Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
DOI: | 10.1590/1807-3107bor-2022.vol36.0044 |
Texto Completo: | https://doi.org/10.1590/1807-3107bor-2022.vol36.0044 http://hdl.handle.net/1843/77835 https://orcid.org/0000-0002-5265-3519 https://orcid.org/0000-0002-0993-936X https://orcid.org/0000-0001-9412-8299 https://orcid.org/0000-0003-2214-5246 https://orcid.org/0000-0003-1496-4137 https://orcid.org/0000-0003-3207-4007 https://orcid.org/0000-0001-6560-9536 https://orcid.org/0000-0002-6066-869X |
Resumo: | The aim of this study was to determine the presence of immature CD1a+ and mature CD83+ dendritic cells in oral squamous cell carcinoma, to compare immunoreactivity between smokers and nonsmokers, and to correlate the results with histopathological grading. In this observational study, twenty-eight paraffin-embedded biopsies of oral squamous cell carcinoma were retrospectively retrieved and submitted to immunohistochemistry for immature CD1a+ and mature CD83+. Descriptive and statistical analyses were performed. The sample consisted of 18 man (64.3%) and 10 women (35.7%), with a mean age of 64.6 years in the nonsmoker group and 53.2 years in the smoker group. The tongue (11 cases, 39.2%) was the most commonly affected anatomical site, followed by gingiva (6 cases, 21.4%). Histopathological grading revealed 7 low-grade and 7 high-grade malignancy cases in each group, and no correlation with the number of positive DCs. The number of immature CD1a+ was not significantly different between smoker and nonsmoker groups, while a lower number of mature CD83+ was detected in the smoker group (p = 0.001). Smoking changes the oral immune system and decreases the ability to activate and mature dendritic cells, which may influence the development and progression of oral squamous cell carcinoma. |
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Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?Dendritic cellsMouth neoplasmsTabaccoImmune systemDendritic cellsMouth neoplasmsImmune systemCorrelation of dataCarcinoma, squamous cellSmokersTongueGingivaImmunohistochemistryThe aim of this study was to determine the presence of immature CD1a+ and mature CD83+ dendritic cells in oral squamous cell carcinoma, to compare immunoreactivity between smokers and nonsmokers, and to correlate the results with histopathological grading. In this observational study, twenty-eight paraffin-embedded biopsies of oral squamous cell carcinoma were retrospectively retrieved and submitted to immunohistochemistry for immature CD1a+ and mature CD83+. Descriptive and statistical analyses were performed. The sample consisted of 18 man (64.3%) and 10 women (35.7%), with a mean age of 64.6 years in the nonsmoker group and 53.2 years in the smoker group. The tongue (11 cases, 39.2%) was the most commonly affected anatomical site, followed by gingiva (6 cases, 21.4%). Histopathological grading revealed 7 low-grade and 7 high-grade malignancy cases in each group, and no correlation with the number of positive DCs. The number of immature CD1a+ was not significantly different between smoker and nonsmoker groups, while a lower number of mature CD83+ was detected in the smoker group (p = 0.001). Smoking changes the oral immune system and decreases the ability to activate and mature dendritic cells, which may influence the development and progression of oral squamous cell carcinoma.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorUniversidade Federal de Minas GeraisBrasilFAO - DEPARTAMENTO DE CLÍNICAUFMG2024-11-05T20:12:56Z2024-11-05T20:12:56Z2022-03-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdfhttps://doi.org/10.1590/1807-3107bor-2022.vol36.00441807-3107http://hdl.handle.net/1843/77835https://orcid.org/0000-0002-5265-3519https://orcid.org/0000-0002-0993-936Xhttps://orcid.org/0000-0001-9412-8299https://orcid.org/0000-0003-2214-5246https://orcid.org/0000-0003-1496-4137https://orcid.org/0000-0003-3207-4007https://orcid.org/0000-0001-6560-9536https://orcid.org/0000-0002-6066-869XengBrazilian Oral ResearchSilene BarbieriLauren Frenzel SchuchAndreia Morales CascaesAna Paula Neutzling GomesSandra Beatriz Chaves TarquinioRicardo Alves de MesquitaAna Carolina Uchoa VasconcelosAdriana Etgesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2024-11-05T20:12:57Zoai:repositorio.ufmg.br:1843/77835Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2024-11-05T20:12:57Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
dc.title.none.fl_str_mv |
Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma? |
title |
Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma? |
spellingShingle |
Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma? Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma? Silene Barbieri Dendritic cells Mouth neoplasms Tabacco Immune system Dendritic cells Mouth neoplasms Immune system Correlation of data Carcinoma, squamous cell Smokers Tongue Gingiva Immunohistochemistry Silene Barbieri Dendritic cells Mouth neoplasms Tabacco Immune system Dendritic cells Mouth neoplasms Immune system Correlation of data Carcinoma, squamous cell Smokers Tongue Gingiva Immunohistochemistry |
title_short |
Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma? |
title_full |
Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma? |
title_fullStr |
Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma? Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma? |
title_full_unstemmed |
Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma? Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma? |
title_sort |
Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma? |
author |
Silene Barbieri |
author_facet |
Silene Barbieri Silene Barbieri Lauren Frenzel Schuch Andreia Morales Cascaes Ana Paula Neutzling Gomes Sandra Beatriz Chaves Tarquinio Ricardo Alves de Mesquita Ana Carolina Uchoa Vasconcelos Adriana Etges Lauren Frenzel Schuch Andreia Morales Cascaes Ana Paula Neutzling Gomes Sandra Beatriz Chaves Tarquinio Ricardo Alves de Mesquita Ana Carolina Uchoa Vasconcelos Adriana Etges |
author_role |
author |
author2 |
Lauren Frenzel Schuch Andreia Morales Cascaes Ana Paula Neutzling Gomes Sandra Beatriz Chaves Tarquinio Ricardo Alves de Mesquita Ana Carolina Uchoa Vasconcelos Adriana Etges |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Silene Barbieri Lauren Frenzel Schuch Andreia Morales Cascaes Ana Paula Neutzling Gomes Sandra Beatriz Chaves Tarquinio Ricardo Alves de Mesquita Ana Carolina Uchoa Vasconcelos Adriana Etges |
dc.subject.por.fl_str_mv |
Dendritic cells Mouth neoplasms Tabacco Immune system Dendritic cells Mouth neoplasms Immune system Correlation of data Carcinoma, squamous cell Smokers Tongue Gingiva Immunohistochemistry |
topic |
Dendritic cells Mouth neoplasms Tabacco Immune system Dendritic cells Mouth neoplasms Immune system Correlation of data Carcinoma, squamous cell Smokers Tongue Gingiva Immunohistochemistry |
description |
The aim of this study was to determine the presence of immature CD1a+ and mature CD83+ dendritic cells in oral squamous cell carcinoma, to compare immunoreactivity between smokers and nonsmokers, and to correlate the results with histopathological grading. In this observational study, twenty-eight paraffin-embedded biopsies of oral squamous cell carcinoma were retrospectively retrieved and submitted to immunohistochemistry for immature CD1a+ and mature CD83+. Descriptive and statistical analyses were performed. The sample consisted of 18 man (64.3%) and 10 women (35.7%), with a mean age of 64.6 years in the nonsmoker group and 53.2 years in the smoker group. The tongue (11 cases, 39.2%) was the most commonly affected anatomical site, followed by gingiva (6 cases, 21.4%). Histopathological grading revealed 7 low-grade and 7 high-grade malignancy cases in each group, and no correlation with the number of positive DCs. The number of immature CD1a+ was not significantly different between smoker and nonsmoker groups, while a lower number of mature CD83+ was detected in the smoker group (p = 0.001). Smoking changes the oral immune system and decreases the ability to activate and mature dendritic cells, which may influence the development and progression of oral squamous cell carcinoma. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03-14 2024-11-05T20:12:56Z 2024-11-05T20:12:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1590/1807-3107bor-2022.vol36.0044 1807-3107 http://hdl.handle.net/1843/77835 https://orcid.org/0000-0002-5265-3519 https://orcid.org/0000-0002-0993-936X https://orcid.org/0000-0001-9412-8299 https://orcid.org/0000-0003-2214-5246 https://orcid.org/0000-0003-1496-4137 https://orcid.org/0000-0003-3207-4007 https://orcid.org/0000-0001-6560-9536 https://orcid.org/0000-0002-6066-869X |
url |
https://doi.org/10.1590/1807-3107bor-2022.vol36.0044 http://hdl.handle.net/1843/77835 https://orcid.org/0000-0002-5265-3519 https://orcid.org/0000-0002-0993-936X https://orcid.org/0000-0001-9412-8299 https://orcid.org/0000-0003-2214-5246 https://orcid.org/0000-0003-1496-4137 https://orcid.org/0000-0003-3207-4007 https://orcid.org/0000-0001-6560-9536 https://orcid.org/0000-0002-6066-869X |
identifier_str_mv |
1807-3107 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Oral Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais Brasil FAO - DEPARTAMENTO DE CLÍNICA UFMG |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais Brasil FAO - DEPARTAMENTO DE CLÍNICA UFMG |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
instname_str |
Universidade Federal de Minas Gerais (UFMG) |
instacron_str |
UFMG |
institution |
UFMG |
reponame_str |
Repositório Institucional da UFMG |
collection |
Repositório Institucional da UFMG |
repository.name.fl_str_mv |
Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG) |
repository.mail.fl_str_mv |
repositorio@ufmg.br |
_version_ |
1822183113277571072 |
dc.identifier.doi.none.fl_str_mv |
10.1590/1807-3107bor-2022.vol36.0044 |