Níveis plasmáticos de IL-6, mobilidade funcional e a qualidade de vida em idosas com dor lombar aguda

• Autor(a) principal: Erica Paulino Silva
• Data de Publicação: 2016
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Institucional da UFMG
• Texto Completo: http://hdl.handle.net/1843/BUBD-AQFK82
• topic: Dor lombar; Mobilidade funcional; Qualidade de vida; Citocinas; Dor lombar; Estilo de vida; Idosos Saude e higiene

Introduction: The low back pain (LBP) is a condition highly prevalent that affects most of the elderly, and the aging of the population has become a reality. Both are strongly associated to immunological alterations that lead to increased concentrations of inflammatory markers including interleukin (IL)-6. Pain negatively affects the functional mobility and can compromise the quality of life. Objective: To investigate the correlation between plasma levels of IL-6, functional mobility and quality of life in elderly with acute LBP. Methods: The study was conducted from a sub-sample of elderly women (65 years) from the epidemiological study Back Complaints in the Elders (BACE). Participants with cognitive alterations, visual, auditory and / or motor deficiencies that afected the mobility test were excluded, as well as presenting an acute inflammatory disease or neoplasia. Measurements of IL-6 were made by blood plasma sample using the ELISA method. Functional mobility was assessed by the Timed Up and Go (TUG) test. Pain was classified according to the numerical pain score and the quality of life by the Short Form questionnaire (36) Health Survey - SF 36. Results: The population was composed by 155 elderly women with a mean age of 70.78 (± 5.30), who presented the IL-6 plasma levels of 1.99 (± 1.70) pg / ml. There was significant positive correlation between IL-6 and the TUG test (p = 0.004, r = 0.230), and negative correlation between IL-6 and two domains of the SF-36: vitality (p = 0.015, r = -0.199) and emotional aspects (p = 0.019, r = -0.191). The longer time for performance of TUG is correlated with a lower score for quality of life in most of its areas and the greater intensity of pain in the last 24 hours (p = 0.012, r = 0.202) and last week (p = 0.002, r = 0.244). Conclusion: Elderly with LBP have impaired health related quality life. Plasma levels of IL-6 correlates with the worst mobility and the worst vitality and emotional aspects of the SF 36. The longer TUG is related to worse scores health related quality life and greater intensity of pain.