido descritos na literatura, incluindo a variante polimórfica do gene da enzima conversora da angiotensina (ECA) e a distribuição da gordura corporal. Objetivo: avaliar a prevalência da HAS entre idosos e sua possível correlação com a variante polimórfica I/D do gene da ECA e outros fatores de risco associados. Métodos: estudo de base populacional com 387 idosos residentes na zona urbana de Ibiaí (MG, Brasil) utilizando, para tal, um modelo hierarquizado. Resultados: à análise estatística, a variante polimórfica do gene da ECA não se mostrou associada à HAS (p = 0,316). Por outro lado, mostraram associação significativa com a HAS os fatores: sexo feminino, ausência de companheiro, consumo de mais de uma porção de sal ao dia e alterações nos índices de massa corporal e na relação cintura-quadril. Conclusão: apesar da variante polimórfica da ECA não ter mostrado influência sobre a prevalência de HAS em idosos, algumas variáveis individuais, socioeconômicas, metabólicas e de hábitos comportamentais mostraram associação com esta condição.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASInternational Journal of Cardiovascular SciencesHipertensãoPolimorfismo (Genética)IdososAngiotensinaHierarchical analysis of hypertension with the polymorphic variant of the ACE gene and other risk factors in the elderlyAnálise hierarquizada da hipertensão arterial sistêmica com a variante polimórfica do gene da ECA e outros fatores de risco em idososinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.scielo.br/j/ijcs/a/4tHcZXwLNMrdrMCjy76Dd4Q/abstract/?lang=enBreno Barreto RibeiroPedro Eleutério dos Santos NetoJairo Evangelista NascimentoJoão Marcus Oliveira AndradeAlanna Fernandes ParaisoSergio Henrique Sousa SantosMarise Fagundes SilveiraAndréa Maria Eleutério de Barros Lima Martinsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44381/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALHierarchical analysis of hypertension with the polymorphic variant of the ace gene and other risk factors in the elderly.pdfHierarchical analysis of hypertension with the polymorphic variant of the ace gene and other risk factors in the elderly.pdfapplication/pdf321579https://repositorio.ufmg.br/bitstream/1843/44381/2/Hierarchical%20analysis%20of%20hypertension%20with%20the%20polymorphic%20variant%20of%20the%20ace%20gene%20and%20other%20risk%20factors%20in%20the%20elderly.pdf294d515fa42bf249b9e2ae657af246a6MD521843/443812022-08-19 09:10:04.38oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-19T12:10:04Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Hierarchical analysis of hypertension with the polymorphic variant of the ACE gene and other risk factors in the elderly |
dc.title.alternative.pt_BR.fl_str_mv |
Análise hierarquizada da hipertensão arterial sistêmica com a variante polimórfica do gene da ECA e outros fatores de risco em idosos |
title |
Hierarchical analysis of hypertension with the polymorphic variant of the ACE gene and other risk factors in the elderly |
spellingShingle |
Hierarchical analysis of hypertension with the polymorphic variant of the ACE gene and other risk factors in the elderly Breno Barreto Ribeiro Hipertensão Polimorfismo (Genética) Idosos Angiotensina |
title_short |
Hierarchical analysis of hypertension with the polymorphic variant of the ACE gene and other risk factors in the elderly |
title_full |
Hierarchical analysis of hypertension with the polymorphic variant of the ACE gene and other risk factors in the elderly |
title_fullStr |
Hierarchical analysis of hypertension with the polymorphic variant of the ACE gene and other risk factors in the elderly |
title_full_unstemmed |
Hierarchical analysis of hypertension with the polymorphic variant of the ACE gene and other risk factors in the elderly |
title_sort |
Hierarchical analysis of hypertension with the polymorphic variant of the ACE gene and other risk factors in the elderly |
author |
Breno Barreto Ribeiro |
author_facet |
Breno Barreto Ribeiro Pedro Eleutério dos Santos Neto Jairo Evangelista Nascimento João Marcus Oliveira Andrade Alanna Fernandes Paraiso Sergio Henrique Sousa Santos Marise Fagundes Silveira Andréa Maria Eleutério de Barros Lima Martins |
author_role |
author |
author2 |
Pedro Eleutério dos Santos Neto Jairo Evangelista Nascimento João Marcus Oliveira Andrade Alanna Fernandes Paraiso Sergio Henrique Sousa Santos Marise Fagundes Silveira Andréa Maria Eleutério de Barros Lima Martins |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Breno Barreto Ribeiro Pedro Eleutério dos Santos Neto Jairo Evangelista Nascimento João Marcus Oliveira Andrade Alanna Fernandes Paraiso Sergio Henrique Sousa Santos Marise Fagundes Silveira Andréa Maria Eleutério de Barros Lima Martins |
dc.subject.other.pt_BR.fl_str_mv |
Hipertensão Polimorfismo (Genética) Idosos Angiotensina |
topic |
Hipertensão Polimorfismo (Genética) Idosos Angiotensina |
description |
Background: hypertension is a clinical condition of multifactorial etiology that imposes serious harm to the health of elderly individuals. Despite the fact that cardiovascular disorders influence the development of hypertension in this age group, several other genetic and environmental factors have been described in the literature, including the polymorphic variant of the angiotensin-converting enzyme (ACE) gene and the distribution of body fat. Objective: to assess the prevalence of hypertension among elderly individuals and its possible correlation with the I/D polymorphic variant of the ACE gene and other associated risk factors. Methods: population-based study using a hierarchical model and including 387 elderly individuals residing in the urban area of Ibiaí (Minas Gerais, Brazil). Results: on statistical analysis, the polymorphic variant of the ACE gene was not associated with hypertension (p = 0.316). On the other hand, there was a significant association between hypertension and the variables female sex, absence of a partner, consumption of more than one portion of salt per day, and changes in body mass index and waist-to-hip ratio. Conclusion: although the polymorphic variant of the ACE gene showed no influence on the prevalence of hypertension in elderly individuals, some variables such as individual, socioeconomic, metabolic, and behavioral habits were associated with this condition. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2022-08-19T12:10:04Z |
dc.date.available.fl_str_mv |
2022-08-19T12:10:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/44381 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.5935/2359-4802.20170031 |
dc.identifier.issn.pt_BR.fl_str_mv |
2359-5647 |
url |
https://doi.org/10.5935/2359-4802.20170031 http://hdl.handle.net/1843/44381 |
identifier_str_mv |
2359-5647 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
International Journal of Cardiovascular Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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