Maternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.1002/jcsm.12986 http://hdl.handle.net/1843/64800 https://orcid.org/0000-0003-0391-7255 https://orcid.org/0000-0002-5738-9374 https://orcid.org/0000-0001-6933-6598 https://orcid.org/0000-0003-2621-3330 https://orcid.org/0000-0002-6171-7940 https://orcid.org/0000-0001-5062-4493 https://orcid.org/0000-0002-2352-6449 https://orcid.org/0000-0002-5731-1219 https://orcid.org/0000-0002-9423-9965 https://orcid.org/0000-0002-9366-2593 https://orcid.org/0000-0002-2325-9571 https://orcid.org/0000-0002-9034-5357 https://orcid.org/0000-0002-9870-9469 |
Resumo: | FAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo |
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2024-02-27T16:21:23Z2024-02-27T16:21:23Z2022-05-181321752187https://doi.org/10.1002/jcsm.129862190-6009http://hdl.handle.net/1843/64800https://orcid.org/0000-0003-0391-7255https://orcid.org/0000-0002-5738-9374https://orcid.org/0000-0001-6933-6598https://orcid.org/0000-0003-2621-3330https://orcid.org/0000-0002-6171-7940https://orcid.org/0000-0001-5062-4493https://orcid.org/0000-0002-2352-6449https://orcid.org/0000-0002-5731-1219https://orcid.org/0000-0002-9423-9965https://orcid.org/0000-0002-9366-2593https://orcid.org/0000-0002-2325-9571https://orcid.org/0000-0002-9034-5357https://orcid.org/0000-0002-9870-9469FAPESP - Fundação de Amparo à Pesquisa do Estado de São PauloBackground Fetal stage is a critical developmental window for the skeletal muscle, but little information is available about the impact of maternal vitamin D (Vit. D) deficiency (VDD) on offspring lean mass development in the adult life of male and female animals. Methods Female rats (Wistar Hannover) were fed either a control (1000 IU Vit. D3/kg) or a VDD diet (0 IU Vit. D3/kg) for 6 weeks and during gestation and lactation. At weaning, male and female offspring were randomly separated and received a standard diet up to 180 days old. Results Vitamin D deficiency induced muscle atrophy in the male (M-VDD) offspring at the end of weaning, an effect that was reverted along the time. Following 180 days, fast-twitch skeletal muscles [extensor digitorum longus (EDL)] from the M-VDD showed a decrease (20%; P < 0.05) in the number of total fibres but an increase in the cross-sectional area of IIB (17%; P < 0.05), IIA (19%; P < 0.05) and IIAX (21%; P < 0.05) fibres. The fibre hypertrophy was associated with the higher protein levels of MyoD (73%; P < 0.05) and myogenin (55% %; P < 0.05) and in the number of satellite cells (128.8 ± 14 vs. 91 ± 7.6 nuclei Pax7 + in the M-CTRL; P < 0.05). M-VDD increased time to fatigue during ex vivo contractions of EDL muscles and showed an increase in the phosphorylation levels of IGF-1/insulin receptor and their downstream targets related to anabolic processes and myogenic activation, including Ser 473Akt and Ser 21/9GSK-3β. In such muscles, maternal VDD induced a compensatory increase in the content of calcitriol (two-fold; P < 0.05) and CYP27B1 (58%; P < 0.05), a metabolizing enzyme that converts calcidiol to calcitriol. Interestingly, most morphological and biochemical changes found in EDL were not observed in slow-twitch skeletal muscles (soleus) from the M-VDD group as well as in both EDL and soleus muscles from the female offspring. Conclusions These data show that maternal VDD selectively affects the development of type-II muscle fibres in male offspring rats but not in female offspring rats and suggest that the enhancement of their size and fatigue resistance in fast-twitch skeletal muscle (EDL) is probably due to a compensatory increase in the muscle content of Vit. D in the adult age.engUniversidade Federal de Minas GeraisUFMGBrasilEEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICAEEFFTO - ESCOLA DE EDUCAÇÃO FISICA, FISIOTERAPIA E TERAPIA OCUPACIONALJournal of Cachexia, Sarcopenia and MuscleVitamina DFetoEsqueletoMúsculosHipertrofiaFetal programmingVitamin DSkeletal muscleMuscle developmentHypertrophyMaternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://onlinelibrary.wiley.com/doi/10.1002/jcsm.12986Natany Garcia ReisNeusa Maria ZanonTatiana E. KoikeAudrei R. SantosElen H. MiyabaraIsis do Carmo KettelhutLuiz Carlos NavegantesAna Paula AssisNatalia LauterbachDawit Albieiro Pinheiro GonçalvesWilian de Assis SilveiraHenrique J. N. MorganRafael ValentimLucas F. AlmeidaLilian do Carmo Heckapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/64800/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALMaternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats.pdfMaternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats.pdfapplication/pdf2741739https://repositorio.ufmg.br/bitstream/1843/64800/2/Maternal%20vitamin%20D%20deficiency%20affects%20the%20morphology%20and%20function%20of%20glycolytic%20muscle%20in%20adult%20offspring%20rats.pdf2c256ab8257fcbdb572849efc4af574aMD521843/648002024-02-27 13:21:24.184oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2024-02-27T16:21:24Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Maternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats |
| title |
Maternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats |
| spellingShingle |
Maternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats Natany Garcia Reis Fetal programming Vitamin D Skeletal muscle Muscle development Hypertrophy Vitamina D Feto Esqueleto Músculos Hipertrofia |
| title_short |
Maternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats |
| title_full |
Maternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats |
| title_fullStr |
Maternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats |
| title_full_unstemmed |
Maternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats |
| title_sort |
Maternal vitamin D deficiency affects the morphology and function of glycolytic muscle in adult offspring rats |
| author |
Natany Garcia Reis |
| author_facet |
Natany Garcia Reis Neusa Maria Zanon Tatiana E. Koike Audrei R. Santos Elen H. Miyabara Isis do Carmo Kettelhut Luiz Carlos Navegantes Ana Paula Assis Natalia Lauterbach Dawit Albieiro Pinheiro Gonçalves Wilian de Assis Silveira Henrique J. N. Morgan Rafael Valentim Lucas F. Almeida Lilian do Carmo Heck |
| author_role |
author |
| author2 |
Neusa Maria Zanon Tatiana E. Koike Audrei R. Santos Elen H. Miyabara Isis do Carmo Kettelhut Luiz Carlos Navegantes Ana Paula Assis Natalia Lauterbach Dawit Albieiro Pinheiro Gonçalves Wilian de Assis Silveira Henrique J. N. Morgan Rafael Valentim Lucas F. Almeida Lilian do Carmo Heck |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Natany Garcia Reis Neusa Maria Zanon Tatiana E. Koike Audrei R. Santos Elen H. Miyabara Isis do Carmo Kettelhut Luiz Carlos Navegantes Ana Paula Assis Natalia Lauterbach Dawit Albieiro Pinheiro Gonçalves Wilian de Assis Silveira Henrique J. N. Morgan Rafael Valentim Lucas F. Almeida Lilian do Carmo Heck |
| dc.subject.por.fl_str_mv |
Fetal programming Vitamin D Skeletal muscle Muscle development Hypertrophy |
| topic |
Fetal programming Vitamin D Skeletal muscle Muscle development Hypertrophy Vitamina D Feto Esqueleto Músculos Hipertrofia |
| dc.subject.other.pt_BR.fl_str_mv |
Vitamina D Feto Esqueleto Músculos Hipertrofia |
| description |
FAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo |
| publishDate |
2022 |
| dc.date.issued.fl_str_mv |
2022-05-18 |
| dc.date.accessioned.fl_str_mv |
2024-02-27T16:21:23Z |
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2024-02-27T16:21:23Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1843/64800 |
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https://doi.org/10.1002/jcsm.12986 |
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2190-6009 |
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https://orcid.org/0000-0003-0391-7255 https://orcid.org/0000-0002-5738-9374 https://orcid.org/0000-0001-6933-6598 https://orcid.org/0000-0003-2621-3330 https://orcid.org/0000-0002-6171-7940 https://orcid.org/0000-0001-5062-4493 https://orcid.org/0000-0002-2352-6449 https://orcid.org/0000-0002-5731-1219 https://orcid.org/0000-0002-9423-9965 https://orcid.org/0000-0002-9366-2593 https://orcid.org/0000-0002-2325-9571 https://orcid.org/0000-0002-9034-5357 https://orcid.org/0000-0002-9870-9469 |
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https://doi.org/10.1002/jcsm.12986 http://hdl.handle.net/1843/64800 https://orcid.org/0000-0003-0391-7255 https://orcid.org/0000-0002-5738-9374 https://orcid.org/0000-0001-6933-6598 https://orcid.org/0000-0003-2621-3330 https://orcid.org/0000-0002-6171-7940 https://orcid.org/0000-0001-5062-4493 https://orcid.org/0000-0002-2352-6449 https://orcid.org/0000-0002-5731-1219 https://orcid.org/0000-0002-9423-9965 https://orcid.org/0000-0002-9366-2593 https://orcid.org/0000-0002-2325-9571 https://orcid.org/0000-0002-9034-5357 https://orcid.org/0000-0002-9870-9469 |
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2190-6009 |
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eng |
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eng |
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Journal of Cachexia, Sarcopenia and Muscle |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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EEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICA EEFFTO - ESCOLA DE EDUCAÇÃO FISICA, FISIOTERAPIA E TERAPIA OCUPACIONAL |
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Universidade Federal de Minas Gerais |
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