Evaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFMG |
| Texto Completo: | http://hdl.handle.net/1843/44259 |
Resumo: | CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
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2022-08-16T11:30:21Z2022-08-16T11:30:21Z2016-0627540741610.1097/CAD.00000000000003421473-5741http://hdl.handle.net/1843/44259CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorThe purpose of the current study was to develop and test a theoretical model that could explain the mechanism of action of gallic acid (GA) in the oral squamous cell carcinoma context for the first time. The theoretical model was developed using bioinformatics and interaction network analysis to evaluate the effect of GA on oral squamous cell carcinoma. In a second step to confirm theoretical results, migration, invasion, proliferation, and gene expression (Col1A1, E-cadherin, HIF-1α, and caspase-3) were performed under normoxic and hypoxic conditions. Our study indicated that treatment with GA resulted in the inhibition of cell proliferation, migration, and invasion in neoplastic cells. Observation of the molecular mechanism showed that GA upregulates E-cadherin expression and downregulates Col1A1 and HIF-1α expression, suggesting that GA might be a potential anticancer compound. In conclusion, the present study demonstrated that GA significantly reduces cell proliferation, invasion, and migration by increasing E-cadherin and repressing Col1A1.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASAnti-Cancer DrugsBoca - CâncerApoptoseÁcido gálicoBioinformáticaCélulas - ProliferaçãoTumoresEvaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://journals.lww.com/anti-cancerdrugs/Fulltext/2016/06000/Evaluation_of_the_antineoplastic_activity_of.4.aspxTalita Antunes GuimarãesLucyana Conceição FariasCarlos Alberto de Carvalho FragaJohn David FeltenbergerGeraldo Aclécio MeloRicardo Della ColettaSergio Henrique Sousa SantosAlfredo Maurício Batista de PaulaAndré Luiz Sena Guimarãesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44259/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALEvaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions.pdfEvaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions.pdfapplication/pdf454849https://repositorio.ufmg.br/bitstream/1843/44259/2/Evaluation%20of%20the%20antineoplastic%20activity%20of%20gallic%20acid%20in%20oral%20squamous%20cell%20carcinoma%20under%20hypoxic%20conditions.pdf27886bb3e7ef323b3b18f2fde4f4ebf6MD521843/442592022-08-16 08:30:22.04oai:repositorio.ufmg.br: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Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-16T11:30:22Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false |
| dc.title.pt_BR.fl_str_mv |
Evaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions |
| title |
Evaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions |
| spellingShingle |
Evaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions Talita Antunes Guimarães Boca - Câncer Apoptose Ácido gálico Bioinformática Células - Proliferação Tumores |
| title_short |
Evaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions |
| title_full |
Evaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions |
| title_fullStr |
Evaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions |
| title_full_unstemmed |
Evaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions |
| title_sort |
Evaluation of the antineoplastic activity of gallic acid in oral squamous cell carcinoma under hypoxic conditions |
| author |
Talita Antunes Guimarães |
| author_facet |
Talita Antunes Guimarães Lucyana Conceição Farias Carlos Alberto de Carvalho Fraga John David Feltenberger Geraldo Aclécio Melo Ricardo Della Coletta Sergio Henrique Sousa Santos Alfredo Maurício Batista de Paula André Luiz Sena Guimarães |
| author_role |
author |
| author2 |
Lucyana Conceição Farias Carlos Alberto de Carvalho Fraga John David Feltenberger Geraldo Aclécio Melo Ricardo Della Coletta Sergio Henrique Sousa Santos Alfredo Maurício Batista de Paula André Luiz Sena Guimarães |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Talita Antunes Guimarães Lucyana Conceição Farias Carlos Alberto de Carvalho Fraga John David Feltenberger Geraldo Aclécio Melo Ricardo Della Coletta Sergio Henrique Sousa Santos Alfredo Maurício Batista de Paula André Luiz Sena Guimarães |
| dc.subject.other.pt_BR.fl_str_mv |
Boca - Câncer Apoptose Ácido gálico Bioinformática Células - Proliferação Tumores |
| topic |
Boca - Câncer Apoptose Ácido gálico Bioinformática Células - Proliferação Tumores |
| description |
CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| publishDate |
2016 |
| dc.date.issued.fl_str_mv |
2016-06 |
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2022-08-16T11:30:21Z |
| dc.date.available.fl_str_mv |
2022-08-16T11:30:21Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/1843/44259 |
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10.1097/CAD.0000000000000342 |
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1473-5741 |
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10.1097/CAD.0000000000000342 1473-5741 |
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http://hdl.handle.net/1843/44259 |
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eng |
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eng |
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Anti-Cancer Drugs |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade Federal de Minas Gerais |
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UFMG |
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Brasil |
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ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
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Universidade Federal de Minas Gerais |
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reponame:Repositório Institucional da UFMG instname:Universidade Federal de Minas Gerais (UFMG) instacron:UFMG |
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