Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | https://doi.org/10.5935/2446-4775.20180013 http://hdl.handle.net/1843/61464 https://orcid.org/0000-0002-7803-4345 https://orcid.org/0000-0002-8831-1609 https://orcid.org/0000-0001-7656-1849 https://orcid.org/0000-0002-0560-8491 |
Resumo: | FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
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2023-11-28T18:53:30Z2023-11-28T18:53:30Z2018122135146https://doi.org/10.5935/2446-4775.201800132446-4775http://hdl.handle.net/1843/61464https://orcid.org/0000-0002-7803-4345https://orcid.org/0000-0002-8831-1609https://orcid.org/0000-0001-7656-1849https://orcid.org/0000-0002-0560-8491FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)In this study, we isolated and characterized dichloromethane and hexane extracts, complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD), of Schinus terebinthifolius fruits. Such complexation may be useful in the formulation of herbal medicines, by improving solubility, or increasing stability by reducing the loss of volatile compounds. The cytotoxicity in osteoblasts, antifungal against Malassezia furfur and antitumor activities were evaluated in Caco-2 cells. The antifungal activity of the extracts and the essential oil in natura or complexed with HP-β-CD against the fungus M. furfur was evaluated by agar diffusion methods and quantitatively by inhibitory concentration (IC). All samples inhibited fungus growth and, when complexed with HP-β-CD, the IC was reduced by 50%. Osteoblast cell viability was not affected by the presence of extracts and oil. The antitumor activity of the extract in dichloromethane was evaluated using Caco-2 cells. The results demonstrated significant reduction in cell viability in the presence of the extract, which makes it a promising candidate for cancer treatment.engUniversidade Federal de Minas GeraisUFMGBrasilFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORAICB - INSTITUTO DE CIÊNCIAS BIOLOGICASICX - DEPARTAMENTO DE QUÍMICARevista FitosAgentes antineoplásicosAtividade antifúngicaAntimicóticosCiclodextrinasAroeira-vermelhaEssencias e óleos essenciais - Uso terapêuticoMatéria médica vegetalDiclorometanoSchinus terebinthifoliusAntifungalAntitumorCyclodextrinMalassezia furfurChemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruitinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.arca.fiocruz.br/handle/icict/27868Mariana S. de OliveiraSávio Morato Lacerda GontijoMarina S. TeixeiraKarina Imaculada Rosa TeixeiraJacqueline Aparecida TakahashiRubén Dario Sinisterra MillánMaría Esperanza Cortés Seguraapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/61464/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALChemical composition and antifungal and anticancer activities of extracts and essential oils of schinus terebinthifolius raddi fruit.pdfChemical composition and antifungal and anticancer activities of extracts and essential oils of schinus terebinthifolius raddi fruit.pdfapplication/pdf556892https://repositorio.ufmg.br/bitstream/1843/61464/2/Chemical%20composition%20and%20antifungal%20and%20anticancer%20activities%20of%20extracts%20and%20essential%20oils%20of%20schinus%20terebinthifolius%20raddi%20fruit.pdf2b27f976464036df177efa09ce549551MD521843/614642023-11-28 15:53:30.78oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2023-11-28T18:53:30Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
| title |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
| spellingShingle |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit Mariana S. de Oliveira Schinus terebinthifolius Antifungal Antitumor Cyclodextrin Malassezia furfur Agentes antineoplásicos Atividade antifúngica Antimicóticos Ciclodextrinas Aroeira-vermelha Essencias e óleos essenciais - Uso terapêutico Matéria médica vegetal Diclorometano |
| title_short |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
| title_full |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
| title_fullStr |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
| title_full_unstemmed |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
| title_sort |
Chemical composition and antifungal and anticancer activities of extracts and essential oils of Schinus terebinthifolius Raddi fruit |
| author |
Mariana S. de Oliveira |
| author_facet |
Mariana S. de Oliveira Sávio Morato Lacerda Gontijo Marina S. Teixeira Karina Imaculada Rosa Teixeira Jacqueline Aparecida Takahashi Rubén Dario Sinisterra Millán María Esperanza Cortés Segura |
| author_role |
author |
| author2 |
Sávio Morato Lacerda Gontijo Marina S. Teixeira Karina Imaculada Rosa Teixeira Jacqueline Aparecida Takahashi Rubén Dario Sinisterra Millán María Esperanza Cortés Segura |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Mariana S. de Oliveira Sávio Morato Lacerda Gontijo Marina S. Teixeira Karina Imaculada Rosa Teixeira Jacqueline Aparecida Takahashi Rubén Dario Sinisterra Millán María Esperanza Cortés Segura |
| dc.subject.por.fl_str_mv |
Schinus terebinthifolius Antifungal Antitumor Cyclodextrin Malassezia furfur |
| topic |
Schinus terebinthifolius Antifungal Antitumor Cyclodextrin Malassezia furfur Agentes antineoplásicos Atividade antifúngica Antimicóticos Ciclodextrinas Aroeira-vermelha Essencias e óleos essenciais - Uso terapêutico Matéria médica vegetal Diclorometano |
| dc.subject.other.pt_BR.fl_str_mv |
Agentes antineoplásicos Atividade antifúngica Antimicóticos Ciclodextrinas Aroeira-vermelha Essencias e óleos essenciais - Uso terapêutico Matéria médica vegetal Diclorometano |
| description |
FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018 |
| dc.date.accessioned.fl_str_mv |
2023-11-28T18:53:30Z |
| dc.date.available.fl_str_mv |
2023-11-28T18:53:30Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1843/61464 |
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https://doi.org/10.5935/2446-4775.20180013 |
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2446-4775 |
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https://orcid.org/0000-0002-7803-4345 https://orcid.org/0000-0002-8831-1609 https://orcid.org/0000-0001-7656-1849 https://orcid.org/0000-0002-0560-8491 |
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https://doi.org/10.5935/2446-4775.20180013 http://hdl.handle.net/1843/61464 https://orcid.org/0000-0002-7803-4345 https://orcid.org/0000-0002-8831-1609 https://orcid.org/0000-0001-7656-1849 https://orcid.org/0000-0002-0560-8491 |
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2446-4775 |
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eng |
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eng |
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Revista Fitos |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS ICX - DEPARTAMENTO DE QUÍMICA |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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Universidade Federal de Minas Gerais (UFMG) |
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