Dietary approach in the treatment of nonalcoholic fatty liver disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | http://dx.doi.org/10.4254/wjh.v7.i24.2522 http://hdl.handle.net/1843/56594 https://orcid.org/0000-0002-2122-5538 https://orcid.org/0000-0002-7107-6446 https://orcid.org/0000-0003-0741-3062 https://orcid.org/0000-0002-9776-4757 https://orcid.org/0000-0001-9459-2294 |
Resumo: | Nonalcoholic fatty liver disease (NAFLD) has been identified as one of the most prevalent chronic liver disease in adults and children populations. NAFLD is usually associated with the metabolic syndrome (MS), which is chiefly related to insulin resistance and its consequences. Insulin resistance has a crucial role in the pathogenesis of hepatic steatosis and potentially nonalcoholic steatohepatitis (NASH). Because of the contemporary epidemics of MS and obesity, the burden of NAFLD is also expected to rise. Unhealthy diets, such as the so-called western diet, are enriched in fructose, trans-fatty acids and saturated fat and seem to be associated with the development of NAFLD. In human studies, certain dietary sugars, particularly fructose, are used as a substrate for lipogenesis leading to hepatic fatty infiltration, inflammation, and possibly fibrosis. Other investigations have shown that fat consumption especially cholesterol and trans/saturated fatty acids are also steatogenic and seem to increase visceral adiposity. The identification of specific dietary components that favor the development of NASH could be important for the management of this disorder. This review focuses on the effects of different dietary approaches to prevent and treat NAFLD emphasizing the macronutrients and energy composition. |
id |
UFMG_1aba2e7d1f24546f33c0ddcdab49e202 |
---|---|
oai_identifier_str |
oai:repositorio.ufmg.br:1843/56594 |
network_acronym_str |
UFMG |
network_name_str |
Repositório Institucional da UFMG |
repository_id_str |
|
spelling |
2023-07-18T16:55:39Z2023-07-18T16:55:39Z2015-10-2872425222534http://dx.doi.org/10.4254/wjh.v7.i24.25221948-5182http://hdl.handle.net/1843/56594https://orcid.org/0000-0002-2122-5538https://orcid.org/0000-0002-7107-6446https://orcid.org/0000-0003-0741-3062https://orcid.org/0000-0002-9776-4757https://orcid.org/0000-0001-9459-2294Nonalcoholic fatty liver disease (NAFLD) has been identified as one of the most prevalent chronic liver disease in adults and children populations. NAFLD is usually associated with the metabolic syndrome (MS), which is chiefly related to insulin resistance and its consequences. Insulin resistance has a crucial role in the pathogenesis of hepatic steatosis and potentially nonalcoholic steatohepatitis (NASH). Because of the contemporary epidemics of MS and obesity, the burden of NAFLD is also expected to rise. Unhealthy diets, such as the so-called western diet, are enriched in fructose, trans-fatty acids and saturated fat and seem to be associated with the development of NAFLD. In human studies, certain dietary sugars, particularly fructose, are used as a substrate for lipogenesis leading to hepatic fatty infiltration, inflammation, and possibly fibrosis. Other investigations have shown that fat consumption especially cholesterol and trans/saturated fatty acids are also steatogenic and seem to increase visceral adiposity. The identification of specific dietary components that favor the development of NASH could be important for the management of this disorder. This review focuses on the effects of different dietary approaches to prevent and treat NAFLD emphasizing the macronutrients and energy composition.A doença hepática gordurosa não alcoólica (DHGNA) foi identificada como uma das doenças crônicas do fígado mais prevalentes em adultos e crianças. A DHGNA geralmente está associada à síndrome metabólica (SM), que está relacionada principalmente à resistência à insulina e suas consequências. A resistência à insulina tem um papel crucial na patogênese da esteatose hepática e da esteatohepatite potencialmente não alcoólica (NASH). Por causa das epidemias contemporâneas de EM e obesidade, espera-se que a carga de DHGNA também aumente. Dietas não saudáveis, como a chamada dieta ocidental, são enriquecidas em frutose, ácidos graxos trans e gordura saturada e parecem estar associadas ao desenvolvimento de DHGNA. Em estudos humanos, certos açúcares da dieta, particularmente a frutose, são usados como substrato para a lipogênese, levando à infiltração gordurosa hepática, inflamação e possivelmente fibrose. Outras investigações mostraram que o consumo de gordura, especialmente colesterol e ácidos graxos trans/saturados, também são esteatogênicos e parecem aumentar a adiposidade visceral. A identificação de componentes dietéticos específicos que favorecem o desenvolvimento de NASH pode ser importante para o manejo desse distúrbio. Esta revisão enfoca os efeitos de diferentes abordagens dietéticas para prevenir e tratar a DHGNA, enfatizando os macronutrientes e a composição energética.FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisengUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAMED - DEPARTAMENTO DE CLÍNICA MÉDICAWorld Journal of HepatologyHepatopatia gordurosa não alcoólicaCarboidratos da dietaGorduras na dietaFrutoseIngestão de energiaNutrientesFatty liverDietary carbohydratesDietary fatsDietary fructoseEnergy intakeDietary approach in the treatment of nonalcoholic fatty liver diseaseAbordagem dietética no tratamento da hepatopatia gordurosa não alcoólicainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.wjgnet.com/1948-5182/full/v7/i24/2522.htmSilvia Marinho Ferolla CostaLuciana Costa SilvaMaria de Lourdes de Abreu FerrariAloísio Sales da CunhaFlaviano Dos Santos MartinsCláudia Alves CoutoTeresa Cristina de Abreu Ferrariapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALDietary approach in the treatment of nonalcoholic fatty liver disease.pdfDietary approach in the treatment of nonalcoholic fatty liver disease.pdfapplication/pdf828248https://repositorio.ufmg.br/bitstream/1843/56594/2/Dietary%20approach%20in%20the%20treatment%20of%20nonalcoholic%20fatty%20liver%20disease.pdf0a6320751f4091918749ce9c5b0e0883MD52LICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/56594/1/License.txtfa505098d172de0bc8864fc1287ffe22MD511843/565942023-07-18 13:55:40.103oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-07-18T16:55:40Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.pt_BR.fl_str_mv |
Dietary approach in the treatment of nonalcoholic fatty liver disease |
dc.title.alternative.pt_BR.fl_str_mv |
Abordagem dietética no tratamento da hepatopatia gordurosa não alcoólica |
title |
Dietary approach in the treatment of nonalcoholic fatty liver disease |
spellingShingle |
Dietary approach in the treatment of nonalcoholic fatty liver disease Silvia Marinho Ferolla Costa Fatty liver Dietary carbohydrates Dietary fats Dietary fructose Energy intake Hepatopatia gordurosa não alcoólica Carboidratos da dieta Gorduras na dieta Frutose Ingestão de energia Nutrientes |
title_short |
Dietary approach in the treatment of nonalcoholic fatty liver disease |
title_full |
Dietary approach in the treatment of nonalcoholic fatty liver disease |
title_fullStr |
Dietary approach in the treatment of nonalcoholic fatty liver disease |
title_full_unstemmed |
Dietary approach in the treatment of nonalcoholic fatty liver disease |
title_sort |
Dietary approach in the treatment of nonalcoholic fatty liver disease |
author |
Silvia Marinho Ferolla Costa |
author_facet |
Silvia Marinho Ferolla Costa Luciana Costa Silva Maria de Lourdes de Abreu Ferrari Aloísio Sales da Cunha Flaviano Dos Santos Martins Cláudia Alves Couto Teresa Cristina de Abreu Ferrari |
author_role |
author |
author2 |
Luciana Costa Silva Maria de Lourdes de Abreu Ferrari Aloísio Sales da Cunha Flaviano Dos Santos Martins Cláudia Alves Couto Teresa Cristina de Abreu Ferrari |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Silvia Marinho Ferolla Costa Luciana Costa Silva Maria de Lourdes de Abreu Ferrari Aloísio Sales da Cunha Flaviano Dos Santos Martins Cláudia Alves Couto Teresa Cristina de Abreu Ferrari |
dc.subject.por.fl_str_mv |
Fatty liver Dietary carbohydrates Dietary fats Dietary fructose Energy intake |
topic |
Fatty liver Dietary carbohydrates Dietary fats Dietary fructose Energy intake Hepatopatia gordurosa não alcoólica Carboidratos da dieta Gorduras na dieta Frutose Ingestão de energia Nutrientes |
dc.subject.other.pt_BR.fl_str_mv |
Hepatopatia gordurosa não alcoólica Carboidratos da dieta Gorduras na dieta Frutose Ingestão de energia Nutrientes |
description |
Nonalcoholic fatty liver disease (NAFLD) has been identified as one of the most prevalent chronic liver disease in adults and children populations. NAFLD is usually associated with the metabolic syndrome (MS), which is chiefly related to insulin resistance and its consequences. Insulin resistance has a crucial role in the pathogenesis of hepatic steatosis and potentially nonalcoholic steatohepatitis (NASH). Because of the contemporary epidemics of MS and obesity, the burden of NAFLD is also expected to rise. Unhealthy diets, such as the so-called western diet, are enriched in fructose, trans-fatty acids and saturated fat and seem to be associated with the development of NAFLD. In human studies, certain dietary sugars, particularly fructose, are used as a substrate for lipogenesis leading to hepatic fatty infiltration, inflammation, and possibly fibrosis. Other investigations have shown that fat consumption especially cholesterol and trans/saturated fatty acids are also steatogenic and seem to increase visceral adiposity. The identification of specific dietary components that favor the development of NASH could be important for the management of this disorder. This review focuses on the effects of different dietary approaches to prevent and treat NAFLD emphasizing the macronutrients and energy composition. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-10-28 |
dc.date.accessioned.fl_str_mv |
2023-07-18T16:55:39Z |
dc.date.available.fl_str_mv |
2023-07-18T16:55:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56594 |
dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.4254/wjh.v7.i24.2522 |
dc.identifier.issn.pt_BR.fl_str_mv |
1948-5182 |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-2122-5538 https://orcid.org/0000-0002-7107-6446 https://orcid.org/0000-0003-0741-3062 https://orcid.org/0000-0002-9776-4757 https://orcid.org/0000-0001-9459-2294 |
url |
http://dx.doi.org/10.4254/wjh.v7.i24.2522 http://hdl.handle.net/1843/56594 https://orcid.org/0000-0002-2122-5538 https://orcid.org/0000-0002-7107-6446 https://orcid.org/0000-0003-0741-3062 https://orcid.org/0000-0002-9776-4757 https://orcid.org/0000-0001-9459-2294 |
identifier_str_mv |
1948-5182 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
World Journal of Hepatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ICB - DEPARTAMENTO DE MICROBIOLOGIA MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Repositório Institucional da UFMG |
collection |
Repositório Institucional da UFMG |
bitstream.url.fl_str_mv |
https://repositorio.ufmg.br/bitstream/1843/56594/2/Dietary%20approach%20in%20the%20treatment%20of%20nonalcoholic%20fatty%20liver%20disease.pdf https://repositorio.ufmg.br/bitstream/1843/56594/1/License.txt |
bitstream.checksum.fl_str_mv |
0a6320751f4091918749ce9c5b0e0883 fa505098d172de0bc8864fc1287ffe22 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
|
_version_ |
1797971244096684032 |