Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?

Detalhes bibliográficos
Autor(a) principal: Silene Barbieri
Data de Publicação: 2022
Outros Autores: Lauren Frenzel Schuch, Andreia Morales Cascaes, Ana Paula Neutzling Gomes, Sandra Beatriz Chaves Tarquinio, Ricardo Alves de Mesquita, Ana Carolina Uchoa Vasconcelos, Adriana Etges
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
DOI: 10.1590/1807-3107bor-2022.vol36.0044
Texto Completo: https://doi.org/10.1590/1807-3107bor-2022.vol36.0044
http://hdl.handle.net/1843/77835
https://orcid.org/0000-0002-5265-3519
https://orcid.org/0000-0002-0993-936X
https://orcid.org/0000-0001-9412-8299
https://orcid.org/0000-0003-2214-5246
https://orcid.org/0000-0003-1496-4137
https://orcid.org/0000-0003-3207-4007
https://orcid.org/0000-0001-6560-9536
https://orcid.org/0000-0002-6066-869X
Resumo: The aim of this study was to determine the presence of immature CD1a+ and mature CD83+ dendritic cells in oral squamous cell carcinoma, to compare immunoreactivity between smokers and nonsmokers, and to correlate the results with histopathological grading. In this observational study, twenty-eight paraffin-embedded biopsies of oral squamous cell carcinoma were retrospectively retrieved and submitted to immunohistochemistry for immature CD1a+ and mature CD83+. Descriptive and statistical analyses were performed. The sample consisted of 18 man (64.3%) and 10 women (35.7%), with a mean age of 64.6 years in the nonsmoker group and 53.2 years in the smoker group. The tongue (11 cases, 39.2%) was the most commonly affected anatomical site, followed by gingiva (6 cases, 21.4%). Histopathological grading revealed 7 low-grade and 7 high-grade malignancy cases in each group, and no correlation with the number of positive DCs. The number of immature CD1a+ was not significantly different between smoker and nonsmoker groups, while a lower number of mature CD83+ was detected in the smoker group (p = 0.001). Smoking changes the oral immune system and decreases the ability to activate and mature dendritic cells, which may influence the development and progression of oral squamous cell carcinoma.
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spelling Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?Dendritic cellsMouth neoplasmsTabaccoImmune systemDendritic cellsMouth neoplasmsImmune systemCorrelation of dataCarcinoma, squamous cellSmokersTongueGingivaImmunohistochemistryThe aim of this study was to determine the presence of immature CD1a+ and mature CD83+ dendritic cells in oral squamous cell carcinoma, to compare immunoreactivity between smokers and nonsmokers, and to correlate the results with histopathological grading. In this observational study, twenty-eight paraffin-embedded biopsies of oral squamous cell carcinoma were retrospectively retrieved and submitted to immunohistochemistry for immature CD1a+ and mature CD83+. Descriptive and statistical analyses were performed. The sample consisted of 18 man (64.3%) and 10 women (35.7%), with a mean age of 64.6 years in the nonsmoker group and 53.2 years in the smoker group. The tongue (11 cases, 39.2%) was the most commonly affected anatomical site, followed by gingiva (6 cases, 21.4%). Histopathological grading revealed 7 low-grade and 7 high-grade malignancy cases in each group, and no correlation with the number of positive DCs. The number of immature CD1a+ was not significantly different between smoker and nonsmoker groups, while a lower number of mature CD83+ was detected in the smoker group (p = 0.001). Smoking changes the oral immune system and decreases the ability to activate and mature dendritic cells, which may influence the development and progression of oral squamous cell carcinoma.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorUniversidade Federal de Minas GeraisBrasilFAO - DEPARTAMENTO DE CLÍNICAUFMG2024-11-05T20:12:56Z2024-11-05T20:12:56Z2022-03-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlepdfapplication/pdfhttps://doi.org/10.1590/1807-3107bor-2022.vol36.00441807-3107http://hdl.handle.net/1843/77835https://orcid.org/0000-0002-5265-3519https://orcid.org/0000-0002-0993-936Xhttps://orcid.org/0000-0001-9412-8299https://orcid.org/0000-0003-2214-5246https://orcid.org/0000-0003-1496-4137https://orcid.org/0000-0003-3207-4007https://orcid.org/0000-0001-6560-9536https://orcid.org/0000-0002-6066-869XengBrazilian Oral ResearchSilene BarbieriLauren Frenzel SchuchAndreia Morales CascaesAna Paula Neutzling GomesSandra Beatriz Chaves TarquinioRicardo Alves de MesquitaAna Carolina Uchoa VasconcelosAdriana Etgesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMG2024-11-05T20:12:57Zoai:repositorio.ufmg.br:1843/77835Repositório InstitucionalPUBhttps://repositorio.ufmg.br/oairepositorio@ufmg.bropendoar:2024-11-05T20:12:57Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.none.fl_str_mv Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
title Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
spellingShingle Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
Silene Barbieri
Dendritic cells
Mouth neoplasms
Tabacco
Immune system
Dendritic cells
Mouth neoplasms
Immune system
Correlation of data
Carcinoma, squamous cell
Smokers
Tongue
Gingiva
Immunohistochemistry
Silene Barbieri
Dendritic cells
Mouth neoplasms
Tabacco
Immune system
Dendritic cells
Mouth neoplasms
Immune system
Correlation of data
Carcinoma, squamous cell
Smokers
Tongue
Gingiva
Immunohistochemistry
title_short Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
title_full Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
title_fullStr Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
title_full_unstemmed Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
title_sort Does smoking habit affect dendritic cell expression in oral squamous cell carcinoma?
author Silene Barbieri
author_facet Silene Barbieri
Silene Barbieri
Lauren Frenzel Schuch
Andreia Morales Cascaes
Ana Paula Neutzling Gomes
Sandra Beatriz Chaves Tarquinio
Ricardo Alves de Mesquita
Ana Carolina Uchoa Vasconcelos
Adriana Etges
Lauren Frenzel Schuch
Andreia Morales Cascaes
Ana Paula Neutzling Gomes
Sandra Beatriz Chaves Tarquinio
Ricardo Alves de Mesquita
Ana Carolina Uchoa Vasconcelos
Adriana Etges
author_role author
author2 Lauren Frenzel Schuch
Andreia Morales Cascaes
Ana Paula Neutzling Gomes
Sandra Beatriz Chaves Tarquinio
Ricardo Alves de Mesquita
Ana Carolina Uchoa Vasconcelos
Adriana Etges
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silene Barbieri
Lauren Frenzel Schuch
Andreia Morales Cascaes
Ana Paula Neutzling Gomes
Sandra Beatriz Chaves Tarquinio
Ricardo Alves de Mesquita
Ana Carolina Uchoa Vasconcelos
Adriana Etges
dc.subject.por.fl_str_mv Dendritic cells
Mouth neoplasms
Tabacco
Immune system
Dendritic cells
Mouth neoplasms
Immune system
Correlation of data
Carcinoma, squamous cell
Smokers
Tongue
Gingiva
Immunohistochemistry
topic Dendritic cells
Mouth neoplasms
Tabacco
Immune system
Dendritic cells
Mouth neoplasms
Immune system
Correlation of data
Carcinoma, squamous cell
Smokers
Tongue
Gingiva
Immunohistochemistry
description The aim of this study was to determine the presence of immature CD1a+ and mature CD83+ dendritic cells in oral squamous cell carcinoma, to compare immunoreactivity between smokers and nonsmokers, and to correlate the results with histopathological grading. In this observational study, twenty-eight paraffin-embedded biopsies of oral squamous cell carcinoma were retrospectively retrieved and submitted to immunohistochemistry for immature CD1a+ and mature CD83+. Descriptive and statistical analyses were performed. The sample consisted of 18 man (64.3%) and 10 women (35.7%), with a mean age of 64.6 years in the nonsmoker group and 53.2 years in the smoker group. The tongue (11 cases, 39.2%) was the most commonly affected anatomical site, followed by gingiva (6 cases, 21.4%). Histopathological grading revealed 7 low-grade and 7 high-grade malignancy cases in each group, and no correlation with the number of positive DCs. The number of immature CD1a+ was not significantly different between smoker and nonsmoker groups, while a lower number of mature CD83+ was detected in the smoker group (p = 0.001). Smoking changes the oral immune system and decreases the ability to activate and mature dendritic cells, which may influence the development and progression of oral squamous cell carcinoma.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-14
2024-11-05T20:12:56Z
2024-11-05T20:12:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1590/1807-3107bor-2022.vol36.0044
1807-3107
http://hdl.handle.net/1843/77835
https://orcid.org/0000-0002-5265-3519
https://orcid.org/0000-0002-0993-936X
https://orcid.org/0000-0001-9412-8299
https://orcid.org/0000-0003-2214-5246
https://orcid.org/0000-0003-1496-4137
https://orcid.org/0000-0003-3207-4007
https://orcid.org/0000-0001-6560-9536
https://orcid.org/0000-0002-6066-869X
url https://doi.org/10.1590/1807-3107bor-2022.vol36.0044
http://hdl.handle.net/1843/77835
https://orcid.org/0000-0002-5265-3519
https://orcid.org/0000-0002-0993-936X
https://orcid.org/0000-0001-9412-8299
https://orcid.org/0000-0003-2214-5246
https://orcid.org/0000-0003-1496-4137
https://orcid.org/0000-0003-3207-4007
https://orcid.org/0000-0001-6560-9536
https://orcid.org/0000-0002-6066-869X
identifier_str_mv 1807-3107
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Oral Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
FAO - DEPARTAMENTO DE CLÍNICA
UFMG
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
Brasil
FAO - DEPARTAMENTO DE CLÍNICA
UFMG
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
repository.name.fl_str_mv Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)
repository.mail.fl_str_mv repositorio@ufmg.br
_version_ 1822183113277571072
dc.identifier.doi.none.fl_str_mv 10.1590/1807-3107bor-2022.vol36.0044