Bioinformatics analysis reveals genes involved in the pathogenesis of ameloblastoma and keratocystic odontogenic tumor

Detalhes bibliográficos
Autor(a) principal: Eliane Macedo Sobrinho Santos
Data de Publicação: 2016
Outros Autores: Hércules Otacílio Santos, Ivoneth dos Santos Dias, Sergio Henrique Sousa Santos, Alfredo Maurício Batista de Paula, John David Feltenberger, André Luiz Sena Guimarães, Lucyana Conceição Farias
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFMG
Texto Completo: http://hdl.handle.net/1843/44214
Resumo: CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
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spelling 2022-08-12T11:45:20Z2022-08-12T11:45:20Z2016-12-06541992192251-9637http://hdl.handle.net/1843/44214CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorPathogenesis of odontogenic tumors is not well known. It is important to identify genetic deregulations and molecular alterations. This study aimed to investigate, through bioinformatic analysis, the possible genes involved in the pathogenesis of ameloblastoma (AM) and keratocystic odontogenic tumor (KCOT). Genes involved in the pathogenesis of AM and KCOT were identified in GeneCards. Gene list was expanded, and the gene interactions network was mapped using the STRING software. “Weighted number of links” (WNL) was calculated to identify “leader genes” (highest WNL). Genes were ranked by K-means method and Kruskal-Wallis test was used (P<0.001). Total interactions score (TIS) was also calculated using all interaction data generated by the STRING database, in order to achieve global connectivity for each gene. The topological and ontological analyses were performed using Cytoscape software and BinGO plugin. Literature review data was used to corroborate the bioinformatics data. CDK1 was identified as leader gene for AM. In KCOT group, results show PCNA and TP53. Both tumors exhibit a power law behavior. Our topological analysis suggested leader genes possibly important in the pathogenesis of AM and KCOT, by clustering coefficient calculated for both odontogenic tumors (0.028 for AM, zero for KCOT). The results obtained in the scatter diagram suggest an important relationship of these genes with the molecular processes involved in AM and KCOT. Ontological analysis for both AM and KCOT demonstrated different mechanisms. Bioinformatics analyzes were confirmed through literature review. These results may suggest the involvement of promising genes for a better understanding of the pathogenesis of AM and KCOT.engUniversidade Federal de Minas GeraisUFMGBrasilICA - INSTITUTO DE CIÊNCIAS AGRÁRIASInternational Journal of Molecular and Cellular MedicineCarcinogêneseTumores odontogênicosCélulas - ProliferaçãoBioinformáticaBioinformatics analysis reveals genes involved in the pathogenesis of ameloblastoma and keratocystic odontogenic tumorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353982/Eliane Macedo Sobrinho SantosHércules Otacílio SantosIvoneth dos Santos DiasSergio Henrique Sousa SantosAlfredo Maurício Batista de PaulaJohn David FeltenbergerAndré Luiz Sena GuimarãesLucyana Conceição Fariasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGLICENSELicense.txtLicense.txttext/plain; charset=utf-82042https://repositorio.ufmg.br/bitstream/1843/44214/1/License.txtfa505098d172de0bc8864fc1287ffe22MD51ORIGINALBioinformatics Analysis Reveals Genes Involved in the Pathogenesis of Ameloblastoma and Keratocystic Odontogenic Tumor.pdfBioinformatics Analysis Reveals Genes Involved in the Pathogenesis of Ameloblastoma and Keratocystic Odontogenic Tumor.pdfapplication/pdf3900403https://repositorio.ufmg.br/bitstream/1843/44214/2/Bioinformatics%20Analysis%20Reveals%20Genes%20Involved%20in%20the%20Pathogenesis%20of%20Ameloblastoma%20and%20Keratocystic%20Odontogenic%20Tumor.pdf1005d9f8b9d5b78e1802bd327eb0493bMD521843/442142022-08-12 08:45:20.976oai:repositorio.ufmg.br:1843/44214TElDRU7vv71BIERFIERJU1RSSUJVSe+/ve+/vU8gTu+/vU8tRVhDTFVTSVZBIERPIFJFUE9TSVTvv71SSU8gSU5TVElUVUNJT05BTCBEQSBVRk1HCiAKCkNvbSBhIGFwcmVzZW50Ye+/ve+/vW8gZGVzdGEgbGljZW7vv71hLCB2b2Pvv70gKG8gYXV0b3IgKGVzKSBvdSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGRlIGF1dG9yKSBjb25jZWRlIGFvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIChSSS1VRk1HKSBvIGRpcmVpdG8gbu+/vW8gZXhjbHVzaXZvIGUgaXJyZXZvZ++/vXZlbCBkZSByZXByb2R1emlyIGUvb3UgZGlzdHJpYnVpciBhIHN1YSBwdWJsaWNh77+977+9byAoaW5jbHVpbmRvIG8gcmVzdW1vKSBwb3IgdG9kbyBvIG11bmRvIG5vIGZvcm1hdG8gaW1wcmVzc28gZSBlbGV0cu+/vW5pY28gZSBlbSBxdWFscXVlciBtZWlvLCBpbmNsdWluZG8gb3MgZm9ybWF0b3Mg77+9dWRpbyBvdSB277+9ZGVvLgoKVm9j77+9IGRlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zvv710aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8gZSBxdWUgY29uaGVjZSBlIGFjZWl0YSBhcyBEaXJldHJpemVzIGRvIFJJLVVGTUcuCgpWb2Pvv70gY29uY29yZGEgcXVlIG8gUmVwb3NpdO+/vXJpbyBJbnN0aXR1Y2lvbmFsIGRhIFVGTUcgcG9kZSwgc2VtIGFsdGVyYXIgbyBjb250Ze+/vWRvLCB0cmFuc3BvciBhIHN1YSBwdWJsaWNh77+977+9byBwYXJhIHF1YWxxdWVyIG1laW8gb3UgZm9ybWF0byBwYXJhIGZpbnMgZGUgcHJlc2VydmHvv73vv71vLgoKVm9j77+9IHRhbWLvv71tIGNvbmNvcmRhIHF1ZSBvIFJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRk1HIHBvZGUgbWFudGVyIG1haXMgZGUgdW1hIGPvv71waWEgZGUgc3VhIHB1YmxpY2Hvv73vv71vIHBhcmEgZmlucyBkZSBzZWd1cmFu77+9YSwgYmFjay11cCBlIHByZXNlcnZh77+977+9by4KClZvY++/vSBkZWNsYXJhIHF1ZSBhIHN1YSBwdWJsaWNh77+977+9byDvv70gb3JpZ2luYWwgZSBxdWUgdm9j77+9IHRlbSBvIHBvZGVyIGRlIGNvbmNlZGVyIG9zIGRpcmVpdG9zIGNvbnRpZG9zIG5lc3RhIGxpY2Vu77+9YS4gVm9j77+9IHRhbWLvv71tIGRlY2xhcmEgcXVlIG8gZGVw77+9c2l0byBkZSBzdWEgcHVibGljYe+/ve+/vW8gbu+/vW8sIHF1ZSBzZWphIGRlIHNldSBjb25oZWNpbWVudG8sIGluZnJpbmdlIGRpcmVpdG9zIGF1dG9yYWlzIGRlIG5pbmd177+9bS4KCkNhc28gYSBzdWEgcHVibGljYe+/ve+/vW8gY29udGVuaGEgbWF0ZXJpYWwgcXVlIHZvY++/vSBu77+9byBwb3NzdWkgYSB0aXR1bGFyaWRhZGUgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCB2b2Pvv70gZGVjbGFyYSBxdWUgb2J0ZXZlIGEgcGVybWlzc++/vW8gaXJyZXN0cml0YSBkbyBkZXRlbnRvciBkb3MgZGlyZWl0b3MgYXV0b3JhaXMgcGFyYSBjb25jZWRlciBhbyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBvcyBkaXJlaXRvcyBhcHJlc2VudGFkb3MgbmVzdGEgbGljZW7vv71hLCBlIHF1ZSBlc3NlIG1hdGVyaWFsIGRlIHByb3ByaWVkYWRlIGRlIHRlcmNlaXJvcyBlc3Tvv70gY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyBubyB0ZXh0byBvdSBubyBjb250Ze+/vWRvIGRhIHB1YmxpY2Hvv73vv71vIG9yYSBkZXBvc2l0YWRhLgoKQ0FTTyBBIFBVQkxJQ0Hvv73vv71PIE9SQSBERVBPU0lUQURBIFRFTkhBIFNJRE8gUkVTVUxUQURPIERFIFVNIFBBVFJPQ++/vU5JTyBPVSBBUE9JTyBERSBVTUEgQUfvv71OQ0lBIERFIEZPTUVOVE8gT1UgT1VUUk8gT1JHQU5JU01PLCBWT0Pvv70gREVDTEFSQSBRVUUgUkVTUEVJVE9VIFRPRE9TIEUgUVVBSVNRVUVSIERJUkVJVE9TIERFIFJFVklT77+9TyBDT01PIFRBTULvv71NIEFTIERFTUFJUyBPQlJJR0Hvv73vv71FUyBFWElHSURBUyBQT1IgQ09OVFJBVE8gT1UgQUNPUkRPLgoKTyBSZXBvc2l077+9cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZNRyBzZSBjb21wcm9tZXRlIGEgaWRlbnRpZmljYXIgY2xhcmFtZW50ZSBvIHNldSBub21lKHMpIG91IG8ocykgbm9tZXMocykgZG8ocykgZGV0ZW50b3IoZXMpIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyBkYSBwdWJsaWNh77+977+9bywgZSBu77+9byBmYXLvv70gcXVhbHF1ZXIgYWx0ZXJh77+977+9bywgYWzvv71tIGRhcXVlbGFzIGNvbmNlZGlkYXMgcG9yIGVzdGEgbGljZW7vv71hLgo=Repositório de PublicaçõesPUBhttps://repositorio.ufmg.br/oaiopendoar:2022-08-12T11:45:20Repositório Institucional da UFMG - Universidade Federal de Minas Gerais (UFMG)false
dc.title.pt_BR.fl_str_mv Bioinformatics analysis reveals genes involved in the pathogenesis of ameloblastoma and keratocystic odontogenic tumor
title Bioinformatics analysis reveals genes involved in the pathogenesis of ameloblastoma and keratocystic odontogenic tumor
spellingShingle Bioinformatics analysis reveals genes involved in the pathogenesis of ameloblastoma and keratocystic odontogenic tumor
Eliane Macedo Sobrinho Santos
Carcinogênese
Tumores odontogênicos
Células - Proliferação
Bioinformática
title_short Bioinformatics analysis reveals genes involved in the pathogenesis of ameloblastoma and keratocystic odontogenic tumor
title_full Bioinformatics analysis reveals genes involved in the pathogenesis of ameloblastoma and keratocystic odontogenic tumor
title_fullStr Bioinformatics analysis reveals genes involved in the pathogenesis of ameloblastoma and keratocystic odontogenic tumor
title_full_unstemmed Bioinformatics analysis reveals genes involved in the pathogenesis of ameloblastoma and keratocystic odontogenic tumor
title_sort Bioinformatics analysis reveals genes involved in the pathogenesis of ameloblastoma and keratocystic odontogenic tumor
author Eliane Macedo Sobrinho Santos
author_facet Eliane Macedo Sobrinho Santos
Hércules Otacílio Santos
Ivoneth dos Santos Dias
Sergio Henrique Sousa Santos
Alfredo Maurício Batista de Paula
John David Feltenberger
André Luiz Sena Guimarães
Lucyana Conceição Farias
author_role author
author2 Hércules Otacílio Santos
Ivoneth dos Santos Dias
Sergio Henrique Sousa Santos
Alfredo Maurício Batista de Paula
John David Feltenberger
André Luiz Sena Guimarães
Lucyana Conceição Farias
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Eliane Macedo Sobrinho Santos
Hércules Otacílio Santos
Ivoneth dos Santos Dias
Sergio Henrique Sousa Santos
Alfredo Maurício Batista de Paula
John David Feltenberger
André Luiz Sena Guimarães
Lucyana Conceição Farias
dc.subject.other.pt_BR.fl_str_mv Carcinogênese
Tumores odontogênicos
Células - Proliferação
Bioinformática
topic Carcinogênese
Tumores odontogênicos
Células - Proliferação
Bioinformática
description CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
publishDate 2016
dc.date.issued.fl_str_mv 2016-12-06
dc.date.accessioned.fl_str_mv 2022-08-12T11:45:20Z
dc.date.available.fl_str_mv 2022-08-12T11:45:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1843/44214
dc.identifier.issn.pt_BR.fl_str_mv 2251-9637
identifier_str_mv 2251-9637
url http://hdl.handle.net/1843/44214
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv International Journal of Molecular and Cellular Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.publisher.initials.fl_str_mv UFMG
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
publisher.none.fl_str_mv Universidade Federal de Minas Gerais
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFMG
instname:Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG
instname_str Universidade Federal de Minas Gerais (UFMG)
instacron_str UFMG
institution UFMG
reponame_str Repositório Institucional da UFMG
collection Repositório Institucional da UFMG
bitstream.url.fl_str_mv https://repositorio.ufmg.br/bitstream/1843/44214/1/License.txt
https://repositorio.ufmg.br/bitstream/1843/44214/2/Bioinformatics%20Analysis%20Reveals%20Genes%20Involved%20in%20the%20Pathogenesis%20of%20Ameloblastoma%20and%20Keratocystic%20Odontogenic%20Tumor.pdf
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