Whey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in mice
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFMG |
Texto Completo: | https://doi.org/10.3389/fmicb.2018.02035 http://hdl.handle.net/1843/56410 https://orcid.org/0000-0001-6055-9541 https://orcid.org/0000-0003-1542-2372 https://orcid.org/0000-0002-2981-5479 https://orcid.org/0000-0002-2410-3499 https://orcid.org/0000-0002-4556-7671 https://orcid.org/0000-0002-0604-8510 https://orcid.org/0000-0002-1835-0303 https://orcid.org/0000-0002-0355-1065 https://orcid.org/0000-0001-8694-3381 https://orcid.org/0000-0002-4775-2280 https://orcid.org/0000-0003-4405-1013 |
Resumo: | Mucositis is a clinically important gastrointestinal inflammatory infirmity, generated by antineoplastic drugs cytotoxic effects. The inflammatory process caused by this disease frequently leads to derangements in the alimentary tract and great malaise for the patient. Novel strategies are necessary for its prevention or treatment, as currently available treatments of mucositis have several limitations in relieving its symptoms. In this context, several research groups have investigated the use of probiotic bacteria, and in particular dairy bacterial strains. Compelling evidences reveal that milk fermented by certain probiotic bacteria has the capacity to ameliorate intestinal inflammatory disorders. In addition, innovative probiotic delivery strategies, based on probiotics incorporation into protective matrices, such as whey proteins, were able to increase the therapeutic effect of probiotic strains by providing extra protection for bacteria against environmental stresses. Therefore, in this study, we evaluated the role of the whey protein isolate (WPI), when added to skim milk fermented by Lactobacillus casei BL23 (L. casei BL23) or by Propionibacterium freudenreichii CIRM-BIA138 (P. freudenreichii 138), as a protective matrix against in vitro stress challenges. In addition, we investigated the therapeutic effect of these fermented beverages in a murine model of mucositis induced by 5-Fluorouracil (5-FU). Our results demonstrated that milk supplementation with 30% (w/v) of WPI increases the survival rate of both strains when challenged with acid, bile salts, high temperature and cold storage stresses, compared to fermented skim milk without the addition of WPI. Moreover, treatment with the probiotic beverages prevented weight loss and intestinal damages in mice receiving 5-FU. We conclude that the presence of WPI maximizes the anti-inflammatory effects of L. casei BL23, but not for P. freudenreichii 138, suggesting that whey protein enhancement of probiotic activity might be strain-dependent. |
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2023-07-17T17:57:25Z2023-07-17T17:57:25Z20189https://doi.org/10.3389/fmicb.2018.020351664-302Xhttp://hdl.handle.net/1843/56410https://orcid.org/0000-0001-6055-9541https://orcid.org/0000-0003-1542-2372https://orcid.org/0000-0002-2981-5479https://orcid.org/0000-0002-2410-3499https://orcid.org/0000-0002-4556-7671https://orcid.org/0000-0002-0604-8510https://orcid.org/0000-0002-1835-0303https://orcid.org/0000-0002-0355-1065https://orcid.org/0000-0001-8694-3381https://orcid.org/0000-0002-4775-2280https://orcid.org/0000-0003-4405-1013Mucositis is a clinically important gastrointestinal inflammatory infirmity, generated by antineoplastic drugs cytotoxic effects. The inflammatory process caused by this disease frequently leads to derangements in the alimentary tract and great malaise for the patient. Novel strategies are necessary for its prevention or treatment, as currently available treatments of mucositis have several limitations in relieving its symptoms. In this context, several research groups have investigated the use of probiotic bacteria, and in particular dairy bacterial strains. Compelling evidences reveal that milk fermented by certain probiotic bacteria has the capacity to ameliorate intestinal inflammatory disorders. In addition, innovative probiotic delivery strategies, based on probiotics incorporation into protective matrices, such as whey proteins, were able to increase the therapeutic effect of probiotic strains by providing extra protection for bacteria against environmental stresses. Therefore, in this study, we evaluated the role of the whey protein isolate (WPI), when added to skim milk fermented by Lactobacillus casei BL23 (L. casei BL23) or by Propionibacterium freudenreichii CIRM-BIA138 (P. freudenreichii 138), as a protective matrix against in vitro stress challenges. In addition, we investigated the therapeutic effect of these fermented beverages in a murine model of mucositis induced by 5-Fluorouracil (5-FU). Our results demonstrated that milk supplementation with 30% (w/v) of WPI increases the survival rate of both strains when challenged with acid, bile salts, high temperature and cold storage stresses, compared to fermented skim milk without the addition of WPI. Moreover, treatment with the probiotic beverages prevented weight loss and intestinal damages in mice receiving 5-FU. We conclude that the presence of WPI maximizes the anti-inflammatory effects of L. casei BL23, but not for P. freudenreichii 138, suggesting that whey protein enhancement of probiotic activity might be strain-dependent.A mucosite é uma enfermidade inflamatória gastrointestinal clinicamente importante, gerada pelos efeitos citotóxicos de drogas antineoplásicas. O processo inflamatório causado por esta doença freqüentemente leva a distúrbios no trato alimentar e grande mal-estar para o paciente. Novas estratégias são necessárias para sua prevenção ou tratamento, pois os tratamentos atualmente disponíveis para mucosite apresentam várias limitações no alívio de seus sintomas. Nesse contexto, vários grupos de pesquisa têm investigado o uso de bactérias probióticas, em particular cepas de bactérias lácteas. Evidências convincentes revelam que o leite fermentado por certas bactérias probióticas tem a capacidade de melhorar os distúrbios inflamatórios intestinais. Além disso, estratégias inovadoras de entrega de probióticos, baseadas na incorporação de probióticos em matrizes protetoras, como proteínas de soro de leite, foram capazes de aumentar o efeito terapêutico de cepas probióticas, fornecendo proteção extra para bactérias contra estresses ambientais. Portanto, neste estudo, avaliamos o papel do isolado de proteína de soro de leite (WPI), quando adicionado ao leite desnatado fermentado por Lactobacillus casei BL23 (L. casei BL23) ou por Propionibacterium freudenreichii CIRM-BIA138 (P. freudenreichii 138), como uma matriz protetora contra desafios de estresse in vitro. Além disso, investigamos o efeito terapêutico dessas bebidas fermentadas em um modelo murino de mucosite induzida por 5-Fluorouracil (5-FU). Nossos resultados demonstraram que a suplementação de leite com 30% (p/v) de WPI aumenta a taxa de sobrevivência de ambas as cepas quando desafiadas com ácido, sais biliares, alta temperatura e estresse de armazenamento a frio, em comparação com leite desnatado fermentado sem adição de WPI. Além disso, o tratamento com as bebidas probióticas preveniu a perda de peso e danos intestinais em camundongos que receberam 5-FU. Concluímos que a presença de WPI maximiza os efeitos antiinflamatórios de L. casei BL23, mas não para P. freudenreichii 138, sugerindo que o aumento da atividade probiótica da proteína de soro de leite pode ser dependente da cepa.CNPq - Conselho Nacional de Desenvolvimento Científico e TecnológicoFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas GeraisCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorengUniversidade Federal de Minas GeraisUFMGBrasilICB - DEPARTAMENTO DE PATOLOGIAFrontiers in MicrobiologyLactobacillusMucositeProbióticosPropionibacteriumProteínas do soro do leiteLactobacillusMucositisProbioticsPropionibacteriumStress toleranceWhey protein isolateWhey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in miceBebida suplementada com isolado de proteína de soro de leite, fermentado por Lactobacillus casei BL23 e Propionibacterium freudenreichii 138, na prevenção de mucosite em camundongosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.frontiersin.org/articles/10.3389/fmicb.2018.02035/fullBárbara Fernandes CordeiroEmiliano Rosa OliveiraSara Heloisa SilvaBruna Machado SavassiLeonardo Borges AcurcioLuisa Lemos SantosJuliana Lima AlvesHerder Carvalho AssisAngelica Thomaz VieiraAna Maria Caetano FariaEnio FerreiraYves le LoirGwénaël JanLuiz Ricardo GoulartVasco Ariston de Carvalho AzevedoRodrigo Dias de Oliveira CarvalhoFillipe Luiz Rosa do Carmoapplication/pdfinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFMGinstname:Universidade Federal de Minas Gerais (UFMG)instacron:UFMGORIGINALWhey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in mice.pdfWhey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in mice.pdfapplication/pdf4100519https://repositorio.ufmg.br/bitstream/1843/56410/2/Whey%20protein%20isolate-supplemented%20beverage%2c%20fermented%20by%20Lactobacillus%20casei%20BL23%20and%20Propionibacterium%20freudenreichii%20138%2c%20in%20the%20prevention%20of%20mucositis%20in%20mice.pdffe615804199275e8ddade829d0408b0fMD52LICENSELicense.txtLicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Whey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in mice |
dc.title.alternative.pt_BR.fl_str_mv |
Bebida suplementada com isolado de proteína de soro de leite, fermentado por Lactobacillus casei BL23 e Propionibacterium freudenreichii 138, na prevenção de mucosite em camundongos |
title |
Whey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in mice |
spellingShingle |
Whey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in mice Bárbara Fernandes Cordeiro Lactobacillus Mucositis Probiotics Propionibacterium Stress tolerance Whey protein isolate Lactobacillus Mucosite Probióticos Propionibacterium Proteínas do soro do leite |
title_short |
Whey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in mice |
title_full |
Whey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in mice |
title_fullStr |
Whey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in mice |
title_full_unstemmed |
Whey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in mice |
title_sort |
Whey protein isolate-supplemented beverage, fermented by Lactobacillus casei BL23 and Propionibacterium freudenreichii 138, in the prevention of mucositis in mice |
author |
Bárbara Fernandes Cordeiro |
author_facet |
Bárbara Fernandes Cordeiro Emiliano Rosa Oliveira Sara Heloisa Silva Bruna Machado Savassi Leonardo Borges Acurcio Luisa Lemos Santos Juliana Lima Alves Herder Carvalho Assis Angelica Thomaz Vieira Ana Maria Caetano Faria Enio Ferreira Yves le Loir Gwénaël Jan Luiz Ricardo Goulart Vasco Ariston de Carvalho Azevedo Rodrigo Dias de Oliveira Carvalho Fillipe Luiz Rosa do Carmo |
author_role |
author |
author2 |
Emiliano Rosa Oliveira Sara Heloisa Silva Bruna Machado Savassi Leonardo Borges Acurcio Luisa Lemos Santos Juliana Lima Alves Herder Carvalho Assis Angelica Thomaz Vieira Ana Maria Caetano Faria Enio Ferreira Yves le Loir Gwénaël Jan Luiz Ricardo Goulart Vasco Ariston de Carvalho Azevedo Rodrigo Dias de Oliveira Carvalho Fillipe Luiz Rosa do Carmo |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bárbara Fernandes Cordeiro Emiliano Rosa Oliveira Sara Heloisa Silva Bruna Machado Savassi Leonardo Borges Acurcio Luisa Lemos Santos Juliana Lima Alves Herder Carvalho Assis Angelica Thomaz Vieira Ana Maria Caetano Faria Enio Ferreira Yves le Loir Gwénaël Jan Luiz Ricardo Goulart Vasco Ariston de Carvalho Azevedo Rodrigo Dias de Oliveira Carvalho Fillipe Luiz Rosa do Carmo |
dc.subject.por.fl_str_mv |
Lactobacillus Mucositis Probiotics Propionibacterium Stress tolerance Whey protein isolate |
topic |
Lactobacillus Mucositis Probiotics Propionibacterium Stress tolerance Whey protein isolate Lactobacillus Mucosite Probióticos Propionibacterium Proteínas do soro do leite |
dc.subject.other.pt_BR.fl_str_mv |
Lactobacillus Mucosite Probióticos Propionibacterium Proteínas do soro do leite |
description |
Mucositis is a clinically important gastrointestinal inflammatory infirmity, generated by antineoplastic drugs cytotoxic effects. The inflammatory process caused by this disease frequently leads to derangements in the alimentary tract and great malaise for the patient. Novel strategies are necessary for its prevention or treatment, as currently available treatments of mucositis have several limitations in relieving its symptoms. In this context, several research groups have investigated the use of probiotic bacteria, and in particular dairy bacterial strains. Compelling evidences reveal that milk fermented by certain probiotic bacteria has the capacity to ameliorate intestinal inflammatory disorders. In addition, innovative probiotic delivery strategies, based on probiotics incorporation into protective matrices, such as whey proteins, were able to increase the therapeutic effect of probiotic strains by providing extra protection for bacteria against environmental stresses. Therefore, in this study, we evaluated the role of the whey protein isolate (WPI), when added to skim milk fermented by Lactobacillus casei BL23 (L. casei BL23) or by Propionibacterium freudenreichii CIRM-BIA138 (P. freudenreichii 138), as a protective matrix against in vitro stress challenges. In addition, we investigated the therapeutic effect of these fermented beverages in a murine model of mucositis induced by 5-Fluorouracil (5-FU). Our results demonstrated that milk supplementation with 30% (w/v) of WPI increases the survival rate of both strains when challenged with acid, bile salts, high temperature and cold storage stresses, compared to fermented skim milk without the addition of WPI. Moreover, treatment with the probiotic beverages prevented weight loss and intestinal damages in mice receiving 5-FU. We conclude that the presence of WPI maximizes the anti-inflammatory effects of L. casei BL23, but not for P. freudenreichii 138, suggesting that whey protein enhancement of probiotic activity might be strain-dependent. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2023-07-17T17:57:25Z |
dc.date.available.fl_str_mv |
2023-07-17T17:57:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1843/56410 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3389/fmicb.2018.02035 |
dc.identifier.issn.pt_BR.fl_str_mv |
1664-302X |
dc.identifier.orcid.pt_BR.fl_str_mv |
https://orcid.org/0000-0001-6055-9541 https://orcid.org/0000-0003-1542-2372 https://orcid.org/0000-0002-2981-5479 https://orcid.org/0000-0002-2410-3499 https://orcid.org/0000-0002-4556-7671 https://orcid.org/0000-0002-0604-8510 https://orcid.org/0000-0002-1835-0303 https://orcid.org/0000-0002-0355-1065 https://orcid.org/0000-0001-8694-3381 https://orcid.org/0000-0002-4775-2280 https://orcid.org/0000-0003-4405-1013 |
url |
https://doi.org/10.3389/fmicb.2018.02035 http://hdl.handle.net/1843/56410 https://orcid.org/0000-0001-6055-9541 https://orcid.org/0000-0003-1542-2372 https://orcid.org/0000-0002-2981-5479 https://orcid.org/0000-0002-2410-3499 https://orcid.org/0000-0002-4556-7671 https://orcid.org/0000-0002-0604-8510 https://orcid.org/0000-0002-1835-0303 https://orcid.org/0000-0002-0355-1065 https://orcid.org/0000-0001-8694-3381 https://orcid.org/0000-0002-4775-2280 https://orcid.org/0000-0003-4405-1013 |
identifier_str_mv |
1664-302X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Frontiers in Microbiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.publisher.initials.fl_str_mv |
UFMG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
ICB - DEPARTAMENTO DE PATOLOGIA |
publisher.none.fl_str_mv |
Universidade Federal de Minas Gerais |
dc.source.none.fl_str_mv |
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Universidade Federal de Minas Gerais (UFMG) |
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UFMG |
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UFMG |
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Repositório Institucional da UFMG |
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Repositório Institucional da UFMG |
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